scholarly journals Effects of Ethanolic Extract of Metracaria chamomela on Some Physiological Parameters in Male Rabbits

2015 ◽  
Vol 39 (2) ◽  
pp. 26-31
Author(s):  
Alia Hussein Ali
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Blood Cell Count

     The aim of this study is to explain the effect of Ethanolic extract 70% of Metracaria chamomella on some physiological parameters in male rabbits. Twelve adult male rabbits were used in this study and were divided equally into two groups: First group was control (C) and received normal saline for four weeks, the second group (Treated group) was intubated orally with ethanolic extract of Metracaria chamomella in a dose 70 mg/kg B.W. for four weeks. Blood samples were collected by heart puncture from each animal at the end of experiment. Blood sample was divided into a part for hematological study and a part for biochemical analysis. The value of serum urea, and creatinine were reduced in animals that received Metracaria chamomella extract at dose of 70 mg/ kg B.W. as compared with the control group. Significant decrease in serum activity of aspartate aminotransferase alanine aminotransferase and alkaline phosphatase activity was observed in Metracaria treated animal as compared with the control group. This study explained that there was significant increase in serum total protein, serum albumin and serum globulin in treated animals as compared with the control group. The value of total cholesterol, serum triacylglycerol, serum low density lipoprotein cholesterol and very low density lipoprotein cholesterol concentration were reduced significantly in animal received Metracaria chamomella extract while the high density lipoprotein cholesterol was elevated significantly as compared with control group. While the effect of Metracaria chamomella extract on blood picture showed no changes in red blood cell count, hemoglobin concentration and hematocrit value but showed significant decrease in platelet count, and significant   increase in white blood cell count as compared with control group. Over all this study explained that Metracaria chamomella extract had Reno protective and hypolipidimic effect in male rabbit.  

scholarly journals Effect of Hyper and Hypothyroidism on Lipid Profile and Liver Function of Male Rats

2011 ◽  
Vol 8 (4) ◽  
pp. 926-933
Author(s):  
Baghdad Science Journal
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Physiological Saline ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Significant Difference

This study was designed to investigate the effect of thyroid hormone disturbance on lipids profiles and liver functions. Eighteen mature male rats Rattus norvegicus were divided into three groups. The first and the second groups were injected subcutaneously with thyroxine (T4) and carbimazol (both at 600 µg/kg BW) respectively on alternate days, to produce recurrent periods of hyper and hypothyroidism .The control group which is the third group was injected with physiological saline. The process continued 4 weeks, after that, injection, blood specimens were collected to estimate serum levels of T3 and T4, Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were determined in the serum. In addition to that, we measure GOT, GPT and CPK enzymes activity. The results showed no significant difference in body weight and a significant increase (P

scholarly journals ARE THE HAPTOGLOBİN LEVELS COMPARABLE TO THE ANTİOXİDANT STATUS LEVELS İN BİCYCLİNG?

2019 ◽  
pp. 1-3
Author(s):  
Sevsen Kulaksızoglu ◽  
Tolga Saka ◽  
Sibel Kulaksızoglu
Keyword(s):  
Antioxidant Status ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Comparison Of The Results

BACKGROUND AND AIMS: This study was designed to determine whether the haptoglobin levels are comparable to the antioxidant status levels. 40 athletes and 30 volunteers were enrolled in the study. MATERIAL AND METHODS: Blood samples for serum malondialdehyde (MDA), total antioxidant status (TAS), haptoglobin, glucose, total cholesterol (TC), triglyceride (TG), very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) and lipoprotein (a) (Lip a) determinations were obtained before and after cyclists completed 300 km bicycle ride. RESULTS: Comparison of the results between the cyclists and control group yielded a signicant difference in serum levels of TG, VLDL-C and LDL-C (P<0.05). The cycling induced a signicant increase in HDL-C, VLDL-C, TG, MDA and TAS levels (P<0.001). Serum LDL-C and Lip a levels were greater before than after cycling (P<0.05). There was no signicant difference among precycling and postcycling haptoglobin levels, whereas the haptoglobin level in control group was signicantly higher than in the cyclists (P<0.001). CONCLUSION: The change in serum antioxidant and lipid levels due to physical activity must be explained as a consequence of the duration of exercise. Further studies are needed to demonstrate haptoglobin's possible role in decreasing oxidative stress during exercise.

scholarly journals Mitigation Effects of Vitamin C and E Against Copper Toxicity in Broiler Chickens, With Reference to Biochemical, Genotoxicity and Pathological Studies

2021 ◽  
Author(s):  
Mohamed Hashem ◽  
Sahar Abd El Hamied ◽  
Eman Ahmed
Keyword(s):  
Vitamin C ◽  
Broiler Chickens ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Feed Consumption ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Vit C

Abstract Copper (Cu) is necessary for biological utility, nevertheless when existing in abundance; it can produce plentiful injurious impacts. This enquiry was carried out to explore the efficiency of individual or combined doses of vitamin C (Vit C) and vitamin E (Vit E) in ameliorating some biochemical, genotoxicity and pathological changes in the liver of copper sulphate (CuSO 4 )-intoxicated chickens. One hundred- one day old broiler chicks were haphazardly divided into 5groups of 20 chicks each. The broilers were fed on basal diet only (control, gp.1 ) or supplemented with 300 mg CuSO 4 /kg diet (Cu, gp.2 ), CuSO 4 + 250 mg Vit C /kg diet (Cu+ Vit C, gp.3 ), CuSO 4 +250 mg Vit E /kg diet (Cu+ Vit E, gp.4 ) and both vitamins C + E (Cu+ Vit C+ Vit E, gp.5 ) for six weeks. The results displayed that CuSO 4 - intoxicated birds (gp.2) had significantly ( p<0.05 ) dwindled body weight, gain and feed consumption with increased feed conversion rate from week 2 till the 6 th week compared with control group. Serum aminotransferases (ALT, AST), and alkaline phosphatase (ALP) were significantly ( p<0.05 ) augmented in CuSO4- exposed group (gp.2) with significantly ( p<0.05 ) drop in serum total protein (TP), albumin, globulins, triglycerides (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), and high density lipoprotein-cholesterol (HDL-C) levels compared to control. Concomitantly, histopathological and DNA changes were perceived in liver of CuSO 4 -intoxicated birds. Co-supplementation of Vit C, and Vit E single-handedly or incorporation to CuSO 4 -intoxicated chickens displayed an enhancement in performance traits and abovementioned changes, especially with those given combination of vitamins. From the extant enquiry, it could be established that supplementation of vitamin C and E were beneficial for alleviation the harmful effects of CuSO 4 on performance and other studied parameters in broiler chickens.

scholarly journals Effect of Magnetic Water on Some Physiological Aspects of Adult Male Rabbits

2012 ◽  
Vol 36 (0E) ◽  
pp. 120-126
Author(s):  
Khalisa Kadim Khudiar
Keyword(s):  
Lipid Profile ◽  
Adult Male ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Total Serum ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Magnetic Water

The present study was undertaken to search out thebeneficial effect of magnetized water on serumantioxidant, lipid profile and total protein of adult male rabbits. Twenty adult male rabbits were randomly divided into two equal groups and were treated daily for 60 days as follows:Group C:Rabbits of this group were allowed to ad libitumsupplyofdrinking water (control group),Group MG:Rabbits of this group were allowed to ad libitum supply of magnetic water.Fasting blood (for 8-12 hrs) samples were drawn by cardiac puncture technique at different times 0, 30 and 60 days of experiment for measuring the following parameters. Serum glutathione concentration (GSH), lipid profile including serum triacylglycerol (TAG), total cholesterol - (TC), high density lipoprotein - cholesterol (HDL-C), low density lipoprotein - cholesterol (LDL-C) and very low density lipoprotein cholesterol - (VLDL-C), total serum protein concentrations (TSP). The result revealed that drinking of magnetic water had beneficial effect on some physiological aspects manifested by a significant elevation in serum GSH, HDL-C and total serum proteins concentration. In addition to significant suppression in serums TC, TAG, LDL-C, and VLDL-C concentrations .In conclusion the results of this study pointed to the prevalence of magnetic water upon normal drinking water in all measures issued.

scholarly journals Primary hypothyroidism as a predictor of the hypogonadism development

2021 ◽  
Vol 17 (6) ◽  
pp. 482-485
Author(s):  
N.V. Pasyechko ◽  
T.Y. Krytskyi ◽  
S.V. Kadubets ◽  
U.V. Naumova ◽  
L.V. Naumova
Keyword(s):  
Blood Level ◽  
Low Density Lipoprotein ◽  
Follicle Stimulating Hormone ◽  
Density Lipoprotein ◽  
Primary Hypothyroidism ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Hormonal Status ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reproductive age with primary hypothyroidism. Materials and methods. Totally 60 males with primary hypothyroidism were included in the study. A comparative analysis of hormonal, anthropometric, and metabolic para­meters in 60 men with hypothyroidism (basic group) and 25 men wi­thout hypothyroidism and other chronic somatic diseases (control group) was performed. The mean age of the subjects was 42.4 ± 2.7 years. Results. It has been established that hypothyroidism was accompanied by an increase in serum concentrations of cholesterol and low-density lipoprotein cholesterol in comparison with control group (25 men without hypothyroidism) indicating metabolic disturbance. The data shows the significant effect of hypothyroidism on testosterone and follicle-stimulating hormone (FSH) serum concentration but not on luteinizing hormone, estradiol levels. Patients with hypothyroidism had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in men with hypothyroidism can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido, and alteration in spermatogenesis. Conclusions. In men with hypothyroidism, changes in hormonal status have been found, which manifested in a decrease in testosterone and an increase in the blood level of follicle-stimulating hormone. The effect of hypothyroidism on the blood level of other hormones (luteini­zing, estradiol, cortisol) has not been established. Hypothyroidism in men is accompanied by changes in lipid metabolism (increased levels of total cholesterol and low-density lipoprotein cholesterol).

scholarly journals Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C)

2017 ◽  
Vol 55 (3) ◽  
pp. 159-166
Author(s):  
Maida Seferovic Saric ◽  
Miljenka-Jelena Jurasic ◽  
Slavica Sovic ◽  
Bojana Kranjcec ◽  
Tatjana Glivetic ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Early Stage ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Ldl Particles

Abstract Background. Usually both hypothyroidism and hyperthyroidism are related to the cardiovascular and cerebrovascular disease development. The relationship between subclinical hypothyroidism has been widely investigated but the findings remain controversial. The aim of the present study was to evaluate the lipid profile in patients with subclinical hypothyroidism (SHypo) in comparison to controls and to determine the association of SHypo and dyslipidemia in attempt to find importance of small dense low-density lipoprotein cholesterol (sdLDL-C) in atherosclerosis. Material and methods. In this study we included 100 women, aged 30 to 70 years that were divided into subgroups according to their age. According to the values of levels of thyroid hormones they were divided into euthyroid (control) group (n = 64) and (newly discovered) subclinical hypothyroidism (SHypo) group (n = 36). A high-sensitivity C-reactive protein (hs-CRP) and lipid profile, including small dense low-density lipoprotein cholesterol (sdLDL-C) were determined. Body weight and height were measured and BMI calculated. History of the current illness, medication, alcohol consumption and cigarettes smoking were noted. Results. Changed lipid profile as well as elevated triglycerides and sdLDL-C were observed in the group with subclinical hypothyroidism compared to the control group. Conclusions. It is important to determine serum lipid levels, especially serum sdLDL-C levels at an early stage of subclinical hypothyroidism, since they represent atherogenic LDL particles and are better indicators for dyslipidaemia in subclinical hypothyroidism and the development of atherosclerosis with potential complications such as cardiovascular and cerebrovascular diseases.

scholarly journals Association of Retinol Binding Protein- 4 (RBP4) with Glycemia, Dyslipidemia, Hypertension, and Obesity in Type 2 Diabetic Iraqi Patients

2020 ◽  
Vol 29 (2) ◽  
pp. 263-270
Author(s):  
Thair L. Jabbar ◽  
Ali A. Kasim
Keyword(s):  
Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Retinol Binding Protein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Retinol Binding Protein 4

Abstract: Background: Retinol binding protein 4 (RBP4), an adipokine that participate in a lipid metabolism or insulin resistance through a complex regulatory network. Recently, RBP4 was reported to be associated with many cardiovascular diseases (CVDs) risk factors in patients of type 2 diabetes mellitus (T2DM). This study aims to study the correlation of  serum RBP4 with some markers of glycemic control, dyslipidemia, hypertension and obesity in T2DM Iraqi patients. Subjects and Methods: one hundred fifty participants were enrolled in this coss-sectional study, 120 of participants were T2DM patients and 30 were apparently healthy individuals to serve as control group. Results: Serum RBP4 levels are higher in T2DM patients with poor glycemic control, dyslipedemia, hypertension, or obesity compared  to the control group. Serum RBP4 is positively correlated with body mass index, fasting blood glucose, glycosylated hemoglobin, systolic blood pressure (P<0.001), and plasma triacylglycerols, very low density lipoprotein cholesterol, and low density lipoprotein cholesterol (P<0.05) and negatively correlated with high density lipoprotein cholesterol (P<0.001). Conclusion: serum RBP4 is correlated with many risk factors of CVD in T2DM Iraqi patients.   keywords: RBP4, type 2 diabetes mellitus, dyslipidemia, hypertension, obesity

scholarly journals Association of Dyslipidemia and Hyperhomocysteinemia in epileptic patients on carbamazepine monotherapy.

2020 ◽  
Vol 27 (02) ◽  
pp. 230-236 ◽  
Author(s):  
Shazia Bano ◽  
Syed Munawar Alam ◽  
Saima Iram
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Carbamazepine Therapy ◽  
Epileptic Patients

Objectives: To observe the association between dyslipidemia and homocysteine level in epileptic patients; especially on carbamazepine monotherapy. Study Design: Cross sectional study. Setting: Neurology Department and Epilepsy Centre of Jinnah Post Graduate Medical Centre, Karachi. Period: From January 2015 – January 2016. Material & Methods: Total 300 subjects, aged more than 15 years were included and divided into three groups.  Group A (100 healthy individuals) was control group, Group B (100 newly diagnosed epileptic patients without antiepileptic therapy), Group C (100 epileptic patients on Carbamazepine therapy, which was further subdivided into C-I (n=33) had epileptic patients on Carbamazepine therapy less than 1 year, C-II (n=33) comprised of epileptic patients on Carbamazepine therapy 1-2 years and C-III (n=33) had epileptic patients on Carbamazepine therapy more than 2 years. Serum lipid profile and homocysteine levels were measured. Results: In patients with different durations of carbamazepine monotherapy; a noteworthy incremental trend in the levels of homocysteine, total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol was observed. Homocysteine was found positively correlated with total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol. Conclusion: In our study dyslipidemia was associated with hyperhomocysteinemia, which in turn was correlated with atherosclerosis in CBZ treated epileptic patients.

scholarly journals Association of Dyslipidemia and Hyperhomocysteinemia in epileptic patients on carbamazepine monotherapy.

2020 ◽  
Vol 27 (02) ◽  
pp. 230-236
Author(s):  
Shazia Bano ◽  
Syed Munawar Alam ◽  
Saima Iram
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Carbamazepine Therapy ◽  
Epileptic Patients

Objectives: To observe the association between dyslipidemia and homocysteine level in epileptic patients; especially on carbamazepine monotherapy. Study Design: Cross sectional study. Setting: Neurology Department and Epilepsy Centre of Jinnah Post Graduate Medical Centre, Karachi. Period: From January 2015 – January 2016. Material & Methods: Total 300 subjects, aged more than 15 years were included and divided into three groups.  Group A (100 healthy individuals) was control group, Group B (100 newly diagnosed epileptic patients without antiepileptic therapy), Group C (100 epileptic patients on Carbamazepine therapy, which was further subdivided into C-I (n=33) had epileptic patients on Carbamazepine therapy less than 1 year, C-II (n=33) comprised of epileptic patients on Carbamazepine therapy 1-2 years and C-III (n=33) had epileptic patients on Carbamazepine therapy more than 2 years. Serum lipid profile and homocysteine levels were measured. Results: In patients with different durations of carbamazepine monotherapy; a noteworthy incremental trend in the levels of homocysteine, total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol was observed. Homocysteine was found positively correlated with total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol. Conclusion: In our study dyslipidemia was associated with hyperhomocysteinemia, which in turn was correlated with atherosclerosis in CBZ treated epileptic patients.

scholarly journals Hypocholesterolaemic and Anti-Atherogenic Effects of Palm-Based Oils (NoveLin I and NoveLin II) in Cholesterol-Fed Rabbits

2020 ◽  
Vol 17 (9) ◽  
pp. 3226
Author(s):  
Che Anishas Che Idris ◽  
Siew Wai Lin ◽  
Ahmad Faizal Abdull Razis
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Olive Oil ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Equal Distribution

NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil.

Sign in / Sign up

Export Citation Format

Share Document