RATIONALE THE EFFECTIVENESS OF TREATMENT OF COMBINED PATHOLOGY OF REPRODUCTIVE SYSTEM CAUSED BY HORMONAL IMBALANCE AND IMMUNE SYSTEM

2021 ◽  
Vol 2 (1) ◽  
pp. 58-61
Author(s):  
Maiorova M.O.

Based on the study of this clinical case, it is possible to evaluate the effectiveness of using dienogest for the treatment of combined pathology – polycystic ovary syndrome (PCOS) and endometriosis of the uterine body - adenomyosis. Given the common pathogenetic links in the formation of these diseases, the presence of an imbalance of the hormonal and immune systems in these diseases, the pharmacological properties of diengogest, its metabolic neutrality and the possibility of long-term use, the proposed management tactics should be considered effective for the treatment of this combined pathology.

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Umayal Branavan ◽  
Sulochana Wijesundera ◽  
Visvanath Chandrasekharan ◽  
Chandrika Wijeyaratne

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder of young women with long-term metabolic risk and prevalence among pre-marital Sri Lankan women is 6.3%. Inheritance of PCOS is likely to be oilgogenic; the genetic basis remaining largely unknown in view of the complex pathophysiology. The genetics of expression of PCOS requires an in-depth study, particularly among Sri Lankan women who have a greater metabolic risk from an early age. The emergence of an unanimously accepted genetic marker for susceptible PCOS was affected based on inconsistent findings. In this review, we summarize the common genetic polymorphisms of PCOS from different countries and outline some genetic polymorphisms that are potentially associated with the risk of PCOS in Sri Lankan women. This information could uncover candidate genes associating with PCOS, which will be valuable for the development of novel diagnostic and treatment method.


2011 ◽  
Vol 96 (5) ◽  
pp. 1271-1274 ◽  
Author(s):  
Miriam Hudecova ◽  
Jan Holte ◽  
Matts Olovsson ◽  
Anders Larsson ◽  
Christian Berne ◽  
...  

2017 ◽  
Vol 32 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Monica Recabarren ◽  
Albert Carrasco ◽  
Daniel Sandoval ◽  
Felipe Diaz ◽  
Teresa Sir-Petermann ◽  
...  

2010 ◽  
Vol 94 (7) ◽  
pp. 2654-2658 ◽  
Author(s):  
Miriam Hudecova ◽  
Jan Holte ◽  
Matts Olovsson ◽  
Lars Lind ◽  
Inger Sundström Poromaa

Author(s):  
Carrie Riestenberg ◽  
Anika Jagasia ◽  
Daniela Markovic ◽  
Richard P Buyalos ◽  
Ricardo Azziz

Abstract Context Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive-aged women, affecting approximately 5-20% of women of reproductive age. A previous estimate noted that the economic burden of PCOS approximates $3.7 billion annually in 2020 USD when considering only the costs of the initial diagnosis and of reproductive endocrine morbidities, not considering the costs of pregnancy-related and long-term morbidities. Objective To estimate the excess prevalence and economic burden of pregnancy-related and long-term health morbidities attributable to PCOS. Data Sources PubMed, EmBase and Cochrane Library. Study Selection Studies in which the diagnosis of PCOS was consistent with the Rotterdam, National Institutes of Health (NIH), or Androgen Excess & PCOS (AE-PCOS) Society criteria, or that used electronic medical record diagnosis codes, or diagnosis based on histopathologic sampling were eligible for inclusion. Studies that included an outcome of interest and a control group of non-PCOS patients who were matched or controlled for body mass index (BMI) were included. Data Extraction Two investigators working independently extracted data on study characteristics and outcomes. Data Synthesis Data was pooled using random-effects meta-analysis. The I 2statistic was used to assess inter-study heterogeneity. The quality of selected studies was assessed using the Newcastle-Ottawa Scale. Results The additional total healthcare-related economic burden due to pregnancy-related and long-term morbidities associated with PCOS in the United States is estimated to be $4.3 billion annually in 2020 USD. Conclusions Together with our prior analysis, the economic burden of PCOS is estimated at $8 billion annually in 2020 USD.


2000 ◽  
Vol 3 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Sarah Wild ◽  
Tracey Pierpoint ◽  
Howard Jacobs ◽  
Paul McKeigue

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