scholarly journals Lower limb immobility and venous thromboembolism risk: Investigating preventive measures

2021 ◽  
Author(s):  
◽  
Irene Braithwaite
Keyword(s):  
Feasibility Study ◽  
Preventive Measures ◽  
Meta Analysis ◽  
Haemodynamic Effect ◽  
Case Control ◽  
Working Environment ◽  
Popliteal Vein ◽  
Case Control Studies ◽  
Vte Prophylaxis ◽  
Work Related

<p>Prolonged work-related seated immobility and lower limb immobilisation (LLI) are two situations in which the risk of venous thromboembolism (VTE) is poorly understood, and no evidence-based guidelines for the reduction of risk exist.  The aim of this research was to investigate the role of prolonged work-related immobility and LLI as risk factors for VTE and to assess the haemodynamic effects and feasibility of two possible preventive measures; the Legflow device during prolonged work-related immobility and an intermittent pneumatic compression device (IPC) during LLI.  Four studies of work-related immobility were conducted: a case-control study to assess the risk of prolonged seated immobility and VTE; a meta-analysis of two case-control studies to assess the risk of VTE in sedentary workers; a study of popliteal vein haemodynamics in ten adults using the Legflow device while seated and a feasibility study of the Legflow device in 96 sedentary office workers in their working environment. Four studies of LLI were completed: a meta-analysis of two case-control studies to assess the association between LLI and VTE risk; an audit of VTE rates in patients with Achilles tendon injury undergoing LLI prescribed prophylactic aspirin; a study of the effect of an IPC device beneath a fibreglass cast on popliteal vein haemodynamics in 24 adults and a feasibility study of the IPC device in patients undergoing LLI at the Fracture Clinic at Wellington Regional Hospital.  There was no association between prolonged seated immobility and VTE (odds ratio (OR) 1.18, 95%CI 0.56 to 2.48, P=0.67). Each additional hour seated in a 24 hour period was associated with VTE (OR 1.08, 95%CI 1.01 to 1.6, P=0.02). There was an association between sedentary occupations and VTE (OR 1.79, 95%CI 1.22 to 2.63, P=0.003). The Legflow device increased popliteal vein peak systolic velocity (PVPSV) (difference between the Legflow-mobilised and immobile limb adjusted for baseline 60.0 cm/s, (95%CI 44.6 to 75.3 P<0.001). In the working environment 50% (95%CI 40 to 60%) of sedentary office workers were adherent (use ≥ four times per day) with the Legflow device.  LLI was associated with VTE (OR 73.1, 95%CI 10.1 to 530, P<0.001). A total of 14/218 (6.4%, 95%CI 3.6% to 10.5%) Achilles tendon patients prescribed aspirin developed VTE, an incidence similar to the 6.3% identified in a previous patient group not routinely prescribed VTE prophylaxis. The haemodynamic effect of the IPC device was not impaired by its placement within a fibreglass leg cast (difference in PVPSV between IPC in-cast and IPC outside-cast -0.8 cm/s, 95%CI -6.5 to 4.9, P=0.78). Only 7/142 (5%, 95%CI 2.0 to 9.9%) of potentially eligible patients utilised the IPC device in the feasibility study.  Prolonged work- and computer-related seated immobility and sedentary professions are associated with VTE. The Legflow increases venous blood flow in seated adults and is a feasible device for use in the office environment. The introduction of aspirin for VTE prophylaxis of VTE during LLI did not influence VTE rates. The haemodynamic effect of the IPC is not impaired in a fibreglass cast, but its use is not a feasible option in the clinical setting of LLI.</p>

scholarly journals Lower limb immobility and venous thromboembolism risk: Investigating preventive measures

2021 ◽  
Author(s):  
◽  
Irene Braithwaite
Keyword(s):  
Feasibility Study ◽  
Preventive Measures ◽  
Meta Analysis ◽  
Haemodynamic Effect ◽  
Case Control ◽  
Working Environment ◽  
Popliteal Vein ◽  
Case Control Studies ◽  
Vte Prophylaxis ◽  
Work Related

<p>Prolonged work-related seated immobility and lower limb immobilisation (LLI) are two situations in which the risk of venous thromboembolism (VTE) is poorly understood, and no evidence-based guidelines for the reduction of risk exist.  The aim of this research was to investigate the role of prolonged work-related immobility and LLI as risk factors for VTE and to assess the haemodynamic effects and feasibility of two possible preventive measures; the Legflow device during prolonged work-related immobility and an intermittent pneumatic compression device (IPC) during LLI.  Four studies of work-related immobility were conducted: a case-control study to assess the risk of prolonged seated immobility and VTE; a meta-analysis of two case-control studies to assess the risk of VTE in sedentary workers; a study of popliteal vein haemodynamics in ten adults using the Legflow device while seated and a feasibility study of the Legflow device in 96 sedentary office workers in their working environment. Four studies of LLI were completed: a meta-analysis of two case-control studies to assess the association between LLI and VTE risk; an audit of VTE rates in patients with Achilles tendon injury undergoing LLI prescribed prophylactic aspirin; a study of the effect of an IPC device beneath a fibreglass cast on popliteal vein haemodynamics in 24 adults and a feasibility study of the IPC device in patients undergoing LLI at the Fracture Clinic at Wellington Regional Hospital.  There was no association between prolonged seated immobility and VTE (odds ratio (OR) 1.18, 95%CI 0.56 to 2.48, P=0.67). Each additional hour seated in a 24 hour period was associated with VTE (OR 1.08, 95%CI 1.01 to 1.6, P=0.02). There was an association between sedentary occupations and VTE (OR 1.79, 95%CI 1.22 to 2.63, P=0.003). The Legflow device increased popliteal vein peak systolic velocity (PVPSV) (difference between the Legflow-mobilised and immobile limb adjusted for baseline 60.0 cm/s, (95%CI 44.6 to 75.3 P<0.001). In the working environment 50% (95%CI 40 to 60%) of sedentary office workers were adherent (use ≥ four times per day) with the Legflow device.  LLI was associated with VTE (OR 73.1, 95%CI 10.1 to 530, P<0.001). A total of 14/218 (6.4%, 95%CI 3.6% to 10.5%) Achilles tendon patients prescribed aspirin developed VTE, an incidence similar to the 6.3% identified in a previous patient group not routinely prescribed VTE prophylaxis. The haemodynamic effect of the IPC device was not impaired by its placement within a fibreglass leg cast (difference in PVPSV between IPC in-cast and IPC outside-cast -0.8 cm/s, 95%CI -6.5 to 4.9, P=0.78). Only 7/142 (5%, 95%CI 2.0 to 9.9%) of potentially eligible patients utilised the IPC device in the feasibility study.  Prolonged work- and computer-related seated immobility and sedentary professions are associated with VTE. The Legflow increases venous blood flow in seated adults and is a feasible device for use in the office environment. The introduction of aspirin for VTE prophylaxis of VTE during LLI did not influence VTE rates. The haemodynamic effect of the IPC is not impaired in a fibreglass cast, but its use is not a feasible option in the clinical setting of LLI.</p>

Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis

2020 ◽  
Vol 17 (2) ◽  
pp. 105-111
Author(s):  
Haitao Liu ◽  
Wei Ge ◽  
Wei Chen ◽  
Xue Kong ◽  
Weiming Jian ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Large Scale ◽  
Late Onset ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Positive Trend ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Aldh2 Gene

Objectives: Previous case-control studies have focused on the relationship between ALDH2 gene polymorphism and late-onset Alzheimer's Disease (LOAD), but no definite unified conclusion has been reached. Therefore, the correlation between ALDH2 Glu504Lys polymorphism and LOAD remains controversial. To analyze the correlation between ALDH2 polymorphism and the risk of LOAD, we implemented this up-to-date meta-analysis to assess the probable association. Methods: Studies were searched through China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals, China Biology Medicine, PubMed, Cochrane Library, Clinical- Trials.gov, Embase, and MEDLINE from January 1, 1994 to December 31, 2018, without any restrictions on language and ethnicity. Results: Five studies of 1057 LOAD patients and 1136 healthy controls met our criteria for the analysis. Statistically, the ALDH2 GA/AA genotype was not linked with raising LOAD risk (odds ratio (OR) = 1.48, 95% confidence interval (CI) = 0.96-2.28, p = 0.07). In subgroup analysis, the phenomenon that men with ALDH2*2 had higher risk for LOAD (OR = 1.72, 95%CI = 1.10-2.67, p = 0.02) was observed. Conclusions: This study comprehends only five existing case-control studies and the result is negative. The positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol or cohort studies should be done to enhance the association between ALDH2 polymorphism and AD or other neurodegenerative diseases.

Respiratory disturbances in fibromyalgia: a systematic review and meta-analysis of case control studies

2021 ◽  
Author(s):  
Araceli Ortiz-Rubio ◽  
Irene Torres-Sánchez ◽  
Irene Cabrera-Martos ◽  
Laura López-López ◽  
Janet Rodríguez-Torres ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Fr561 COLONIC SPIROCHETES AND GASTROINTESTINAL PATHOLOGY AND SYMPTOMS: A META-ANALYSIS OF CASE-CONTROL STUDIES

2021 ◽  
Vol 160 (6) ◽  
pp. S-364
Author(s):  
Kening Fan ◽  
Prema M. Nair ◽  
Guy D. Eslick ◽  
Grace Burns ◽  
Nicholas J. Talley ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Gastrointestinal Pathology

scholarly journals Running and Knee Osteoarthritis: A Systematic Review and Meta-analysis

2016 ◽  
Vol 45 (6) ◽  
pp. 1447-1457 ◽  
Author(s):  
Kate A. Timmins ◽  
Richard D. Leech ◽  
Mark E. Batt ◽  
Kimberley L. Edwards
Keyword(s):  
Systematic Review ◽  
Full Text ◽  
Meta Analysis ◽  
Positive Association ◽  
Case Control ◽  
Case Control Studies ◽  
Eligibility Criteria ◽  
Knee Oa ◽  
Knee Joint Surgery ◽  
Newcastle Ottawa Scale

Background: Osteoarthritis (OA) is a chronic condition characterized by pain, impaired function, and reduced quality of life. A number of risk factors for knee OA have been identified, such as obesity, occupation, and injury. The association between knee OA and physical activity or particular sports such as running is less clear. Previous reviews, and the evidence that informs them, present contradictory or inconclusive findings. Purpose: This systematic review aimed to determine the association between running and the development of knee OA. Study Design: Systematic review and meta-analysis. Methods: Four electronic databases were searched, along with citations in eligible articles and reviews and the contents of recent journal issues. Two reviewers independently screened the titles and abstracts using prespecified eligibility criteria. Full-text articles were also independently assessed for eligibility. Eligible studies were those in which running or running-related sports (eg, triathlon or orienteering) were assessed as a risk factor for the onset or progression of knee OA in adults. Relevant outcomes included (1) diagnosis of knee OA, (2) radiographic markers of knee OA, (3) knee joint surgery for OA, (4) knee pain, and (5) knee-associated disability. Risk of bias was judged by use of the Newcastle-Ottawa scale. A random-effects meta-analysis was performed with case-control studies investigating arthroplasty. Results: After de-duplication, the search returned 1322 records. Of these, 153 full-text articles were assessed; 25 were eligible, describing 15 studies: 11 cohort (6 retrospective) and 4 case-control studies. Findings of studies with a diagnostic OA outcome were mixed. Some radiographic differences were observed in runners, but only at baseline within some subgroups. Meta-analysis suggested a protective effect of running against surgery due to OA: pooled odds ratio 0.46 (95% CI, 0.30-0.71). The I2 was 0% (95% CI, 0%-73%). Evidence relating to symptomatic outcomes was sparse and inconclusive. Conclusion: With this evidence, it is not possible to determine the role of running in knee OA. Moderate- to low-quality evidence suggests no association with OA diagnosis, a positive association with OA diagnosis, and a negative association with knee OA surgery. Conflicting results may reflect methodological heterogeneity. More evidence from well-designed, prospective studies is needed to clarify the contradictions.

scholarly journals The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case–control studies

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ali Baradaran ◽  
Hojat Dehghanbanadaki ◽  
Sara Naderpour ◽  
Leila Mohammadi Pirkashani ◽  
Abdolhalim Rajabi ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Newcastle Ottawa Scale ◽  
Prevalence Of Obesity ◽  
Quantitative Analyses ◽  
H Pylori

Abstract Introduction The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa. Methods We searched international databases including Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all case–control studies reporting the effect of H. pylori on obesity and vice versa, which had been published in English between January 1990 and June 2019. The quality of included studies was assessed by the Modified Newcastle–Ottawa Scale for Case–Control studies. The logarithm of the odds ratio (OR) and its standard error was used for the meta-analysis. Results Eight case–control studies with 25,519 participants were included for qualitative and quantitative analyses. The pooled analysis showed that obese participants had a higher risk of H. pylori infection than lean participants with an odds ratio of 1.46 (95%CI: 1.26, 1.68). Also, the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02). Conclusion The results of this meta-analysis showed that there was a positive correlation between the risk of H. pylori infection and the prevalence of obesity development. Thus, H. pylori positive patients were more likely to be obese, and obese individuals had higher risks of H. pylori infection.

scholarly journals Meta-analysis reveals significant association between FOXP3 polymorphisms and susceptibility to Graves’ disease

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110041
Author(s):  
Guiqin Tan ◽  
Xin Wang ◽  
Guangbing Zheng ◽  
Juan Du ◽  
Fangyu Zhou ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Pooled Analysis ◽  
Case Control ◽  
Graves Disease ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Asian Populations ◽  
Knowledge Infrastructure ◽  
Independent Case

Objective This meta-analysis aimed to determine the associations between the rs3761547, rs3761548, and rs3761549 single-nucleotide polymorphisms (SNPs) of the forkhead box P3 ( FOXP3) gene and susceptibility to Graves’ disease (GD). Methods Case–control studies with information on the associations between the rs3761547, rs3761548, and rs3761549 FOXP3 SNPs and GD published before 01 May 2020 were identified in the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases. Data from the studies were analyzed using RevMan version 5.3. Results Seven independent case–control studies including 4051 GD patients and 4569 controls were included in the meta-analysis. The overall pooled analysis indicated that FOXP3/rs3761548 and FOXP3/rs3761549 polymorphisms were significantly associated with GD susceptibility (rs3761548: A vs. C, odds ratio [OR] = 1.32, 95% confidence interval [CI] 1.05–1.67; rs3761549: TT vs. CC, OR = 1.98, 95%CI 1.49–2.65; (TT + TC) vs. CC, OR = 1.44, 95%CI 1.11–1.88). In contrast, the FOXP3/rs3761547 polymorphism was not associated with GD susceptibility. Subgroup analysis according to ethnicity showed that rs3761548 was associated with GD in Asians but not in Caucasians, whereas rs3761549 was associated in both Asians and Caucasians. Conclusion This meta-analysis demonstrated that FOXP3/rs3761548 and FOXP3/rs3761549 SNPs were significantly associated with susceptibility to GD, at least in Asian populations.

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