scholarly journals Diabetes insípida perioperatoria secundaria a litio.

2020 ◽  
Vol 12 (2) ◽  
pp. 1
Author(s):  
Yaiza Beatriz Molero Díez ◽  
María Gómez Fernández ◽  
Francisco García Lázaro
Keyword(s):  
Case Report ◽  
Diabetes Insipidus ◽  
Collecting Duct ◽  
Secondary Diabetes ◽  
Renal Concentrating Mechanism ◽  
Intraoperative Period ◽  
Medullary Collecting Duct ◽  
Trastorno Bipolar ◽  
Term Maintenance

La diabetes insípida es una patología caracterizada por la eliminación de volúmenes muy elevados de orina diluida. La hormona antidiurética es la encargada de regular la reabsorción de agua en el túbulo colector.  Podemos diferenciar dos variantes, la neurogénica o central y la nefrogénica o secundaria según el nivel que esté afectado. Varios fármacos han sido relacionados con la pérdida de la capacidad concentradora renal de la orina, siendo el litio uno de ellos. Presentamos el caso de una paciente sometida a intervención quirúrgica por estenosis benigna de píloro en tratamiento farmacológico con litio por trastorno bipolar que durante el periodo intraoperatorio comenzó con diuresis elevada sospechándose diabetes insípida. ABSTRACT Lithium-induced Perioperative Diabetes Insipidus–A Case Report Diabetes insipidus is a pathology characterized by the elimination of large amounts of dilute urine. The antidiuretic hormone is responsible of water reabsorption in medullary collecting duct in the kidney. There are two main types of diabetes insipidus, on one hand the neurogenic or central diabetes insipidus and on the other hand the nephrogenic or secondary diabetes insipidus, depending on the level that is affected. Several drugs have been related to loss of renal concentrating mechanism, being the lithium one of them. We present a case report of a patient undergoing surgery for benign pyloric stenosis in pharmacological long-term maintenance treatment of bipolar disorder with lithium. During the intraoperative period the patient began with high urine output and diabetes insipidus was suspected.

scholarly journals Actinic cheilitis: a case report and a review of the literature

2016 ◽  
Vol 31 (1) ◽  
pp. 45
Author(s):  
Dasaiev M. Dutra ◽  
Maria Auxiliadora G do Nascimento ◽  
Maria Sueli Marques Soares
Keyword(s):  
Case Report ◽  
Triamcinolone Acetonide ◽  
Acute Phase ◽  
Inflammatory Process ◽  
Premalignant Lesions ◽  
Review Of The Literature ◽  
Actinic Cheilitis ◽  
Anti Inflammatory ◽  
Term Maintenance

Objective: This article presents a case report of actinic cheilitis with an acute inflammatory process and need for anti- inflammatory treatment.Case Report: Triamcinolone acetonide in Orabase was prescribed 3 times a day for 15 days, and the patient was advised to use sunscreen and hats. After 7 days, there was a significant improvement in the acute phase and the patient was kept under observation.Conclusion: It is emphasized that it is important to intervene in the evolution of the inflammatory process in premalignant lesions in order to prevent its long-term maintenance.

Long-term maintenance lorazepam for catatonia: a case report

2011 ◽  
Vol 33 (1) ◽  
pp. 82.e1-82.e3 ◽  
Author(s):  
Sandeep Grover ◽  
Munish Aggarwal
Keyword(s):  
Case Report ◽  
Term Maintenance

scholarly journals Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct

2008 ◽  
Vol 295 (3) ◽  
pp. C661-C678 ◽  
Author(s):  
Ming-Jiun Yu ◽  
Trairak Pisitkun ◽  
Guanghui Wang ◽  
Juan F. Aranda ◽  
Patricia A. Gonzales ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Large Scale ◽  
Collecting Duct ◽  
Rat Kidney ◽  
Apical Region ◽  
Annexin 2 ◽  
Associated Proteins ◽  
Medullary Collecting Duct ◽  
Renal Collecting Duct

In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter UT-A. To discover proteins potentially involved in vasopressin action in rat kidney collecting ducts, we enriched membrane “raft” proteins by harvesting detergent-resistant membranes (DRMs) of the inner medullary collecting duct (IMCD) cells. Proteins were identified and quantified with LC-MS/MS. A total of 814 proteins were identified in the DRM fractions. Of these, 186, including several characteristic raft proteins, were enriched in the DRMs. Immunoblotting confirmed DRM enrichment of representative proteins. Immunofluorescence confocal microscopy of rat IMCDs with antibodies to DRM proteins demonstrated heterogeneity of raft subdomains: MAL2 (apical region), RalA (predominant basolateral labeling), caveolin-2 (punctate labeling distributed throughout the cells), and flotillin-1 (discrete labeling of large intracellular structures). The DRM proteome included GPI-anchored, doubly acylated, singly acylated, cholesterol-binding, and integral membrane proteins (IMPs). The IMPs were, on average, much smaller and more hydrophobic than IMPs identified in non-DRM-enriched IMCD. The content of serine 256-phosphorylated AQP2 was greater in DRM than in non-DRM fractions. Vasopressin did not change the DRM-to-non-DRM ratio of most proteins, whether quantified by tandem mass spectrometry (LC-MS/MS, n = 22) or immunoblotting ( n = 6). However, Rab7 and annexin-2 showed small increases in the DRM fraction in response to vasopressin. In accord with the long-term goal of creating a systems-level analysis of transport regulation, this study has identified a large number of membrane-associated proteins expressed in the IMCD that have potential roles in vasopressin action.

Overdenture as a Restorative Option for Hypocalcified-hypoplastic Amelogenesis imperfecta: A Case Report

2009 ◽  
Vol 10 (3) ◽  
pp. 67-73 ◽  
Author(s):  
Valentim Adelino Ricardo Baräo ◽  
Wirley Gonçalves Assunção ◽  
Claudia Misue Kanno ◽  
Célia Tomiko Matida Hamata Saito ◽  
Juliana Aparecida Delben
Keyword(s):  
Case Report ◽  
Treatment Time ◽  
Amelogenesis Imperfecta ◽  
Oral Rehabilitation ◽  
Noninvasive Treatment ◽  
Minimal Invasiveness ◽  
Restorative Treatment ◽  
Time Required ◽  
Term Maintenance

Abstract Aim The aim of this report is to describe the restorative treatment of an 18-year-old patient diagnosed with autossomal recessive hypocalcified-hypoplastic amelogenesis imperfect (AI). Background Esthetic and functional rehabilitations in AI cases are challenging and should consider individual aspects, such as age, socioeconomic status, AI type, and intraoral condition. Report AI was diagnosed in an 18-year-old patient. Summary Considering the short length of crowns and roots, patient life expectancy, minimal invasiveness, amount of treatment time required, and lower costs, oral rehabilitation with overdentures provided an adequate functional and esthetic rehabilitation of the patient. Clinical Significance This report demonstrated overdentures to be a viable, relatively inexpensive, and noninvasive treatment choice of a patient with AI with concerns about treatment longevity, invasiveness, cost, esthetics, and long-term maintenance. Citation Assunção WG, Barão VAR, Kanno CM, Saito CTMH, Delben JA. Overdenture as a Restorative Option for Hypocalcified-hypoplastic Amelogenesis imperfecta: A Case Report. J Contemp Dent Pract 2009 May; (10)3:067-073.

Urea transporters in kidney and erythrocytes

1997 ◽  
Vol 273 (3) ◽  
pp. F321-F339 ◽  
Author(s):  
J. M. Sands ◽  
R. T. Timmer ◽  
R. B. Gunn
Keyword(s):  
Structural Model ◽  
Collecting Duct ◽  
Molecular Data ◽  
Urea Transport ◽  
Urea Transporter ◽  
Vasa Recta ◽  
Countercurrent Exchange ◽  
Systematic Nomenclature ◽  
Medullary Collecting Duct

Physiological and molecular data demonstrate that urea transport in kidney and erythrocytes is regulated by specific urea transporter proteins. The urea transporter in the terminal inner medullary collecting duct permits very high rates of regulated transepithelial urea transport and results in the delivery of large amounts of urea into the deepest portions of the inner medulla, where it is needed to maintain a high interstitial osmolality for concentrating the urine maximally. The urea transporter in erythrocytes permits these cells to lose urea rapidly as they ascend through the ascending vasa recta, thereby preventing loss of urea from the medulla. Urea lost from the medulla would decrease concentrating ability by decreasing the efficiency of countercurrent exchange, as occurs in individuals who lack the Kidd antigen. The recent cloning of cDNAs for these two urea transporters has begun to yield new insights into the mechanisms underlying acute and long-term regulation of urea transport and should permit exciting new insights in the future. This review focuses on the physiological and biophysical evidence that established the concept of urea transporters, the subsequent cloning of cDNAs for urea transporters, and the recent integrative studies into the regulation of urea transport. We also propose a new systematic nomenclature and a new structural model for urea transporters.

Maintenance of Implant Supported Overdenture: A Case Report

2008 ◽  
Vol 2 (3) ◽  
pp. 70-72
Author(s):  
Dilip G Nayak ◽  
Ashita S Uppoor ◽  
Manoj Humagain
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Female Patient ◽  
Oral Hygiene ◽  
Standard Protocol ◽  
Typical Characteristic ◽  
Professional Care ◽  
Characteristic Features ◽  
Term Maintenance

ABSTRACT The long term success of dental implants likely requires the maintenance of healthy periimplant tissues because the soft tissue seal around implants is best when the surrounding mucosa is not inflamed. For this reason, good oral hygiene and regular professional care are essential to maintaining implants. However, despite many years of experience with the implants, there is no standard protocol which defined the most effective regimen for long term implant maintenance. This is a case report of a 63 year old female patient who presented to our clinics with the typical characteristic features of periimplantitis. A special emphasis on the non surgical management of such patient and need of periodic recall for long term maintenance has been highlighted in this case report which will be beneficial to general practioneers as well as periodontologists in management of such patients.

The effects of collecting duct active NaCl reabsorption and inner medulla anatomy on renal concentrating mechanism

1996 ◽  
Vol 270 (5) ◽  
pp. F900-F911 ◽  
Author(s):  
X. Wang ◽  
A. S. Wexler
Keyword(s):  
Collecting Duct ◽  
Three Dimensional ◽  
Hydraulic Permeability ◽  
Three Dimensional Model ◽  
Duct Epithelium ◽  
Collecting Ducts ◽  
Renal Concentrating Mechanism ◽  
Medullary Collecting Duct ◽  
Collecting Duct Epithelium

First, the representation of the inner medulla incorporates an exaggerated radial separation between tubules, vessels, and collecting ducts; and, second, the hydraulic permeability in the upper portion of the inner medullary collecting ducts was erroneously set to zero. In the current work, we explore the role of collecting duct hydraulic permeability and anatomical heterogeneity via mathematical modeling. The model predicts concentrated urine for measured values of the hydraulic permeability and homogeneous lower inner medulla as long as net active NaCl reabsorption is incorporated in the upper inner medullary collecting duct epithelium. This new three-dimensional model results in two recycling paths. The upper portion of the inner medulla recycles NaCl, whereas the lower portion recycles urea.

Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin

2003 ◽  
Vol 284 (4) ◽  
pp. F701-F717 ◽  
Author(s):  
Birgitte Mønster Christensen ◽  
Weidong Wang ◽  
Jørgen Frøkiær ◽  
Søren Nielsen
Keyword(s):  
Plasma Membrane ◽  
Receptor Antagonist ◽  
Collecting Duct ◽  
Rat Kidney ◽  
Apical Plasma Membrane ◽  
Brattleboro Rats ◽  
Short Term ◽  
Principal Cells ◽  
Medullary Collecting Duct

The purpose of the present study was to examine whether there is axial heterogeneity in the basolateral plasma membrane (BLM) localization of AQP2 and whether altered vasopressin action or medullary tonicity affects the BLM localization of AQP2. Immunocytochemistry and immunoelectron microscopy revealed AQP2 labeling of the BLM in connecting tubule (CNT) cells and inner medullary collecting duct (IMCD) principal cells in normal rats and vasopressin-deficient Brattleboro rats. In contrast there was little basolateral AQP2 labeling in cortical (CCD) and outer medullary collecting duct principal cells. Short-term desamino-Cys1, D-Arg8 vasopressin (dDAVP) treatment (2 h) of Brattleboro rats caused no increase in AQP2 labeling of the BLM. In contrast, long-term dDAVP treatment (6 days) of Brattleboro rats caused an increased BLM labeling in CNT, CCD, and IMCD. Treatment of normal rats with V2-receptor antagonist for 60 min caused retrieval of AQP2 from the apical plasma membrane. Moreover, AQP2 labeling of the BLM was unchanged in CNT and IMCD but increased in CCD. In conclusion, there is an axial heterogeneity in the subcellular localization of AQP2 with prominent AQP2 labeling of the BLM in CNT and IMCD. There was no increase in AQP2 labeling of the BLM in response to short-term dDAVP. Moreover, acute V2-receptor antagonist treatment did not cause retrieval of AQP2 from the BLM. In contrast, long-term dDAVP treatment caused a major increase in AQP2 expression in the BLM in CCD.

Long-term regulation of collecting duct water permeability: freeze-fracture analysis of isolated perfused tubules

1994 ◽  
Vol 266 (5) ◽  
pp. F723-F730 ◽  
Author(s):  
J. B. Wade ◽  
S. Nielsen ◽  
R. A. Coleman ◽  
M. A. Knepper
Keyword(s):  
Water Permeability ◽  
Collecting Duct ◽  
Freeze Fracture ◽  
High Water ◽  
Fracture Analysis ◽  
Single Particles ◽  
Medullary Collecting Duct ◽  
Low Incidence

Terminal inner medullary collecting duct (IMCD) segments from water-restricted rats have high osmotic permeabilities despite the absence of vasopressin (AVP). We performed freeze-fracture analysis of individual IMCD segments from such animals following measurement of their water permeability (Pf). IMCD segments from control rats did not have a high Pf in the absence of AVP (88 +/- 15 microns/s) and had a low incidence of E-face intramembrane particle (IMP) clusters (9.6 +/- 2.7 clusters/100 microns 2). Segments exposed to 0.1 nM AVP in vitro had enhanced Pf (1,060 +/- 210 microns/s) and cluster incidence (122 +/- 33 clusters/100 microns 2). IMCD segments isolated from rats dehydrated for 48 h and perfused without AVP exposure had an elevated Pf (605 +/- 71 microns/s) and a high incidence of clusters (166 +/- 36 clusters/100 microns 2). There also was an increase in the number of single particles between clusters in tubules from dehydrated rats (2.5-fold) and in AVP-treated tubules (3.6-fold). These findings indicate that IMP clusters are associated with high water permeability in tubules from dehydrated animals independent of continued AVP exposure. The increased incidence of particles between clusters suggests that water channels may also occur outside of cluster domains.

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