There has been a great deal of interest in veterinary medicine in drugs that support the body during chemotherapeutic treatment. The authors conducted a study of the drug’s effect on the development of carcinosarcoma in the mono regimen. The growth pattern of artificially induced Walker-256 sarcoma in 3-month-old Wistar rats in the post-lactation period was studied. The study was conducted at the Department of Pharmacology and General Pathology, Faculty of Veterinary Medicine.The study was conducted at the Department of Pharmacology and General Pathology, Faculty of Veterinary Medicine. The objects of the study were Wistar rats, female rats of three months of age, weighing 150-200 g in the post-lactation period. Rats of both groups were infected with Walker 256 sarcoma by injection into the thigh muscle at a dose of 106 ml/head. Rats in the experimental group were additionally administered metformin at 30 mg/head daily with water. Histological, cytological and haematological studies were performed on days 14 and 21 from the time of infection of the rats with the tumour. Under the action of metformin, the number of erythrocytes, leukocytes, lymphocytes, monocytes and granulocytes in Walker-256 sarcoma-infected rats increased, the concentration of haemoglobin decreased, and the number of platelets did not change. In the biopsy specimen of control rats compared to the counterparts of the experimental groups, the concentration of monocytes was increased. The number of eosinophils and nuclear polymorphism was decreased under the influence of metformin. In addition, metformin-induced neuropsychiatric abnormalities in rats, such as appetite perversion and cannibalism. The more pronounced inflammatory response in the experimental group indicates that further study of the drug’s effect on the development of various neoplasms is necessary, as this is an essential factor in the choice of the treatment strategy.
Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
