scholarly journals Variant Creutzfeldt-Jakob disease in a Canadian resident

2002 ◽  
Vol 6 (33) ◽  
Author(s):  
◽  
◽  
Keyword(s):  
Surveillance System ◽  
Collaborative Study ◽  
Personal Communication ◽  
National Network ◽  
Incidence Data ◽  
First Case ◽  
Collaborative Study Group ◽  
Jakob Disease ◽  
The Uk ◽  
Health Canada

Variant Creutzfeldt-Jakob disease (vCJD) has been confirmed in a resident of Saskatchewan, Canada (1). The patient, a man under the age of 50, was first notified to the Canadian national CJD surveillance system at Health Canada in April 2002 when his clinical presentation, age, and history of residence in the United Kingdom (UK) led Canadian doctors to suspect vCJD. Post-mortem examination of brain tissues by experts in Canada and the UK has now confirmed the diagnosis of vCJD. Since 1998, when the national CJD surveillance system was launched, all suspect cases of CJD are reported to Health Canada through a national network of specialist physicians. Incidence data are also shared with European and other allied countries as part of the Collaborative Study Group of CJD (EUROCJD, http://www.eurocjd.ed.ac.uk/euroindex.htm). This patient is the first case of vCJD reported in Canada, which together with 6 cases reported in France and one each in the Republic of Ireland, Italy and USA, brings the total number of cases with onset outside the UK to 10 (personal communication National CJD Surveillance Unit, Edinburgh).

scholarly journals Low incidence of Creutzfeldt-Jakob disease in Europe

2002 ◽  
Vol 6 (44) ◽  
Author(s):  
A M Molesworth ◽  
L Pritchard ◽  
H Ward
Keyword(s):  
Recent Article ◽  
Collaborative Study ◽  
European Countries ◽  
Study Group ◽  
Marked Rise ◽  
Regional Variations ◽  
Collaborative Study Group ◽  
Jakob Disease ◽  
Low Incidence ◽  
Ongoing Surveillance

A recent article on the incidence of Creutzfeldt-Jakob disease (CJD) in Germany shows consistently low rates of disease between 1994 and 2001, at less than one case per million inhabitants (1). CJD is a predominantly sporadic disorder, distributed worldwide with a reported incidence of about one in a million per year. Figures for Germany are in line with most other European countries (see European and Allied Countries Collaborative Study Group of CJD (EUROCJD), http://www.eurocjd.ed.ac.uk) but contrast with neighbouring Switzerland where a marked rise was observed in 2001, corresponding to an incidence of 2.7 per million that year (2, see figure). Although differences in case ascertainment and raised awareness of the disease in recent years are likely to account for regional variations in reported rates of CJD, ongoing surveillance of CJD is essential to monitor the situation to see if the pattern is sustained, both in Europe and worldwide.

scholarly journals Isolation and characterization of the new SARS-CoV-2 variant in travellers from the United Kingdom to India: VUI-202012/01 of the B.1.1.7 lineage

2021 ◽  
Vol 28 (2) ◽  
Author(s):  
Pragya D Yadav ◽  
Dimpal A Nyayanit ◽  
Rima R Sahay ◽  
Prasad Sarkale ◽  
Jayshri Pethani ◽  
...  
Keyword(s):  
United Kingdom ◽  
Severe Acute Respiratory Syndrome ◽  
Surveillance System ◽  
The United Kingdom ◽  
Isolation And Characterization ◽  
New Variant ◽  
The Uk ◽  
Local Transmission

We have isolated the new severe acute respiratory syndrome coronavirus-2 variant of concern 202 012/01 from the positive coronavirus disease 2019 cases that travelled from the UK to India in the month of December 2020. This emphasizes the need for the strengthened surveillance system to limit the local transmission of this new variant.

Radiation Oncology Education Collaborative Study Group Annual Spring Symposium: Initial Impact and Feedback

2021 ◽  
Author(s):  
David M. Rosenberg ◽  
Steve E. Braunstein ◽  
Emma C. Fields ◽  
Erin F. Gillespie ◽  
Jillian R. Gunther ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Collaborative Study ◽  
Study Group ◽  
Oncology Education ◽  
Collaborative Study Group

Delivering a shared library management system for Wales

2016 ◽  
Vol 37 (6/7) ◽  
pp. 385-395 ◽  
Author(s):  
Gareth Wyn Owen
Keyword(s):  
Management System ◽  
Review Of Literature ◽  
Content Type ◽  
Implementation Phase ◽  
Library Management ◽  
First Case ◽  
Library Management System ◽  
The Uk ◽  
Practical Implications

Purpose A case study of the Wales Higher Education Libraries Forum (WHELF) project to procure and implement a shared library management system (LMS) for all universities in Wales, together with the National Health Service Libraries in Wales and the National Library of Wales. In particular, the purpose of this paper is to explore the drivers to this collaboration, outline the benefits achieved and the framework to realise further benefits. Design/methodology/approach Case study review of the process, together with a review of literature on consortia and LMSs. Findings WHELF has developed into a more mature consortium through procuring and implementing a shared LMS. The process has delivered tangible benefits and is driving more work to realise further benefits. Research limitations/implications As the WHELF Shared LMS project is only nearing the end of the implementation phase, many of the anticipated operational benefits cannot be reported. Practical implications Useful case study for other consortia or potential consortia. Originality/value WHELF is in vanguard of consortia developments in the UK, and this is the first case study of the project.

Sporadic Creutzfeldt-Jakob disease in a 18-year-old in the UK

The Lancet ◽  
1995 ◽  
Vol 346 (8983) ◽  
pp. 1155-1156 ◽  
Author(s):  
D. Bateman ◽  
D. Hilton ◽  
S. Love ◽  
M. Zeidler ◽  
J. Beck ◽  
...  
Keyword(s):  
Jakob Disease ◽  
The Uk

scholarly journals Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yu Ning Liu ◽  
Jingwei Zhou ◽  
Tingting Li ◽  
Jing Wu ◽  
Shu Hua Xie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Epithelial Cells ◽  
Diabetic Kidney Disease ◽  
Early Stage ◽  
Collaborative Study ◽  
Oxidative Activity ◽  
Dependent Manner ◽  
Diabetic Kidney ◽  
Collaborative Study Group

The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly decreased the urinary protein and HAVCR1 excretion, inhibited the interstitial expansion, and downregulated the renal cell apoptosis and interstitial fibrosis. Renoprotection was also associated with a reduction in renocortical/urinary oxidative activity and the normalization of renal klotho expression. However, all of these actions were not observed when SDX was administered only at the late stage of diabetic nephropathy (from week 13 to 24). In vitro, advanced glycation end products (AGEs) dose-dependently enhanced the oxidative activity but lowered the klotho expression in cultured proximal tubule epithelial cells (PTECs). Also, H2O2 could downregulate the expression of klotho in a dose-dependent manner. However, overexpression of klotho reduced the HAVCR1 production and the cellular apoptosis level induced by AGEs or H2O2. Our study suggests that SDX may prevent the progression of DKD at the early stage by upregulating renal klotho expression, which inhibits the tubulointerstitial injury induced by oxidative stress.

scholarly journals Country-Specific Prevalence and Incidence of Youth-Onset Type 2 Diabetes: A Narrative Literature Review

2020 ◽  
Vol 76 (5) ◽  
pp. 289-296 ◽  
Author(s):  
Jane L. Lynch ◽  
Margarita Barrientos-Pérez ◽  
Mona Hafez ◽  
Muhammad Yazid Jalaludin ◽  
Margarita Kovarenko ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diagnostic Criteria ◽  
Incidence Rates ◽  
National Guidelines ◽  
Incidence Data ◽  
Epidemiology Data ◽  
The Usa ◽  
The Uk ◽  
Country Specific

<b><i>Background:</i></b> With increased awareness of type 2 diabetes (T2D) in children and adolescents, an overview of country-specific differences in epidemiology data is needed to develop a global picture of the disease development. <b><i>Summary:</i></b> This study examined country-specific prevalence and incidence data of youth-onset T2D published between 2008 and 2019, and searched for national guidelines to expand the understanding of country-specific similarities and differences. Of the 1,190 articles and 17 congress abstracts identified, 58 were included in this review. Our search found the highest reported prevalence rates of youth-onset T2D in China (520 cases/100,000 people) and the USA (212 cases/100,000) and lowest in Denmark (0.6 cases/100,000) and Ireland (1.2 cases/100,000). However, the highest incidence rates were reported in Taiwan (63 cases/100,000) and the UK (33.2 cases/100,000), with the lowest in Fiji (0.43 cases/100,000) and Austria (0.6 cases/100,000). These differences in epidemiology data may be partly explained by variations in the diagnostic criteria used within studies, screening recommendations within national guidelines and race/ethnicity within countries. <b><i>Key Messages:</i></b> Our study suggests that published country-specific epidemiology data for youth-onset T2D are varied and scant, and often with reporting inconsistencies. Finding optimal diagnostic criteria and screening strategies for this disease should be of high interest to every country. <b><i>Trial Registration:</i></b> Not applicable.

scholarly journals Latest quarterly analysis of variant Creutzfeldt-Jakob disease incidence in the UK shows continued slow-down

2003 ◽  
Vol 7 (18) ◽  
Author(s):  
N J Andrews
Keyword(s):  
United Kingdom ◽  
Disease Incidence ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk

Five new cases of variant Creutzfeldt-Jakob disease (vCJD) were diagnosed in the United Kingdom (UK) in the first quarter of 2003, bringing the total number of confirmed or probable cases to 134 (1). Five deaths occurred in the first quarter, bringing the total number of deaths to 126. The total number of onsets and deaths by year are shown in the table.

scholarly journals Initial European Commission response to possible vCJD transmission by blood

2003 ◽  
Vol 7 (51) ◽  
Author(s):  
Keyword(s):  
European Commission ◽  
Secretary Of State ◽  
Jakob Disease ◽  
The Uk

Following the information made available yesterday by the UK Secretary of State for Health about the possibility of transmission of variant Creutzfeld-Jakob Disease

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