Correlation between Overactive Bladder Syndrome and Severity of Coronary Artery Disease in Postmenopausal Women

AbstractObjectiveThe objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease.DesignPlasma AR concentrations were measured by a validated GC–MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ.SettingA prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial.SubjectsFor the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women.ResultsMean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre.ConclusionsPlasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.

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Plasma levels of cyclic GMP and endothelin in postmenopausal women with unstable coronary artery disease

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.1080/00365519950185517 ◽

1999 ◽

Vol 59 (5) ◽

pp. 325-333 ◽

Cited By ~ 3

Author(s):

N E Nielsen ◽

J Ahlner ◽

J Malmstedt ◽

K P Öhman ◽

E. Swahn

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Postmenopausal Women ◽

Cyclic Gmp ◽

Plasma Levels ◽

Unstable Coronary Artery Disease ◽

Artery Disease

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Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

Biology ◽

10.3390/biology10111139 ◽

2021 ◽

Vol 10 (11) ◽

pp. 1139

Author(s):

Ewelina Anna Dziedzic ◽

Wiktor Smyk ◽

Izabela Sowińska ◽

Marek Dąbrowski ◽

Piotr Jankowski

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Risk Factor ◽

Coronary Artery ◽

Serum Level ◽

Postmenopausal Women ◽

Coronary Atherosclerosis ◽

History Of ◽

Artery Disease ◽

The Impact

Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.

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