scholarly journals Photodynamic Therapy for Advanced Rectal Cancer: A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Lemei Chen ◽  
Yanping Liu ◽  
Ping Xie ◽  
Huizhen Fan
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Photodynamic Therapy ◽  
Palliative Treatment ◽  
Treatment Process ◽  
Advanced Colorectal Cancer ◽  
Advanced Rectal Cancer ◽  
Tumor Treatment ◽  
Potential Value ◽  
Case Data

Objective: To investigate the potential value of PDT(photodynamic therapy) in the treatment of rectal cancer by reviewing the diagnosis and treatment process of a patient with advanced rectal cancer who lost the opportunity of surgery. Methods: Select the case data of a patient receiving photodynamic therapy in our hospital, and analyze the photodynamic mechanism, safety and efficiency, and discuss the efficacy of photodynamic therapy. Results: After the patient received photodynamic therapy, re-examination of the endoscopy showed that the intestinal cavity was smoother than before, the bowel was difficult, and the symptoms of blood in the stool improved. Conclusion: Photodynamic therapy can be used as a radical or palliative treatment for clinical tumor treatment. Because of its advantages of minimally invasive, tissue-specific, repetitive and synergistic radiotherapy and chemotherapy, it plays an important role in early or middle-advanced colorectal cancer and is worthy of clinical promotion.

EXPERIENCE OF THE APPLICATION OF THERMOCHEMIORRADIOTHERAPY IN COMBINED TREATMENT OF DYSTAL CANCER OF DIRECT INTESTINE

2019 ◽  
Vol 65 (1) ◽  
pp. 131-134
Author(s):  
Zhanna Startseva ◽  
Sergey Afanasev ◽  
Dina Plaskeeva
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Primary Tumor ◽  
Advanced Colorectal Cancer ◽  
Combined Treatment ◽  
Locally Advanced ◽  
Chemoradiation Therapy ◽  
Locally Advanced Colorectal Cancer

The article describes the experience of using ther-mochioradiotherapy in the combined treatment of distal locally advanced colorectal cancer, as well as comparing the effectiveness of treatment with chemoradiation therapy. The use of the proposed method as a component of the combined treatment of patients with rectal cancer allowed to increase the percentage of organ-preserving operations. As a result of thermochemotherapy, the prevalence of the primary tumor was significantly reduced, as a result of which the number of sphincter-bearing operations was reduced by almost 2 times (p

scholarly journals Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2693
Author(s):  
Rachael E. Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Mark Glenn ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Cancer Cell Lines ◽  
Locally Advanced Rectal Cancer ◽  
Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines

Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer. We aimed to assess the radiosensitising effect of biological and pharmacological manipulation of AC and elucidate the underlying mechanism. AC manipulation in three colorectal cancer cell lines (HT29, HCT116 and LIM1215) was achieved using siRNA and plasmid overexpression. Carmofur and a novel small molecular inhibitor (LCL521) were used as pharmacological AC inhibitors. Using clonogenic assays, we demonstrate that an siRNA knockdown of AC enhanced X-ray radiosensitivity across all colorectal cancer cell lines compared to a non-targeting control siRNA, and conversely, AC protein overexpression increased radioresistance. Using CRISPR gene editing, we also generated AC knockout HCT116 cells that were significantly more radiosensitive compared to AC-expressing cells. Similarly, two patient-derived organoid models containing relatively low AC expression were found to be comparatively more radiosensitive than three other models containing higher levels of AC. Additionally, AC inhibition using carmofur and LCL521 in three colorectal cancer cell lines increased cellular radiosensitivity. Decreased AC protein led to significant poly-ADP ribose polymerase-1 (PARP-1) cleavage and apoptosis post-irradiation, which was shown to be executed through a p53-dependent process. Our study demonstrates that expression of AC within colorectal cancer cell lines modulates the cellular response to radiation, and particularly that AC inhibition leads to significantly enhanced radiosensitivity through an elevation in apoptosis. This work further solidifies AC as a target for improving radiotherapy treatment of locally advanced rectal cancer.

Use of photodynamic therapy in the palliation of massive advanced rectal cancer

1991 ◽  
Vol 34 (7) ◽  
pp. 600-605 ◽  
Author(s):  
Hanoch Kashtan ◽  
Moshe Z. Papa ◽  
Brian C. Wilson ◽  
Alexander A. Deutch ◽  
Hartley S. Stern
Keyword(s):  
Rectal Cancer ◽  
Photodynamic Therapy ◽  
Advanced Rectal Cancer

scholarly journals A Complete Response Case in a Patient with Multiple Lung Metastases of Rectal Cancer Treated with Bevacizumab plus XELIRI Therapy

2017 ◽  
Vol 10 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Hiroki Hashida ◽  
Hironaga Satake ◽  
Satoshi Kaihara
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Lung Metastases ◽  
Complete Response ◽  
Advanced Rectal Cancer ◽  
Computed Tomography Scan ◽  
First Line ◽  
Metastatic Lung ◽  
Tomography Scan ◽  
Line Chemotherapy

It has been reported that many patients with lung metastasis of colorectal cancer (CRC) underwent chemotherapy with fluorouracil, folinic acid, oxaliplatin, irinotecan, or capecitabine. There is a small number of reports about the capecitabine and irinotecan (XELIRI) plus bevacizumab (BV) therapy for patients with metastatic CRC in Japan. We report a case of successful BV+XELIRI therapy for rectal cancer with multiple lung metastases as first-line chemotherapy. A 53-year-old female presented with advanced rectal cancer and metastatic lung tumors. Following surgery, the patient was treated with XELIRI+BV. After 6 courses, a computed tomography scan showed complete response of the lung metastases. No recurrence has occurred for 3 years after chemotherapy was stopped.

Thrombin activatable fibrinolysis inhibitor, tissue factor pathway inhibitor, and prothrombin fragment 1+2 levels in patients with advanced colorectal cancer.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 615-615
Author(s):  
Tarik Salman ◽  
Ahmet Bilici ◽  
Cagatay Arslan ◽  
Umut Varol ◽  
Ibrahim Yildiz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Advanced Colorectal Cancer ◽  
Coagulation Cascade ◽  
Clinicopathologic Characteristics ◽  
Prothrombin Fragment ◽  
Fibrinolysis Inhibitor ◽  
Tissue Factor Pathway

615 Background: Thromboembolism is common in cancer patients.Thrombin activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI) and prothrombin fragment 1+2 (F1+2) are newly identified molecules involved in coagulation and fibrinolysis. The aim of this study was to investigate the relationship between clinicopathologic characteristics and TAFI, TFPI and F1+2 levels in patients with advanced colorectal cancer. Methods: Eighty-two patients (32 metastatic, 50 locally advanced disease) diagnosed with colorectal cancer in the medical oncology clinic, without history of thromboembolism, had not undergone an intervention, and not on medication affecting coagulation were included in the study. Serum TAFI, TFPI, and prothrombin F1+2 levels were evaluated via enzyme-linked immunosorbent assay. Clinicopathologic characteristics of the patients were investigated retrospectively from the medical records of the patients. Results: The plasma TAFI, TFPI, and prothrombin F1+2 levels were high in 70, 71, and 96% of the patients, respectively. Prothrombin F1+2 levels were higher among patients with lower performance scores. TFPI levels were higher among patients with tumor grades of 2 and 3. TAFI levels were higher among rectal cancer cases. Conclusions: There is an association between tumor grade and coagulation cascade. The higher prothrombin F1+2 levels, an indicator of active coagulation cascade, among patients with low performance scores may indicate that the coagulation cascade of these patients is more active. Higher TAFI levels among rectal cancer patients may be related to the natural course of the disease

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