scholarly journals Effect of combination therapy with sodium valproate, Peg-interferon and prednizolone on clinical findings in HTLV-1 associated spastic paraparesis (HAM/TSP) Patients

2013 ◽  
Vol 5 (1) ◽  
pp. 83-88
Author(s):  
Ali Shoeibi ◽  
Mohammad Mahdi Ehtemadi ◽  
Reza Boostani ◽  
Seyed Abdolrahim Rezaei ◽  
Sahar Fadaei ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Sodium Valproate ◽  
Spastic Paraparesis ◽  
Clinical Findings

Combined Therapy for Migraine Prevention? Clinical Experience with A β-Blocker Plus Sodium Valproate in 52 Resistant Migraine Patients

Cephalalgia ◽  
2003 ◽  
Vol 23 (10) ◽  
pp. 961-962 ◽  
Author(s):  
J Pascual ◽  
R Leira ◽  
JM Láinez
Keyword(s):  
Combination Therapy ◽  
Sodium Valproate ◽  
Combined Therapy ◽  
Episodic Migraine ◽  
Controlled Trials ◽  
Migraine Prevention ◽  
Open Label ◽  
History Of ◽  
Β Blocker ◽  
Β Blockers

The aim was to explore whether combining a β-blocker and sodium valproate could lead to an advantage in efficacy in patients with migraine previously resistant to the two medications in monotherapy. Fifty-two patients (43 women) with a history of episodic migraine with or without aura, and previously unresponsive to β-blockers and sodium valproate in monotherapy, were treated with a combination of propranolol or nadolol and sodium valproate in an open-label fashion. Eight patients (15%) discontinued due to adverse events. Fifteen (29%) did not respond. The remaining 29 cases (56%) showed response (>50% reduction in migraine days). The response was excellent in nine (17%). From this open trial, combination therapy with a β-blocker and sodium valproate appears to be a good migraine preventative in some previously resistant migraine cases. Controlled trials are now necessary to determine the true advantage in efficacy of this combination in difficult to treat migraineurs.

scholarly journals Anti-seizure Medication Prescription in Adult Outpatients With Epilepsy in China, 2013–2018

2021 ◽  
Vol 12 ◽  
Author(s):  
Lingyan Yu ◽  
Wenjie Zhu ◽  
Xiuping Zhu ◽  
Yan Lu ◽  
Zhenwei Yu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Sodium Valproate ◽  
Medication Prescription ◽  
Chinese Adult ◽  
Current State ◽  
State Of Research ◽  
Cooperative Project ◽  
National Trends ◽  
Chinese Yuan ◽  
Common Combination

This study aimed to assess the national trends in anti-seizure medication (ASM) prescription in Chinese adult outpatients with epilepsy over a 6-year period from 2013 to 2018. Prescriptions for adult outpatients with epilepsy from hospitals in six major cities were extracted from the database of the Hospital Prescription Analysis Cooperative Project. Trends in the annual prescriptions and expenditure of ASM were analyzed. Prescription patterns (monotherapy or combination therapy) were also assessed. A total of 225,767 prescriptions from 60 hospitals were eligible and extracted for analysis. The number of ASM prescriptions increased from 28,360 in 2013 to 44,110 in 2018, and the corresponding cost increased from 9,452,990 Chinese Yuan (CNY) in 2013 to 14,627,865 CNY in 2018. The share of newer ASM use increased continuously, accounting for 56.75% of prescriptions and 85.03% of expenditure in 2018. The most frequently prescribed ASMs were sodium valproate and levetiracetam. The proportion of sodium valproate use decreased, while the proportion of levetiracetam use increased dramatically in terms of both ASM prescriptions and expenditure. Monotherapy was more frequent than combination therapy. The three most common combination therapies were sodium valproate/lamotrigine, levetiracetam/oxcarbazepine, and sodium valproate/levetiracetam. In summary, ASM use increased rapidly in terms of the number of ASM prescriptions and cost during the 6-year period, which raises concern regarding the rational use and pharma-economic profiles of ASMs. In place of valproate, levetiracetam became the most frequently used ASM. The development of ASM prescription is in line with therapy guidelines and reflects the current state of research in China.

scholarly journals Recruiting individuals into the HTLV cohort study in the United Kingdom: clinical findings and challenges in the first six years, 2003 to 2009

2011 ◽  
Vol 16 (46) ◽  
Author(s):  
L J Brant ◽  
C Cawley ◽  
K L Davison ◽  
G P Taylor ◽  
collective the HTLV National Register Steering Group
Keyword(s):  
Cohort Study ◽  
United Kingdom ◽  
Blood Donation ◽  
Spastic Paraparesis ◽  
Clinical Findings ◽  
T Lymphotropic Virus ◽  
The United Kingdom ◽  
Multicentre Cohort Study ◽  
The Uk

Human T-lymphotropic virus (HTLV) infection is rare in the United Kingdom (UK) and few studies are available worldwide. Following introduction of blood donation testing in 2002, a cohort of individuals could be identified and prospectively recruited to describe progression and onset of disease. Here we describe baseline characteristics of participants, and evaluate recruitment into the UK HTLV National Register over the first six years, from July 2003 to June 2009. A multicentre cohort study recruited participants from the UK blood services (recipients and donors) and specialist HTLV clinics. Almost half of the 148 participants recruited were blood donors, nine were blood transfusion recipients, 40 contacts and 29 clinic attendees (nine asymptomatic and 20 symptomatic). Most participants were HTLV-1 positive (n=115); 11 had HTLV-2 and 22 were HTLV-negative. Baseline self-completion questionnaires were received for 83%. The most commonly reported condition was a past operation/serious illness (69%). Twenty-six participants reported four or more possible signs/symptoms of HTLV-1-associated myelopathy/tropical spastic paraparesis. Recruitment into a study of a rare, long-term infection is challenging. This cohort will enable descriptions of HTLV-associated disease progression amongst people recruited from varying sources; it is the first prospective study of its kind in Europe.

scholarly journals Combination therapy of oropharyngeal inflammatory diseases in children

2016 ◽  
Vol 1 (1) ◽  
pp. 54-57 ◽  
Author(s):  
D. V. Usenko ◽  
A. V. Gorelov
Keyword(s):  
Combination Therapy ◽  
Infectious Diseases ◽  
Lymphoid Tissue ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Clinical Findings ◽  
Non Communicable Diseases

Inflammatory oropharyngeal pathologies are diverse in etiology and include infectious diseases, lesions of the lymphoid tissue of the pharynx, as well as non-communicable diseases. The article summarizes the results of studies and clinical findings on the effectiveness Lysobact in the treatment of inflammatory diseases of the oropharynx in children.

scholarly journals Application of variable number of tandem repeats typing to describe familial outbreaks of brucellosis in Argentina

2010 ◽  
Vol 59 (6) ◽  
pp. 648-652 ◽  
Author(s):  
Nidia E. Lucero ◽  
Marina Tenenbaum ◽  
Nestor R. Jacob ◽  
Gabriela I. Escobar ◽  
Pauline Groussaud ◽  
...  
Keyword(s):  
High Resolution ◽  
Combination Therapy ◽  
Disease Prevention ◽  
Dairy Products ◽  
Tandem Repeats ◽  
Variable Number ◽  
Clinical Findings ◽  
Adequate Treatment ◽  
Foodborne Outbreaks ◽  
Means Of Transmission

Consumption of inadequately pasteurized dairy products is the most common means of transmission of brucellosis. This report describes two foodborne outbreaks that occurred in families infected after consumption of fresh home-made cheese bought in different Argentine provinces. High resolution variable number of tandem repeats (VNTR)-based analysis revealed two well-defined groups comprising essentially identical profiles and corresponding to the two different outbreaks. Similar clinical findings in members of the same family could indicate that the differential virulence of different bacterial clones, as indicated by VNTR data, could have influenced the course of the disease. We observed the importance of adequate treatment in early stages of the disease; combination therapy and extended treatment for 6 weeks or longer yielded significantly better results. The risk of the foodborne transmission of this zoonotic disease and disease prevention should be considered.

Clinical Findings with SAL Audiometry: Some Further Observations

1965 ◽  
Vol 30 (4) ◽  
pp. 325-335
Author(s):  
George E. Lynn ◽  
Jack A. Willeford
Keyword(s):  
Clinical Findings

Spinal Impairment Evaluation: Fifth Edition Changes

2001 ◽  
Vol 6 (1) ◽  
pp. 1-3
Author(s):  
Robert H. Haralson
Keyword(s):  
Spinal Cord ◽  
Lower Extremity ◽  
Range Of Motion ◽  
Upper Extremity ◽  
Spinal Cord Injuries ◽  
Clinical Findings ◽  
Fourth Edition ◽  
Treatment Results ◽  
Standard Terminology ◽  
Made In

Abstract The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, was published in November 2000 and contains major changes from its predecessor. In the Fourth Edition, all musculoskeletal evaluation and rating was described in a single chapter. In the Fifth Edition, this information has been divided into three separate chapters: Upper Extremity (13), Lower Extremity (14), and Spine (15). This article discusses changes in the spine chapter. The Models for rating spinal impairment now are called Methods. The AMA Guides, Fifth Edition, has reverted to standard terminology for spinal regions in the Diagnosis-related estimates (DRE) Method, and both it and the Range of Motion (ROM) Method now reference cervical, thoracic, and lumbar. Also, the language requiring the use of the DRE, rather than the ROM Method has been strengthened. The biggest change in the DRE Method is that evaluation should include the treatment results. Unfortunately, the Fourth Edition's philosophy regarding when and how to rate impairment using the DRE Model led to a number of problems, including the same rating of all patients with radiculopathy despite some true differences in outcomes. The term differentiator was abandoned and replaced with clinical findings. Significant changes were made in evaluation of patients with spinal cord injuries, and evaluators should become familiar with these and other changes in the Fifth Edition.

Familial cold urticaria. Clinical findings

1974 ◽  
Vol 110 (3) ◽  
pp. 382-388 ◽  
Author(s):  
H. M. Doeglas
Keyword(s):  
Clinical Findings ◽  
Cold Urticaria
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