Role of miRNA in distinguishing primary brain tumors from secondary tumors metastatic to the brain

Abstract Introduction Laser Interstitial Thermotherapy (LITT; also known as Stereotactic Laser Ablation or SLA), is a minimally invasive treatment modality that has recently gained prominence in the treatment of malignant primary and metastatic brain tumors and radiation necrosis and studies for treatment of spinal metastasis has recently been reported. Methods Here we provide a brief literature review of the various contemporary uses for LITT and their reported outcomes. Results Historically, the primary indication for LITT has been for the treatment of recurrent glioblastoma (GBM). However, indications have continued to expand and now include gliomas of different grades, brain metastasis (BM), radiation necrosis (RN), other types of brain tumors as well as spine metastasis. LITT is emerging as a safe, reliable, minimally invasive clinical approach, particularly for deep seated, focal malignant brain tumors and radiation necrosis. The role of LITT for treatment of other types of tumors of the brain and for spine tumors appears to be evolving at a small number of centers. While the technology appears to be safe and increasingly utilized, there have been few prospective clinical trials and most published studies combine different pathologies in the same report. Conclusion Well-designed prospective trials will be required to firmly establish the role of LITT in the treatment of lesions of the brain and spine.

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The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Nature Communications ◽

10.1038/s41467-017-01686-y ◽

2017 ◽

Vol 8 (1) ◽

Cited By ~ 21

Author(s):

Kevin Boyé ◽

Nadège Pujol ◽

Isabel D Alves ◽

Ya-Ping Chen ◽

Thomas Daubon ◽

...

Keyword(s):

Brain Tumors ◽

Cross Talk ◽

Primary Brain Tumors

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Role of SOD2 Ala16Val polymorphism in primary brain tumors

Biomedical Reports ◽

10.3892/br.2019.1192 ◽

2019 ◽

Author(s):

Ayca Taş ◽

Yavuz Silig ◽

Hatice Pinarbaşi ◽

Mustafa G�relik

Keyword(s):

Brain Tumors ◽

Primary Brain Tumors

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Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes

Journal of Neurosurgery ◽

10.3171/jns.1992.76.3.0513 ◽

1992 ◽

Vol 76 (3) ◽

pp. 513-519 ◽

Cited By ~ 41

Author(s):

Stephen C. Saris ◽

Paul Spiess ◽

Daniel M. Lieberman ◽

Shan Lin ◽

Stuart Walbridge ◽

...

Keyword(s):

Brain Tumors ◽

Interleukin 2 ◽

Tumor Infiltrating Lymphocytes ◽

Similar Response ◽

Content Type ◽

Primary Brain Tumors ◽

Infiltrating Lymphocytes ◽

The Brain ◽

Fine Print

✓ Methods have recently been described for the isolation and expansion of lymphocytes that have trafficked into animal and human tumors. These CD8-positive tumor-infiltrating lymphocytes (TIL's) have exceptional trafficking ability to, and efficacy against, tumor targets in extracranial sites. Prior to Phase I clinical trials for patients with gliomas, adoptive immunotherapy with TIL's was studied in a mouse model of primary brain tumors to determine if intracerebral tumors have a similar response. Glioma 261 (GL261) tumors were grown in the subcutaneous space of C57BL/6 mice. After enzymatic digestion, the cells were incubated in vitro with interleukin-2 (IL-2) until a confluent population of T lymphocytes was present. The in vitro efficacy of these TIL's was tested against fresh GL261 targets with a chromium release assay; the in vivo efficacy was tested against GL261 tumors in the liver and against irradiated and nonirradiated GL261 tumors in the brain. Mice received one of the following: intraperitoneal saline; intraperitoneal IL-2 (7500 to 50,000 U three times daily for 5 days); IL-2 plus intravenous TIL's (1 to 3 × 107 cells); 10 Gy cranial irradiation; irradiation plus IL-2; or irradiation plus IL-2 plus TIL's. The TIL preparation killed 77% of tumor targets in 4 hours at an effector:target ratio of 100:1. In animals with GL261 tumors in the liver, at 2 weeks there were 93 ± 37, 128 ± 45, and 21 ± 14 liver metastases in the control, IL-2, and IL-2 plus TIL groups, respectively. However, in animals with GL261 tumors in the brain, no treatment group had an increased survival rate compared to the control group. It is concluded that, although TIL and IL-2 immunotherapy can be used effectively to treat brain tumors in vitro and at sites outside the central nervous system, it is ineffective against the same type of tumor in the brain. Different methods of delivery or different combinations of these immunomodulators may be more effective; however, based on these findings, treatment of patients with IL-2 and TIL cannot be recommended until efficacy has been demonstrated in an animal model.

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Role of magnetic resonance spectroscopy in grading of primary brain tumors

The Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1016/j.ejrnm.2016.03.011 ◽

2016 ◽

Vol 47 (2) ◽

pp. 577-584 ◽

Cited By ~ 6

Author(s):

Radwa Kamel Abdel Naser ◽

Afaf Abdel Kader Hassan ◽

Amr Mohamed Shabana ◽

Nagham Nabil Omar

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Brain Tumors ◽

Resonance Spectroscopy ◽

Primary Brain Tumors

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Operative treatment of primary brain tumors localized in motor zone with direct corticalis electrostimulation: Series of 62 patients

Acta chirurgica iugoslavica ◽

10.2298/aci1101053t ◽

2011 ◽

Vol 58 (1) ◽

pp. 53-59

Author(s):

Goran Tasic ◽

Branislav Nestorovic ◽

Ivan Milic ◽

Igor Nikolic ◽

Vladimir Jovanovic ◽

...

Keyword(s):

Glioblastoma Multiforme ◽

Brain Tumors ◽

Surgical Resection ◽

Diagnostic Procedures ◽

Radical Resection ◽

Subtotal Resection ◽

Low Grade ◽

General Anesthetics ◽

Primary Brain Tumors ◽

The Brain

In spite of the progress made in diagnostic procedures and development of the operating rooms technology, considerable neurological deficit after operation of tumors localized in the brain motor zone commits one to direct intraoperative identification of the motor zone. By introducing direct electrocortical stimulation into the routine intraoperative application the primary goal has been achieved - reaching the maximum degree of radicalness of surgical resection while preserving motor centres in the cerebral cortex. Method: We are hereby demonstrating a series of 60 patients operated for primary brain tumors localized in the area in the front and around the central sulcus. All operations have been performed under the general anesthetics. During the operations the method of direct electrostimulation (ES) was used for the purpose of identifying motor centres. Results: Intraoperatively a level of subtotal resection was achieved in 22 cases, while radical resection was possible in 38 cases. Significantly higher level of radicalness of surgical resection of the low grade glioma tumor was confirmed statistically in relation to the group of patients with glioblastoma multiforme by applying the ES cortex (p<0,05). Patients with slow developing brain glioma have statistically considerably higher KI value in relation to the KI values in the group of patients with glioblastoma multiforme (p<0,01). Difference in the measured values of distance from the coronal suture based on the results of MRI measuring and finding obtained by ES, has shown a statistically considerably higher difference with glioblastoma multiforme 8,26+4,288mm when comapred to slowly developing astrocitoma 5,88+3,080 (p<0,05). Conclusion: Electrostimulation of the brain cortex is a safe, simple and precise method for identification of the brain motor zone which enables prevention of additional postoperative deficit and higher level of surgical radicalness.

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The Practical Application of Emerging Technologies Influencing the Diagnosis and Care of Patients With Primary Brain Tumors

American Society of Clinical Oncology Educational Book ◽

10.1200/edbk_280955 ◽

2020 ◽

pp. e35-e46 ◽

Cited By ~ 1

Author(s):

Leland S. Hu ◽

Daniel J. Brat ◽

Orin Bloch ◽

Shakti Ramkissoon ◽

Glenn J. Lesser

Keyword(s):

Brain Tumors ◽

Surgical Navigation ◽

Tumor Biology ◽

Primary Brain Tumors ◽

Tumor Treating Fields ◽

Histopathologic Diagnosis ◽

Therapeutic Decision Making ◽

Next Generation Sequencing Ngs ◽

Ngs Data

Over the past decade, a variety of new and innovative technologies has led to important advances in the diagnosis and management of patients with primary malignant brain tumors. New approaches to surgical navigation and tumor localization, advanced imaging to define tumor biology and treatment response, and the widespread adoption of a molecularly defined integrated diagnostic paradigm that complements traditional histopathologic diagnosis continue to impact the day-to-day care of these patients. In the neuro-oncology clinic, discussions with patients about the role of tumor treating fields (TTFields) and the incorporation of next-generation sequencing (NGS) data into therapeutic decision-making are now a standard practice. This article summarizes newer applications of technology influencing the pathologic, neuroimaging, neurosurgical, and medical management of patients with malignant primary brain tumors.

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THE ROLE OF VASCULAR MICROENVIRONMENT IN THE FORMATION AND DEVELOPMENT OF BRAIN TUMORS

Problems in oncology ◽

10.37469/0507-3758-2018-64-5-570-577 ◽

2018 ◽

Vol 64 (5) ◽

pp. 570-577

Author(s):

Aleksandr Dorosevich ◽

N. Buzgan

Keyword(s):

Stem Cells ◽

Brain Tumors ◽

Tumor Cells ◽

Cell Lines ◽

Crucial Role ◽

Tumor Stem Cells ◽

Intercellular Interactions ◽

Resident Cell ◽

The Brain

Processes of neovascularization are key for the growth and spread of tumor cells. This article describes unique patterns of angiogenesis, which are considered as specific exclusively for brain tumors. At present the role of specialized perivascular niches in the development of oncological processes of the brain acquires a growing importance in the eyes of researchers. Perivascular niches play a crucial role in intercellular interactions between resident cell lines in the development of the tumor process and are also a source of tumor stem cells.

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