scholarly journals Low Serum Iron Status Is Associated With Low Incidence of Coronary Artery Disease In Women

2022 ◽  
Author(s):  
Shuren Guo ◽  
Xiaohuan Mao ◽  
Xiaohua Li ◽  
Huan Ouyang
Keyword(s):  
Coronary Artery ◽  
Serum Level ◽  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Protective Role ◽  
Artery Disease ◽  
Iron Binding Capacity ◽  
Low Serum

Abstract Background: Disorders of iron metabolism has been implicated in cardiovascular disease. However, the association of serum ferritin and coronary artery disease (CAD) remains inconsistent. Here, we investigated the associations of serum iron metabolism with the incidence of CAD, the severity of coronary artery stenosis, metabolic biomarkers, and 1-year restenosis after coronary artery revascularization. Methods: A total of 643 CAD patients and 643 healthy controls were enrolled to assess the associations of serum iron status with the presence of CAD, the severity of CAD, and 1-year rehospitalization after revasculation. Serum iron metabolism and other metabolic markers were measured in all subjects. All statistical analyses were analyzed using SPSS22.0 software and STATA statistical package.Results: Serum level of iron metabolism markers, including serum iron, ferritin, unsaturated transferrin iron binding capacity (UIBC), Total iron binding capacity (TIBC) levels, in CAD groups was significantly higher than the control group (P<0.001). UIBC and TIBC were negatively correlated with ferritin in both sexes. Serum level of iron (OR=0.806, 95% CI (0.687-0.944), UIBC (OR=0.919, 95% CI (0.852-0.992), and TIBC (OR=0.864, 95% CI (0.787-0.95) were found to have a protective role for CAD in women (P<0.05, Table 3). The OR for ferritin was significant in the both sexes (OR=1.029, 95% CI (1.002-1.058) in men, OR=1.02, 95% CI (1.005-1.034) in women, P<0.05). Conclusion: Low Serum level of iron, UIBC, TIBC and ferritin levels were found to have a protective role for CAD in women, but not in men. Elevated serum ferritin is independently and positively associated with CAD in men and women.

scholarly journals Acute responses of iron indices in Quarter Horses during a 3-barrel racing exercise

2018 ◽  
Vol 87 (2) ◽  
pp. 109-114
Author(s):  
Clarisse S. Coelho ◽  
Mario Cappi Neto ◽  
Marcela B. Binda ◽  
Fernanda A. Teixeira ◽  
Renan S. Carvalho ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Exercise Physiology ◽  
Transferrin Saturation ◽  
Haemoglobin Concentration ◽  
Kolmogorov Smirnov ◽  
Iron Binding Capacity ◽  
Iron Profile

Energy metabolism and physical performance are dependent on sufficient iron metabolism. Therefore, studies evaluating the iron profile are necessary to elucidate this trace mineral requirements and its role in the equine exercise physiology. The aim of this study was to evaluate the influence of barrel racing exercise on serum iron profile of Quarter horses. Twenty-two regularly trained Quarter horses (8 females and 14 males, 4.8 ± 2.4 years old, mean body weight 431.7 ± 33.9 kg) were enrolled in this study with the owner’s informed consent. All horses were evaluated at T0 (at rest), T1 (immediately after barrel racing trial), T2 (30 min after trial) and T3 (2 h after trial). At these time points, blood samples were taken to determine the packed cell volume (PCV), red blood cell count (RBC), haemoglobin concentration (Hb), total protein (TP), serum iron (SI), total iron-binding capacity (TIBC) and transferrin saturation (TSAT). Variables were analyzed for normality through Kolmogorov-Smirnov test and comparisons were made using Tukey test, considering P < 0.05. The imposed exercise challenge significantly altered PCV, RBC, haemoglobin concentration, TP, SI and TSAT, with higher values were recorded at T1. These findings can be linked to an increased demand as a result of physical activity. Significant changes occurred in the iron status in physically well-conditioned Quarter horses during the barrel racing exercise. Better understanding of iron metabolism in horses will help determine the actual necessity of supplementation.

scholarly journals NEOPTERIN AND INTERFERON-GAMMA AS IMMUNE RESPONSE MARKERS IN BETATHALASSEMIA MAJOR PATIENTS

2018 ◽  
Vol 11 (9) ◽  
pp. 192
Author(s):  
Shahad F Obeid ◽  
Sanad B Al-a'araji ◽  
Bassam F Matti ◽  
Hayder Adnan Fawzi
Keyword(s):  
Immune System ◽  
Interferon Gamma ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
System Response ◽  
Iron Binding ◽  
Ifn Γ ◽  
Immune System Response ◽  
Iron Binding Capacity

Objective: The assessment of neopterin and interferon-gamma (IFN-γ) levels as a part of immune system response about serum iron status in β-thalassemia (TM) major patients.Methods: Spectrophotometry applied for the estimation of iron status including serum iron level, total iron-binding capacity, and unsaturated iron-binding capacity. Enzyme-linked immunosorbent assay (ELISA) applied for the estimation of the serum cytokines included neopterin and IFN-γ also serum ferritin estimation by ELISA from 130 β-TM major patients where they divided according to serum ferritin level (< and ≥2500 ng/mL).Results: The neopterin and IFN-γ concentration showed significantly increased with direct correlation among TM patient group when compared to the normal healthy control group. However, there was no significant difference between different levels of serum ferritin.Conclusion: The increased serum level of neopterin and IFN-γ found in patients with β-TM may be due to the direct effect of iron on cellular immune cells beside of immune system response to the effect of iron toxicity on different body organs. There was a direct moderate relationship between neopterin and IFN-γ.

Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease

2014 ◽  
Vol 233 (2) ◽  
pp. 454-459 ◽  
Author(s):  
Toru Miyoshi ◽  
Masayuki Doi ◽  
Shinichi Usui ◽  
Mutsumi Iwamoto ◽  
Masahito Kajiya ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Level ◽  
Related Protein ◽  
Anti Inflammatory ◽  
Artery Disease ◽  
Low Serum

scholarly journals Evaluation of Erythrocytes, Platelets, and Serum Iron Profile in Dogs with Chronic Enteropathy

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Veronica Marchetti ◽  
George Lubas ◽  
Andrea Lombardo ◽  
Michele Corazza ◽  
Grazia Guidi ◽  
...  
Keyword(s):  
Serum Iron ◽  
Activity Index ◽  
Binding Capacity ◽  
Iron Status ◽  
Disease Activity Index ◽  
Microcytic Anemia ◽  
Chronic Enteropathy ◽  
Before And After ◽  
Iron Binding Capacity ◽  
Iron Profile

The aim of this study is to evaluate iron status, erythrocyte, and platelet modifications in dogs with chronic enteropathy (CE). Dogs were grouped as food-responsive diarrhea (FRD, ), antibiotic-responsive diarrhea (ARD, ), and steroid-responsive diarrhea (SRD, ) relating to therapeutic-response. Clinical and haematological findings, evidence of gastrointestinal blood loss, and iron metabolism were evaluated before and after treatment. A mild normocytic or microcytic anemia and thrombocytosis were identified, respectively in 18.0% and 31.8% of CE dogs. No significant differences between pre- and posttreatment of hematocrit, haemoglobin, and mean corpuscular volume, platelet count and mean platelet volume were found. Statistical analysis pointed out significant differences between pre- and posttreatment in serum iron () and unsaturated iron binding capacity (UIBC) (). No significant correlations were found between these parameters and canine Inflammatory Bowel Disease activity index and pattern of CE as well.

scholarly journals DISTURBANCE OF IRON METABOLISM AND ULTRASTRUCTURAL FEATURES OF THE GINGIVA IN PATIENTS WITH Β-THALASSEMIA MAJOR

2018 ◽  
Vol 22 (5) ◽  
pp. 255-261
Author(s):  
Ramida Vaqif qizi Shadlinskaya ◽  
E. K Gasimov ◽  
S. A Israfilova
Keyword(s):  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Periodontal Diseases ◽  
Thalassemia Major ◽  
Control Group ◽  
Periodontal Tissues ◽  
Metabolism Disorder ◽  
Pathogenetic Factor ◽  
Iron Binding Capacity

Introduction: β-thalassemia major is a hereditary blood disease, a main pathogenetic factor of which is the disruption of the synthesis of β-chains of hemoglobin. Inevitable metabolic disorders that occur during regular blood transfusion form an additional risk of damage and cellular modification of organs and tissues, including the oral cavity. Aim: determination of the pathogenetic role of iron metabolism disorder in the development of chronic inflammatory periodontal diseases in patients with β-thalassemia. Material and methods: 12 patients with β - thalassemia major who had periodontal diseases were examined in the Republican Center of Thalassemia in Baku (average age is 18 ± 1.3 years). The control group consisted of 16 somatically healthy individuals with intact gingiva tissues (the average age is 18.0 ± 0.7 years). Serum Iron, ferritin, hepcidin, total iron-binding capacity (TIBC), level of Il2, Il6, Il10, TNFα were measured from peripheral blood samples. To determine the ultra-structural study of the periodontal tissues in patients with β-thalassemia major, the method of electron microscopy studies of gingiva biopsies was used. Results of the study: The study revealed an increase in the level of serum iron and ferritin against the background of a progressively decreasing TIBC in patients with β-thalassemia major. Also activation of pro-inflammatory cytokines - TNFα, Il6, Il10 was observed in homozygous patients. Metabolic indicators are compared with ultrastructural features of cellular elements of a gum. Signs of accumulation of iron in cellular elements both of its own plate and of the epithelial cover were compared. The presence of iron was recorded in immunocompetent cells - macrophages and lymphocytes. Conclusion: Summarizing the data obtained, we can conclude that deproteinization of ferritin cores and their detection both in the cytoplasm and in the nucleoplasm of immunocompotent cells leads to irreversible degenerative changes in cellular elements of the gingiva. The authors link the development of the generalized inflammatory - degenerative process in the periodontium with revealed exchange -structural violations.

scholarly journals Low serum iron is associated with anemia in CKD stage 1–4 patients with normal transferrin saturations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pei-Hua Yu ◽  
Ming-Yen Lin ◽  
Yi-Wen Chiu ◽  
Jia-Jung Lee ◽  
Shang-Jyh Hwang ◽  
...  
Keyword(s):  
Serum Iron ◽  
Reference Group ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Reactive Protein ◽  
Ckd Stage ◽  
Adjusted Logistic Regression ◽  
Stage 1 ◽  
Low Serum

AbstractLow transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency. Because malnutrition and inflammation are associated with low TIBC in chronic kidney disease (CKD), TSAT might not reflect iron status or risk for anemia. We examined whether low serum iron was a risk factor for anemia in CKD patients with normal TSAT. Thus we compare the risk for anemia in 2500 CKD stage 1–4 patients divided by TSAT (cutoff: 20%) and serum iron (cutoff: 70 μg/dL in men, 60 μg/dL in women). Our results confirmed low TIBC (< 200 μg/dL) was associated with hypoalbuminemia and high C-reactive protein. In fully-adjusted logistic regression, both “normal TSAT low iron” and “low TSAT low iron” groups were associated with baseline anemia (hemoglobin < 11 g/dL) (odds ratios (OR) 1.56; 95% confidence interval (CI) 1.13–2.16 and OR 2.36; 95% CI 1.76–3.18, respectively) compared with the reference group (normal TSAT normal iron). Sensitivity tests with different cutoffs for TSAT and iron also showed similar results. In patients without anemia, both groups were associated with anemia after 1 year (OR 1.69; 95% CI 1.00–2.83 and OR 1.94; 95% CI 1.11–3.40, respectively). In conclusion, CKD stage 1–4 patients with normal TSAT but low serum iron are still at risk for anemia.

scholarly journals Ameliorative Effect of L-Arginine as Antioxidant Agent on Hematological and Testicular Functions in Lead-Induced Toxicity in Male Rats

2018 ◽  
pp. 1-8
Author(s):  
Marwan A. Ibrahuim
Keyword(s):  
Binding Capacity ◽  
Iron Status ◽  
Hematological Parameters ◽  
Protective Role ◽  
Male Rats ◽  
Daily Injection ◽  
Heme Synthesis ◽  
Ameliorative Effect ◽  
Iron Binding Capacity ◽  
Induced Changes

Aims: The present study aimed to elucidate the protective role of L-Arginine on lead – induced suppression of the pathway of heme synthesis and the toxicity of lead on testis. Methodology: The current study included two experiments; the first was carried out on two groups to follow up the changes that could occur in iron status and reproductive system of male rats because of the lead exposure. The second experiment, three comparisons were made between three groups of rats with lead treatment only and other three groups rats with lead treatment followed by additional of daily injection of L-Arginine intraperitoneal about 500 mg L-Arginine / kg.b.wt. / day for 10, 20 and 30 days after the end of lead treatment. Results: Lead significantly abolished heme synthesis presented by decrease in Hb, Fe and ceruloplasmin (Cp) and elevation in total iron binding capacity (TIBC) and serum ferritin. Furthermore, testosterone (total and free) significantly decreased after rats treated with 1% lead acetate while, estradiol (E2) and acid phosphatase (total and prostatic) were elevated. The concentration of dehydroepiandrosterone sulphat (DHEA-S) did not change after lead treatment. Conclusion: Daily treatment with 500 mg L-Arginine/kg body weight prevented the suppressive effects of lead on hematological parameters and testicular functions. The mechanism of L-Arginine action on lead induced changes was attributed to protection of antioxidant capacity in cells in addition to the ability of L-Arginine to scavenge free radicals and acts as cell membrane stabilizer.

Transferrin Index: An Alternative Method for Calculating the Iron Saturation of Transferrin

1992 ◽  
Vol 38 (10) ◽  
pp. 2078-2081 ◽  
Author(s):  
J Beilby ◽  
J Olynyk ◽  
S Ching ◽  
A Prins ◽  
N Swanson ◽  
...  
Keyword(s):  
Iron Overload ◽  
Serum Iron ◽  
Binding Capacity ◽  
Clinical Chemistry ◽  
Iron Status ◽  
Laboratory Methods ◽  
Control Subjects ◽  
Iron Saturation ◽  
Iron Binding Capacity ◽  
Better Than

Abstract We surveyed 140 clinical chemistry laboratories in Australia to establish which laboratory methods they used to determine serum iron status: 125 measured serum iron (Fe), 85 measured transferrin (TRF), 47 measured total iron-binding capacity (TIBC), and 14 measured both TRF and TIBC. Of the 55 laboratories routinely reporting TRF saturation (TS), 16 calculated TS directly as (Fe/TIBC) x 100, and 9 used [Fe/(TRF x 2)] x 100. Thirty laboratories measured TRF and converted it to an equivalent TIBC concentration; the derived TIBC was then used to calculate TS. We measured iron, TIBC, and TRF concentrations in 94 control subjects, 59 patients with alcoholic liver disease (ALD), and 20 with proven genetic hemochromatosis (GH). TS was compared with a transferrin index (TI = Fe/TRF) to determine whether both methods were sensitive for GH screening and which method gave the fewest false-positive results with discrimination limits of &gt; 55% and &gt; 1.0, respectively. All GH patients were detected by both TS and TI at these limits. One control subject had a TI &gt; 1.0, whereas three control subjects had a TS &gt; 55%. Nine patients with ALD had a TI &gt; 1.0 and 11 ALD patients had a TS &gt; 55%. Some iron-overload patients had lower than expected TS values compared with TI, possibly because of ferritin interference in the TIBC assay. Also, the precision of the TRF assay was better than that of the TIBC assay: CVs of 1.85-3.68% vs 6.17%. We therefore recommend that calculated TI replace TS in screening for iron overload.

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