scholarly journals Retinal involvement in type 1 diabetics, an experience from a specialized diabetes care unit of Karachi, Pakistan.

2020 ◽  
Vol 27 (07) ◽  
pp. 1382-1385
Author(s):  
Sharjeel Sultan ◽  
Jai Parkash Panjwani ◽  
Abdul Rasheed Khokar ◽  
Anum Butt ◽  
Asher Fawwad ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Slit Lamp ◽  
Severity Scale ◽  
Tractional Retinal Detachment ◽  
Disease Severity Scale ◽  
Convenience Sampling ◽  
Medical University ◽  
Study Setting ◽  
Slit Lamp Biomicroscopy

Objectives: To evaluate frequency of retinopathy in type 1 diabetics. Study design: Retrospective Study. Setting: Diabetes Unit (BIDE) of Baqai Medical University (BMU) Hospital of Karachi, Pakistan. January 2017 to September 2018. Material & Methods: Convenience sampling was done to collect clinical, biochemical, demographic and anthropometric measurements. Ophthalmic screening was performed by funduscopy at a slit lamp biomicroscopy with the help 90 D fundus lens. Modified Early Treatment Diabetic Retinopathy Disease Severity Scale (ETDRS) was used for the categorization. Results: Overall retinopathy was observed in around seven percent (7%) participants. On further examination by the ophthalmologist, 2 (5.1%) and 1 (2.3%) cases were grouped into STDR group and1 (2.6%) into NSTDR group. The frequency of mild to moderate and moderate to severe non proliferative diabetic retinopathy (NPDR) was found in 2.5% cases each. Whereas, tractional retinal detachment TRD and CSME were found in 2.6% cases each. Conclusion: This study highlights the importance of screening of retinopathy in type 1 diabetics to avoid insult on.

scholarly journals Effectiveness of optometrist screening for diabetic retinopathy using slit-lamp biomicroscopy

Eye ◽  
2001 ◽  
Vol 15 (5) ◽  
pp. 595-601 ◽  
Author(s):  
Somdutt Prasad ◽  
Girish G Kamath ◽  
Karen Jones ◽  
Louis G Clearkin ◽  
Russell P Phillips
Keyword(s):  
Diabetic Retinopathy ◽  
Slit Lamp ◽  
Slit Lamp Biomicroscopy

scholarly journals Hubungan antara tajam penglihatan dengan derajat non-proliferative diabetic retinopathy pada pasien diabetes melitus tipe 2

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Ade John Nursalim ◽  
Vera Sumual
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
American Academy ◽  
Disease Severity ◽  
P Value ◽  
Severity Scale ◽  
North Sulawesi ◽  
Snellen Chart ◽  
Disease Severity Scale ◽  
Diabetes Melitus

Abstract: This study aimed to determine the relationship between visual acuity and degree of Non Proliverative Diabetic Retinopathy (NPDR) in patients with type 2 diabetes mellitus (T2DM). This study was conducted in Retina Subdivision Ophthalmology Department Prof. Dr. R. D. Kandou Hospital, Manado, North Sulawesi, Indonesia. Samples were 354 eyes. Visual acuity examination was performed on all patients diagnosed with NPDR by using a Snellen chart at 6 meters distance. NPDR degree was graded according to the International Clinical Diabetic Retinopathy Disease Severity Scale of the American Academy of Ophthalmology. Correlation analysis between visual acuity and the NPDR degree was done by using Kruskal Wallis test which showed a P value of 0.185 (> 0.05). Conclusion: Visual acuity had no significant relationship to the degree of NPDR.Keywords: visual acuity, NPDR, T2DMAbstrak: Penelitian ini bertujuan untuk mengetahui hubungan antara tajam penglihatan dengan derajat Non Proliverative Diabetic Retinopathy (NPDR) pada penyandang diabetes melitus tipe 2 (DMT2). Penelitian ini dilakukan di Poliklinik Mata Subdivisi Retina RSUP Prof. Dr. R. D. Kandou Manado, Provinsi Sulawesi Utara, Indonesia. Sampel penelitian berjumlah 354 mata. Pemeriksaan visus dilakukan pada semua pasien yang terdiagnosis NPDR dengan menggunakan Snellen chart pada jarak 6 meter. Penilaian derajat NPDR berdasarkan International Clinical Diabetic Retinopathy Disease Severity Scale dari American Academy of Ophthalmology. Analisis hubungan visus dengan derajat NPDR dilakukan dengan uji statistik Kruskal Wallis yang menunjukkan nilai P = 0,185 (>0,05). Simpulan: Tidak terdapat hubungan bermakna antara tajam penglihatan (visus) dan derajat NPDR.Kata kunci: visus, NPDR, DMT2

Comparison of Smartphone Ophthalmoscopy With Slit-Lamp Biomicroscopy for Grading Diabetic Retinopathy

2015 ◽  
Vol 159 (2) ◽  
pp. 360-364.e1 ◽  
Author(s):  
Andrea Russo ◽  
Francesco Morescalchi ◽  
Ciro Costagliola ◽  
Luisa Delcassi ◽  
Francesco Semeraro
Keyword(s):  
Diabetic Retinopathy ◽  
Slit Lamp ◽  
Slit Lamp Biomicroscopy

Polymorphisms of the Plasminogen Activator Inhibitor- 1 Gene in Type 1 and Type 2 Diabetes, and in Patients with Diabetic Retinopathy

1994 ◽  
Vol 71 (06) ◽  
pp. 731-736 ◽  
Author(s):  
M W Mansfield ◽  
M H Stickland ◽  
A M Carter ◽  
P J Grant
Keyword(s):  
Diabetic Retinopathy ◽  
Plasminogen Activator Inhibitor ◽  
Allelic Frequency ◽  
Repeat Sequence ◽  
Dinucleotide Repeat ◽  
Plasminogen Activator Inhibitor 1 ◽  
The Difference ◽  
Pai 1

SummaryTo identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two dinucleotide repeat polymorphisms were studied. In 519 Caucasian diabetic subjects (192 type 1, 327 type 2) and 123 Caucasian control subjects there were no differences in the frequency of the Hind III restriction alleles (type 1 vs type 2 vs control: allele 1 0.397 vs 0.420 vs 0.448; allele 2 0.603 vs 0.580 vs 0.552) nor in the allelic frequency at either dinucleotide repeat sequence. In 86 subjects with no retinopathy at 15 years or more from diagnosis of diabetes and 190 subjects with diabetic retinopathy there was no difference in the frequency of Hind III restriction alleles (retinopathy present vs retinopathy absent: allele 1 0.400 vs 0.467; allele 2 0.600 vs 0.533) nor in the allelic frequencies at either dinucleotide repeat sequence. The results indicate that there is no or minimal influence of the PAI-1 gene on either PAI-1 levels or the development of diabetic retinopathy in patients with diabetes mellitus.

The Level of Cytokines in the Vitreous Body of Severe Proliferative Diabetic Retinopathy Patients Undergoing Posterior Vitrectomy

2018 ◽  
Vol 24 (27) ◽  
pp. 3276-3281 ◽  
Author(s):  
Dorota Raczyńska ◽  
Katarzyna A. Lisowska ◽  
Krzysztof Pietruczuk ◽  
Joanna Borucka ◽  
Mateusz Ślizień ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Vitreous Body ◽  
Control Group ◽  
Slit Lamp ◽  
Corrected Visual Acuity ◽  
Cytokine Levels ◽  
Pars Plana ◽  
Eye Examination

Objective: The objective of the study was to compare cytokine levels in the vitreous body of patients with proliferative diabetic retinopathy (PDR) undergoing posterior vitrectomy. Patients and methods: The study included 39 patients (39 eyes) undergoing pars plana vitrectomy (PPV). Patients were divided into three groups: patients with proliferative diabetic retinopathy (PDR) without aflibercept injection prior to the surgery, PDR patients administered aflibercept injection prior to the surgery, and patients without diabetes mellitus (control group). All patients underwent a comprehensive eye examination one day before and 3 weeks after the surgery, including measurements of: best-corrected visual acuity (BVCA) and intraocular pressure (IOP), slit-lamp examination and spectral domain optical coherence tomography (SOCT). Concentrations of cytokines: IL-6, IL-8, IL-12p70, TNF, IL-10, IL-1β were measured in the vitreous body of patients with BD™ Cytometric Bead Array (CBA) Human Inflammatory Cytokines Kit. Results: PDR patients who received pretreatment with aflibercept injection showed significantly lower concentrations of IL-12p70, TNF, IL-10 and IL-1β in the vitreous body compared to the control group. Meanwhile, patients without prior aflibercept injection had a significantly higher concentration of IL-8. There was also a significant positive correlation between IOP before PPV and IL-8 concentration in both PDR patients’ groups. Conclusion: Findings of our study suggest an important role of IL-8 in the development of severe PDR. Aflibercept administration on the day before elective vitrectomy facilitated the surgery.

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