TYPES OF CHITOZAN MODIFICATION BY USING VARIOUS DERIVATIVE AGENTS

The prevalence of the study of chitosan is associated with favorable biological properties of the polymer: low toxicity, biodegradability, and biocompatibility with cells of the human body. Chitosan is a complex aminopolysaccharide consisting of two types of monosaccharaides: 2-acetamide-D-glucose and 2-amino-D-glucose connected by a 1,4-β-glycosidic bond, obtained by chitosan by chitin deacetylation. Chitosan has hemostatic, hypolipedymic and antimicrobial activity against gram-positive and gram-negative microorganisms. However, the preparation of various drugs based on it is accompanied by difficulties in the development of biodegradable compositions that are related to the field of application. For the immobilization of various compounds used as drugs for the treatment of complications associated with damage to the skin, it is possible to use chitosan in dissolved form, converted into a salt form. However, salt forms of chitosan are water-soluble polymers, which leads to the rapid degradation of the matrix and the release of the drug from it, due to hydrophilicity. Additional lipophilization is required to obtain insoluble chitosan structures. Therefore, various modified chitosan structures are used that have suitable properties for the manufacture of a medicament. In addition, lipophilization of the chitosan structure allows the immobilization of more lipophilic structures. The purpose of this work was to study the literature and patent data sources for conducting information-analytical search of the approach. That led to the choice of a modified chitosan structure for its use in the pharmaceutical development of finished dosage forms. The article considers various types of derivatizing agents and the properties of modified chitosan structures.