Clinical study on electrophysiological evaluation of asymptomatic neuropathy in alcohol dependence syndrome

Background: Alcohol dependence is a significant public health problem, contributing to the global health burden. Due to its immense socio-economic burden, various psychosocial, psychological, and pharmacological approaches have attempted to alter the behaviour of the patient misusing or abusing alcohol, but their efficacy is modest at best. Therefore, there is a search for newer treatment approaches, including noninvasive brain stimulation in the management of alcohol dependence. We plan to study the efficacy of Prefrontal Cortex Transcranial direct current stimulation Treatment in Alcohol dependence syndrome (PreCoTTA). Methods: Two hundred twenty-five male patients with alcohol dependence syndrome will be randomized into the three study arms (2 active, left dorsolateral prefrontal cortex and left orbitofrontal cortex, and 1 sham) to receive a total of 14 tDCS sessions (10 continuous and 4 booster sessions). Data will be collected from them at five different time points on clinical, neuropsychological and biochemical parameters. In addition, 225 healthy age and education matched controls will be administered the neuropsychological test battery at baseline for comparison with the patient group. Discussion: The proposed study aims to explore the use of non-invasive brain stimulation; tDCS as a treatment alternative. We also aim to overcome the methodological gaps of limited sample sizes, fewer tDCS intervention sessions, lack of long term follow ups to measure the sustainability of gains and lack comprehensive measures to track changes in functioning and abstinence after tDCS intervention. The main outcomes include clinical (reduction in cue-induced craving, time to first drink and QFI); neuropsychological (risk-taking, impulsivity, and other neuropsychological domains) and biochemical markers (BDNF, leptin and adiponectin). The findings of the study will have translational value as it may help to improve the clinician’s ability to effectively manage craving in patients with alcohol dependence syndrome. Furthermore, we will have a better understanding of the neuropsychological and biochemical effects of non-invasive brain stimulation techniques which are of interest in the comprehensive treatment of addiction disorders. Trial registration: The study has been registered with the Clinical Trials Registry-India (CTRI/2020/09/027582) on September 03rd 2020.

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Calcium Channel Antagonists Attenuate the Alcohol Dependence Syndrome

Novel Pharmacological Interventions for Alcoholism ◽

10.1007/978-1-4612-2878-3_46 ◽

1992 ◽

pp. 356-365

Author(s):

C. A. Naranjo ◽

T. Fan

Keyword(s):

Alcohol Dependence ◽

Calcium Channel ◽

Calcium Channel Antagonists ◽

Alcohol Dependence Syndrome

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Alcohol-related seizures may be associated with more severe depression, alcohol dependence syndrome, and more pronounced alcohol-related problems

Epilepsy & Behavior ◽

10.1016/j.yebeh.2018.10.023 ◽

2019 ◽

Vol 91 ◽

pp. 81-85 ◽

Cited By ~ 1

Author(s):

Evija Gutmane ◽

Normunds Suna ◽

Anastasija Tomilova ◽

Lelde Liepina ◽

Valdis Folkmanis ◽

...

Keyword(s):

Alcohol Dependence ◽

Severe Depression ◽

Alcohol Dependence Syndrome ◽

Alcohol Related Problems

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Lipid profile in patients with alcohol dependence syndrome

Annals of Clinical Chemistry and Laboratory Medicine ◽

10.3126/acclm.v1i1.12312 ◽

2015 ◽

Vol 1 (1) ◽

pp. 29-32

Author(s):

Mithileshwer Raut ◽

Prashant Regmi ◽

Saroj Prasad Ojha ◽

Bharat Jha

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Lipid Metabolism ◽

Alcohol Use ◽

Alcohol Dependence ◽

Lipid Profile ◽

Consumption Pattern ◽

Cholesterol Levels ◽

Alcohol Dependence Syndrome ◽

The Mean

BACKGROUND: Alcohol dependence syndrome (ADS) has become a global public health challenge because of its high prevalence and the concomitant increase in risk of liver disease, cardiovascular disease and premature death. Influence of alcohol use on lipid metabolism is well recognized. Investigations had been carried out in the earlier period on abnormal lipid profile as a risk factor for Coronary Heart disease (CHD). Patients of alcohol dependence usually have a consumption pattern of more heavy use. Therefore it is useful to study the lipid profile in patients of alcohol dependence, to understand the effects of increasing levels of consumption. METHODS: This cross-sectional study was conducted in TU Teaching Hospital. ADS patients were screened by the consultant psychiatrist using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire. A total of 89 patients scored positive on the AUDIT as having alcohol-related problems and were included in the study. 89 ADS patients and 89 healthy controls both male and female were enrolled as participants. Blood Pressure and other anthropometric parameters were measured while fasting blood samples were analyzed for serum lipid profile. SPSS program was used to analyze data, t-test & Spearman's correlation coefficient was used to find correlation. RESULTS: Among the ADS cases 95% were current smokers. Mean age of cases and controls was 35.42±5.6 & 34.53±3.5 years respectively. The mean total cholesterol levels were found to be higher in cases (5.41±0.70) than controls (3.79±0.74) with a strong statistical significance (p<0.001). Also, Mean triglyceride (TG) levels (2.09±0.72), along with the mean HDL-cholesterol (1.66±0.40) and LDL-cholesterol levels (2.79±0.81) were also elevated in cases when compared to the control samples (p<0.001). CONCLUSION: This study has demonstrated definitive lipid profile changes in patients of alcohol dependence, with some correlation to the liver dysfunction. Alcohol causes alteration in various parameters of lipid metabolism including those which predispose to CHD. Low to moderate alcohol use over prolonged periods has been linked to have protective influence for development of coronary heart disease (CHD), through increase in high density lipoprotein cholesterol (HDL-C) levels. DOI: http://dx.doi.org/10.3126/acclm.v1i1.12312 Ann. Clin. Chem. & Lab. Med. 1(1) 2015: 29-32

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REGIONAL EPIDEMIOLOGY OF ALCOHOLIC DEPENDENCE SYNDROME

Health Care of the Russian Federation ◽

10.18821/0044-197x-2019-63-2-79-85 ◽

2019 ◽

Vol 63 (2) ◽

pp. 79-85

Author(s):

Raisa Ya. Khamitova ◽

D. V. Loskutov

Keyword(s):

Public Health ◽

Alcohol Consumption ◽

Alcohol Dependence ◽

Urban Areas ◽

Psychotic Disorders ◽

Chronic Alcoholism ◽

Alcoholic Beverages ◽

Consumption Pattern ◽

Positive Trend ◽

Alcohol Dependence Syndrome

Introduction. There are variable patterns of alcohol consumption in Russia that differ significantly between the regions. Awareness and knowledge of those regional differences are key to the effectiveness of measures to prevent and minimise possible damage to public health caused by alcohol consumption. The purpose. To identify regional characteristics of the dynamics of alcoholism and alcoholic psychosis and dependencies with indicators of the implementation and consumption of alcohol in Mari El in 2006-2017. Material and methods. In a retrospective analysis, they included state statistics and bulletins of the Office of Rospotrebnadzor on RME on the primary incidence and prevalence of alcohol dependence syndrome, chronic alcoholism, AP, acute alcohol poisoning, sales of alcohol through a distribution network in 2006-2017. Results. In the reported period of 2006-2017 there was a decline in determination coefficient (R2) from 0.76 to 0.96 for newly diagnosed cases of alcohol dependence in general, alcoholic psychosis and alcoholism in Mari El. There was a significant decline from 221.6 to 47.5 per 100 thousand in the range of values between regions, but higher rates remained among the rural and urban areas (p = 0.0002). The dynamics of the prevalence of alcoholic psychotic disorders and alcoholism were also on decline. Conclusion. The direction and extent of changes in the medical consequences of alcohol consumption (such as primary morbidity and prevalence of alcohol dependence syndrome, alcoholic psychosis and alcoholism, average duration of the course, number of alcoholic psychosis) in the region and indicators of the implementation and consumption of alcoholic beverages in the reported period can be evaluated as positive. It is crucial to ensure the positive trend in the alcohol consumption pattern and impact on public health in the region becomes a long-lasting one. At the same time, it is necessary to increase attention to the assistance and treatment provided to drug users patient.

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