scholarly journals Acute responses of iron indices in Quarter Horses during a 3-barrel racing exercise

2018 ◽  
Vol 87 (2) ◽  
pp. 109-114
Author(s):  
Clarisse S. Coelho ◽  
Mario Cappi Neto ◽  
Marcela B. Binda ◽  
Fernanda A. Teixeira ◽  
Renan S. Carvalho ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Exercise Physiology ◽  
Transferrin Saturation ◽  
Haemoglobin Concentration ◽  
Kolmogorov Smirnov ◽  
Iron Binding Capacity ◽  
Iron Profile

Energy metabolism and physical performance are dependent on sufficient iron metabolism. Therefore, studies evaluating the iron profile are necessary to elucidate this trace mineral requirements and its role in the equine exercise physiology. The aim of this study was to evaluate the influence of barrel racing exercise on serum iron profile of Quarter horses. Twenty-two regularly trained Quarter horses (8 females and 14 males, 4.8 ± 2.4 years old, mean body weight 431.7 ± 33.9 kg) were enrolled in this study with the owner’s informed consent. All horses were evaluated at T0 (at rest), T1 (immediately after barrel racing trial), T2 (30 min after trial) and T3 (2 h after trial). At these time points, blood samples were taken to determine the packed cell volume (PCV), red blood cell count (RBC), haemoglobin concentration (Hb), total protein (TP), serum iron (SI), total iron-binding capacity (TIBC) and transferrin saturation (TSAT). Variables were analyzed for normality through Kolmogorov-Smirnov test and comparisons were made using Tukey test, considering P < 0.05. The imposed exercise challenge significantly altered PCV, RBC, haemoglobin concentration, TP, SI and TSAT, with higher values were recorded at T1. These findings can be linked to an increased demand as a result of physical activity. Significant changes occurred in the iron status in physically well-conditioned Quarter horses during the barrel racing exercise. Better understanding of iron metabolism in horses will help determine the actual necessity of supplementation.

scholarly journals Evaluation of Erythrocytes, Platelets, and Serum Iron Profile in Dogs with Chronic Enteropathy

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Veronica Marchetti ◽  
George Lubas ◽  
Andrea Lombardo ◽  
Michele Corazza ◽  
Grazia Guidi ◽  
...  
Keyword(s):  
Serum Iron ◽  
Activity Index ◽  
Binding Capacity ◽  
Iron Status ◽  
Disease Activity Index ◽  
Microcytic Anemia ◽  
Chronic Enteropathy ◽  
Before And After ◽  
Iron Binding Capacity ◽  
Iron Profile

The aim of this study is to evaluate iron status, erythrocyte, and platelet modifications in dogs with chronic enteropathy (CE). Dogs were grouped as food-responsive diarrhea (FRD, ), antibiotic-responsive diarrhea (ARD, ), and steroid-responsive diarrhea (SRD, ) relating to therapeutic-response. Clinical and haematological findings, evidence of gastrointestinal blood loss, and iron metabolism were evaluated before and after treatment. A mild normocytic or microcytic anemia and thrombocytosis were identified, respectively in 18.0% and 31.8% of CE dogs. No significant differences between pre- and posttreatment of hematocrit, haemoglobin, and mean corpuscular volume, platelet count and mean platelet volume were found. Statistical analysis pointed out significant differences between pre- and posttreatment in serum iron () and unsaturated iron binding capacity (UIBC) (). No significant correlations were found between these parameters and canine Inflammatory Bowel Disease activity index and pattern of CE as well.

scholarly journals Study Iron Homeostasis of Infected and Non-Infected Iraqi Camels with Trypanosomiasis

2020 ◽  
Vol 44 (2) ◽  
pp. 35-44
Author(s):  
Laith S.G. Al-Rubaie
Keyword(s):  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Cutoff Point ◽  
Iron Binding ◽  
Dromedary Camels ◽  
Point Test ◽  
Iron Binding Capacity

Trypanosomiasis is one of the common parasitic diseases, which infects the dromedary camels and decreases the numbers of these animals in Iraq. To get the best knowledge of the changes of iron status in camels infected with trypanosomiasis, in an attempt to take advantage of these variables as markers for infection, we designed this study. The current study conducted in blood sample collection from155 dromedary camels, 33 were infected (21.29%), according to the status of infection with Trypanosoma evansi that depends on blood smear examination as a golden test. Results denote significant differences of infection ratio by sex and age, from total of 132 male tested, 29 (21.96%) infected, distributed into 12 (%41.37) of age ≤ 2 years and 17 (58.62) of ≥ 2 years. From 23 female tested, 4 (17.39%) were infected at age ≤ 2 years. Furthermore, the results of this study demonstrated significant (p˂0.05) decrease in total serum iron, transferrin saturation, ferritin, whereas increased in total iron binding capacity and unsaturated iron binding capacity in the infected male and female camels with different age. Analyzed data of iron status parameters denoted that the cutoff point test between sensitivity (97) and specificity (100) for serum iron is (≤67.26), for transferrin saturation is (≤17.23) between the sensitivity and specificity (100) and (≥378.66), for total iron binding capacity between the sensitivity and specificity (93.9 and 96.7) respectively. Also, the cutoff point test between the sensitivity (100) and specificity (96.7) for unsaturated iron binding capacity is (≥301.27) and ferritin concentration has a cutoff point is (≤ 249.88) for the sensitivity (100) and specificity (99.2). It could be concluded from what was stated in the results of the current study, that the measurement of the concentration of serum ferritin could be considered as a good marker for the T. evansi infection

scholarly journals Impact of dietary intervention with a functional food supplement to combat anemia - the blood iron metabolic disorder among the coffee plantation laborers

2013 ◽  
Vol 3 (1) ◽  
pp. 21
Author(s):  
Vasantha Esther Rani ◽  
Samuel Paulraj
Keyword(s):  
Functional Food ◽  
Serum Iron ◽  
Dietary Intervention ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Iron Binding ◽  
Coffee Plantation ◽  
Iron Binding Capacity ◽  
Iron Profile ◽  
The Impact

Objective: To assess the nutritional status and other nutrition related problems of the workers. To design, implement and evaluate the impact of dietary intervention for the nutritional metabolic disorder which is directly related to productivity.Background: Indian economy greatly relies on agriculture. Agriculture is set to play a more dynamic role in the economy. The present study focuses on the nutritional status with special reference to the blood iron profile of manual coffee plantation laborers belonging to Kodaikannal, Tamil Nadu, India. The outcome of this study on the dietary intervention, based on nutritional picture of coffee plantation laborers, will have a nationwide application because of the simplified, stable coffee plantation operations throughout India.Method: Experiments were carried out in three phases. In the first phase, the personal background of the laborers was assessed. In the second phase, the nutritional and health status of the laborers, through dietary survey comprising 24 Hour Food Recall record and weighment of cooked food consumed for three consecutive days, clinical and biochemical profile were studied. The serum iron was measured with the total iron binding capacity, from which the transferrin saturation was calculated. In the third phase, dietary intervention was implemented with a nutrient rich nutraceutical food supplement - spirulina incorporated soup. The supplementation was extended for a period of 120 days. The subjects were grouped into control and the experimental group. The control group was given plain soup and the experimental group was administered with soup incorporated with spirulina. The impact of intervention on the biochemical and nutritional profile of the laborers was reassessed in similar working conditions.Results: A deficit of 0.1 mg to 0.3 mg of iron intake per kg body weight in the male and female laborers was observed when compared to their RDA. The clinical pictures reveal that 94 percent suffered from anemia, 56 percent showed anemic signs of spooning of nails (koilonychyia), 36 percent of the subjects had glossitis (mouth ulcer), 16 percent suffered from bleeding gums, 4 percent had cheilosis (ulceration of tongue) and 28 percent had angular stomatitis. The average hemoglobin level was 8.6 ± 1.12g/dl for men and 8.1±1.01g/dl for women which are 28 and 37 percent less than normal respectively. Dietary intervention of 5g of spirulina in 150 ml of soup had significantly improved the blood iron profile. Among the male laborers, 10 percent who suffered from severe anemia with 7.9 g.dl-1 hemoglobin before intervention were shifted to moderate levels of 9.4 g.dl-1, 30 percent who suffered from mild anemia were shifted to normal ones and among 60 percent of male laborers who were moderately anemic, 50 percent reverted to normalcy.Conclusion: In the present study it was observed that the habitual dietary intake showed deficiency in consumption of iron rich foods and the clinical picture revealed the signs and symptoms of anemia The blood iron profile - Hemoglobin (Hb), Serum Iron, Transferrin Saturation, Serum Ferritin, Total Iron Binding Capacity (TIBC) and Unsaturated Iron Binding Capacity (UIBC) were greatly influenced by dietary intervention with the functional food Spirulina incorporated soup The blood hemoglobin content increased by 21 percent i.e from 10.9 to 13.3g.dl-1. Serum iron, serum ferritin and transferrin levels showed a consistent and progressive rise while TIBC and UIBC reduced resulting in a positive iron balance. Keywords: Dietary intervention, functional food, Spirulina, hemoglobin, anemia

Changes of iron metabolism during pregnancy and the establishment of reference intervals for pregnant Chinese women

2019 ◽  
Vol 56 (5) ◽  
pp. 556-563
Author(s):  
Yuanqing Yang ◽  
Rong Wang ◽  
Hongmin Jiang ◽  
Min Hu ◽  
Aiguo Tang ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Reference Intervals ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Binding Capacity

Background Abnormalities of iron metabolism in pregnancy pose risks for maternal and fetal health. Robust reference intervals for iron metabolism indices have not been established in a pregnant Chinese population. The purpose of this study was to derive reference intervals for indices of iron metabolism during pregnancy in a Chinese population. Methods A total of 360 healthy pregnant women were recruited and divided into three groups of 120 by gestational age: first trimester (1–13 weeks), second trimester (14–27 weeks) and third trimester (≥28 weeks). An additional 120 healthy non-pregnant women were recruited as the non-pregnant control group. Serum ferritin was measured by electrochemiluminescence immunoassay. Serum iron and total iron-binding capacity were measured by a direct bathophenanthroline method. Transferrin saturation value was calculated with formula TS = SI/TIBC. The reference intervals were established using a non-parametric method. Results In first and second trimesters (combined), the reference intervals for serum ferritin, serum iron, total iron-binding capacity and transferrin saturation are 14.7–184.3 mg/L, 14.50–33.45 µmol/L, 36.53–68.81 µmol/L and 19.04–64.76%, respectively. In the third trimester, the reference intervals for serum ferritin, serum iron, total iron-binding capacity and transferrin saturation are 7.2–122.2 mg/L, 5.83–21.52 µmol/L, 49.40–122.76 µmol/L and 8.22–52.75%, respectively. Conclusion The reference intervals for iron metabolism indices for healthy pregnant Chinese women were established in accordance with CLSI C28-A3 guidelines. This will be a valuable tool for clinical practice and research.

scholarly journals Study of Glycation of Transferrin and its Effect on Biomarkers of Iron Status in Uncontrolled Diabetes Mellitus Patients

2020 ◽  
Author(s):  
Dunna Sabitha ◽  
E Manasvi Dawson ◽  
Shashank Nand Krishna Tiwari ◽  
P Swetha ◽  
Shaik Mohammad Naushad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Lower Percentage ◽  
Correlation Pattern ◽  
Uncontrolled Diabetes ◽  
Percentage Saturation

Introduction: Diabetes Mellitus (DM) is a metabolic condition linked by the inability to produce enough insulin and/or to respond to insulin. This can lead to a number of acute and chronic health problems. In erythrocytes, transferrin is the main source of iron. Alterations in transferrin glycation affect transferrin saturation because the affinity of transferrin for Fe3+ is extremely high but it decreases progressively with increasing glycation. Aim: To investigate the influence of uncontrolled diabetes on transferrin glycation and iron metabolism. Materials and Methods: A total of 136 samples from 3 groups of HbA1c levels (<6.0% non-diabetic, 6.4-8% diabetic, >8.0%-uncontrolled DM) were studied for the correlation pattern of iron with other variables. Chi square test and student’s t-test were performed to reveal the association between serum free iron levels and other variables with DM. Results: Serum iron has shown to be depleted significantly (p=0.02) along with percentage saturation (p=0.0006) with increase in diabetic severity. No significant differences were observed in serum ferritin in controlled DM and uncontrolled samples. Total Iron Binding Capacity (TIBC) was found to be significantly increased in uncontrolled DM samples (p=0.01). Abnormal transferrin was observed uncontrolled diabetes with subsequent depletion in transferrin, which in turn results in low serum iron, lower percentage saturation and high TIBC. Conclusion: Uncontrolled diabetes affects the glycation of transferrin also thus perturbating iron metabolism. The present study emphasises the need to monitor transferrin glycation status and iron deficiency anaemia in subjects with uncontrolled diabetes.

scholarly journals Hepcidin and iron metabolism disorders in patients with chronic kidney disease

2013 ◽  
Vol 70 (4) ◽  
pp. 368-373 ◽  
Author(s):  
Marija Jelic ◽  
Tatjana Cvetkovic ◽  
Vidojko Djordjevic ◽  
Goran Damnjanovic ◽  
Predrag Vlahovic ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iron Metabolism ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
High Sensitivity ◽  
Iron Binding ◽  
Hepcidin Level ◽  
Iron Binding Capacity

Bacground/Aim. Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). Methods. The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation. The HD group was divided in four subgroups according to the level of serum ferritin (up to 100; 100-199; 200-499 and over 500 ng/mL). Parameters of anemia, iron status, inflamation and hepcidin level were evaluated. Results. The HD patients had a significantly lower eritrocyte count, erythrocytes indexes, hemoglobin and transferrin saturation and significantly higher iron, ferritin, hepcidin and total iron binding capacity (TIBC). The HD subgroups up to 199 ng/mL of serum feritin had lower high-sensitivity Creactive protein (hsCRP), iron and higher unbuffered iron binding capacity (UIBC), transferrin saturation and TIBC compared to the HD subgroups over 200 ng/mL. The lowest and the highest ferritin subgroups had the highest hepcidin level and it showed significant correlation with ferritin. Conclusion. Hepcidin may serve as a marker for better diagnosing and monitoring anemia and iron metabolism disorders in CKD.

scholarly journals Iron Metabolism Disturbance in a French Cohort of ALS Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Charlotte Veyrat-Durebex ◽  
Philippe Corcia ◽  
Aleksandra Mucha ◽  
Simon Benzimra ◽  
Cindy Mallet ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Ferritin Level ◽  
Transferrin Saturation ◽  
Body Weight Loss ◽  
Disease Evolution ◽  
Als Patients

Objective.The aim of this study was to assess iron status in a cohort of amyotrophic lateral sclerosis (ALS) patients compared to controls in order to evaluate these parameters as a risk factor or a modifying factor of ALS.Methods.We collected serum iron, ferritin, transferrin, total iron-binding capacity, and transferrin saturation coefficient (TSC) from 104 ALS patients at the time of diagnosis and from 145 controls. We reported phenotypic characteristics and evolution parameters such as ALSFRS-R and forced vital capacity at diagnosis and after one year of follow-up. In a first step we compared iron status between ALS patients and controls, and then we evaluated the relation between iron status and disease evolution of ALS patients using univariate and multivariate analysis.Results.We observed increased concentrations of serum iron (P=0.002) and ferritin (P<0.0001) and increased TSC (P=0.017) in ALS patients. We also showed an association between markers of iron status and high body weight loss in ALS patients. The multivariate analysis of survival highlighted a significant relation between ferritin level and disease duration (P=0.038).Conclusion.This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS.

scholarly journals Low Serum Iron Status Is Associated With Low Incidence of Coronary Artery Disease In Women

2022 ◽  
Author(s):  
Shuren Guo ◽  
Xiaohuan Mao ◽  
Xiaohua Li ◽  
Huan Ouyang
Keyword(s):  
Coronary Artery ◽  
Serum Level ◽  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Protective Role ◽  
Artery Disease ◽  
Iron Binding Capacity ◽  
Low Serum

Abstract Background: Disorders of iron metabolism has been implicated in cardiovascular disease. However, the association of serum ferritin and coronary artery disease (CAD) remains inconsistent. Here, we investigated the associations of serum iron metabolism with the incidence of CAD, the severity of coronary artery stenosis, metabolic biomarkers, and 1-year restenosis after coronary artery revascularization. Methods: A total of 643 CAD patients and 643 healthy controls were enrolled to assess the associations of serum iron status with the presence of CAD, the severity of CAD, and 1-year rehospitalization after revasculation. Serum iron metabolism and other metabolic markers were measured in all subjects. All statistical analyses were analyzed using SPSS22.0 software and STATA statistical package.Results: Serum level of iron metabolism markers, including serum iron, ferritin, unsaturated transferrin iron binding capacity (UIBC), Total iron binding capacity (TIBC) levels, in CAD groups was significantly higher than the control group (P<0.001). UIBC and TIBC were negatively correlated with ferritin in both sexes. Serum level of iron (OR=0.806, 95% CI (0.687-0.944), UIBC (OR=0.919, 95% CI (0.852-0.992), and TIBC (OR=0.864, 95% CI (0.787-0.95) were found to have a protective role for CAD in women (P<0.05, Table 3). The OR for ferritin was significant in the both sexes (OR=1.029, 95% CI (1.002-1.058) in men, OR=1.02, 95% CI (1.005-1.034) in women, P<0.05). Conclusion: Low Serum level of iron, UIBC, TIBC and ferritin levels were found to have a protective role for CAD in women, but not in men. Elevated serum ferritin is independently and positively associated with CAD in men and women.

scholarly journals IRON STATUS IN PREECLAMPSIA

2008 ◽  
Vol 15 (01) ◽  
pp. 74-80
Author(s):  
TASNEEM ZAFAR ◽  
ZAFAR IQBAL
Keyword(s):  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Correlation Study ◽  
Total Iron ◽  
Control Group ◽  
Iron Binding ◽  
Iron Binding Capacity

Objective: To evaluate iron status in pregnancy induced hypertension and role of iron in the etiologyand pathogenesis of pre-eclampsia. Design: Coefficient correlation study. Place and Duration. At Department ofBiochemistry, Frontier Medical College, Abbottabad with collaboration of Department of Obstetrics and Gynecology,Ayub Medical Complex, Abbottabad from March 2006-March 2007. Material and Methods: Study was performed onhundred pregnant women of age ranging between 15-35 years and having gestational age between28 to 34 weeks.Fifty obstetric patients were identified as having pre-eclampsia. Fifty healthy pregnant subjects were taken as controls,having uncomplicated pregnancies and were normotensive throughout gestation and without proteinuria. Results:Results depicts that mean age of pre-eclamptic group was significantly low (P<0.001) as compared to control. Bothparameters, Hemoglobin and Haematocrit were significantly higher (P<0.05) in pre-eclamptic as compared to controls.Serum iron, serum ferritin and transferrin saturation were significantly higher (P<0.001) in pre-eclamptic in comparisonwith control group. Total iron binding capacity and unsaturated iron binding capacity were significantly lower (P<0.001)in pre-eclamptic group when compared to control group. Correlation coefficient between serum iron, total iron bindingcapacity (TIBC), serum ferritin, unsaturated iron binding capacity (UIBC) and systolic and diastolic blood pressure inpre-eclamptic group showed no significant positive correlation in any parameter. Conclusion: It is concluded thathemoglobin, haematocrit, serum iron, serum ferritin and transferrin saturation are significantly increased in pregnantwomen that later develops pre-eclampsia. Excess iron is postulated as casual factor in the oxidative stress ie; in itsradical form, which may be involved in the pathogenesis of pre-eclampsia. Therefore, iron status of pregnant womenshould be assessed before giving iron supplements as these may cause more harm than benefit.

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