scholarly journals Lipid profile in patients with alcohol dependence syndrome

2015 ◽  
Vol 1 (1) ◽  
pp. 29-32
Author(s):  
Mithileshwer Raut ◽  
Prashant Regmi ◽  
Saroj Prasad Ojha ◽  
Bharat Jha
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Metabolism ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Lipid Profile ◽  
Consumption Pattern ◽  
Cholesterol Levels ◽  
Alcohol Dependence Syndrome ◽  
The Mean

BACKGROUND: Alcohol dependence syndrome (ADS) has become a global public health challenge because of its high prevalence and the concomitant increase in risk of liver disease, cardiovascular disease and premature death. Influence of alcohol use on lipid metabolism is well recognized. Investigations had been carried out in the earlier period on abnormal lipid profile as a risk factor for Coronary Heart disease (CHD). Patients of alcohol dependence usually have a consumption pattern of more heavy use. Therefore it is useful to study the lipid profile in patients of alcohol dependence, to understand the effects of increasing levels of consumption. METHODS: This cross-sectional study was conducted in TU Teaching Hospital. ADS patients were screened by the consultant psychiatrist using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire. A total of 89 patients scored positive on the AUDIT as having alcohol-related problems and were included in the study. 89 ADS patients and 89 healthy controls both male and female were enrolled as participants. Blood Pressure and other anthropometric parameters were measured while fasting blood samples were analyzed for serum lipid profile. SPSS program was used to analyze data, t-test & Spearman's correlation coefficient was used to find correlation. RESULTS: Among the ADS cases 95% were current smokers. Mean age of cases and controls was 35.42±5.6 & 34.53±3.5 years respectively. The mean total cholesterol levels were found to be higher in cases (5.41±0.70) than controls (3.79±0.74) with a strong statistical significance (p<0.001). Also, Mean triglyceride (TG) levels (2.09±0.72), along with the mean HDL-cholesterol (1.66±0.40) and LDL-cholesterol levels (2.79±0.81) were also elevated in cases when compared to the control samples (p<0.001). CONCLUSION: This study has demonstrated definitive lipid profile changes in patients of alcohol dependence, with some correlation to the liver dysfunction. Alcohol causes alteration in various parameters of lipid metabolism including those which predispose to CHD. Low to moderate alcohol use over prolonged periods has been linked to have protective influence for development of coronary heart disease (CHD), through increase in high density lipoprotein cholesterol (HDL-C) levels. DOI: http://dx.doi.org/10.3126/acclm.v1i1.12312 Ann. Clin. Chem. & Lab. Med. 1(1) 2015: 29-32

scholarly journals KESESUAIAN KOLESTEROL LDL HASIL PERHITUNGAN SEJUMLAH FORMULA DENGAN KOLESTEROL LDL DIREK METODE ENZIMATIK

2021 ◽  
Vol 5 (2) ◽  
pp. 281
Author(s):  
Dona Liazarti ◽  
May Valzon
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ldl Cholesterol ◽  
Clinical Chemistry ◽  
Inclusion Criteria ◽  
Altman Plot ◽  
Cholesterol Levels ◽  
The Mean ◽  
Friedewald Formula ◽  
Enzymatic Methods

Increased cholesterol levels are the main cause of coronary heart disease. The results of examining LDL must be precise and accurate, but direct LDL examination (LDL-Direct) is quite expensive to do in a place with limited facilities so various experiments are carried out to get LDL formula (LDL-Cal) that is appropriate than formula commonly used, Friedewald formula. The aimed of this study was to determine the correlation between LDL cholesterol from calculation a number formulas with direct LDL cholesterol in order to obtain the best formula to be applied in laboratory of Lubuk Sikaping Hospital. This research was conducted on 75 patients who did lipid profile examination in laboratory of Lubuk Sikaping Hospital, who meet the inclusion criteria. Examination of total cholesterol, HDL, LDL and triglycerides were carried out by enzymatic methods on clinical chemistry analyzer. LDL cholesterol also calculated by several formulas namely Friedelwald formula (TC- (TG/5) -HDL), Chen formula (90% nonHDLC-10% TG), Anandaraja formula (0.9 TC- (0.9 TG/5) -28), Puavilai formula (TC-HDLC-TG/6), Vujovic formula (TC-HDLC-TG/3), and Cordova formula (3/4 (TC-HDLC.) Bland & Altman plot was used to compare the calculated LDL cholesterol level of each formula with the direct LDL. The mean LDL levels were 136.41 (35.92); 116.64 (32.72); 117.03 (30.83); 121.95 (32.79); 121.83 (33.23); 96.84 (32.47); 109.97 (28.24) for Direct, Friedelwald, Chen, Anandaraja, Puavilai, Vujovic, and Cordova respectively. Based on the Bland & Altman Plot, the calculation of LDL cholesterol from the Chen formula has the best compatibility with LDL-Direk with the mean difference of 19.3867 ± 19.0489 mg / dl at triglyceride levels <400 mg / dl, so it can be applied at RSUD Lubuk Sikaping with limited facilities. Keywords: LDL Cholesterol; LDL-Direct; LDL-CalAbstrakPeningkatan kadar kolesterol merupakan penyebab utama penyakit jantung koroner. Hasil pemeriksaan kadar LDL serum harus tepat dan akurat, namun pemeriksaan kadar LDL secara langsung (LDL-Direk) cukup mahal untuk dilakukan di tempat dengan fasilitas terbatas sehingga dilakukan berbagai percobaan untuk mendapatkan formula perhitungan LDL (LDL-Cal) yang lebih tepat dibandingkan formula yang telah umum digunakan yaitu formula Friedewald. Penelitian ini bertujuan untuk mengetahui kesesuaian antara kolesterol LDL hasil perhitungan sejumlah formula dengan kolesterol LDL direk sehingga diperoleh formula perhitungan terbaik untuk dapat diterapkan di laboratorium RSUD Lubuk Sikaping. Penelitian ini dilakukan terhadap 75 orang pasien yang melakukan pemeriksaan profil lipid lengkap ke Laboratorium RSUD Lubuk Sikaping. yang memenuhi kriteria inklusi. Pemeriksaan kolesterol total, HDL, LDL dan trigliserida dilakukan dengan metode enzimatik pada alat kimia klinik otomatis. Untuk kolesterol LDL juga dihitung dengan beberapa rumus yaitu formula Friedelwald (TC-(TG/5)-HDL). formula Chen (90%nonHDLC-10%TG), formula Anandaraja (0.9 TC- (0.9 TG/5)-28), formula Puavilai (TC-HDLC-TG/6), formula Vujovic (TC-HDLC-TG/3), dan formula Cordova (3/4 (TC-HDLC). Bland & Altman plot digunakan untuk membandingkan antara kadar kolesterol LDL hasil hitung masing-masing formula dengan LDL direk. Rerata kadar LDL (mg/dl) berturut-turut adalah 136,41 (35,92); 116,64 (32,72); 117,03 (30,83); 121,95 (32,79); 121,83 (33,23); 96,84 (32,47); 109,97 (28,24) untuk LDL-Direk, Friedelwald, Chen, Anandaraja, Puavilai, Vujovic, dan Cordova. Berdasarkan Bland & Altman Plot, perhitungan kolesterol LDL Formula Chen memiliki kesesuaian paling baik dengan LDL-Direk dengan selisih rerata 19,3867 ± 19,0489 mg/dl pada kadar trigliserida < 400 mg/dl, sehingga dapat diterapkan di RSUD Lubuk Sikaping dengan fasilitas yang terbatas.

scholarly journals Study on Role of Nitric Oxide and High Sensitive C - reactive protein in subjects with Coronary Heart Disease

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3068-3072
Author(s):  
Keerthi Karini ◽  
Thirunavukkarasu Jaishankar ◽  
Kasthuri Natarajan ◽  
Balasubramanian Kannan
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Profile ◽  
Research Centre ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Mean ◽  
Hs Crp

Nitric Oxide (NO) where produced by endothelial nitric oxide synthase (eNOS) enzyme which are inhibited by C-reactive protein (CRP) which causes endothelial dysfunction and cardiovascular events. In the current study, we evaluated the association of NO with hs-CRP in subjects with coronary heart disease. This Case-Control study was conducted 60 CHD patients and 60 healthy controls in age group of 30 to 55 years at SRM Medical College Hospital and Research Centre on subjects attending the Cardiology and medicine OP. Blood samples were collected after overnight fasting for analysis of Lipid Profile, High sensitive C-reactive protein. Nitric Oxide and High sensitive C-reactive protein is measured by ELISA method and Lipid Profile is measured using Auto Analyzer AU480. Statistical analysis was done using Student ‘t’ test and Pearson correlation analysis used to the variable between two groups. The mean level of LDL-C (161.9±27.46) and hs-CRP (6.80±1.35) were significantly elevated in CHD subjects when compared to the normal healthy controls. And the mean level of Nitric Oxide (12.97±1.20) were decreased significantly in CHD group when compared to controls. Increased oxidative stress associated with low grade inflammation lead to diminished bioavailability of nitric oxide.

scholarly journals Cholesterol Screening in Children and Family History of Coronary Heart Disease.

Circulation ◽  
2001 ◽  
Vol 103 (suppl_1) ◽  
pp. 1369-1369
Author(s):  
Viktorina N Muratova ◽  
Syed S Islam ◽  
Emily C Spangler ◽  
Ellen W Demerath ◽  
William A Neal
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Lipid Profile ◽  
School Children ◽  
Preventive Health Care ◽  
Blood Cholesterol ◽  
Cholesterol Screening ◽  
Cholesterol Levels ◽  
History Of

P94 Background: Selective blood cholesterol screening of children based upon National Cholesterol Education Program (NCEP) guidelines of family history of premature cardiovascular disease (CVD) or parental hypercholesterolemia is inadequate in a population with high prevalence of coronary heart disease (CHD), low levels of cholesterol screening, low socio-economic status (SES) and diminished access to preventive health care. We hypothesize that universal cholesterol screening of pre-pubertal school children may be effective in identifying children and their parents with abnormal lipid levels in this high risk rural population. Fifth grade school children from seven rural Appalachian counties participated in a school based cholesterol screening program. Data on family history of premature CHD, anthropometric and blood pressure measurements, tobacco smoke exposure, dietary history and physical activity levels were collected at the time of screening. Seven hundred and nine 5 th grade students ( mean age 10.8 years) participated in the program. One hundred seventy four (24.5%) were considered presumptively dyslipidemic after non-fasting finger- stick (FS) cholesterol screening. Thirty six percent of these dyslipidemic children had a fasting lipid profile done. Dyslipidemia was confirmed in 37(59%) of these children. FS cholesterol levels were significantly correlated with fasting TC (r=0.80 p < 0.0001). Among confirmed dyslipidemic children, family history was not a good predictor of dyslipidemia (sensitivity 21.6%). Seventy nine parents of dyslipidemic children participated in fasting lipid profile assessment. Fifty two parents (67%) were dyslipidemic, most of them (79%) did not have a family history of premature CHD or hypercholesterolemia. FS cholesterol levels were also correlated with fasting TC of fathers (r=0.46 p=0.01), and mothers (r=0.32 p=0.02). Conclusion: Significant correlation exists between non-fasting FS cholesterol levels of children and subsequent fasting lipid profile of children and their parents. Family history has low sensitivity in predicting children with elevated serum cholesterol concentrations.

Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease

2014 ◽  
Vol 21 (30) ◽  
pp. 3455-3465 ◽  
Author(s):  
G.D. Kolovou ◽  
V. Kolovou ◽  
P.M. Kostakou ◽  
S. Mavrogeni
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Metabolism ◽  
Body Mass

scholarly journals Lipid profile and prognosis in patients with coronary heart disease: a meta-analysis of prospective cohort studies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiangmei Zhao ◽  
Dongying Wang ◽  
Lijie Qin
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cohort Studies ◽  
Lipid Profile ◽  
Prospective Cohort ◽  
Cardiac Death ◽  
Meta Analysis ◽  
Prospective Cohort Studies ◽  
All Cause Mortality ◽  
Reduced Risk

Abstract Background This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD). Methods The PubMed, Embase, and Cochrane Library electronic databases were systematically searched for prospective cohort study published through December 2019, and the pooled results were calculated using the random-effects model. Results Twenty-one studies with a total of 76,221 patients with CHD met the inclusion criteria. The per standard deviation (SD) increase in triglyceride was associated with a reduced risk of major adverse cardiovascular events (MACE). Furthermore, the per SD increase in high-density lipoprotein cholesterol (HDL-C) was associated with a reduced risk of cardiac death, whereas patients with lower HDL-C were associated with an increased risk of MACE, all-cause mortality, and cardiac death. Finally, the risk of MACE was significantly increased in patients with CHD with high lipoprotein(a) levels. Conclusions The results of this study suggested that lipid profile variables could predict major cardiovascular outcomes and all-cause mortality in patients with CHD.

Association of serum lipid profile and family history of coronary heart disease among middle aged Lithuanian adults

2018 ◽  
Vol 275 ◽  
pp. e215
Author(s):  
S. Kutkiene ◽  
Z. Petrulioniene ◽  
A. Laucevicius ◽  
U. Gargalskaite ◽  
A. Saulyte ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Middle Aged ◽  
History Of
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