scholarly journals Recurrence of glioblastoma multiforme in a childhood: A case report

2020 ◽  
Vol 8 (3) ◽  
pp. 407-412
Author(s):  
Fahimma ◽  
Yuyun Yueniwati ◽  
Dessika Rahmawati ◽  
Dessika Rahmawati
Keyword(s):  
Case Report ◽  
Glioblastoma Multiforme ◽  
Unusual Case ◽  
Treatment Options ◽  
Tumor Resection ◽  
Left Hemiparesis ◽  
Therapeutic Approaches ◽  
Imaging Evaluation ◽  
Initial Manifestation ◽  
Different Characteristics

GBM is a highly aggressive malignant tumor that rarely happens in children. Pediatric GBM is the primary cause of death in children with brain neoplasms. Treatment of GBM is a difficult and challenging condition, especially in pediatric GBM. Surgical tumor resection combined with chemoradiotherapy suggests as standard therapeutic approaches for GBM. However, the recurrence of GBM is an inevitable event and can occur in more than 90% of patients. We present an unusual case of an 11-years-old girl with recurrence of GBM. She complained of progressive headache and left hemiparesis as an initial manifestation. She was diagnosed with GBM three years before. Near-total surgical resection followed with chemotherapy, and radiotherapy was done after the diagnosis. Head imaging showed a smaller lesion, and her symptoms were improved significantly. Two years after, she was admitted to the hospital with worsening symptoms. Imaging evaluation showed the enlargement of tumor lesions. Recurrence of GBM is a great challenge to manage, and there are no well-defined management protocols. Several studies suggest that treatment options may follow the adult patients' approach, but pediatric GBM has significantly different characteristics than adults.

scholarly journals Orbital Lymphangioma: Case Report and Management Paradigms

2017 ◽  
Vol 36 (02) ◽  
pp. 136-140
Author(s):  
Alex Roman ◽  
Larissa Bianchini ◽  
Bárbara Battistel ◽  
Miguel Franzoi Neto ◽  
Daniela Schwingel
Keyword(s):  
Case Report ◽  
Present Report ◽  
Pediatric Population ◽  
Treatment Options ◽  
Tumor Resection ◽  
Neck Region ◽  
Systemic Circulation ◽  
Needle Aspiration ◽  
Intralesional Injection ◽  
Sclerosing Agents

Introduction Lymphangioma is a rare congenital vascular malformation of the head and neck region isolated from the systemic circulation. It has a benign etiology, and represents 1–3% of all orbital tumors. These hamartomas often present in the pediatric population with a slightly female predilection. They have a lymphocytic composition, and may increase in size with episodes of viral infection, causing proptosis. Discussion The management of this lesion is controversial, hardly curative, and depends on the clinical presentation. The treatment options include partial surgical resection of the major cyst, needle aspiration, surgical debulking, systemic steroids, sildenafil, intralesional injection of the sclerosing agents, and local radiotherapy. Case Report In the present report, we describe an uncommon case of lymphangioma in a 6-year-old female who was first submitted to neurosurgery for tumor resection and received sildenafil therapy later, with promising results. Conclusion The treatment of orbital lymphangiomas remains a controversial topic, and the use of sildenafil along with needle aspiration and microsurgical removal is a viable option of treatment. However, many issues, such as the ideal duration of the therapy, the dosage regimen and the recurrence rate, still remain unclear. Our case report adds promising data on this pathology, even though larger trials are needed to properly elucidate the remaining questions.

Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme

2008 ◽  
Vol 108 (2) ◽  
pp. 236-242 ◽  
Author(s):  
Borimir J. Darakchiev ◽  
Robert E. Albright ◽  
John C. Breneman ◽  
Ronald E. Warnick
Keyword(s):  
Glioblastoma Multiforme ◽  
Treatment Options ◽  
Tumor Resection ◽  
Progression Free Survival ◽  
Recurrent Glioblastoma ◽  
Karnofsky Performance Scale ◽  
Recurrent Glioblastoma Multiforme ◽  
Brain Necrosis ◽  
Bcnu Wafers ◽  
Recurrent Gbm

Object Effective treatment options are limited for patients with recurrent glioblastoma multiforme (GBM), and survival is usually <1 year. Novel treatment approaches are needed. Localized adjunct treatment with carmustine (BCNU) wafers or permanent, low-activity 125I seed implants has been shown to be effective for GBM. This study assessed the efficacy and safety of these therapies in combination following tumor resection. Methods Thirty-four patients with recurrent GBM were treated with maximal tumor resection followed by implantation of BCNU wafers and permanent 125I seeds into the tumor cavity. Patients were followed up with clinical evaluations and magnetic resonance imaging studies once every 3 months. Survival and progression-free survival (PFS) were evaluated. Results During follow-up, local disease progression was observed in 27 patients, and 23 of them died. The median survival period was 69 weeks, and the median PFS was 47 weeks. The 12-month survival and PFS rates were 66 and 32%, respectively. Baseline factors associated with prolonged survival included Karnofsky Performance Scale score ≥ 70, 125I seed activity ≥ 0.8 mCi/cm3 of tumor cavity, and age < 60 years. Brain necrosis developed in 8 patients (24%) and was successfully treated with surgery or hyperbaric oxygen therapy. Conclusions The use of adjunct therapy combining BCNU wafers and permanent 125I seeds resulted in survival that compares favorably with data from similar studies performed in patients with recurrent GBM. The incidence of brain necrosis appeared to be higher than that expected with either treatment alone, although the necrosis was manageable and did not affect survival. This novel approach warrants further investigation in recurrent and newly diagnosed GBM.

scholarly journals Proceeding of Glioblastoma Multiforme (GBM): An Advanced Overview

2020 ◽  
pp. 1-5
Author(s):  
Niraj Kumar Srivastava ◽  
Niraj Kumar Srivastava ◽  
Somnath Mukherjee
Keyword(s):  
Glioblastoma Multiforme ◽  
Magnetic Resonance ◽  
Histopathological Examination ◽  
Imaging Techniques ◽  
Tumor Resection ◽  
Genetic Alterations ◽  
Resonance Spectroscopy ◽  
Central Nervous System Tumor ◽  
Therapeutic Approaches ◽  
Diagnostic Significance

Glioblastoma multiforme (GBM) is a central nervous system tumor of grade IV histological malignancy according to the WHO classification. GBM is an extraordinary tumor and the worldwide incidence is less than 10 per 100,000 individuals. The prognosis of this tumor is meagre and survival rate is 15 months subsequent to diagnosis. Such an atrocious image of this tumor is responsible for a major issue of public health. This tumor develops from normal glial cells through multistep oncogenesis. Genetic alterations and deregulations of molecular pathways are responsible for development of both primary and secondary GBM. Diagnosis of GBM is performed by imaging techniques. These non-invasive imaging techniques are magnetic resonance imaging (MRI), computed tomography (CT) and Positron emission tomography (PET). Definitive diagnosis of GBM is based on histopathological examination of the intra operatively removed tumor or its parts, using traditional histological, cytologic and histochemical methods. NMR (Nuclear Magnetic Resonance) spectroscopy based possible diagnostic significance of GBM is also reported. Treatment of glioblastoma multiforme includes tumor resection, as well as radiotherapy and chemotherapy. Nanomedicine and bacterial protein based therapeutic approaches are in the developmental stage. There is always need of the development of new therapeutic approaches for GBM to improve the survival and quality of life.

scholarly journals P13.07 Multi-omics as a tool for elucidating temozolomide resistance in glioblastoma multiforme

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii63-iii63
Author(s):  
F Fabro ◽  
E Tóth ◽  
L J M Dekker ◽  
T M Luider ◽  
T M Pierson ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Treatment Options ◽  
Tumor Resection ◽  
Treatment Strategies ◽  
Recurrent Glioblastoma ◽  
Biological Information ◽  
Patient Specific ◽  
Complex Nature ◽  
Current Standard ◽  
Medical Software

Abstract BACKGROUND Glioblastoma multiforme is the most common and aggressive brain tumor in adults, with an average overall survival of 14 months. Current standard of care consists of tumor resection followed by radiotherapy with concomitant temozolomide and adjuvant temozolomide. However, glioblastoma recurs in all patients. The causes reside in the enhanced invasiveness and resistance to treatment, giving a clear indication that recurrent and resistant glioblastoma biology must be understood better in order to achieve future treatment strategies to benefit the patients. The complex nature of recurrent glioblastoma makes its understanding still a challenging achievement in the field. Nowadays multi-omics approaching is developing further and further and it may be used to unravel, by combining different layers of biological information, a comprehensive view of the changes occurring during the treatment. MATERIAL AND METHODS A discovery set of 13 primary patient-derived glioblastoma stem-like cultures were analysed, comprising selected resistant, induced resistant and with pre-existing resistance conditions. A characterization of transcriptome, proteome and phosphoproteome was performed using RNAseq and liquid chromatography mass spectrometry. Additional 10 paired primary and recurrent tumor tissues were utilized as a validation set. The data obtained was visualised, explored and integrated through TIBCO Spotfire, Ingenuity Pathway Analysis, STRING and COREMINE medical software. RESULTS Genetic regulatory processes such as DNA repair mechanism, mRNA splicing and chromatin assembly were shown to be common over-represented trends in resistant and recurrent glioblastomas as a result of increased genomic instability and stress deriving from acute an repeated temozolomide exposure. Due to the immense heterogeneity of glioblastomas, other proteins and genes here identified as differentially expressed need a further investigation as they also may play an important role in relevant biological processes in a patient-specific way. CONCLUSION This study provides further understanding of glioblastoma biology revealing an association with processes of recurrence and temozolomide resistance, moreover offering potential therapeutic targets for better treatment options for glioblastoma patients.

Cardiac Tamponade As the Initial Manifestation of Metastatic Adenocarcinoma from the Colon: A Case Report

2007 ◽  
Vol 10 (4) ◽  
pp. E329-E330 ◽  
Author(s):  
Jia-Lin Chen ◽  
Tsai-Wang Huang ◽  
Po-Shun Hsu ◽  
MD Chao-Yang, ◽  
Chien-Sung Tsai
Keyword(s):  
Case Report ◽  
Cardiac Tamponade ◽  
Metastatic Adenocarcinoma ◽  
Initial Manifestation

Chylopericardium following Atrial Septal Defect Repair: Case Report

2005 ◽  
Vol 8 (1) ◽  
pp. 23 ◽  
Author(s):  
Sanjay Kumar ◽  
Bharati Sinha
Keyword(s):  
Case Report ◽  
Atrial Septal Defect ◽  
Cardiac Tamponade ◽  
Unusual Case ◽  
Septal Defect ◽  
Clinical Course ◽  
Defect Repair ◽  
Cardiac Operations

Chylopericardium after intrapericardial cardiac operations is extremely rare. We present an unusual case of postoperative chylopericardium with cardiac tamponade following atrial septal defect repair, and we comment on the clinical course and treatment.

Case Report: An Unusual Case of systemic Hydatid Disease

2011 ◽  
Vol 4 (7) ◽  
pp. 537-538
Author(s):  
Dr. Saurabh Chaudhuri ◽  
◽  
Dr. Priscilla Joshi ◽  
Dr. Mohit Goel ◽  
Dr. Wasim Siddiqui
Keyword(s):  
Case Report ◽  
Hydatid Disease ◽  
Unusual Case

Premalignant and Malignant Lesions of the Heterotopic Pancreas in the Esophagus: a Case Report and Review of the Literature

2015 ◽  
Vol 24 (2) ◽  
pp. 235-239 ◽  
Author(s):  
Jan Ulrych ◽  
Vladimir Fryba ◽  
Helena Skalova ◽  
Zdenek Krska ◽  
Tomas Krechler ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Unusual Case ◽  
Accurate Diagnosis ◽  
Heterotopic Pancreas ◽  
Premalignant Lesions ◽  
Resected Specimen ◽  
Review Of The Literature ◽  
Severe Dysphagia ◽  
Malignant Lesions

Heterotopic pancreas is a congenital pathology of the gastrointestinal tract, particularly rare in the esophagus. Both symptomatology and findings during preoperative examinations are non-specific and therefore do not often lead to an accurate diagnosis, which is usually revealed only by histopathological assessment of a resected specimen. We report an unusual case of a patient suffering from severe dysphagia caused by heterotopic pancreas in the distal esophagus with chronic inflammation and foci of premalignant changes. This article also reviews 14 adult cases of heterotopic pancreas in the esophagus previously reported in the literature, with the aim of determining the clinical features of this disease and possible complications including rare premalignant lesions and malignant transformation. Especially with regard to those complications, we suggest that both symptomatic and incidentally found asymptomatic lesions should be resected.

Ciliated cyst of the maxilla following trauma: An unusual case report

2014 ◽  
Vol 1 ◽  
pp. 1-3 ◽  
Author(s):  
Harsha Vardhan Gowthamnath ◽  
J.S. Jesija ◽  
K. Saraswathi Gopal
Keyword(s):  
Case Report ◽  
Unusual Case ◽  
Unusual Case Report ◽  
Ciliated Cyst
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