scholarly journals Evaluation of Serum Magnesium, Iron, Copper and Zinc Levels in Ischemic and Hemorrhagic Stroke Patients and Healthy Controls

2018 ◽  
Vol 2 (1) ◽  
pp. 6-10
Author(s):  
Hojatollah Moemeni ◽  
Durdi Qujeq ◽  
Alijan Ahmadi Ahangar ◽  
Karimollah Hajian ◽  
Hadi Parsian ◽  
...  
Keyword(s):  
Hemorrhagic Stroke ◽  
Serum Magnesium ◽  
Healthy Controls ◽  
Stroke Patients ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Levels

scholarly journals Adrenomedullin Is a Diagnostic and Prognostic Biomarker for Acute Intracerebral Hemorrhage

2021 ◽  
Vol 43 (1) ◽  
pp. 324-334
Author(s):  
Francisco J. Julián-Villaverde ◽  
Laura Ochoa-Callejero ◽  
Eva Siles ◽  
Esther Martínez-Lara ◽  
Alfredo Martínez
Keyword(s):  
Hemorrhagic Stroke ◽  
Prognostic Biomarker ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Nitroso Compounds ◽  
Healthy Controls ◽  
Stroke Patients ◽  
Important Health ◽  
Acute Intracerebral Hemorrhage ◽  
Changes Over Time

Hemorrhagic stroke remains an important health challenge. Adrenomedullin (AM) is a vasoactive peptide with an important role in cardiovascular diseases, including stroke. Serum AM and nitrate–nitrite and S-nitroso compounds (NOx) levels were measured and compared between healthy volunteers (n = 50) and acute hemorrhagic stroke patients (n = 64). Blood samples were taken at admission (d0), 24 h later (d1), and after 7 days or at the time of hospital discharge (d7). Neurological severity (NIHSS) and functional prognosis (mRankin) were measured as clinical outcomes. AM levels were higher in stroke patients at all times when compared with healthy controls (p < 0.0001). A receiving operating characteristic curve analysis identified that AM levels at admission > 69.0 pg/mL had a great value as a diagnostic biomarker (area under the curve = 0.89, sensitivity = 80.0%, specificity = 100%). Furthermore, patients with a favorable outcome (NIHSS ≤ 3; mRankin ≤ 2) experienced an increase in AM levels from d0 to d1, and a decrease from d1 to d7, whereas patients with unfavorable outcome had no significant changes over time. NOx levels were lower in patients at d0 (p = 0.04) and d1 (p < 0.001) than in healthy controls. In conclusion, AM levels may constitute a new diagnostic and prognostic biomarker for this disease, and identify AM as a positive mediator for hemorrhagic stroke resolution.

scholarly journals Serum Iron Levels and Copper-to-Zinc Ratio in Sickle Cell Disease

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 180
Author(s):  
Charles Antwi-Boasiako ◽  
Gifty Dankwah ◽  
Robert Aryee ◽  
Charles Hayfron-Benjamin ◽  
Alfred Doku ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Serum Levels ◽  
Zinc Homeostasis ◽  
Healthy Controls ◽  
Cell Disease ◽  
Flame Atomic Absorption ◽  
Iron Copper ◽  
Copper And Zinc

Background and Objectives: Altered copper and zinc homeostasis may influence the antioxidant defense system and consequently lead to oxidative stress and associated complications in sickle cell disease (SCD) patients. Iron levels have been reported to increase in sickle cell patients due to frequent blood transfusion, chronic intravenous haemolysis and increased absorption of iron from the gastrointestinal tract. These elevated levels of iron may also lead to extensive oxidative damage. The current study evaluated serum levels of iron, copper and zinc in SCD patients and “healthy” controls. Materials and Methods: The study was a cross-sectional one, comprising 90 SCD patients with Haemoglobin SS and Haemoglobin SC genotypes and 50 HbAA “healthy” controls. Serum levels of iron, copper and zinc were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS manufactured by VARIAN Australia Pty Ltd, VIC, Australia). Copper and zinc ratios were calculated and analyzed. Results: Serum levels of iron and copper were significantly elevated in the SCD patients, compared to their “healthy” counterparts (p < 0.001). These levels were further increased in patients with haemoglobin SS in vaso-occlusive crises (HbSS VOCs). Serum zinc levels were, however, significantly lower in the SCD patients, particularly during vaso-occlusion. The copper-to-zinc ratio was also found to be significantly higher in the SCD patients. Conclusion: Elevated copper-to-zinc ratio may be a biomarker of sickle cell oxidative stress and associated complications. The ratio may also be informative for the management of sickle cell oxidative burden. The significantly lower levels of zinc in the SCD patients may warrant zinc supplementation.

Iron, Copper and Zinc Levels in Serum and Cirrhotic Liver of Patients with and without Hepatocellular Carcinoma

Oncology ◽  
1989 ◽  
Vol 46 (5) ◽  
pp. 293-296 ◽  
Author(s):  
Naofumi Nagasue ◽  
Hitoshi Kohno ◽  
Yu-Chung Chang ◽  
Teruhisa Nakamura
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cirrhotic Liver ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Levels

scholarly journals Estimation of Serum Copper and Zinc Levels in Oral Submucous Fibrosis: An Atomic Absorption Spectroscopic Study

2013 ◽  
Vol 14 (5) ◽  
pp. 801-805 ◽  
Author(s):  
H Neethi
Keyword(s):  
Spectroscopic Study ◽  
Atomic Absorption ◽  
Oral Submucous Fibrosis ◽  
Serum Copper ◽  
Stage I ◽  
Healthy Controls ◽  
Copper And Zinc ◽  
Submucous Fibrosis ◽  
The Mean ◽  
Zinc Levels

ABSTRACT Background and objectives Biochemical derangements of microelements although reported in oral cancer is poorly understood in oral submucous fibrosis (OSMF). Hence, the present study was carried out to estimate and compare the serum copper and zinc levels among different histopathological stages of OSMF with that of healthy controls. Materials and methods Thirty histopathologically diagnosed cases of OSMF and 30 healthy controls reporting to MS Ramaiah Dental College and Hospital (MSRDCH), Bengaluru, were included in the study. The histopathological staging of OSMF was done as per criteria given by Pindborg and Sirsat (1966). Blood samples were collected and the serum copper and zinc levels were estimated using atomic absorption spectroscopy. The results were statistically analyzed using independent t-test and Kruskal-Wallis test. Results The mean serum copper levels were increased (p < 0.0005) and zinc levels were decreased (p < 0.01) in OSMF patients when compared to that of controls. The mean serum copper levels showed an increasing trend from stage I to IV (p = 0.004) while zinc levels showed a decreasing trend from stage I to IV (p = 0.04) in OSMF patients. Conclusion The serum copper and zinc levels in OSMF showed a significant difference in comparison to that of controls and between the histopathological stages. These findings indicate that serum copper and zinc may have a contributory role in the etiopathogenesis of OSMF. Clinical relevance Although the role of the trace elements as etiological factors is minor, derangements noted in the serum copper and zinc levels could be correlated with diseased progression and possibly explain the transformation of OSMF into malignancy. Thus, they can be used as prognostic markers and can be of value for proactive intervention. How to cite this article Neethi H, Patil S, Rao RS. Estimation of Serum Copper and Zinc Levels in Oral Submucous Fibrosis: An Atomic Absorption Spectroscopic Study. J Contemp Dent Pract 2013;14(5):801-805.

The comparative study of serum iron, copper, and zinc levels between bladder cancer patients and a control group

2009 ◽  
Vol 42 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Hamid Mazdak ◽  
Faranak Yazdekhasti ◽  
Ahmad Movahedian ◽  
Nooshin Mirkheshti ◽  
Mohammad Shafieian
Keyword(s):  
Bladder Cancer ◽  
Comparative Study ◽  
Cancer Patients ◽  
Serum Iron ◽  
Control Group ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Levels ◽  
The Comparative Study

scholarly journals The associations between serum trace elements and bone mineral density in children under 3 years of age

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ziyi Wu ◽  
Yuhao Yuan ◽  
Jian Tian ◽  
Feng Long ◽  
Wei Luo
Keyword(s):  
Bone Mineral Density ◽  
Trace Elements ◽  
Bone Mineral ◽  
Zinc Concentration ◽  
Serum Magnesium ◽  
Mineral Density ◽  
The Third ◽  
Copper And Zinc ◽  
Serum Trace Elements ◽  
Zinc Levels

AbstractWe examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determine the associations of age and serum trace elements with BMD. Multivariable logistic regression analysis was used to test the correlation of five serum trace elements with BMD after adjustments for potential confounding factors in children under 3 years of age. Significant associations between age and four serum trace elements and BMD were found. Compared to the group with the lowest serum levels detected, the adjusted odds ratio (OR) for the incidence of normal bone mineral density in the third magnesium concentration tertile, the third iron concentration tertile, the fifth copper concentration quintile, the third zinc concentration quintile, and the fifth zinc concentration quintile were 1.30 (95% confidence interval (CI) 1.02–1.67), 1.43 (95% CI 1.11–1.84), 1.42 (95% CI 1.04–1.94), 1.46 (95% CI 1.05–2.04), and 1.48 (95% CI 1.06–2.06), respectively. However, there was no significant correlation between serum lead level and BMD in this study. Age and serum magnesium, iron, copper, and zinc levels are positively associated with BMD in children under 3 years old.

Tissue Iron, Copper and Zinc Levels in Offspring of Iron-Sufficient and Iron-Deficient Rats

1981 ◽  
Vol 111 (2) ◽  
pp. 266-275 ◽  
Author(s):  
Adria Rothman Sherman ◽  
Nancy Tschiember Tissue
Keyword(s):  
Iron Copper ◽  
Copper And Zinc ◽  
Tissue Iron ◽  
Iron Deficient ◽  
Zinc Levels
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