CORRELATION BETWEEN TEMPERATURE OF THE MUCOUS MEMBRANE AND SECRETION OF THE HARD PALATE MINOR SALIVARY GLANDS IN DIFFERENT TERMS OF USING THE FULL REMOVABLE DENTURES

Some reports state that the morphology, histochemistry and innervation of mucous membrane in rats are quite similar to that in humans. Most experimental studies on the impact of certain factors on the human body involve laboratory animals, rats in particular. In our previous experimental studies we used rats to study the effect of acrylic monomer on salivary glands in order to further extrapolate data to the morphological features of minor salivary glands of rats and humans. This study was aimed at investigating morphology of glandular area of the hard palate mucosa of intact albino rats with subsequent extrapolation of the results obtained to human body. The experimental studies were conducted on adult Wistar rats aged 1 to 1.5 years. The light microscopy (slight magnification) of transverse sections of the hard palate mucosa samples of albino rats revealed the mucous membrane and well-developed submucous layer with numerous minor salivary glands within its structure. The findings confirm the similarity between the structure of minor salivary glands of rats and humans that supports the rational choice of experimental animals for subsequent extrapolation of the resulting data.

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Mucoepidermoid carcinoma of the hard palate in a 9-year-old girl (clinical case)

Head and neck tumors (HNT) ◽

10.17650/2222-1468-2019-9-3-89-96 ◽

2019 ◽

Vol 9 (3) ◽

pp. 89-96 ◽

Cited By ~ 1

Author(s):

К. А. Zolotarev ◽

A. М. Mudunov ◽

R. V. Shishkov ◽

V. G. Polyakov ◽

Yu. V. Alymov ◽

...

Keyword(s):

Medical Research ◽

Salivary Glands ◽

Histological Examination ◽

Mucous Membrane ◽

Mucoepidermoid Carcinoma ◽

Hard Palate ◽

Clinical Case ◽

Research Center ◽

Minor Salivary Glands ◽

National Medical

The objective of the work is to demonstrate the signs of mucoepidermoid carcinoma of the minor salivary glands in pediatric patients on a clinical example.Clinical case. In August 2017, a girl of 9 years old appeared in the area of the right half of the hard palate. The dentist at the place of residence diagnosed an abscess in the area of the hard palate, performed the lancing and drainage of the “abscess”, prescribed antibiotic therapy. After 3.5 months (in December 2017), hyperemia and an increase in the volume of the mucous membrane reappeared in the same zone. Reapplied to the dentist. The girl was sent to the Oral and Maxillofacial Surgery Department, where the hard palate formation was removed on 23.01.2018; according to histological examination a highly differentiated tumor of the hard palate was diagnosed. The girl was sent for a consultation to the N. N. Blokhin National Medical Research Center of Oncology, where histological preparations were reviewed: a fragment of the mucous membrane of the hard palate covered with squamous epithelium, with the growth of low-grade mucoepidermoid cancer (from the minor salivary glands of the hard palate). A biopsy of the postoperative scar 3 mm long and of the formation of a hard palate 1 mm in diameter was performed; during histological examination of the biopsy material tumor cells were not detected (the material was represented by fibrous tissue). Despite the biopsy results, taking into account the medical history, the results of a review of histological preparations, the rarity and high aggressiveness of the tumor, poor prognosis for relapse, lack of data for regional and distant metastases, at the concilium it was accepted the decision to conduct repeated surgery. In the Surgical Department No. 1 of the Research Institute of Pediatric Oncology and Hematology, N. N. Blokhin National Medical Research Center of Oncology on 13.03.2018 a resection of the hard palate was performed with plastic surgery of the defect with a mixed skin-muscle flap on the vascular pedicle.Conclusion. Mucoepidermoid cancer of the minor salivary glands of the hard palate in children and adolescents can be manifested by the presence of a slowly growing, painless, pale blue tumor. For a correct clinical and morphological diagnosis, a biopsy of the tumor is necessary, further the removal of the tumor is recommended with resection of the hard palate, in view of the high risk of tumor spreading in the thickness of the bone.

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Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽

10.33883/jms.v15i1.124 ◽

2012 ◽

Vol 15 (1) ◽

pp. 76-77

Author(s):

Mohd Athar ◽

K S Sodhi ◽

S Kala ◽

R K Maurya ◽

S Chauhan ◽

...

Keyword(s):

Local Recurrence ◽

Natural History ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Clinical Course ◽

Fatal Outcome ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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Nicotine stomatitis in smokers: a case report

Journal of Dentomaxillofacial Science ◽

10.15562/jdmfs.v3i1.708 ◽

2018 ◽

Vol 3 (1) ◽

pp. 58

Author(s):

Doni MS. Prabowo ◽

Haris B. Widodo

Keyword(s):

Case Report ◽

Salivary Glands ◽

Medical History ◽

Smokeless Tobacco ◽

Hard Palate ◽

World Population ◽

Minor Salivary Glands ◽

White Spots ◽

The World ◽

History Of

Objective: The aim of this study is to describe and analyse nicotine stomatitis in smokers. Of the world population that consumes tobacco, Asia and Australia make up 57% of tobacco consumers. Tobacco can be consumed by various ways such as smoked tobacco, commonly known as cigarettes, or smokeless tobacco. Cigarettes are known to cause nicotine stomatitis in the oral cavity.Methods: A 28-year-old man patient came with complaints of white spots on his hard palate. The patient has a medical history of asthma as a child and has been taking salbutamol. The patient has been smoking 3 packs of cigarettes a day since being 16 years old.Results: Nicotine stomatitis that occurs on the hard palate appears as circular reddish shapes on the orifice of minor salivary glands. These lesions are formed from physically irritation caused by smoking. The lesions were benign and reversible.Conclusion: Thought appropriate examination and treatment, these lesions were healed.

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Mucocele: A case report with brief review

Asian Pacific Journal of Nursing and Health Sciences ◽

10.46811/apjnh/4.1.5 ◽

2021 ◽

Vol 4 (1) ◽

pp. 35-37

Author(s):

Kalpna Thakur ◽

Lucky Jindal ◽

Nitish Bhat

Keyword(s):

Case Report ◽

Connective Tissue ◽

Salivary Glands ◽

Mucous Membrane ◽

Mucous Membrane Pemphigoid ◽

Minor Salivary Glands ◽

Bullous Lesion ◽

Retention Cysts

Mucocele is a clinical term that basically includes two phenomenon i.e. mucus extravasation and mucus retention. Cysts arising in connection with minor salivary glands are common and about 90 per cent of cases are of the mucous extravasation type. These lesions are typically painless, dome-shaped, and fluctuant; they appear blue in colour secondary to the presence of mucin under the mucosa. The vesicular appearance created by the superficial nature of the mucin spillage, causes a separation of the epithelium from the connective tissue. The pathologist must be aware of this lesion and should not mistake it microscopically for a vesiculo-bullous lesion, especially mucous membrane pemphigoid. Here, we present a case report on mucocele with a brief review.

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The mouth

10.1093/med/9780198767831.003.0011 ◽

2021 ◽

pp. 397-434

Author(s):

Daniel R. van Gijn ◽

Jonathan Dunne

Keyword(s):

Oral Cavity ◽

Salivary Glands ◽

Soft Palate ◽

Hard Palate ◽

Aerodigestive Tract ◽

Minor Salivary Glands ◽

Mylohyoid Muscle ◽

Muscular Structure ◽

The Common ◽

Mobile Tongue

The mouth is the common aperture to the aerodigestive tract. With the coordinated assistance of the tongue and lips it contributes to the formation of meaningful sound whilst the presence of intact dental arches allow for mastication. The oral cavity proper represents the atrium beyond the lips reaching to the palatoglossal arches posteriorly, where the oropharynx begins beyond the oropharnygeal isthmus. It is restricted by the cheeks laterally, the hard and soft palate superiorly and the mobile tongue resting on the mylohyoid muscle inferiorly. The paired major salivary glands drain into the oral cavity along with numerous minor salivary glands. The tongue is a thick, mucosa covered muscular structure concerned with mastication, taste, talking and swallowing. The palate is the roof of the mouth, separating the oral and nasal cavities and participating in speech and swallowing. It can be divided into two parts: a bony anterior hard palate and soft posterior palate.

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Exérese cirúrgica de adenoma pleomórfico em palato: relato de caso

ARCHIVES OF HEALTH INVESTIGATION ◽

10.21270/archi.v9i5.4999 ◽

2020 ◽

Vol 9 (5) ◽

pp. 449-452

Author(s):

Laís Guimarães Pinto ◽

Nathalia Farias Dantas de Figueiredo ◽

Thaynara Cavalcante Moreira Romão ◽

Lucas André Barros Ferreira ◽

Murilo Quintão dos Santos ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Hard Palate ◽

Minor Salivary Gland ◽

Minor Salivary Glands ◽

Mucin 1 ◽

Histologic Study ◽

Clin Pathol ◽

Minor Salivary Gland Tumors

Introdução: O adenoma pleomórfico (AP) é um tumor de glândulas salivares, misto, benigno composto de células epiteliais e mioepiteliais dispostas em vários padrões morfológicos, demarcadas dos tecidos circundantes por uma cápsula fibrosa. Dentre as glândulas salivares, é predominante nas intraorais com maior frequência no palato. Sua etiopatologia ainda é controversa. Objetivo: Relatar um caso clínico de adenoma pleomórfico localizado em região póstero lateral direito, do palato tratado cirurgicamente. Relato do Caso: Paciente, sexo feminino, 55 anos, foi encaminhada com laudo histopatológico de adenoma pleomórfico. Ao exame físico, foi observou um aumento de volume caracterizado como um nódulo séssil, consistente à palpação, localizado em palato duro direito, com aproximadamente 4cm de extensão em seu maior diâmetro, superfície íntegra, coloração normal e indolor. Ao exame tomográfico, imagem unilocular, bem delimitada, com reabsorção óssea local. Como tratamento, optou-se pela exérese cirúrgica da lesão sob anestesia geral, a qual foi realizada sem intercorrências. Paciente atualmente se encontra com 1 ano de pós-operatório sem sinais de recidiva. Conclusão: O tipo de tratamento descrito apresenta excelente prognóstico, com baixas taxas de recidiva.Descritores: Adenoma Pleomorfo; Cirurgia Bucal; Patologia Bucal.ReferênciasSharma A, Deshmukh S, Shaikh A, Dabholkar J. Pleomorphic adenoma of the minor salivary gland of the cheek. Singapore Med J. 2013;54(9):e183-4. Arumugam P, Christopher PJ, Kumar S, Kengasubbiah S, Shenoy V. Pleomorphic adenoma of the palate: a. case report. Cureus 11(3):e4308.Khan MN, Raza SS, Hussain Zaidi SA, Haq IU, Hussain AK, Nadeem MD, Farid K. Pleomorphic Adenoma Of Minor Salivary Glands. J Ayub Med Coll Abbottabad. 2016;28(3):620-22. Chaturvedi M, Jaidev A, Thaddanee R, Khilnani AK. Large Pleomorphic Adenoma of Hard Palate. Ann Maxillofac Surg. 2018;8(1):124-126.Oliveira LJ, Castro HHO, Leão PLR, Leal RM, Horta MCR, Souza PEA. Tratamento de adenoma pleomórfico em palato: relato de 2 casos e revisão de literatura. Rev Port Estomatol Med Dent Cir Maxilofac. 2016;57(1):55-61.Porto DE, Cavalcante JR, Cavalcante Júnior JR, Costa MCF, Pereira SM. Adenoma Pleomórfico de Parótida – Relato de Caso. Rev cir traumatol buco-maxilo-fac. 2014;14(2):15-18;Melo MNB, Nogueira Neto JN, Souza SR, Dultra FKAA, Dultra JA. Adenoma pleomórfico em lábio superior: Relato de caso. Rev. cir. traumatol. buco-maxilo-fac.2016;16(2):40-3.Erdem MA, Cankaya AB, Güven G, Olgaç V, Kasapoğlu C. Pleomorphic adenoma of the palate. J Craniofac Surg. 2011;22(3):1131-4.Takahashi H, Fujita S, Tsuda N, Tezuka F, Okabe H. Intraoral minor salivary gland tumors: a demographic and histologic study of 200 cases. Tohoku J Exp Med. 1990;161(2):111-28. Loiola RF, Matos FR, Nonaka CFW, Lopes FF, Cruz MCFN. Perfil epidemiológico das neoplasias de glândulas salivares diagnosticadas em São Luís-MA. J Bras Patol Med Lab. 2009;45(5):413-20.Tiago RSL, Castro GA, Ricardo LAC, Bühler RB, Fava AS. Adenoma pleomórfico de parótida: aspectos clínicos, diagnósticos e terapêuticos. Rev Bras Otorrinolaringol. 2003;69(4):485-89.Khan MN, Raza SS, Hussain Zaidi SA, Haq IU, Hussain AK, Nadeem MD, Farid K. Pleomorphic Adenoma Of Minor Salivary Glands. J Ayub Med Coll Abbottabad. 2016;28(3):620-22. Soares AB, Demasi APD, Altemani A, Araújo VC. Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. Histopathology. 2011; 58(3):377-82.Soares AB, Demasi AP, Tincani AJ, Martins AS, Altemani A, de Araújo VC. The increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma. J Clin Pathol. 2012;65(3):272-77.Maia FPA, Oliveira PRK, Santos JVQM, Costa DFN, Andrade ESS. Abordagem minimamente invasiva para tratamento de adenoma pleomórfico em palato: caso clínico. Rev Cir Traumatol Bucomaxilofac. 2019;19(3):21-4.

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THE EFFECT OF MONOMER OF REMOVABLE DENTURE BASE RESIN ON THE STRUCTURAL ORGANIZATION OF THE GLANDULAR ZONE OF ALBINO RAT HARD PALATE IN THE EXPERIMENT

Wiadomości Lekarskie ◽

10.36740/wlek202012120 ◽

2020 ◽

Vol 73 (12) ◽

pp. 2667-2671

Author(s):

Yevhenii S. Khilinich ◽

Vadym Yu. Davydenko ◽

Ivan І. Starchenko ◽

Mykhailo Ya. Nidzelskyi ◽

Hanna М. Davydenko ◽

...

Keyword(s):

Salivary Glands ◽

Mucous Membrane ◽

Hard Palate ◽

Structural Organization ◽

Experimental Studies ◽

Basal Layer ◽

Acrylic Resin ◽

Albino Rats ◽

Denture Base ◽

Removable Denture

The aim: The paper presents the findings of the study of the 3 month-long effect of the monomer of the “Ftorax” denture base acrylic resin on the structural organization of the mucous membrane and the condition of the salivary glands of the albino rats’ hard palate during the experiment. Materials and methods:To achieve this goal, experimental studies involved mature rats, whose hard palate mucosa was smeared with 2% aqueous solution of the monomer of the “Ftorax” denture base acrylic resin twice a day in the morning and evening. The animals were sacrificed on day 30 of the experiment and following 3 months. Results: The findings of the studies of the structural organization of the mucous membrane and the analysis of the micropreparations of the mucous membrane of the hard palate of the animals of Group III have revealed substantial pathological changes both in the covering epithelium and in the lamina propria. The comparison between the intact animals and group of animals subjected to the 3 month-long effect of the monomer showed a significant thickening of the epithelial layer; a decrease in the mitotic index in the basal layer; impaired stratification of the cellular elements of the spinous layer; manifestations of exudative purulent inflammation, cystic and sclerotic changes in the excretory ducts; increase in the amount of connective tissue in the lobules of the salivary glands; decrease in the volume of the secretory parenchyma. Conclusions: Based on the findings of the study we can conclude that the prolonged effect of the monomer of the denture base acrylic resins leads to disorder of the structural organization of the glandular zone of the hard palate; in its submucous layer the total volume of the salivary glands decreases, which, in turn, significantly reduces secretion and leads to hyposalivation.

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