scholarly journals Frequency of severe liver cirrhosis and hepatocellular carcinoma caused by hepatitis B and C in a tertiary care hospital.

2021 ◽  
Vol 28 (10) ◽  
pp. 1452-1456
Author(s):  
M. Umer Bin Arshad ◽  
Naveed Asghar ◽  
Talha Shamshad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Severe Liver ◽  
Cross Sectional ◽  
Class C

Objective: Liver cirrhosis is one of the most widespread diseases in underdeveloped countries. Study Design: Cross Sectional Study. Setting: Nishtar Hospital Multan. Period: January 2020 to March 2020. Material & Methods: Three hundred and ninety seven of admitted patients were included and patients falling in class C of child Turcotte Pugh classification of liver cirrhosis were determined. Prevalence of hepatocellular carcinoma and cause of cirrhosis in these patients was also determined. Statistical Package for Social Sciences (SPSS 23.0) was used for analysis. Results: Out of 397 patients included in the study 25.4 % or 101 had class C cirrhosis, out of these 5.94% or 6 also had hepatocellular carcinoma. With respect to age of initial diagnosis of the illness 25.7% or 26 were in age interval 31-40yrs, 24.8% or 25 in interval 41-50yrs, 20.8% or 21 in interval 51-60 yrs. Hepatitis C (67.3%) comes out to be the commonest of all causes of chronic liver disease, followed by other causes (18.8%), then both hepatitis C and B (7.9%) and hepatitis B alone (5.9%). Conclusion: Our study concluded that approximately 1 in every 4 patients admitted in medical wards of a tertiary care hospital have severe liver cirrhosis caused most commonly by hepatitis C with most common age of presentation being 30-60 years. Approximately 6 out of 100 of these patients also had hepatocellular carcinoma.

scholarly journals Burden and baseline characteristics of patients with decompensated liver disease in Tertiary Care Hospital Gujrat.

2021 ◽  
Vol 28 (02) ◽  
pp. 165-170
Author(s):  
Irfan Younus ◽  
Muhammad Zahid Ali ◽  
Muhammad Ajmal ◽  
Hina Akhtar ◽  
Javeria Ali ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Decompensated Cirrhosis ◽  
Care Hospital ◽  
Medical Department ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Gi Bleed

Objective: To determine the load, clinical and laboratory findings of the patients with decompensated cirrhosis admitted in medical department of tertiary care hospital and to make plan for the improvement of these patients. Study Design: Cross Sectional study. Setting: Department of medicine of Aziz Bhatti Shaheed Teaching Hospital, Gujrat. Period: from 1st January 2019 to 31st March 2019. Material & Methods: All 964 patients who were admitted included in study, clinical and laboratory features of patients with decompensated cirrhosis were recorded. Results: Male were in majority (53.7%), median age was 39 years. Decompensated cirrhosis was found  in  216 (22.4%), patients due to complication of  Diabetes Mellitus were 170 (17.6%), COPD & Asthma was found in 130 patients(13.5%), Stroke & Hypertension in 126 patients while Gastroenteritis 6% and infectious diseases RTI, UTI, Enteric Fever etc were present in 46 patients. Among 216 patients, one hundred & seventy eight were Hepatitis C Positive, fifteen had Hepatitis B, and eight had history of alcohol consumption. Seven patients were both Hepatitis B and C positive while in 3.6% etiology was other than mentioned above. Ascites was noted in two hundred six patients, 36.5% had variceal bleed while 51 admitted due to encephalopathy. Conclusion: HCV related cirrhosis and its complications like upper GI bleed, encephalopathy, ascites and hepatoma are major burden on our hospitals and need special attention.

Characteristics and Frequency of Hepatitis C among Children With Β-Thalassemia Visiting Tertiary Care Hospital

2021 ◽  
Vol 15 (10) ◽  
pp. 2576-2577
Author(s):  
Huda Abbas ◽  
Zunaira Javed ◽  
Sadia Bashir ◽  
Wajahat Hussain ◽  
Nadia Tufail ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Blood Transfusion ◽  
Rural Areas ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Blood Transfusions ◽  
Care Hospital ◽  
Cross Sectional ◽  
Safe Blood ◽  
Public And Private Sector

Aim: To find the characteristics and frequency of hepatitis C among children with β-Thalassemia. Methodology: It was a cross sectional type of study conducted in tertiary care hospital of Bahawalpur for a period of 6 months from from January 2021 to June 2021. Sample size was 51 patients. Patients suffering from β-Thalassemia and were undergoing blood transfusions in large amounts were included. Results: β-Thalassemia is more common in Males (67%) than females (33%) with most of the cases detected in the patients who were living in rural areas (61%). Moreover, with the increase in number of transfusions the threat of HCV increases. Conclusion: Blood transfusion is a lifesaving intervention. There is a need to pay an immediate attention towards the bio safety practice in both the public and private sector blood banks. There must be strict rules and regulations for safe blood transfusions in Pakistan. Keywords: Thalassemia; HCV; Blood transfusion; HB electrophoresis

scholarly journals Comparative Study of Compliance between Sofosbuvir and Interferon in the Management of Viral Hepatitis at Tertiary Care Hospital of Gambat, Sindh, Pakistan

2021 ◽  
pp. 1-8
Author(s):  
Sajid Ali ◽  
Zuheeb Ahmed ◽  
Marvi Metlo ◽  
Tahseen Ahmed ◽  
Shahzad Ali ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Hepatitis C ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Duration Of Action ◽  
N 93

Introduction: Hepatitis can be defined as inflammation of the liver. Hepatitis may be acute or chronic. It is estimated that in 2017, approximately 15 million people suffered from Hepatitis in Pakistan suffering from hepatitis. 150–200 million people, or approximately ~3% of the world's population, are living with chronic Hepatitis C. Methodology: A descriptive cross-sectional study was conducted on 300 patients selected by purposive sampling who were reported with Hepatitis-C and co infection of Hepatitis-C + Hepatitis-B, at a tertiary care hospital Gambat. A series of questions were asked from reported patients regarding symptoms and compliance. Results: The results were analyzed by using SPSS-22. Among the 300 patients some were on sofosbuvir (n=150, 50%), which the others were on interferon (n=150, 50%). The findings showed that most of the patients on interferon were non-compliant (n=125,83.3%), and only (n=25, 16.7%) are compliant. Among non-compliant factors, fear from injection was reported in (n=42, 33.6), technique for injection (n=38, 30.4%), prolong duration of action (n=35, 28%), adverse drug reaction (n=26, 20.8%). Better compliance was observed with sofosbuvir (n=93, 62.8%) and non-compliant were (57, 38%). Conclusion: This study concluded that better compliance was achieved with sofosbuvir as compared to interferon, rate of ADR’S were also less with sofosbuvir.

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