scholarly journals Evaluation of silent cerebral ischemia and cognitive functions in young and middle- aged patients with metabolic syndrome

2022 ◽  
Vol 5 (1) ◽  
pp. 135-146
Author(s):  
Gulmine Dundar Yalcinkaya ◽  
Sehnaz Basaran
Author(s):  
Zueva I.B. ◽  
Yushkova I.D. ◽  
Makarenko S.V. ◽  
Kim Y.V.

Nowadays, there is a tendency for an increasing prevalence of metabolic syndrome (MS) among middle-aged patients. It seems relevant to determine the quality of life in patients with MS and cognitive impairment (CI) in this age group. Aim of the study. Studying the quality of life in patients with MS and CI. Material and methods. In total, 208 people were examined. Out of a total number, 178 patients were divided into 2 groups: some were diagnosed with MS and CI, and some patients had MS but no cognitive deficit. The comparison group consisted of 30 healthy individuals of comparable age. All patients underwent neuropsychological testing. The method of cognitive evoked potential (P300) with the use of EMG/VP Nicolet Viking Select was chosen to quantitatively assess cognitive functions of the patients. Quality of life was assessed by the use of SF 36. Results and discussion. In the group with MS and CI, compared with patients who have MS but no cognitive disorders, the indicators of general health were lower (52.30±13.90 and 58.22±10.96 points, respectively, p<0.05), physical functioning (69.23±19.79 and 77.13±15.46 points, respectively, p<0.05), emotional role functioning (42.17±21.79 and 56.93±19.84 points, respectively, p<0.05), self-assessment of mental state (53.68±11.84 and 58.39±12.4 points, respectively, p<0.05). In patients with MS and cognitive disorders, a strong association was found between the results of the MMSE test (r=0.39; p=0.015), the Wechsler memory test score (r=0.29; p=0.014), the FAB test score (r=0.43; p=0.018), and physical functioning scores. Mental health scores were associated with the results of the Wexler test (r=0.27; p=0.014). In the group with MS and CI, there was a positive correlation between the amplitude of P300 and indicators of physical functioning (r=0.40; p=0.016). Findings. In the group of patients with MS and CI, compared with patients without cognitive disorders, there is a decrease in the quality of life, especially in indicators of physical functioning. The quality-of-life parameters of patients with MS are associated with cognitive functions determined both by neuropsychological testing and by P300.


2007 ◽  
Vol 4 (3) ◽  
pp. 241-242 ◽  
Author(s):  
Uditha Bulugahapitiya ◽  
Sajith Siyambalapitiya ◽  
Jabulani Sithole ◽  
Devaka Fernando ◽  
Iskandar Idris

Kardiologiia ◽  
2018 ◽  
Vol 17 (5) ◽  
pp. 23-31
Author(s):  
V. A. Parfenov ◽  
◽  
T. M. Ostroumova ◽  
E. M. Pеrepelova ◽  
V. A. Perepelov ◽  
...  

Medicina ◽  
2008 ◽  
Vol 44 (8) ◽  
pp. 609 ◽  
Author(s):  
Gytė Damulevičienė ◽  
Vita Lesauskaitė ◽  
Jūratė Macijauskienė

The aim of this study was to assess nutritional status of aged surgical patients, to determine the prevalence of malnutrition and factors associated with it. Material and methods. A total of 156 patients aged 45 years and more, treated at the Departments of Surgery and Urology of Kaunas 2nd Clinical Hospital, were enrolled in the study. Elderly group (aged 65 years and more) consisted of 99 patients, and middle-aged group (45 to 64 years old) of 57 patients. The following anthropometric measurements were performed: weight, height, mid-arm circumference; hemoglobin, serum albumin level, and total lymphocyte count were determined. Standard assessment scales included Instrumental Activities of Daily Living, Geriatric Depression Scale, and Mini Mental State Exam. Statistical analysis was performed with the help of SPSS 12.0. Results. Malnutrition was diagnosed in 53.5% of older patients and in 15.8% of middle-aged patients (P<0.05). Obesity was diagnosed in 32.3% of elderly patients and in 40.4% of middle-aged patients (P<0.05). Among men, obese patients made up 20%, among women – 54.4% (P<0.05). Malnutrition was more prevalent among elderly patients who underwent urgent operations than in patients who underwent planned operations (69.6% and 34.1%, respectively; P<0.05) and among elderly patients with impaired cognitive functions than among those without impaired cognitive functions (in 100% of patients with medium impaired cognitive function, in 59.3% of patients with mild impaired cognitive function, and in 44.4% of patients with unimpaired cognitive function, P<0.05). Malnourished elderly patients had lower functional level than the remaining (IADL score of 3.97 and 4.75 for men, 5.38 and 6.89 for women, respectively; P<0.05). The prevalence of malnutrition did not differ significantly in the groups of older patients with depression, probable depression and not depressed patients – 75.0%, 57.7%, and 46.7%, respectively (P>0.05). Conclusions. Malnutrition was diagnosed more frequently in elderly surgical patients than in middle-aged patients. Obesity was more common in women than in men. The prevalence of obesity was not associated with age. Malnutrition in elderly surgical patients was associated with poor functional status, impaired cognitive function, and urgent operation.


2017 ◽  
Vol 50 (3) ◽  
pp. 298-323 ◽  
Author(s):  
Kyung Ju Lee ◽  
Junguk Hur ◽  
Kyung-Sook Yang ◽  
Mi-Kyoung Lee ◽  
Sung-Jae Lee

We aimed to examine the biophysical and psychological effects of two different types of forests on women with metabolic syndrome (MetS). Seventy-one middle-aged Korean women participated in a half-day healing program at either Saneum Recreational Forest (a wild forest) or Seoul Forest (a tended forest) depending on their preference. The participants’ biophysical parameters and Profile of Mood States (POMS) were measured before and after the healing program. The two groups differed significantly in acute insulin responses, pulse rate, oxidative stress markers, and stress hormone level, suggesting better homeostasis in the wild forest. The POMS suggested that the mean vigor and confusion scores significantly decreased in the wild forest. Considering the significantly more favorable acute insulin reaction and levels of oxidative stress and the trend toward positive mood state in the wild forest, we recommend that middle-aged patients with MetS participate in healing programs in wild forests.


Global Heart ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e28
Author(s):  
E. Rinkūnienė ◽  
A. Jucevičienė ◽  
V. Dženkevičiūtė ◽  
Ž. Petrulionienė ◽  
R. Puronaitė ◽  
...  

2020 ◽  
Vol 29 (3) ◽  
pp. 46-53
Author(s):  
T.V. Kolesnyk ◽  
A.V. Nadiuk ◽  
H.A. Kosova

Objective – to determine the level of anxiety and depression, to investigate cognitive functions and the status of physical activity in patients with hypertension, depending on age.Materials and methods. We examined 67 patients with hypertension I–III stage (atherosclerotic plaque and/or myocardial infarction in history). According to age classification (WHO, 2012) patients were randomized into 3 groups: group I – 25 middle-aged patients, group II – 22 elderly patients, group III – 20 patients of senile age. The highest level of education, the total number of education years; duration of arterial hypertension; anthropometric data and the office blood pressure were assessed. We used an individual approach to determine the target level of blood pressure according to the recommendations ESC/ESH 2018. Cognitive functions were evaluated using the MoCA-test and the Clock Drawing Test. The level of anxiety and depression was determined by the results of the Hospital scale of anxiety and depression.Results. According to the data obtained, a statistically greater degree of depression was recorded among eldery patients in comparison with other groups. Only in this group, a higher level of depression was associated with less time that patients spent for regular exercise during the week. Among middle-aged patients with arterial hypertension, the absence of anxiety and depression was detected in 56.0 %. At the same time, in the group of senile age, 75.0 % of patients were diagnosed with manifestations of anxiety and depression of varying severity. It is important to notice that in the group of senile age the median level of anxiety was higher, although nonsignificantly, in comparison with other groups and met the criteria for subclinical anxiety. Results of multivariate correlation analysis showed that a high level of anxiety in middle-aged patients was associated with an earlier age of arterial hypertension verification, as well as with waist circumference increase and the waist/hip circumference ratio. Among elderly patients, a higher level of anxiety was determined in the presence of physical inactivity and among patients of senile age, an increase in anxiety level was associated with a shorter duration of education and a decrease in cognitive functions. Conclusions. The highest level of depression was diagnosed among people of senile age, which was associated with the presence of physical inactivity. The groups did not differ statistically in level of anxiety, however, an increase in its severity in the middle-aged group was associated with an earlier age of hypertension verification and an increase in the degree of abdominal obesity, among elderly patients – with hypodynamia, and in the group of senile age – with a low level of education and the presence of cognitive dysfunctions.


2018 ◽  
Vol 2 (4) ◽  
pp. 201
Author(s):  
S. V. Shut ◽  
�. A. Trybrat ◽  
Z. O. Borysova ◽  
A. A. Trybrat

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