scholarly journals Clinicopathological Variants of Breast Cancer in a Tertiary Care Hospital in Pakistan

2021 ◽  
Vol 15 (1) ◽  
pp. 28-31
Author(s):  
Raja Najam ul Haq ◽  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Tertiary Care ◽  
Age Groups ◽  
Subsequent Treatment ◽  
Cancer Type ◽  
Care Hospital ◽  
Elderly Age

Background: Breast cancer is a growing phenomenon among females which has ever-lasting ramifications on the patient as well as the family. The only way of subjugating breast cancer is through an efficient and effective screening and subsequent treatment process. Objective: This study aimed at identifying the different clinicopathological patterns of breast cancer and the age group most frequently targeted by CA breast. Study Design: A prospective study. Settings: Fauji Foundation Hospital (FFH), Rawalpindi and Foundation University Medical College (FUMC) Pakistan. Duration: Six months from January 2018 to June 2018. Methodology: This study included 224 female patients, irrespective of their nationality by convenience sampling, who underwent any kind of breast surgery. The patients were evaluated according to their age, side of breast involved, site of lump in the breast, histopathology report and type of lesion (inflammatory, benign or malignant). The data was entered and analyzed using IBM SPSS version 25. Results: Our study sample of 224 individuals was found to have about 23 different histopathological variants of breast cancer. Invasive ductal carcinoma was found in almost all age groups and it was also the most common variant (80.8%), followed by invasive lobular carcinoma (4%). Majority of the cases were recorded in the elderly age bracket from 55 to 65 years. Right breast was found to be involved in 53.6% of the cases whereas left breast involvement was at 44.2%. 5 patients had lesions in both of their breasts. Upper outer quadrant was affected in 88% females followed by upper inner quadrant (6.7%). All four quadrants were involved in only 3 patients. Conclusion: This study concluded that invasive ductal carcinoma is the commonest clinical as well as pathological type of CA breast. 181 females out of a total of 224 had invasive ductal carcinoma. Therefore, this particular breast cancer type merits our special attention. Our study further concluded that most of the breast pathologies were found in elderly females aged between 55 and 65 years.

scholarly journals The Utilization of Physics Parameter to Classify Histopathology Types of Invasive Ductal Carcinoma (IDC) and Invasive Lobular Carcinoma (ILC) by using K-Nearest Neighbourhood (KNN) Method

2018 ◽  
Vol 8 (4) ◽  
pp. 2442
Author(s):  
Anak Agung Ngurah Gunawan ◽  
I Wayan Supardi ◽  
S. Poniman ◽  
Bagus G. Dharmawan
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Diagnose Breast Cancer ◽  
Object Based ◽  
Computer Aided ◽  
The Mean ◽  
Learning Data

<p>Medical imaging process has evolved since 1996 until now. The forming of Computer Aided Diagnostic (CAD) is very helpful to the radiologists to diagnose breast cancer. KNN method is a method to do classification toward the object based on the learning data which the range is nearest to the object. We analysed two types of cancers IDC dan ILC. 10 parameters were observed in 1-10 pixels distance in 145 IDC dan 7 ILC. We found that the Mean of Hm(yd,d) at 1-5 pixeis the only significant parameters that distingguish IDC and ILC. This parameter at 1-5 pixels should be applied in KNN method. This finding need to be tested in diffrerent areas before it will be applied in cancer diagnostic.</p>

scholarly journals Histopathological Study of Malignant Neoplasm of Breast of Different Age and Sex Groups In a Tertiary Care Hospital

2018 ◽  
Vol 5 (2) ◽  
pp. 42-44
Author(s):  
Nazmun Nahar ◽  
Mohammed Iqbal ◽  
Kazi Md Shahidur Rahman ◽  
Md Abdullah Yusuf ◽  
Shahed Iqbal ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Breast Neoplasm ◽  
Ductal Carcinoma ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Care Hospital ◽  
Age Group ◽  
Breast Lump ◽  
Malignant Breast ◽  
Age And Sex

Background: Various types of female breast cancer associated with rapidly increasing age incidence. Objective: The purpose of the present study was to find out the frequency of different types of malignant neoplasm of breast in different age and sex.Methodology: This cross-sectional study was carried out at the Department of Pathology, Chittagong Medical College, Chittagong, Bangladesh from May 2005 to June 2006. Patients presented with breast lump of different age and sex were subjected to this study. Details gross examination was done followed by H & E staining for histopathological study.Result: A total number of 48 samples were selected after fulfilling the inclusion and exclusion criteria. This present study conducted in 27 specimens out of 48 breast lump. Among these benign and malignant were 21 and 27, respectively. Majority of the malignancy found in age group 41-50 years. Histopathologically Invasive ductal carcinoma was common 81.5%.There was significant association between different age group and type of neoplasm. In relation to sex malignant breast neoplasm was more common in female.Conclusion: In conclusion invasive ductal carcinoma was the commonest lesion of breast. In relation to sex malignant breast neoplasm was more common in female.Journal of Current and Advance Medical Research 2018;5(2):42-44

Application of Ultrasonography in the Pathological Study of Breast Cancer in Female Patients with Breast Lesions

2020 ◽  
Vol 10 (4) ◽  
pp. 947-953
Author(s):  
Yajuan Wang ◽  
Yuan Fu ◽  
Guangsen Li ◽  
Tianlang Jin
Keyword(s):  
Breast Cancer ◽  
Blood Flow ◽  
Invasive Ductal Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Medullary Carcinoma ◽  
Pathological Classification ◽  
Significant Difference ◽  
The Relationship

The retrospective analysis of the ultrasonographic features of 108 cases of breast cancer confirmed by surgery and pathology, namely the relationship between mass boundary, posterior echo, calcification and blood flow signal and pathological type, was to explore the features of ultrasound sonography of breast cancer. The link between pathological typing. The results of the study showed that the ultrasound showed that the border of the nvasive ductal carcinoma was mostly burr-like. The ultrasound showed that the border of the invasive lobular carcinoma was mostly strong echo halo. The medullary carcinoma had a clear boundary, while the intraductal carcinoma showed more unclear borders. There was no significant difference in the relationship between the boundary of the mass and the pathological types. Ultrasound of invasive ductal carcinoma and invasive lobular carcinoma showed a posterior echo attenuation, and medullary carcinoma showed more posterior echo enhancement. The relationship between the echo of the posterior mass of the tumor and the pathological types was statistically different. The detection rate of ultrasound calcification in invasive ductal carcinoma and invasive lobular carcinoma was higher. The calcification in medullary carcinoma was less common. The calcification in the pathology of intraductal carcinoma was better. High, but ultrasound can only detect half of it. There was no significant difference in the relationship between calcification and pathological types in the tumor; ultrasound showed that most of the blood flow signals were abundant, suggesting that there was no statistical difference between the blood flow classification and the pathological classification of the tumor. The results of the thesis indicate that the ultrasound characteristics of breast cancer have a high diagnostic value for its pathological classification.

scholarly journals Clinical pathological and epidemiological study of triple negative breast cancer

2017 ◽  
Vol 5 (6) ◽  
pp. 2657
Author(s):  
Arun Ajay ◽  
Priya Radhakrishnan
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Tertiary Care ◽  
High Rate ◽  
Care Hospital ◽  
Breast Carcinomas ◽  
Significant Difference ◽  
Her 2 ◽  
Epidemiological Characteristics

Background: Worldwide breast cancer is the most frequently diagnosed life threatening cancer in women and a leading cause of cancer death among women. In Kerala, India around 30% of cancer-affected women have carcinoma breast. Breast carcinomas which do not express estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER-2/neu) receptors are known as triple negative breast carcinomas (TNBC). They are extremely aggressive with poor prognosis. Here the authors described the clinical pathological and epidemiological characters of triple negative breast carcinomas in a tertiary care hospital in Kerala, India and compare with non-TNBC.Methods: It was a cross sectional comparative study. Clinical, pathological and epidemiological characteristics of 75 cases of TNBC were compared with that of 225 cases of non-TNBC presented in Department of General Surgery, Government medical college, Kozhikode, Kerala, India between a period from March 2014 to October 2015 (20 months). Patients were recruited after obtaining an informed consent. ER, PR, HER-2/neu status were determined by immunohistochemical staining. Data obtained were statistically analyzed using SPSS software.Results: Triple negative breast carcinoma was significantly associated with a younger age (mean age 43.67 years), early age of menarche. Commonly seen in premenopausal age group (78.7%). Patients with the triple-negative carcinoma had relatively large tumors (mean size 4.45cm compared to 3.14cm) and a high rate of node positivity (86.67%). More advanced stage at diagnosis with high grade tumor characteristics. Most common histopathology was invasive ductal carcinoma (98.7%) but no statistical difference was noted with non-TNBC.Conclusions: No significant difference was noted between TNBC and non TNBC on comparing family history, parity, age at 1st child birth, OCP use. The outcome of the disease following treatment was unable to study due to short time frame of the study.

DIFFERENTIAL DIAGNOSIS OF NASAL MASS IN A TERTIARY CARE HOSPITAL OF JHARKHAND

2021 ◽  
pp. 6-7
Author(s):  
Md Raihan ◽  
Suraj Sinha ◽  
Sona Pathak ◽  
Sunil Kumar Mahto
Keyword(s):  
Differential Diagnosis ◽  
Tertiary Care ◽  
Age Groups ◽  
Nasal Discharge ◽  
Care Hospital ◽  
Elderly Age ◽  
Female Ratio ◽  
Nasal Mass ◽  
Abnormal Growth ◽  
Male To Female

Background: Nasal mass is abnormal growth in the nose, which may be benign or malignant and may be unilateral or bilateral. Nasal masses in most patients present with complaints of nasal obstruction. It may cause nasal discharge, epistaxis and anosmia. A nasal mass can have various differential diagnosis which this study aims to explore. Material and Methods: A retrospective study of histopathologically diagnosed cases of nasal masses for a period 3 years from January 2017 to December 2019. Results: Out of 95 patients 55 (57.89%) male and 40 (42.10%) female, male to female ratio is 1.37:1 with a mean age of 23 years (range= 2-63 years). Most of the cases 94(98.95%) were non-malignant and only 1(1.05%) was malignant (Adenoid cystic carcinoma). Malignancy of sinonasal tract is rare. Conclusion: With this study we can say that nasal masses are more common in males than females, adults age groups affected more than elderly age groups. It is also inferred that most of the nasal masses are benign in nature and very few cases are malignant in nature.

Comparison of Oncotype DX Recurrence Score by Histologic Types of Breast Carcinoma

2015 ◽  
Vol 139 (12) ◽  
pp. 1546-1549 ◽  
Author(s):  
Philip E. Bomeisl ◽  
Cheryl L. Thompson ◽  
Lyndsay N. Harris ◽  
Hannah L. Gilmore
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Recurrence Score ◽  
Mucinous Carcinoma ◽  
Oncotype Dx ◽  
Histologic Type ◽  
Histologic Types ◽  
Oncotype Dx Recurrence Score

ContextOncotype DX (ODX) is a widely used commercial assay that estimates the risk of distant recurrence and may predict the benefit of chemotherapy in a subset of breast cancers. Some studies have shown the ability to predict Oncotype DX recurrence score (ODXRS), based on routinely reported pathologic features; however, there are limited data correlating specific histologic type of breast cancer to ODXRS.ObjectiveTo compare ODXRS to specific histologic types of breast cancer.DesignOne hundred eighty-four cases were sent for ODXRS testing and the results were compared with histologic type and grade.ResultsThe highest average ODXRS was seen in invasive ductal carcinoma with micropapillary features (29) followed by invasive ductal carcinoma not otherwise specified (mean = 19.4, SD = 11.6), invasive mucinous carcinoma (mean = 17.2, SD = 5.9), invasive lobular carcinoma (mean = 15.7, SD = 7.2), mixed ductal and lobular carcinoma (mean = 14.1, SD = 7.7), tubular carcinoma (10.0), and mixed ductal and mucinous carcinoma (mean = 8.0, SD = 4.2). Most tumors that had a high ODXRS were grade 3 invasive ductal carcinoma, representing 13 of a total of 20 cases (65%). Interestingly, 3 of the 4 cases of pure invasive mucinous carcinoma had an intermediate ODXRS.ConclusionsAlthough the numbers are small, our findings raise further awareness of the significance between histologic type and grade, and RS in breast cancer. In some special histologic types of breast cancer, particularly those considered to follow either an excellent or poor clinical course by histology alone, it is unclear whether the ODXRS results are as meaningful as in carcinomas of no special type. Further investigation with higher numbers and outcome data is needed.

scholarly journals A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

2014 ◽  
Vol 03 (03) ◽  
pp. 179-181 ◽  
Author(s):  
Jitendra Singh Nigam ◽  
Poonam Yadav ◽  
Neelam Sood
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Tertiary Care ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Carcinoma Breast ◽  
Demographic Profile ◽  
Referral Center ◽  
Retrospective Audit

Abstract Background: Data on the demographic profile of breast cancer patients from Delhi is scarce and whatever is available is from higher referral center. Our hospital caters to patients from an urban population of the lower socioeconomic strata and is a representation of cases at a tertiary care hospital in west Delhi. In Delhi, breast cancer (26.8%) is commonest cancer among the female followed by cervix (12.5%), gallbladder (7.2%), ovary (7.1%), and uterus (3.3%). Aims and Objectives: A retrospective audit of breast cancer patients presenting at a tertiary referral center from 2004 to 2011. Materials and Methods: A total of 328 cases diagnosed as carcinoma breast on histopathology from year 2004 to 2011 were retrieved and studied retrospectively with regards to demographic profile and their histological features with estrogen receptor (ER), progesterone receptor (PR), and Her2neu status.Results: The median age of presentation was 49 years of age. Infiltrating ductal carcinoma (IDC, not otherwise specified (NOS)) was the commonest histopathological variant (81.40%) followed by medullary carcinoma (10.36%) and mucinous carcinoma (2.74%). Triple negative were found to be the commonest group comprising 39.4% of all the cases followed by ER and PR both positive. Pathological tumor, node, and metastasis (TNM) staging showed most common group was T 2 N 0 M 0 ( 19.5%) followed by T 2 N 1 M 0 (17.1%) and T 2 N 2 M 0 (14%). Conclusion: The incidence of breast cancer in the India and include a higher incidence of ER, PR, and Her2neu negative disease in west Delhi.

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