scholarly journals Risk Factors of Laryngeal Carcinoma in Otorhinolaryngology-Head and Neck Division of Dr. Hasan Sadikin Hospital Bandung

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Sarah A Putri ◽  
Yussy A Dewi ◽  
Birgitta M Dewayani
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Head And Neck ◽  
Laryngeal Carcinoma ◽  
Laryngopharyngeal Reflux ◽  
Smoking Habit ◽  
Neck Surgery ◽  
Smoking History ◽  
Case Group ◽  
Carcinoma Larynx

Laryngeal carcinoma is a squamous cell malignancy of larynx epithelial with the Indonesian incidence of 2.0 per 100,000 men and 0.2 per 100,000 women. The risk factors of laryngeal carcinoma include age, sex, family history, smoking habit, alcohol drink, and gastroesophangeal reflux disease (GERD)/ laryngopharyngeal reflux (LPR). This study aimed to know some risk factors for laryngeal carcinoma mentioned in Dr. Hasan Sadikin Hospital, Bandung. Hospital-based unmatched case control study was selected as the methods, involving 80 patients in Oncology Clinic of Otorhinolaryngology-Head and Neck Surgery Department, Dr. Hasan Sadikin General Hospital. The medical records of the carcinoma larynx patients was taken as a study instrument. The results were age percentage of 50-79 years old in the case group is 82.5% therefore, it increase the risk of having laryngeal carcinoma by 7.29 times. Male respondents dominate in the case group (90%) with OR =6.00. Respondents with GERD in the case group is 45%, increasing the risk 15.54 times and these results was significant (p<0.005). Other analyzed variables, such as family history, smoking history, and alcohol consumption is not significant statistically (p>0.005). This study shows the results of age, sex, and GERD/LPR are corresponding with the results with previous studies. Otherwise, the results of smoking, alcohol, and family history are not. Therefore, old age, male sex, and GERD increase the risk of having laryngeal carcinoma.

Risk factors for surgical site infection after supraclavicular flap reconstruction in patients undergoing major head and neck surgery

Head & Neck ◽  
2016 ◽  
Vol 38 (11) ◽  
pp. 1615-1620 ◽  
Author(s):  
Neerav Goyal ◽  
Kevin S. Emerick ◽  
Daniel G. Deschler ◽  
Derrick T. Lin ◽  
Bharat B. Yarlagadda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Surgical Site Infection ◽  
Head And Neck ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Site Infection ◽  
Flap Reconstruction ◽  
Supraclavicular Flap

Impact of Young Age on the Presentation of Saccular Intracranial Aneurysms: Population-Based Analysis of 4082 Patients

Neurosurgery ◽  
2017 ◽  
Vol 82 (6) ◽  
pp. 815-823 ◽  
Author(s):  
Sari Räisänen ◽  
Juhana Frösen ◽  
Mitja I Kurki ◽  
Terhi Huttunen ◽  
Jukka Huttunen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Intracranial Aneurysms ◽  
De Novo ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Population Based ◽  
Young Age ◽  
Smoking History ◽  
Old Patients ◽  
First Diagnosis

Abstract BACKGROUND Formation and rupture of saccular intracranial aneurysms (sIAs) may have different pathobiologies in patients with younger age at first diagnosis of sIA disease. OBJECTIVE To study the phenotype of sIA disease and formation of new (de novo) sIAs in patients below 40 yr. METHODS A population-based cohort study was conducted in 613 young (&lt;40 yr) sIA patients with first diagnosis between 1980 and 2014 and total angiographic follow-up of 3768 yr. RESULTS Of the 613 sIA patients &lt;40 yr, 508 had aneurysmal subarachnoid hemorrhage (sIA-SAH) and 105 unruptured sIA(s) at first sIA diagnosis. Hypertension was 2 times less common among &lt;40 than &gt;40-yr-old patients (unruptured and ruptured). Smoking was very prevalent in &lt;40-yr-old patients (33% in SAH, 68% unruptured). SAH patients &lt;40 yr more often had family history of sIA, and lower PHASES scores (age omitted, P &lt; .001). Ruptured sIAs were small (&lt;7 mm) in 33% of 39 to 30 yr patients, in 44% of 29 to 20 yr patients, and 57% of &lt;19 yr patients. Their shape was irregular in 90%, 94%, and 95%, respectively. Smoking history (hazard ratio [HR] 2.8, 95% confidence interval [CI] 1.2-7.0), family history for sIAs (HR 3.1, 95% CI 1.3-7.7), and age at presentation (HR .91 per year, 95% CI .85-.98) were risk factors for de novo sIA formation, diagnosed in 4% even after 20 yr (median 11.8 yr). CONCLUSION Smoking and family history are risk factors for sIA formation and aneurysmal SAH at young age. Young aneurysmal SAH patients had lower PHASES scores and often rupture from a small sIA, suggesting need for more aggressive management.

Risk factors associated with a second primary lung cancer (SPLC) in patients (pts) with a previous initial primary lung cancer (IPLC).

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13166-e13166
Author(s):  
Misako Nagasaka ◽  
Dina Farhat ◽  
Kimberly Belzer ◽  
Seongho Kim ◽  
Hirva Mamdani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Family History ◽  
Surgical Resection ◽  
Tobacco Use ◽  
Primary Lung Cancer ◽  
Smoking History ◽  
Factors Associated ◽  
Increased Risk ◽  
First Diagnosis

e13166 Background: The risk for development of a SPLC after treatment of an IPLC is around 1% to 2% per pt per year. The aim of this study was to characterize the risk factors associated with the development of a SPLC. Methods: Pts registered in the Karmanos Cancer Institute Tumor Registry diagnosed with an IPLC between 2000 and 2017 were included in this study. Pts with an IPLC who later developed a SPLC were matched for age, histology and stage to pts with an IPLC who did not develop a SPLC. SPLC was defined as a second lung cancer with a different pathology or if the same pathology, anatomically, molecularly, or chronologically distinct. Six variables including: stage at IPLC, histology, family history, surgery as a primary treatment for IPLC, and smoking history (determined by pack years, and continued tobacco use after first diagnosis) were reviewed. Logistic and Cox regression analyses were performed to determine the relationship of these characteristics with the development of a SPLC, and their association with overall survival (OS). Results: 121 pts with IPLC who later developed an SPLC were identified and compared to 120 pts with IPLC who did not develop a SPLC. Logistic analyses did not show that stage at first diagnosis, histology, family history, smoking history, and continued tobacco use after first diagnosis to be relevant for increased risk of SPLC. Pts who were primarily treated with surgical resection had a significantly higher probability of developing a SPLC (Odds Ratio: 0.24, 95% CI: 0.12 to 0.48, p < 0.001). Pts who did not have surgical resection as their primary mode of treatment for IPLC had a significantly higher risk of death than those who received surgical resection (HR 3.02, 95% CI: 1.99 to 4.57; p < 0.001). Conclusions: Based on our findings, pts who had surgical resection for an IPLC were found to have improved OS and a higher possibility of developing a SPLC. Stage at first diagnosis of IPLC, histology, family history, smoking history and continued use of tobacco after first diagnosis did not correlate with increased risk for SPLC. These results warrant further investigation and if confirmed could have an impact on surveillance recommendations post resection of initial lung cancers.

Surgical Site Infections in Major Head and Neck Surgeries Involving Pedicled Flap Reconstruction

2016 ◽  
Vol 126 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Neerav Goyal ◽  
Bharat B. Yarlagadda ◽  
Daniel G. Deschler ◽  
Kevin S. Emerick ◽  
Derrick T. Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Head And Neck ◽  
Free Flap ◽  
Operating Time ◽  
Surgical Site Infections ◽  
Free Flaps ◽  
Neck Surgery ◽  
Pedicled Flap ◽  
American Society ◽  
Clean Contaminated

Objective: To evaluate surgical site infections (SSI) after pedicled reconstruction in head and neck surgery. Methods: Records of patients with pedicled flap reconstructions between 2009 and 2014 at Massachusetts Eye and Ear were reviewed. Onset of SSI or fistula ≤30 days postoperatively was noted. A free flap cohort was reviewed for comparison. Results: Two hundred and eight pedicled reconstructions were performed for cancer (83%), osteoradionecrosis (7%), and other reasons (10%). Most (72%) cases were clean-contaminated and American Society of Anesthesiologists classification 3 or higher (73%); 63% of patients had prior radiation. The SSIs occurred in 9.1% and were associated with a longer length of stay ( P = .004) but no particular risk factors. Seventeen patients developed a fistula (11 without SSI). The SSI rates were not significantly different between pedicled and free flaps, but pedicled flap patients were older, more likely to have had prior surgery and/or radiation, and be methicillin-resistant Staphylococcus aureus positive. In the combined population, multivariate analysis demonstrated clean-contaminated wound classification ( P = .03), longer operating time ( P = .03), and clindamycin prophylaxis ( P = .009) as SSI risk factors. Conclusions: The SSI rate following pedicled flap surgeries was low and similar to free flap surgeries despite a significantly different population. No specific risk factors were associated with developing a pedicled flap SSI.

scholarly journals Interstitial Lung Disease Associated With Cetuximab in Patients With Head and Neck Carcinoma: A Single-Institution Experience in Japan

2019 ◽  
Vol 103 (11-12) ◽  
pp. 528-533
Author(s):  
Hiroki Sato ◽  
Kiyoaki Tsukahara ◽  
Isaku Okamoto ◽  
Soichiro Takase ◽  
Kunihiko Tokashiki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Head And Neck ◽  
Performance Status ◽  
Head And Neck Carcinoma ◽  
Smoking History ◽  
Advanced Squamous Cell Carcinoma ◽  
Lung Disorder ◽  
Neck Carcinoma

Objective: This study retrospectively analyzed the risk of interstitial lung disease with cetuximab using risk factors known to be associated with interstitial lung disease during administration of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI). Summary of background data: Cetuximab is an inhibitor of EGFR commonly used for advanced squamous cell carcinoma of the head and neck. Interstitial lung disease is a rare but serious adverse event of cetuximab. EGFR-TKIs are molecularly targeted drugs resembling cetuximab and show increased risk of interstitial lung disease associated with positive smoking history, age &gt;55 years, preexisting lung disorder, and poor performance status. Methods: Among 44 patients treated with cetuximab for advanced squamous cell carcinoma of the head and neck between March 2013 and April 2015 at Tokyo Medical University, 6 patients developed interstitial lung disease. Smoking history, age, preexisting lung disorder, and performance status were examined for these 6 patients. Results: Two of these 6 patients died due to interstitial lung disease. All patients with interstitial lung disease were &gt;55 years old and had a history of smoking. Three patients with interstitial lung disease had a preexisting lung disorder. Performance status was 0 in 4 patients and 1 in 2 patients. Conclusions: Age &gt;55 years, smoking history, and preexisting lung disease may represent risk factors for interstitial lung disease during cetuximab treatment for head and neck carcinoma, whereas performance status may not.

Abstract 1528: Gender Differences In The Effect Of Traditional Cardiac Risk Factors On Age At Presentation With Stemi

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
William Herzog ◽  
Thomas Aversano
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Family History ◽  
Female Gender ◽  
Smoking History ◽  
Men And Women ◽  
History Of ◽  
Males And Females ◽  
Artery Disease

For coronary artery disease (CAD), female gender is ’protective’, so that women typically present with clinically apparent CAD a decade later than men. We examined the extent to which traditional cardiovascular risk factor influence the age at presentation with STEMI in men and women. The Cardiovascular Patient Outcomes Research Team (C-PORT) primary PCI registry includes 7197 patients (5070 males and 2109 females) who presented with STEMI at 33 participating hospitals. The table below depicts the average age at presentation with STEMI in males and females with and without diabetes, hypercholesterolemia, hypertension, a family history of coronary artery disease and smoking history (current or former). The effect of smoking, family history and hypertension on age at presentation remained significant in multivariate analysis in both men and women. In both males and females, a family history of CAD and a positive smoking history are associated with presentation with STEMI at a younger age. Both have a greater effect in females. This is particularly true of smoking with lowers the age of presentation by 9 years in women, compared with 3.8 years in men. Male and female patients with a history of hypertension are older at presentation with STEMI, perhaps because the anti-ischemic effects of anti-hypertensive medications. We conclude that while the effect of most traditional risk factors for CAD on age at presentation with STEMI are similar in men and women, smoking lowers the age at presentation to a much greater degree in women. In women who do not smoke, STEMI is delayed for a decade or more compared to men; for women who do, the protective effect of female gender is nearly obliterated.

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