scholarly journals IN VITRO STUDIES ON THE PROTECTIVE EFFECT OF TANNIC ACID OF U87 CELLS INDUCED BY BETA-AMYLOID

2021 ◽  
Author(s):  
Gülüzar ÖZBOLAT ◽  
Ares ALİZADE
Keyword(s):  
Protective Effect ◽  
Tannic Acid ◽  
Beta Amyloid ◽  
In Vitro Studies ◽  
U87 Cells

Protective Effect of Isothiocyanates from Cruciferous Vegetables on Breast Cancer: Epidemiological and Preclinical Perspectives

2020 ◽  
Vol 20 ◽  
Author(s):  
Suong N.T. Ngo ◽  
Desmond B. Williams
Keyword(s):  
Breast Cancer ◽  
Protective Effect ◽  
Animal Studies ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Human Studies ◽  
In Vitro Studies ◽  
Cochrane Library ◽  
Cruciferous Vegetables

Background: The effect of cruciferous vegetable intake on breast cancer survival is controversial at present. Glucosinolates are the naturally occurring constituents found across the cruciferous vegetables. Isothiocyanates are produced from the hydrolysis of glucosinolates and this reaction is catalysed by the plant-derived enzyme myrosinase. The main isothiocyanates (ITCs) from cruciferous vegetables are sulforaphane, benzyl ITC, and phenethyl ITC, which had been intensively investigated over the last decade for their antibreast cancer effects. Objective: The aim of this article is to systematically review the evidence from all types of studies, which examined the protective effect of cruciferous vegetables and/or their isothiocyanate constituents on breast cancer. Methods: A systematic review was conducted in Pubmed, EMBASE, and the Cochrane Library from inception to 27 April 2020. Peerreviewed studies of all types (in vitro studies, animal studies, and human studies) were selected. Results: The systematic literature search identified 16 human studies, 4 animal studies, and 65 in vitro studies. The effect of cruciferous vegetables and/or their ITCs intake on breast cancer survival was found to be controversial and varied greatly across human studies. Most of these trials were observational studies conducted in specific regions, mainly in the US and China. Substantial evidence from in vitro and animal studies was obtained, which strongly supported the protective effect of sulforaphane and other ITCs against breast cancer. Evidence from in vitro studies showed sulforaphane and other ITCs reduced cancer cell viability and proliferation via multiple mechanisms and pathways. Isothiocyanates inhibited cell cycle, angiogenesis and epithelial mesenchymal transition, as well as induced apoptosis and altered the expression of phase II carcinogen detoxifying enzymes. These are the essential pathways which promote the growth and metastasis of breast cancer. Noticeably, benzyl ITC showed a significant inhibitory effect on breast cancer stem cells, a new dimension of chemoresistance in breast cancer treatment. Sulforaphane and other ITCs displayed anti-breast cancer effects at variable range of concentrations and benzyl isothiocyanate appeared to have a relatively smallest inhibitory concentration IC50. The mechanisms underlying the cancer protective effect of sulforaphane and other ITCs have also been highlighted in this article. Conclusion: Current preclinical evidence strongly supports the role of sulforaphane and other ITCs as potential therapeutic agents for breast cancer, either as adjunct therapy or combined therapy with current anti-breast cancer drugs, with sulforaphane appeared to display the greatest potential.

In vitro studies on the interactions of blood lipid level‐related biological molecules with gallic acid and tannic acid

2019 ◽  
Vol 99 (15) ◽  
pp. 6882-6892 ◽  
Author(s):  
Xiangquan Zeng ◽  
Zhongting Sheng ◽  
Xiangxin Li ◽  
Xinguang Fan ◽  
Weibo Jiang
Keyword(s):  
Gallic Acid ◽  
Tannic Acid ◽  
Lipid Level ◽  
Blood Lipid ◽  
In Vitro Studies ◽  
Biological Molecules ◽  
Blood Lipid Level

scholarly journals Investigation of the protective effect of thymoquinone of U87 cells induced by beta-amyloid

2021 ◽  
Vol 122 (10) ◽  
pp. 748-752
Author(s):  
G. Ozbolat ◽  
A. Alizade
Keyword(s):  
Protective Effect ◽  
Beta Amyloid ◽  
U87 Cells

scholarly journals Protective Effect of Borage Seed Oil and Gamma Linolenic Acid on DNA: In Vivo and In Vitro Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56986 ◽  
Author(s):  
Inmaculada Tasset-Cuevas ◽  
Zahira Fernández-Bedmar ◽  
María Dolores Lozano-Baena ◽  
Juan Campos-Sánchez ◽  
Antonio de Haro-Bailón ◽  
...  
Keyword(s):  
Protective Effect ◽  
Linolenic Acid ◽  
Seed Oil ◽  
In Vitro Studies ◽  
Gamma Linolenic Acid

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

2008 ◽  
Vol 31 (3) ◽  
pp. 316-326 ◽  
Author(s):  
S. Arancibia ◽  
M. Silhol ◽  
F. Moulière ◽  
J. Meffre ◽  
I. Höllinger ◽  
...  
Keyword(s):  
Protective Effect ◽  
Beta Amyloid

scholarly journals Effect of folic acid on animal models, cell cultures, and human oral clefts: a literature review

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Zita C. Bendahan ◽  
Lina M. Escobar ◽  
Jaime E. Castellanos ◽  
María C. González-Carrera
Keyword(s):  
Folic Acid ◽  
Animal Models ◽  
Protective Effect ◽  
Cleft Lip And Palate ◽  
Cell Types ◽  
Water Soluble ◽  
In Vitro Studies ◽  
Main Body ◽  
Different Cell Types

Abstract Background Folate is a naturally occurring, water-soluble B vitamin. The synthetic form of this compound is folic acid (FA), the deficiency of which is linked to neural tube disorders (NTD), which can be prevented by consuming it before, or during the early months of, pregnancy. However, the effect of FA on oral cleft formation remains controversial. The aim of the present study was to review the evidence concerning the effect of FA on the formation of cleft lip and palate (CLP) in both animals and humans, as well as its impact on different cell types. A search was conducted on various databases, including MEDLINE, EMBASE, and Central, for articles published until January 2020. Main body Current systematic reviews indicate that FA, alone or in combination with other vitamins, prevents NTD; however, there is no consensus on whether its consumption can prevent CLP formation. Conversely, the protective effect of FA on palatal cleft (CP) induction has been inferred from animal models; additionally, in vitro studies enumerate a cell-type and dose-dependent effect of FA on cell viability, proliferation, and differentiation, hence bolstering evidence from epidemiological studies. Conclusions Meta-analysis, animal models, and in vitro studies demonstrated the protective effect of FA against isolated CP; however, the heterogeneity of treatment protocols, doses, and FA administration method, as well as the different cell types used in in vitro studies, does not conclusively establish whether FA prevents CLP formation.

In vitro - studies with antler bone cells: Structure forming capacity, osteocalcin production and influence of sex steroids

2006 ◽  
Vol 15 (04) ◽  
pp. 245-257 ◽  
Author(s):  
H. J. Rolf ◽  
K. G. Wiese ◽  
H. Siggelkow ◽  
H. Schliephake ◽  
G. A. Bubernik
Keyword(s):  
Sex Steroids ◽  
Bone Cells ◽  
In Vitro Studies ◽  
Osteocalcin Production
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