scholarly journals COMMON PIGMENTED SKIN LESIONS

2018 ◽  
Vol 25 (01) ◽  
pp. 78-83
Author(s):  
Amjad Ali Khan ◽  
Abdul Shaheed Asghar ◽  
Israr Ahmed Akhund ◽  
Muhammad Ishaq
Keyword(s):  
Clinical Diagnosis ◽  
Malignant Tumors ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Seborrheic Keratosis ◽  
Melanocytic Nevi ◽  
Medical College ◽  
Hematoxylin And Eosin ◽  
Pigmented Skin Lesions ◽  
Year 2013

Objectives: The purpose of this study is; firstly, to study the histopathologicalspectrum of the pigmented skin lesions in the community, to signify that not all pigmented skinlesions are malignant melanomas; secondly, to assess the age-wise distribution of the commonpigmented skin lesions; and thirdly, to determine the commonly affected body sites by thesepigmented skin lesions. Study Design: Retrospective/Observational study. Setting: CharsadaTeaching Hospital affiliated with Jinnah Medical College Peshawar. Period: 100 consecutivecases with clinical diagnosis of pigmented skin lesion, starting in the year 2013. Methods: Inthis study, 100 consecutive surgical pathology cases with clinical diagnosis of pigmented skinlesion were retrieved from the archives of Charsada Teaching Hospital affiliated with JinnahMedical College Peshawar. All the specimens were incisional biopsies of skin, fixed in 10%formalin, embedded in paraffin, and stained with Hematoxylin and Eosin stains. Results: Onanalyzing 100 consecutive pigmented skin lesions (n=100) starting from the year 2013, it wasfound thatthe large majority of these lesions were benign. The most common pigmented skinlesion was melanocytic nevus. Moreover, majority of pigmented skin lesions were seen infemales. Seborrheic keratosis and malignant tumors, like basal cell carcinoma and squamouscell carcinomas, were more commonly seen in males in the 6th and 7th decades of life; whereas,dermatofibroma and post-inflammatory pigmentation were more common in females in the 4thand 5th decades of life. Overall, the pigmented skin lesions were more common in the 3rd, 4th, and5th decades of life with peak in the 4th decade. Skin of face was the most common site affectedby melanocytic nevi and malignant epidermal skin tumors. Conclusions: In conclusion, mostof the pigmented skin lesions are benign, encountered in the 4th decade of life, and commonlyaffect the skin of face. Also, most of the melanocytic nevi are encountered in females, whilemost of the malignant epidermal neoplasms are encountered in males affecting the skin of face.

Distinctive Dermatoscopic Features of Acral Lentiginous Melanoma in Situ from Plantar Melanocytic Nevi and Their Histopathologic Correlation

1998 ◽  
Vol 2 (4) ◽  
pp. 199-204 ◽  
Author(s):  
Yasuhiro Kawabata ◽  
Kunihiko Tamaki
Keyword(s):  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Entire Surface ◽  
Acral Lentiginous Melanoma ◽  
Melanocytic Nevi ◽  
Melanoma In Situ ◽  
Technical Advances ◽  
Surface Profiles ◽  
Histopathologic Findings

Background: An acral lentiginous melanoma in situ on the sole is often difficult to differentiate with the naked eye from an acquired plantar melanocytic nevus. Recent technical advances in epiluminescence microscopy have contributed to the differentiation of these two pigmented skin lesions. Objective: In this study, the correlation between dermatoscopic and histopathologic findings of acral lentiginous melanoma in situ on the sole are compared to those of acquired plantar melanocytic nevi. Methods: Three acral lentiginous melanomas in situ on the sole, and two cases of acral lentiginous melanoma were compared with 50 acquired plantar melanocytic nevi by means of dermatoscopy and histopathology. Results: The dermatoscopic surface profiles of acquired melanocytic nevi were composed of linear pigmentation accentuated mainly on the sulcus superficialis. Histologically, some areas of the sulcus superficialis corresponded to rete ridges of the epidermis, and nests of nevus cells were also often located there. In contrast, the acral lentiginous melanomas in situ showed diffuse, irregularly shaped pigmentation distributed in a disorderly fashion over the entire surface. Histologically, isolated areas of proliferation and small nest formations of atypical melanocytes were irregularly distributed in the epidermis. Conclusion: A distinctive dermatoscopic feature of acral lentiginous melanoma in situ is diffuse and irregular pigmentation over the entire surface of the lesion. This feature is helpful for differentiating acral lentiginous melanoma in situ from acquired plantar melanocytic nevi.

scholarly journals Dermoscopic Features of Pigmented Bowen's Disease in a Japanese Female Mimicking Malignant Melanoma

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Takayuki Inoue ◽  
Ken Kobayashi ◽  
Mizuki Sawada ◽  
Sumiko Ishizaki ◽  
Haruo Ito ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Skin Lesions ◽  
Japanese Woman ◽  
Bowen’S Disease ◽  
Seborrheic Keratosis ◽  
Bowen's Disease ◽  
Pathologic Features ◽  
Old Japanese ◽  
History Of ◽  
Pigmented Skin Lesions

Various structures have been reported for dermoscopic features of pigmented Bowen's disease (BD), which could be a mimic of various pigmented skin lesions. A 79-year-old Japanese woman presented with a 3-year history of brown-black macule on her right upper arm without symptom. Dermoscopic examination demonstrated irregular flossy streaks, irregular brown dots/globules, blue-whitish regression structures, and overlaying whitish scaly areas. We suspected pigmented skin lesions including seborrheic keratosis, pigmented eccrine poroma, and malignant melanoma and excised completely with a 5 mm margin. Histopathological features were consistent with a diagnosis of pigmented BD. Although similar dermoscopic features might be revealed in pigmented skin lesions and it may occasionally be difficult to distinguish between pigmented BD and other pigmented skin lesions, dermoscopy would be useful in speculating pathologic features of pigmented BD.

scholarly journals The Development of a Skin Cancer Classification System for Pigmented Skin Lesions Using Deep Learning

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1123 ◽  
Author(s):  
Shunichi Jinnai ◽  
Naoya Yamazaki ◽  
Yuichiro Hirano ◽  
Yohei Sugawara ◽  
Yuichiro Ohe ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Malignant Tumors ◽  
Skin Lesions ◽  
Training Dataset ◽  
Clinical Image ◽  
Benign Tumors ◽  
Clinical Images ◽  
Predictive Values ◽  
Test Dataset ◽  
Pigmented Skin Lesions

Recent studies have demonstrated the usefulness of convolutional neural networks (CNNs) to classify images of melanoma, with accuracies comparable to those achieved by dermatologists. However, the performance of a CNN trained with only clinical images of a pigmented skin lesion in a clinical image classification task, in competition with dermatologists, has not been reported to date. In this study, we extracted 5846 clinical images of pigmented skin lesions from 3551 patients. Pigmented skin lesions included malignant tumors (malignant melanoma and basal cell carcinoma) and benign tumors (nevus, seborrhoeic keratosis, senile lentigo, and hematoma/hemangioma). We created the test dataset by randomly selecting 666 patients out of them and picking one image per patient, and created the training dataset by giving bounding-box annotations to the rest of the images (4732 images, 2885 patients). Subsequently, we trained a faster, region-based CNN (FRCNN) with the training dataset and checked the performance of the model on the test dataset. In addition, ten board-certified dermatologists (BCDs) and ten dermatologic trainees (TRNs) took the same tests, and we compared their diagnostic accuracy with FRCNN. For six-class classification, the accuracy of FRCNN was 86.2%, and that of the BCDs and TRNs was 79.5% (p = 0.0081) and 75.1% (p < 0.00001), respectively. For two-class classification (benign or malignant), the accuracy, sensitivity, and specificity were 91.5%, 83.3%, and 94.5% by FRCNN; 86.6%, 86.3%, and 86.6% by BCD; and 85.3%, 83.5%, and 85.9% by TRN, respectively. False positive rates and positive predictive values were 5.5% and 84.7% by FRCNN, 13.4% and 70.5% by BCD, and 14.1% and 68.5% by TRN, respectively. We compared the classification performance of FRCNN with 20 dermatologists. As a result, the classification accuracy of FRCNN was better than that of the dermatologists. In the future, we plan to implement this system in society and have it used by the general public, in order to improve the prognosis of skin cancer.

scholarly journals Dermoscopic Features of Facial Pigmented Skin Lesions

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Yana Goncharova ◽  
Enas A. S. Attia ◽  
Khawla Souid ◽  
Inna V. Vasilenko
Keyword(s):  
Retrospective Analysis ◽  
Actinic Keratosis ◽  
Skin Lesions ◽  
Vascular Pattern ◽  
Lentigo Maligna ◽  
Diagnostic Challenge ◽  
Seborrheic Keratosis ◽  
Solar Lentigo ◽  
Pigmented Skin Lesions ◽  
Pigmented Actinic Keratosis

Four types of facial pigmented skin lesions (FPSLs) constitute diagnostic challenge to dermatologists; early seborrheic keratosis (SK), pigmented actinic keratosis (AK), lentigo maligna (LM), and solar lentigo (SL). A retrospective analysis of dermoscopic images of histopathologically diagnosed clinically-challenging 64 flat FPSLs was conducted to establish the dermoscopic findings corresponding to each of SK, pigmented AK, LM, and SL. Four main dermoscopic features were evaluated: sharp demarcation, pigment pattern, follicular/epidermal pattern, and vascular pattern. In SK, the most specific dermoscopic features are follicular/epidermal pattern (cerebriform pattern; 100% of lesions, milia-like cysts; 50%, and comedo-like openings; 37.50%), and sharp demarcation (54.17%). AK and LM showed a composite characteristic pattern named “strawberry pattern” in 41.18% and 25% of lesions respectively, characterized by a background erythema and red pseudo-network, associated with prominent follicular openings surrounded by a white halo. However, in LM “strawberry pattern” is widely covered by psewdonetwork (87.5%), homogenous structureless pigmentation (75%) and other vascular patterns. In SL, structureless homogenous pigmentation was recognized in all lesions (100%). From the above mentioned data, we developed an algorithm to guide in dermoscopic features of FPSLs.

scholarly journals Clinico-histopathological correlation of pigmented skin lesions: A hospital based study at BPKIHS

2019 ◽  
Vol 9 (2) ◽  
pp. 1550-1554
Author(s):  
Isha Bohra ◽  
Punam Paudyal ◽  
Anju Pradhan ◽  
Dhan Kesar Khadka
Keyword(s):  
Malignant Tumors ◽  
Skin Lesions ◽  
Pathological Examination ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Melanocytic Lesions ◽  
Benign Pathology ◽  
Seborrhoeic Keratosis ◽  
Pigmented Skin Lesions ◽  
Age Range

Background: Pigmented skin lesions refers to melanocytic as well as nonmelanocytic lesions. Pigmentation is not just a cosmetic deformity but can also reflect underlying benign pathology as nevi or malignant lesions as melanoma. With this study we intend to evaluate the spectrum of pigmented skin lesions and to correlate the clinical diagnosis with the histological diagnosis. Materials and Methods: This is a hospital based cross sectional descriptive study where clinicohistopathological evaluation of 46 cases of pigmented skin lesions were analyzed on paraffin embedded tissue sections for a duration of 1 year at the Department of Pathology, B. P. Koirala Institute of Health Sciences. Results: Out of the 46 cases evaluated there were 32 cases of melanocytic lesions comprising of benign melanocytic nevi (n=27), malignant melanoma (n=5) and 14 cases of nonmelanocytic lesions including basal cell carcinoma and seborrhoeic keratosis (5 cases each). Angiokeratoma (n=1), sebaceous hyperplasia (n=1), trichoepitheloma (n=1) and venous haemangioma (n=1). The age range was from 8-83 years with slight female predominance (52.2%) and the most common site involved was head and neck (58.7%). 76.1% of the patients belonged to the Terai region. Clinicohistopathological correlation showed positive correlation in 26 cases (56.5%) and negative correlation in 20 cases (43.5%). Conclusions: Pigmented skin lesions are common presenting problem, while majority are benign a small minority can be malignant. So, clinically pigmented skin lesions should be submitted for pathological examination in order not to miss a small percentage of malignant tumors and to differentiate melanocytic lesions from its nonmelanocytic mimickers.

scholarly journals Giant congenital melanocytic nevi (garment variety): a case report

2021 ◽  
Vol 8 (9) ◽  
pp. 1625
Author(s):  
Om Prakash Singh ◽  
Vikas Kumar ◽  
Rahul Kumar
Keyword(s):  
Malignant Melanoma ◽  
Psychological Intervention ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Melanocytic Nevi ◽  
Black Skin ◽  
Giant Congenital Melanocytic Nevi ◽  
And Migration ◽  
Congenital Melanocytic Nevi

Giant congenital melanocytic nevi (GCMN) are large brown-to-black skin lesions caused due to genetic mutations which lead to defective proliferation, differentiation and migration of melanoblasts which are precursor cells of melanocytes. There is a mutation in the NRAS gene causing abnormal proliferation of embryonic melanoblasts. Congenital melanocytic nevus is primarily a clinical diagnosis. The malignant melanoma and neurocutaneous melanosis are the two major complications associated with GCMN. The risk of transformation of GCMN to malignant melanoma varies between 0 and 3.8%. About 1% of live births presents with a CMN. The incidence of GCMN is estimated at less than 1: 20,000 newborns. The variety ‘garment-like’ of GCMN is even scarcer, 1: 5,00,000. GCMN has got major psychosocial impact on the patient and his family due to its unsightly appearance. Treatment includes surgical and non-surgical procedures, psychological intervention and clinical follow-up, with special attention to changes in color, texture on the surface of the lesion. We presented a case of 1-day-old female neonate born with GCMN in our hospital.

scholarly journals Evolving eponymous signs in diagnostic dermoscopy

2021 ◽  
Vol 7 (2) ◽  
pp. 98-106
Author(s):  
Shashank Bhargava ◽  
Atul Bothra ◽  
Seujee Das ◽  
Anshu Maheswari ◽  
Mehak Singh
Keyword(s):  
Basal Cell Carcinoma ◽  
Early Diagnosis ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Lesions ◽  
Skin Melanoma ◽  
Blue Nevus ◽  
Seborrheic Keratosis ◽  
Pigmented Skin Lesions ◽  
Clinical Dermatology

Dermoscopy is a very useful technique devised for an earlier diagnosis of skin melanoma with a clinic-pathological correlation. Later it was found to be beneficial for the diagnosis of many other pigmented skin lesions, such as seborrheic keratosis, pigmented basal cell carcinoma, hemangioma, blue nevus, atypical nevus, and mole, which can often clinically simulate melanoma. Of late, its use in general clinical dermatology is growing with the recognition of new and specific patterns in conditions such as hair disorders, inflammatory disorders, and infections/infestation. It is still in the evolving phase and many new signs are described presently. Eponyms are used almost daily in dermatology practice. The eponyms in dermoscopy, trichoscopy, and onychoscopy are based on the imaginative capability of the authors and they have been very much successful in describing them. It becomes easier to memorize and identify the various appearances for early diagnosis and management. In this article we attempt to highlight the various dermoscopic signs described in dermatology.

scholarly journals The Role in Teledermoscopy of an Inexpensive and Easy-to-Use Smartphone Device for the Classification of Three Types of Skin Lesions Using Convolutional Neural Networks

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 451
Author(s):  
Federica Veronese ◽  
Francesco Branciforti ◽  
Elisa Zavattaro ◽  
Vanessa Tarantino ◽  
Valentina Romano ◽  
...  
Keyword(s):  
Neural Networks ◽  
Convolutional Neural Networks ◽  
Low Cost ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Ease Of Use ◽  
Small Data ◽  
Seborrheic Keratosis ◽  
Data Set ◽  
Face To Face

Background. The use of teledermatology has spread over the last years, especially during the recent SARS-Cov-2 pandemic. Teledermoscopy, an extension of teledermatology, consists of consulting dermoscopic images, also transmitted through smartphones, to remotely diagnose skin tumors or other dermatological diseases. The purpose of this work was to verify the diagnostic validity of images acquired with an inexpensive smartphone microscope (NurugoTM), employing convolutional neural networks (CNN) to classify malignant melanoma (MM), melanocytic nevus (MN), and seborrheic keratosis (SK). Methods. The CNN, trained with 600 dermatoscopic images from the ISIC (International Skin Imaging Collaboration) archive, was tested on three test sets: ISIC images, images acquired with the NurugoTM, and images acquired with a conventional dermatoscope. Results. The results obtained, although with some limitations due to the smartphone device and small data set, were encouraging, showing comparable results to the clinical dermatoscope and up to 80% accuracy (out of 10 images, two were misclassified) using the NurugoTM demonstrating how an amateur device can be used with reasonable levels of diagnostic accuracy. Conclusion. Considering the low cost and the ease of use, the NurugoTM device could be a useful tool for general practitioners (GPs) to perform the first triage of skin lesions, aiding the selection of lesions that require a face-to-face consultation with dermatologists.

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