Study of rate of cooling and warming at different sites of the body following extracorporeal cooling and rewarming in patients during open heart surgery

Anyone anxious to know more about developments in the rapidly-expanding field of surgical repair of congenital defects of the heart by open-heart techniques will find this paper instructive. The various types of apparatus which have been used to maintain the circulation and oxygenation of blood outside the body, leaving the heart free for surgical repair, are described. The physiologic changes during total-body perfusion and the means taken to insure homeostasis during the procedure are discussed. The author gives a brief description of his experience in the repair of congenital defects of the heart with the various techniques. A considerable body of interesting information is provided in a succinct and clear fashion for the general reader.

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Effects of cardiopulmonary bypass on the coagulation system

Cardiology in the Young ◽

10.1017/s1047951100001645 ◽

1993 ◽

Vol 3 (3) ◽

pp. 251-256 ◽

Cited By ~ 1

Author(s):

L. Henry Edmunds

Keyword(s):

Cardiopulmonary Bypass ◽

Heart Surgery ◽

Open Heart Surgery ◽

The Body ◽

Coagulation System ◽

Open Heart ◽

Vasoactive Substances

Cardiopulmonary bypass makes a mess of homeostasis. Extracorporeal perfusion produces pulseless flow without physiologic controls, showers microemboli throughout the body, and brings blood diluted with additives to an enzymatic boil. Much of the morbidity associated with open heart surgery is due to contact of blood with the synthetic surfaces of the extracorporeal perfusion circuit. Bypass temporarily impairs function of every organ, alters concentrations of over 25 vasoactive substances within the plasma, and causes massive retention of fluid. In short, cardiopulmonary bypass makes patients sick.

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Clinical evaluation of the LeukoGuard (LG-6) arterial line filter for routine open-heart surgery

Perfusion ◽

10.1177/026765919300800608 ◽

1993 ◽

Vol 8 (6) ◽

pp. 489-496 ◽

Cited By ~ 49

Author(s):

David A Palanzo ◽

Norman J Manley ◽

Ralph M Montesano ◽

Geary L Yeisley ◽

David Gordon

Keyword(s):

Clinical Evaluation ◽

Heart Surgery ◽

Open Heart Surgery ◽

Cost Effective ◽

The Body ◽

Experimental Investigations ◽

Arterial Line ◽

X Rays ◽

Open Heart ◽

Activated Neutrophils

Research has demonstrated that leucocyte depletion diminishes the deleterious effects that activated neutrophils have on the body following cardiopulmonary bypass (CPB). A clinical evaluation involving 36 patients (18 in each group) was conducted to compare the use of the Pall LG-6 (leucocyte-depleting) arterial line filter with the Pall EC PLUS filter for postoperative complications and lung function on routine open-heart cases. No differences were found between the groups for postoperative chest tube drainage, urine output, on bypass platelet drop, chest X-rays, blood usage and circulating elastase levels. Statistically significant differences were observed between immediately post-CPB pO 2 values and ventilator hours (EC PLUS = 13.3, LG-6 = 9.2). Many of the advantages of using leucocyte depletion that have been illustrated through experimental investigations were comparable to our clinical observations. We conclude that using the LG-6 leucocyte-depleting arterial line filter is a cost-effective method to reduce the complications known as 'postperfusion' syndrome.

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Effect of Open-Heart Surgery on the Body Composition of Infants and Young Children

Pediatric Research ◽

10.1203/00006450-198107000-00009 ◽

1981 ◽

Vol 15 (7) ◽

pp. 1024-1028 ◽

Cited By ~ 29

Author(s):

Yves W Brans ◽

Harry S Dweck ◽

Howard B Harris ◽

Grant V S Parr ◽

Penrhyn E Bailey ◽

...

Keyword(s):

Body Composition ◽

Young Children ◽

Heart Surgery ◽

Open Heart Surgery ◽

The Body ◽

Open Heart ◽

Infants And Young Children

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Posttraumatic Growth following Open-heart Surgery: The Role of Religious Coping and the Underlying Mechanism

PsycEXTRA Dataset ◽

10.1037/e576422013-001 ◽

2013 ◽

Author(s):

Amy Ai

Keyword(s):

Posttraumatic Growth ◽

Religious Coping ◽

Heart Surgery ◽

Open Heart Surgery ◽

Underlying Mechanism ◽

Open Heart

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The Hemostatic Mechanism after Open-Heart Surgery

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646707 ◽

1978 ◽

Vol 39 (02) ◽

pp. 474-487 ◽

Cited By ~ 2

Author(s):

E R Cole ◽

F Bachmann ◽

C A Curry ◽

D Roby

Keyword(s):

Extracorporeal Circulation ◽

Heart Surgery ◽

Polyacrylamide Gel Electrophoresis ◽

Open Heart Surgery ◽

Coagulation System ◽

Open Heart ◽

Time Activity ◽

Post Surgery ◽

Plasma Fractions ◽

The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

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Blood Coagulation Studies and Extracorporeal Circulation in Man

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655073 ◽

1967 ◽

Vol 18 (03/04) ◽

pp. 634-646 ◽

Cited By ~ 6

Author(s):

N Thurnherr

Keyword(s):

Blood Coagulation ◽

Extracorporeal Circulation ◽

Blood Clotting ◽

Heart Surgery ◽

Open Heart Surgery ◽

Fibrinolytic System ◽

Open Heart ◽

Clotting Factors ◽

Blood Clotting Factors

SummaryBlood clotting investigations have been executed in 25 patients who have undergone open heart surgery with extracorporeal circulation. A description of alterations in the activity of blood clotting factors, the fibrinolytic system, prothrombin consumption and platelets during several phases of the operation is given.

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