DYNAMICS AND STRUCTURE OF CONGENITAL MALFORMATIONS AND HEREDITARY DISEASES IN NEWBORNS OF KURSK REGION

2021 ◽  
pp. 171-177
Author(s):  
Solodoukhina D.P. ◽  
Shlyapcev I.I.
Keyword(s):  
Public Health ◽  
Birth Defects ◽  
Congenital Malformations ◽  
Analytical Study ◽  
Hereditary Diseases ◽  
Health Programs ◽  
Cardiovascular Pathology ◽  
Public Health Programs ◽  
Perinatal Center ◽  
Kursk Region

The article presents analysis of congenital malformations and hereditary diseases in newborns of Kursk region from the position of public health. Methodology of work includes retrospective analytical study of screening lists and discharge records in case-histories of the Regional perinatal center of Kursk; content-analysis of medical-statistical reports of the medical-genetic consulting center of Kursk regional clinical hospital. In the result of the study there were detected trends in main congenital pathologies of newborns in Kursk region during the years 2015-2019, as well as structure of birth defects by localization. The most prevalent congenital malformations in newborns in Kursk region were cardiovascular pathology, urinary system anomalies, chromosome diseases and central nervous system anomalies. Factors detected as associated with congenital malformations in newborns included low birth weight and living in rural area. The results of the study are applicable for the development of public health programs aimed at improvement of preventive services and organization of medical care for children with birth defects.

Risk Attitudes and Behavior Among Norwegian Adolescents

2005 ◽  
Vol 10 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Hilde Iversen ◽  
Torbjørn Rundmo ◽  
Hroar Klempe
Keyword(s):  
Public Health ◽  
Traffic Safety ◽  
Behavior Modification ◽  
Health Programs ◽  
Risk Attitudes ◽  
Community Based ◽  
Public Health Programs ◽  
The Core ◽  
And Behavior ◽  
Attitudes And Behavior

Abstract. The core aim of the present study is to compare the effects of a safety campaign and a behavior modification program on traffic safety. As is the case in community-based health promotion, the present study's approach of the attitude campaign was based on active participation of the group of recipients. One of the reasons why many attitude campaigns conducted previously have failed may be that they have been society-based public health programs. Both the interventions were carried out simultaneously among students aged 18-19 years in two Norwegian high schools (n = 342). At the first high school the intervention was behavior modification, at the second school a community-based attitude campaign was carried out. Baseline and posttest data on attitudes toward traffic safety and self-reported risk behavior were collected. The results showed that there was a significant total effect of the interventions although the effect depended on the type of intervention. There were significant differences in attitude and behavior only in the sample where the attitude campaign was carried out and no significant changes were found in the group of recipients of behavior modification.

scholarly journals Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana (TyVEGHA) Using a Cluster-Randomized Controlled Phase IV Trial: Trial Design and Population Baseline Characteristics

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 281
Author(s):  
Andrea Haekyung Haselbeck ◽  
Birkneh Tilahun Tadesse ◽  
Juyeon Park ◽  
Malick M. Gibani ◽  
Ligia María Cruz Espinoza ◽  
...  
Keyword(s):  
Public Health ◽  
Blood Culture ◽  
Typhoid Fever ◽  
Conjugate Vaccine ◽  
Incidence Rates ◽  
Health Programs ◽  
Public Health Programs ◽  
High Burden ◽  
Pan African ◽  
Cluster Randomized

Typhoid fever remains a significant health problem in sub-Saharan Africa, with incidence rates of >100 cases per 100,000 person-years of observation. Despite the prequalification of safe and effective typhoid conjugate vaccines (TCV), some uncertainties remain around future demand. Real-life effectiveness data, which inform public health programs on the impact of TCVs in reducing typhoid-related mortality and morbidity, from an African setting may help encourage the introduction of TCVs in high-burden settings. Here, we describe a cluster-randomized trial to investigate population-level protection of TYPBAR-TCV®, a Vi-polysaccharide conjugated to a tetanus-toxoid protein carrier (Vi-TT) against blood-culture-confirmed typhoid fever, and the synthesis of health economic evidence to inform policy decisions. A total of 80 geographically distinct clusters are delineated within the Agogo district of the Asante Akim region in Ghana. Clusters are randomized to the intervention arm receiving Vi-TT or a control arm receiving the meningococcal A conjugate vaccine. The primary study endpoint is the total protection of Vi-TT against blood-culture-confirmed typhoid fever. Total, direct, and indirect protection are measured as secondary outcomes. Blood-culture-based enhanced surveillance enables the estimation of incidence rates in the intervention and control clusters. Evaluation of the real-world impact of TCVs and evidence synthesis improve the uptake of prequalified/licensed safe and effective typhoid vaccines in public health programs of high burden settings. This trial is registered at the Pan African Clinical Trial Registry, accessible at Pan African Clinical Trials Registry (ID: PACTR202011804563392).

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