scholarly journals A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

2014 ◽  
Vol 03 (03) ◽  
pp. 179-181 ◽  
Author(s):  
Jitendra Singh Nigam ◽  
Poonam Yadav ◽  
Neelam Sood
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Tertiary Care ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Carcinoma Breast ◽  
Demographic Profile ◽  
Referral Center ◽  
Retrospective Audit

Abstract Background: Data on the demographic profile of breast cancer patients from Delhi is scarce and whatever is available is from higher referral center. Our hospital caters to patients from an urban population of the lower socioeconomic strata and is a representation of cases at a tertiary care hospital in west Delhi. In Delhi, breast cancer (26.8%) is commonest cancer among the female followed by cervix (12.5%), gallbladder (7.2%), ovary (7.1%), and uterus (3.3%). Aims and Objectives: A retrospective audit of breast cancer patients presenting at a tertiary referral center from 2004 to 2011. Materials and Methods: A total of 328 cases diagnosed as carcinoma breast on histopathology from year 2004 to 2011 were retrieved and studied retrospectively with regards to demographic profile and their histological features with estrogen receptor (ER), progesterone receptor (PR), and Her2neu status.Results: The median age of presentation was 49 years of age. Infiltrating ductal carcinoma (IDC, not otherwise specified (NOS)) was the commonest histopathological variant (81.40%) followed by medullary carcinoma (10.36%) and mucinous carcinoma (2.74%). Triple negative were found to be the commonest group comprising 39.4% of all the cases followed by ER and PR both positive. Pathological tumor, node, and metastasis (TNM) staging showed most common group was T 2 N 0 M 0 ( 19.5%) followed by T 2 N 1 M 0 (17.1%) and T 2 N 2 M 0 (14%). Conclusion: The incidence of breast cancer in the India and include a higher incidence of ER, PR, and Her2neu negative disease in west Delhi.

To Determine the Prevalence of Obesity in Breast Cancer Patients

2021 ◽  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Cancer Patients ◽  
Body Mass ◽  
Tertiary Care ◽  
Overweight And Obesity ◽  
World Health ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Prevalence Of Obesity

Background: Breast Cancer is one of the leading causes of death worldwide. Pakistan alone has the highest rate of Breast Cancer than any other Asian country as approximately 90000 new cases are diagnosed every year out of which 40000 dies. Obesity is also a critical public health problem growing with every passing year in Pakistan and worldwide. Research studies are being conducted worldwide regarding the relation between the two problems. Objective: The objective of this study is to determine the prevalence of obesity in breast cancer patients in a tertiary care hospital in Karachi, Pakistan. Methods: BMI is used as a screening tool for overweight and obesity. According to World Health Organization, a body mass index (BMI) over 25 is considered overweight, and over 30 is obese. A retrospective analysis of 262 patients diagnosed with Breast Cancer during 2019 and 2020 was performed. Patients’ hospital records in Oncology were reviewed. The weight in kilograms and height in centimeters of patients were reviewed. Their BMI was calculated and recorded using the SPSS system. Results: The median BMI was 28.25 kg/m2 with an interquartile range of 25.15 - 31.99 kg/m2. Nearly 80% of the study participants had body mass index higher than normal levels (n=203, 77.5%) and out of them approximately half were overweight (n=104, 51.2%) and the remaining were obese (n=99, 48.7%). Conclusion: We conclude from our study that body mass index is positively correlated with breast cancer occurrence and thus the proportion of females having BMI >= 25 was significantly higher among patients.

scholarly journals DRUG PRESCRIPTION PATTERN OF BREAST CANCER PATIENTS IN A TERTIARY CARE HOSPITAL IN WEST BENGAL: A CROSS-SECTIONAL AND QUESTIONNAIRE-BASED STUDY

2018 ◽  
Vol 11 (3) ◽  
pp. 398
Author(s):  
Anjan Adhikari ◽  
Dipesh Chakraborty ◽  
Rania Indu ◽  
Sangita Bhattacharya ◽  
Moumita Ray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Patients ◽  
West Bengal ◽  
Tertiary Care Hospital ◽  
Drug Prescription ◽  
Tertiary Care ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Cross Sectional

 Objective: Cancer is a disease of uncontrolled division of cells in any part of the body. Breast cancer most common in women accounts for 13% of the death worldwide. The objective of the present study was to evaluate the drug prescription pattern of breast carcinoma patients in a tertiary care hospital of West Bengal.Methods: This was a cross-sectional observational questionnaire-based study done for a period of 6 months at the Department of Pharmacology in Collaboration with the Department of Surgery and Department of Radiotherapy of a Tertiary Care Hospital at Kolkata, West Bengal, India. Female patients with breast cancer (originated from epithelial tissues) of different types and grade attending surgery outdoor patient department were taken as subjects for the study, after signing informed consent.Results: The present study evaluated 28 patients (n=28) diagnosed as breast cancer by the physicians of the department of surgery and radiotherapy. It was observed that breast cancer was mostly found in the middle age group. Breast carcinoma in postmenopausal women accounted to 75%. The most prevalent breast cancer was invasive ductal carcinoma, accounting to 75% of the study population. 5-Fluorouracil, epirubicin, doxorubicin, cyclophosphamide, docetaxel/paclitaxel, and carboplatin were mostly used as chemotherapeutic agent.Conclusion: Breast carcinoma being a prevalent type of cancer in females, the present study tried to evaluate the pattern of prescribing chemotherapeutic agents for breast cancer patients in a tertiary care hospital. Such study is essential to evaluate and refine the therapeutic regimen of the cancer patients to reduce their sufferings.

scholarly journals Assessment of quality of life in breast cancer patients at a tertiary care hospital

2013 ◽  
Vol 4 (1) ◽  
pp. 15 ◽  
Author(s):  
G Damodar ◽  
T Smitha ◽  
S Gopinath ◽  
S Vijayakumar ◽  
YedukondalaA Rao
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Breast Cancer Patients

scholarly journals Immunohistochemical Profile of Breast Cancer Patients at a Tertiary Care Hospital in New Delhi, India

2015 ◽  
Vol 16 (12) ◽  
pp. 4959-4964 ◽  
Author(s):  
Dinesh Chandra Doval ◽  
Anila Sharma ◽  
Rupal Sinha ◽  
Kapil Kumar ◽  
Ajay Kumar Dewan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
New Delhi ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Immunohistochemical Profile

scholarly journals Clinicopathological Profile of Breast Cancer Patients at a Tertiary Care Hospital in Marathwada Region of Westen India

2016 ◽  
Vol 17 (4) ◽  
pp. 2195-2198 ◽  
Author(s):  
Unmesh Vidyadhar Takalkar ◽  
Shilpa Balaji Asegaonkar ◽  
Umesh Kulkarni ◽  
Pushpa R Kodlikeri ◽  
Ujwala Kulkarni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Clinicopathological Profile

scholarly journals Olanzapine versus aprepitant for the prophylaxis of Chemotherapy-induced nausea and vomiting in patients receiving Taxane/ Adriamycin/ Cyclophosphamide (TAC) regimen for post-mastectomy breast cancer

2020 ◽  
Vol 11 (4) ◽  
pp. 7932-7936
Author(s):  
Joyita Krishnamurthi ◽  
Lakshmi Kanthamma S ◽  
Jayalakshmi N ◽  
Praveen D ◽  
Ranadheer Chowdary P ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Serotonin Receptor ◽  
Prospective Observational Study ◽  
Breast Cancer Incidence ◽  
Tertiary Care ◽  
Antipsychotic Agent ◽  
Nausea And Vomiting ◽  
Care Hospital ◽  
Breast Cancer Patients

Breast cancer is mainly formed in the tissues of the breast, and it spreads through the lymphatic system. They are mostly found in women rather than men. The breast cancer incidence has been increasing globally, with 1 in 8 women developing cancer in their lifetime. This prospective observational study was conducted to determine the Chemotherapy-Induced Nausea and Vomiting (CINV) in post-mastectomy breast cancer patients for nine months in a tertiary care hospital. Sixty patients were divided into two groups where one arm received Olanzapine, and the other received aprepitant. Both the arms were analysed for the severity of nausea and vomiting. Aprepitant (APT) is a neurokinin one receptor antagonist (NK1RA) which is used as antiemetic in the prophylaxis of CINV. Olanzapine (OLP) is a second-generation antipsychotic agent, which works by blocking the serotonin receptor. The objective of the study is to Evaluate the Safety and Efficacy of APT versus OLP in preventing CINV in breast cancer patients on Docetaxel-Adriamycin-Cyclophosphamide regimen. The OLP is more effective than APT in antiemetic therapy.

scholarly journals E-cadherin Gene Promoter Hyper-methylation in Blood Samples from Breast Cancer Cases

2021 ◽  
Author(s):  
Sadia Ajaz ◽  
Sani-e-Zehra Zaidi ◽  
Saleema Mehboob Ali ◽  
Aisha Siddiqa ◽  
Mohammad Ali Memon
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Tertiary Care ◽  
Gene Promoter ◽  
Promoter Hypermethylation ◽  
Care Hospital ◽  
Breast Cancer Patients ◽  
Blood Samples ◽  
E Cadherin

In carcinomas, dissemination of cancer cells via blood or lymph circulation constitutes an early event. E-cadherin is a transmembrane calcium dependent adhesion protein. Cellular de-differentiation and plasticity, underlying metastasis, is attributed to the loss of function of E-cadherin (cdh1) gene. The loss of gene expression may arise from promoter hypermethylation, which has been reported in multiple cancers. In the present pilot project, sixty (60) blood samples were collected from the breast cancer patients at a tertiary care hospital in Karachi, Pakistan. DNA was isolated from the cells circulating in the peripheral blood of the participants. Promoter hypermethylation was investigated through sodium-bisulfite treatment of DNA followed by methylation-specific PCR. In 53.3% of the patients, E-cadherin gene promoter hypermethylation was observed. Promoter hypermethylation of E-cadherin has been reported in DNA isolated from the tissue specimen. However, to the best of our knowledge this is the first report of E-cadherin promoter hypermethylation in cells isolated from the peripheral blood of breast cancer patients from a geographically specific population. The results have important implications in tumour staging and selection of treatment regimens.

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