scholarly journals Comparison of Methods for Glucosamine Production from Achatina fulica Shells Waste

2020 ◽  
Vol 4 (1) ◽  
pp. 15-22
Author(s):  
Siti Maesunah Gilang Maya ◽  
Raden Roro Fine Ayu Putri ◽  
Aisyah Sahara ◽  
Galuh Adhiyaksa Ashari ◽  
Abdurrahman Zaky ◽  
...  
Keyword(s):  
Economic Value ◽  
New Product ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Food Sources ◽  
High Yield ◽  
Snail Population ◽  
Agricultural Pests ◽  
Glucosamine Hydrochloride ◽  
Hydrolysis Of

Osteoarthritis is a degenerative joint disease. This disease occurs when the joint feels painful due to mild inflammation that arises due to activity with the bone of end friction joints. Glucosamine has been proven to stimulate the production of cartilage and inhibit the enzyme that destroys cartilage. Glucosamine which was obtained from the hydrolysis of chitin occurs in a variety of animals such as the shell of crustacea, insects, arthropods, and the shell of molluscs (snail shells). There is a large snail population in Indonesia. Some restaurants and people make use by product snails as food sources. However, this process leaves snail shell as a by product. The high yield of glucosamine produced from snail shells use methods such as reflux+water bath and reflux+magnetic stirrer was 1.47%. Glucosamine hydrochloride was obtained through autoclave at 121 °C and pressure 1 atm for 70 minutes. The presence of chitin, chitosan, glucosamine was confirmed using FTIR spectroscopy. A joint pain ointment was prepared using glucosamine hydrochloride from snail shells concentration at 1 % w/w. Results of this research will be very useful for the reduction of agricultural pests while simultaneously generating a new product that can lift the economic value of snail shells. Keywords: Chitin, Chitosan, Glucosamine, Osteoarthritis, Snail Shells

Apportionment of Impairment from Meniscal Tears and Knee Arthritis

2013 ◽  
Vol 18 (5) ◽  
pp. 1-10 ◽  
Author(s):  
Charles N. Brooks ◽  
James B. Talmage
Keyword(s):  
Medial Meniscus ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Detailed Knowledge ◽  
Meniscal Tears ◽  
Knee Arthritis ◽  
Degenerative Arthritis ◽  
Study Results ◽  
Physical Findings ◽  
Causation Analysis

Abstract Meniscal tears and osteoarthritis (osteoarthrosis, degenerative arthritis, or degenerative joint disease) are two of the most common conditions involving the knee. This article includes definitions of apportionment and causes; presents a case report of initial and recurrent tears of the medial meniscus plus osteoarthritis (OA) in the medial compartment of the knee; and addresses questions regarding apportionment. The authors, experienced impairment raters who are knowledgeable regarding the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), show that, when instructions on impairment rating are incomplete, unclear, or inconsistent, interrater reliability diminishes (different physicians may derive different impairment estimates). Accurate apportionment of impairment is a demanding task that requires detailed knowledge of causation for the conditions in question; the mechanisms of injury or extent of exposures; prior and current symptoms, functional status, physical findings, and clinical study results; and use of the appropriate edition of the AMA Guides. Sometimes the available data are incomplete, requiring the rating physician to make assumptions. However, if those assumptions are reasonable and consistent with the medical literature and facts of the case, if the causation analysis is plausible, and if the examiner follows impairment rating instructions in the AMA Guides (or at least uses a rational and hence defensible method when instructions are suboptimal), the resulting apportionment should be credible.

3. Degenerative joint disease

2000 ◽  
Vol 81 (3B) ◽  
pp. s67-s72
Author(s):  
Victoria A. Brander ◽  
Darryl L. Kaelin ◽  
Terry H. Oh ◽  
Peter A.C. Lim
Keyword(s):  
Degenerative Joint Disease ◽  
Joint Disease

Osteotomy for Correction of Premature Growth Plate Closure in 24 Dogs

1994 ◽  
Vol 07 (03) ◽  
pp. 129-135 ◽  
Author(s):  
C.W. Miller ◽  
P.W. Morgan
Keyword(s):  
Corrective Osteotomy ◽  
Functional Results ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Angular Deformity ◽  
Dynamic Correction ◽  
Age At Surgery ◽  
Limb Deformities ◽  
The Mean ◽  
A Prospective Study

SummaryTwenty-four dogs (27 limbs) were evaluated after surgery for correction of forelimb angular limb deformities. Partial ulnar ostectomies or definitive corrective osteotomies were performed depending upon the age of the dog. According to owner assessment nine of fourteen limbs were considered functionally good, or excellent, after partial ulnar ostectomies. Younger dogs appeared to have better functional results after dynamic correction with the mean age at surgery of dogs with good to excellent results being 6.5 months contrasted to the mean age at surgery of dogs with fair to poor results being 9.75 months. Ten of fourteen limbs were considered functionally good or excellent after definitive corrective osteotomy. One dog had definitive osteotomy after partial ulnar ostectomy in order to further correct a residual angular deformity. However, 58% of the limbs with radiographic follow-up had signs of degenerative joint disease (DJD). There were not significant differences between neither degree of angulation remaining after surgery and the functional result nor the degree of angulation remaining after surgery and the development of DJD. A prospective study is warranted to more objectively assess the efficacy of surgical correction of angular limb deformities in dogs.Twenty-four dogs were evaluated after surgery for correction of forelimb angular limb deformities. The results are described.

Anticoagulant Properties of Three Mucopolysaccharides Used in Rheumatology

1983 ◽  
Vol 50 (03) ◽  
pp. 652-655 ◽  
Author(s):  
F Bauer ◽  
P Schulz ◽  
G Reber ◽  
C A Bouvier
Keyword(s):  
Factor Xa ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Thrombin Time ◽  
Coagulation Tests ◽  
Amplification System ◽  
Relative Potencies ◽  
In Vivo Administration

SummaryThree mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor X a activity and the dilute thrombin time. One of the compounds, Arteparon®, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon® acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon® confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

The Gut Microbiota of Rats under Experimental Osteoarthritis and Administration of Chondroitin Sulfate and Probiotic

2020 ◽  
Vol 82 (6) ◽  
pp. 64-73
Author(s):  
O.H. Korotkyi ◽  
◽  
T.V. Luhovska ◽  
T.M. Serhiychuk ◽  
K.O. Dvorshchenko ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Chondroitin Sulfate ◽  
Joint Inflammation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Quantitative Composition ◽  
Combined Administration ◽  
Osteoarthritis Progression ◽  
Experimental Osteoarthritis ◽  
Gut Microbiota Composition

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and joint inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome and inflammation, two important components of osteoarthritis progression. Aim. In this study we investigated the effect of chondroitin sulfate and probiotics on the gut microbiome in monoiodoacetate-induced osteoarthritis model in rats. Methods. The species and quantitative composition of feces were determined using diagnostic media with selective properties. Further identification of isolated microorganisms was carried out according to morphological, tinctorial, physiological and metabolic parameters. The results are presented in the form of lg CFU/g. Results. Induction of osteoarthritis caused significant increasing the number of opportunistic enterobacteria and lactose-negative Escherichia coli against the decreasing of lacto- and bifidobacteria that may indicate a dysbiotic condition. Coadministration of chondroitin sulfate and probiotic bacteria has led to improvement the quantitative composition of the gut microbiota in experimental animals, the numerous of Bifidobacterium, Lactobacillus were increasing against decreasing the quantitative composition of opportunistic microorganisms. Conclusions. Monoiodoacetate-induced osteoarthritis caused dysbiosis of gut in rat. We observed beneficial effect of combined administration of chondroitin sulfate and probiotics on gut microbiota composition in rats with experimental osteoarthritis. Thus, adding of supplements like probiotics to standard treatment of osteoarthritis may have potentials to prevent and treat this disease.

Sosialisasi Daur Ulang Sampah Sebagai Upaya Pengembangan Eko-Budaya di Lingkungan Desa Sayang Jatinangor Kabupaten Sumedang

2017 ◽  
Vol 1 (2) ◽  
pp. 29
Author(s):  
Sri Rijati ◽  
Tania Intan ◽  
Mega Subekti
Keyword(s):  
Economic Value ◽  
Geographical Location ◽  
New Product ◽  
Household Waste ◽  
Public Concern ◽  
Priority Area ◽  
The Public ◽  
Negative Behaviour

This activity aims to growth awareness and public concern over the use of household waste. One effective way is tomake the process of recycling of waste in order to be a new product that has economic value. Sayang village, Jatinangor inSumedang district became one of priority area for the organization of this event. Its geographical location which is relativelyclose to the area of education is one reason for choosing this village. The activities in the form of Program Pengabdian kepadaMasyarakat Dosen (PPMD) is carried out by means of lectures, demonstrations and practices / trainings. The high productionof household waste and negative behaviour regarding garbage is actually an issue that is closely related to cultural behaviour.Therefore, the solution is actually should be also related with the issue of people’s mindset about the garbage. Recycling wastebins in order to produce a product that has economic value to be an alternative way to change people's mindsets about thegarbage that have tended to be negative. This activity is considered successful because of the participation of the public,especially mothers of households is quite high and active in a series of events

Allogenic Mesenchymal Stem Cells as a Treatment for Equine Degenerative Joint Disease: A Pilot Study

2014 ◽  
Vol 9 (6) ◽  
pp. 497-503 ◽  
Author(s):  
Sarah Broeckx ◽  
Marc Suls ◽  
Charlotte Beerts ◽  
Aurelie Vandenberghe ◽  
Bert Seys ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pilot Study ◽  
Degenerative Joint Disease ◽  
Joint Disease

Self-Repair in Degenerative Joint Disease

2013 ◽  
Vol 5 (3) ◽  
pp. 273-287 ◽  
Author(s):  
Valerio Di Nicola ◽  
Renato Di Nicola
Keyword(s):  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Self Repair

Maltol inhibits the progression of osteoarthritis via the nuclear factor-erythroid 2-related factor-2/heme oxygenase-1 signal pathway in vitro and in vivo

2021 ◽  
Author(s):  
Ding-Chao Zhu ◽  
Yi-Han Wang ◽  
Jia-Hao Lin ◽  
Zhi-Min Miao ◽  
Jia-Jing Xu ◽  
...  
Keyword(s):  
Cartilage Degeneration ◽  
Degenerative Joint Disease ◽  
Signal Pathway ◽  
Joint Disease ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Articular Cartilage Degeneration

Osteoarthritis (OA) is a common degenerative joint disease characterized by articular cartilage degeneration and inflammation. Currently, there is hardly any effective treatment for OA due to its complicated pathology and...

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