scholarly journals Body Mass Index and Indicators of Lipid Exchange in Liver Steatosis of Alcoholic and Nonalcoholic Genesis in Residents of Rural Area: Similarities and Differences

2019 ◽  
Vol 4 (3) ◽  
pp. 23-27
Author(s):  
N. V. Mikhaylova ◽  
I. L. Petrunko
Keyword(s):  
Body Mass Index ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Rural Area ◽  
Body Mass ◽  
Rural Areas ◽  
Liver Steatosis ◽  
Alcoholic Fatty Liver ◽  
Lipid Exchange ◽  
Lipid Metabolism Disorders

Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are serious health problems. Features of liver steatosis (LS) due to NAFLD and ALD in rural areas, including lipid metabolism indicators, depending on body mass index (BMI), have not been thoroughly studied.Aim. To study the features of lipid metabolism in residents of rural area in LS due to NAFLD and ALD depending on the BMI.Materials and Methods: 1152 residents of a rural therapeutic site were surveyed. Lipidograms and BMI were analyzed in patients with LS at NAFLD and ALD.Results. There were no patients with a reduced BMI in the rural medical site. Persons with BMI ≥ 25 among patients with LS on the background of NAFLD (98.2 %) are significantly more frequent than on the background of ALD (55.1 %) (p < 0.001). Among subjects with normal BMI there were more patients with ALD (44.9 %) than with NAFLD (1.8 %) (p < 0.001). There were no significant differences in age in patients with in NAFLD depending on BMI (p > 0.05). Patients with LS of ALD with an increased BMI were older than those with a normal index (p < 0.05). Also, there were no differences in lipidograms with LS on the background of NAFLD and ALD depending on BMI (p > 0.05). Triglyceride levels (TG) and atherogenic coefficient (AC) were significantly higher (p < 0.05 in both cases) in LS with ALD than in patients with NAFLD. Findings. Disorders of lipid metabolism were found in patients with LS with both increased BMI and normal. At the rural therapeutic site, patients with LS due to ALD have more pronounced lipid metabolism disorders than those ones with NAFLD, regardless of BMI.

scholarly journals Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver disease in 2 decades: the NAGALA study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takuro Okamura ◽  
Yoshitaka Hashimoto ◽  
Masahide Hamaguchi ◽  
Akihiro Obora ◽  
Takao Kojima ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Abdominal Ultrasonography ◽  
Alcoholic Fatty Liver ◽  
The Past ◽  
Significant Difference ◽  
Alcoholic Fatty Liver Disease

Abstract Background In this study, to clarify the evolving background of people with non-alcoholic fatty liver disease (NAFLD), we compared the current prevalence of NAFLD with that of 2 decades ago. Methods We included two cohorts. The past cohort was from 1994 to 1997 and included 4279 men and 2502 women. The current cohort was from 2014 to 2017 and included 8918 men and 7361 women. NAFLD was diagnosed by abdominal ultrasonography. Results The prevalence of NAFLD increased in both genders throughout these 2 decades (18.5% in the past cohort and 27.1% in the current cohort for men; and 8.0% in the past cohort and 9.4% in the current cohort for women). The prevalence of hyperglycemia increased, whereas the prevalence of low high-density lipoprotein cholesterol levels and hypertriglyceridemia significantly decreased. There was no significant difference in the mean body mass index. Multivariate analysis revealed that the prevalence of obesity and body mass index were significantly associated with the prevalence of NAFLD in both the past and current cohorts. Conclusions The incidence of NAFLD significantly increased throughout these 2 decades, and obesity is the most prevalent factor. Thus, body weight management is an essential treatment option for NAFLD.

852 NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) MAY DEVELOP IN PATIENTS WITH NORMAL BODY MASS INDEX (BMI)

2011 ◽  
Vol 54 ◽  
pp. S340 ◽  
Author(s):  
E. Margariti ◽  
M. Deutsch ◽  
S. Manolakopoulos ◽  
G. Kaflri ◽  
D. Tiniakos ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Normal Body Mass Index ◽  
Alcoholic Fatty Liver ◽  
Normal Body ◽  
Alcoholic Fatty Liver Disease

Body Mass Index as a Predictor of Mortality for Severe Non-alcoholic Fatty Liver Disease

2015 ◽  
Vol 110 ◽  
pp. S855-S856
Author(s):  
Ashley H. Davis-Yadley ◽  
Seth Lipka ◽  
Ghulamullah Shahzad ◽  
Steven B. Clayton ◽  
Ambuj Kumar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals CLINICAL FEATURES AND LABORATORY PARAMETERS IN PREGNANT WOMEN WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND OBESITY

2021 ◽  
pp. 5-13
Author(s):  
L. V. BAHNIY ◽  
S. N. HERYAK ◽  
N. I. BAHNIY
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Pregnant Women ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
The Body ◽  
Alcoholic Fatty Liver ◽  
Group I ◽  
Alcoholic Fatty Liver Disease

Today, non-alcoholic fatty liver disease (NAFLD) is a common pathology and pressing problem in pregnant women, especially among overweight, as the incidence of obese women of childbearing age is rapidly increasing. Disorders of lipid metabolism, which is an integral part of this disease, lead to pathological changes in the functional state of the liver, which in turn have a negative impact on pregnancy and lead to the formation of obstetric and perinatal complications. THE AIM OF OUR STUDY was to evaluate the clinical and laboratory markers of liver disorders in pregnant women with NAFLD depending on body mass index. MATERIALS AND METHODS. We’ve examined 98 pregnant women with NAFLD at the stage of non-alcoholic steatohepatitis (NASH) in combination with obesity. The age of the examined women ranged from 21 to 35 years (mean age 30.5 ± 1.5 years). The control group consisted of 30 almost healthy pregnant women. Depending on the body mass index (BMI), all surveyed women are divided into three groups: Group I - overweight pregnant women, Group II - pregnant women with grade I obesity, Group III - pregnant women with grade II obesity. We evaluated the incidence of major clinical complaints and changes in blood biochemical parameters in pregnant women depending on the increasing of BMI. RESULTS. When comparing the clinical manifestations of NAFLD on the stage of NASH in pregnant, the highest frequency is observed in the group of examined women with severe obesity compared with the group of patients with moderate obesity and overweight: symptoms of asthenic syndrome (increased fatigue, sleep disturbances, emotional lability, decreased and increased appetite) in 91.6.0%, 79.1% and 61.5% of patients (p<0.05), manifestations of dyspepsia  (constipation, nausea, flatulence) - in 87.5%, 54% and 34.6% patients (p <0.05), feeling of heaviness or moderate pain in the right hypochondrium - in 62.5% 50% and 30.7% of patients, respectively (p <0.05). CONCLUSIONS. It has been established that pregnant women with non-alcoholic fatty liver disease on the stage of nonalcoholic steatohepatitits have pronounced clinical picture of the disease, which depends on the increase in BMI. It was found that in pregnant women with NAFLD liver dysfunction occurs on the background of grade I obesity, which can be considered as an early marker of steatohepatitis and risk of obstetric complications.

scholarly journals Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2978
Author(s):  
Stanislav Kotlyarov ◽  
Aleksei Bulgakov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Pulmonary Disease ◽  
Fatty Liver Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Alcoholic Fatty Liver ◽  
Lipid Metabolism Disorders

Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have increased the attention of clinicians and researchers to the problem of NAFLD. The research results allow us to emphasize the systemicity and multifactoriality of the pathogenesis of liver parenchyma lesion. At the same time, many aspects of its classification, etiology, and pathogenesis remain controversial. Local and systemic metabolic disorders are also a part of the pathogenesis of chronic obstructive pulmonary disease and can influence its course. The present article analyzes the metabolic pathways mediating the links of impaired lipid metabolism in NAFLD and chronic obstructive pulmonary disease (COPD). Free fatty acids, cholesterol, and ceramides are involved in key metabolic and inflammatory pathways underlying the pathogenesis of both diseases. Moreover, inflammation and lipid metabolism demonstrate close links in the comorbid course of NAFLD and COPD.

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