scholarly journals Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat

2014 ◽  
Vol 2 (04) ◽  
pp. 114-120
Author(s):  
Anil Kumar ◽  
B. P. Kumbhar ◽  
S. C. Burli ◽  
S. S. Mali ◽  
S. D. Dongare , ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Kidney Stone ◽  
Glycolic Acid ◽  
Stone Formation ◽  
Oral Treatment ◽  
Ethanolic Extract ◽  
Related Effect ◽  
Pharmacological Screening ◽  
Kidney Stone Formation ◽  
Urinary Supersaturation

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted in a significant increase in the levels of calcium and oxalate. Treatment of ethanolic extract of Aristolochia indica 100mg/kg body weight for 30 days revealed a dose –related effect in the reduction of lithogenic substances, following glycolic acid induced urolithiasis. Simultaneous oral treatment with at a dose of ethanolic extract of Aristolochia indica 100mg/kg for 30 days significantly reversed the ethylene glycol induced nepharolithiasis and urolithiasis. Presumably by preventing the urinary supersaturation of lithogenic substances. Especially of oxalate and calcium. These observation indicate that ethanolic extract of Aristolochia indica can play an important role in the prevention of disorders associated with kidney stone formation.

scholarly journals Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat

2014 ◽  
Vol 2 (04) ◽  
Author(s):  
B P Kumbhar ◽  
S C Burli ◽  
S S Mali ◽  
S D Dongare ◽  
P V Patrekar
Keyword(s):  
Ethylene Glycol ◽  
Kidney Stone ◽  
Glycolic Acid ◽  
Stone Formation ◽  
Oral Treatment ◽  
Ethanolic Extract ◽  
Related Effect ◽  
Pharmacological Screening ◽  
Kidney Stone Formation ◽  
Urinary Supersaturation

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted in a significant increase in the levels of calcium and oxalate. Treatment of ethanolic extract of Aristolochia indica 100mg/kg body weight for 30 days revealed a dose –related effect in the reduction of lithogenic substances, following glycolic acid induced urolithiasis. Simultaneous oral treatment with at a dose of ethanolic extract of Aristolochia indica 100mg/kg for 30 days significantly reversed the ethylene glycol induced nepharolithiasis and urolithiasis. Presumably by preventing the urinary supersaturation of lithogenic substances. Especially of oxalate and calcium. These observation indicate that ethanolic extract of Aristolochia indica can play an important role in the prevention of disorders associated with kidney stone formation.

scholarly journals Effect of theCopaifera langsdorffiiDesf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Rejane Barbosa de Oliveira ◽  
Eduardo Barbosa Coelho ◽  
Marina Rezende Rodrigues ◽  
Ana Rita de Mello Costa-Machado ◽  
João Paulo Barreto de Sousa ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Kidney Stone ◽  
Biochemical Parameters ◽  
Leaf Extract ◽  
Stone Formation ◽  
Osteopontin Expression ◽  
Copaifera Langsdorffii ◽  
Kidney Stone Formation ◽  
Different Doses

The potential of theCopaifera langsdorffiileaves extract to prevent stone formation was analyzed by means of an ethylene glycol (EG) animal model of nephrolithiasis and anin vitrocrystallization assay. Different doses of theC. langsdorffiileaves extract were administered to rats treated with EG. Urine biochemical parameters were quantified. CaOx deposits count and analysis of osteopontin expression were conducted on kidneys fixed in formalin. Thein vitroassay was performed by turbidimetry. Phytochemical analyses of the extract were accomplished by HPLC-UV-DAD, and several compounds were isolated.C. langsdorffiileaf extract was able to avoid stone formation. The number of deposits was50.30±31.29at the higher extract dose, compared to the value of179.5±45.96achieved with the EG control. Significantly lower oxalate levels and OPN expression and increased citrate levels were observed after extract administration. In thein vitroassay, the extract diluted the formed crystals. Phytochemical analyses showed that the extract is rich in phenolic compounds that are capable of preventing stone formation. Thus, on the basis of our results, we suggest that theC. langsdorffiileaf extract has potential application in the prevention of kidney stone formation.

The controversial association of gut and urinary microbiota with kidney stone formation

2021 ◽  
pp. 105257
Author(s):  
Narjess Bostanghadiri ◽  
Pardis Ziaeefar ◽  
Fatemeh Sameni ◽  
Mohammad Mahmoudi ◽  
Ali Hashemi ◽  
...  
Keyword(s):  
Kidney Stone ◽  
Stone Formation ◽  
Urinary Microbiota ◽  
Kidney Stone Formation

scholarly journals ANTIUROLITHIC ACTIVITY OF BERBERIS TRIFOLIATA EXTRACT ON INDUCED UROLITHIASIS IN RATS BY ZINC DISC IMPLANTATION

2017 ◽  
Vol 15 (1) ◽  
pp. 168
Author(s):  
Raymundo Alejandro Pérez-Hernández ◽  
Silvia Guadalupe Treviño-Moreno ◽  
Gilberto Arévalo- Martínez ◽  
Eduardo Sánchez -García ◽  
Catalina Leos-Rivas ◽  
...  
Keyword(s):  
Kidney Stone ◽  
Methanolic Extract ◽  
Stone Formation ◽  
Final Weight ◽  
The Difference ◽  
Postsurgical Recovery ◽  
Kidney Stone Formation ◽  
Treatment Of Urolithiasis ◽  
Different Doses

Background: In clinical therapy, there is no satisfactory drug available for treatment of urolithiasis, especially for the prevention of their recurrence. The aim of this work was to evaluate in vivo antiurolithic activity of methanolic extract of Berberis trifoliata leaves. Material and methods: Urolithiasis was induced in Wistar rats by zinc disc implantation in urinary bladder. Upon postsurgical recovery, different doses of the methanolic extract of B. trifoliata leaves (50, 100 and 150 mg/kg body weight) were administered orally to zinc disc implanted rats for a period of 20 days. Antiurolithiatic activity was evaluated by measuring the difference between the weight of the implanted zinc discs at the time of implantation and the final weight of the dried calculi taken out from the bladder at the end of the 20 days period of treatment. Results: Extract of B. trifoliata significantly reduced calculi deposition around the implanted zinc disc at all doses (50, 100, and 150 mg/kg). Conclusion: Treatment with methanolic extract of B. trifoliata is useful agent against the kidney stone formation.

scholarly journals PD31-10 STATIN INTAKE REDUCES KIDNEY STONE FORMATION

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Andrew Cohen ◽  
Melanie Adamsky ◽  
Charles Nottingham ◽  
Jaclyn Pruitt ◽  
Brittany Lapin ◽  
...  
Keyword(s):  
Kidney Stone ◽  
Stone Formation ◽  
Kidney Stone Formation
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