Cesarean Hysterectomy in Abnormally Invasive Placenta: The Role of Prenatal Diagnosis

An abnormally invasive placenta (AIP) is a placenta that cannot be removed spontaneously or manually without causing severe bleeding. It is a dangerous condition associated with a high rate of maternal and perinatal morbidity and mortality due to the high rate of massive bleeding and visceral injuries. The standardized ultrasound diagnostic criteria have helped improve its early diagnosis, which is essential to plan coordinated actions to reduce associated morbimortality. We present a case report in which ultrasound diagnosis played a decisive role, enabling the coordination of a multidisciplinary team and improving the immediate care of both mother and newborn. Cesarean hysterectomy was performed with minimal blood loss and a good postsurgical recovery.

Assessment of potential antiurolithiatic property of Carissa carandas Linn. leaves on zinc disc insertion - incited urolithiasis in wistar male albino rats

The goal of the research was to assess the antiurolithiatic property of Carissa carandas Linn. leaf extract in rats. The rats were segregated into 6 groups of 6 rats each. Calcium oxalate urolithiasis was surgically incited by insertions of pre-weighed and sterile zinc disc in bladders of animals. This was also followed by supplementing 0.75% v/v ethane-1, 2-diol (Ethylene glycol) in quaffing water ad libitum for 28 days. Upon postsurgical recovery period (3 days), Cystone (750 mg/kg) and three doses of EELCC (Ethanolic extract of leaves of Carissa carandas Linn.) namely 100, 200, and 400 mg/kg b.w., were given to zinc disc inserted animals for the duration of 28 days by oral route. Antiurolithiatic property was assessed by measuring the urinary volume, weight of the calculi, estimating the pH and analyzing the proportion of diverse biological markers in urine and serum specimens. An outstanding reduction in urine output and pH were noticed in zinc disc inserted rats, which were intercepted by the remedial extract. The extract also produced a significant enhancement in rate of glomerular filtration (GFR) and reduced the calculi deposition throughout the inserted zinc disc. The elevated levels of serum and urinary biochemical parameters like creatinine, urea, calcium, blood urea nitrogen (BUN), oxalate, and uric acid were also prevented by the extract. A significant (P< 0.01) potential antiurolithiatic property is observed at 400 mg/kg of EELCC.

ANTIUROLITHIC ACTIVITY OF BERBERIS TRIFOLIATA EXTRACT ON INDUCED UROLITHIASIS IN RATS BY ZINC DISC IMPLANTATION

Background: In clinical therapy, there is no satisfactory drug available for treatment of urolithiasis, especially for the prevention of their recurrence. The aim of this work was to evaluate in vivo antiurolithic activity of methanolic extract of Berberis trifoliata leaves. Material and methods: Urolithiasis was induced in Wistar rats by zinc disc implantation in urinary bladder. Upon postsurgical recovery, different doses of the methanolic extract of B. trifoliata leaves (50, 100 and 150 mg/kg body weight) were administered orally to zinc disc implanted rats for a period of 20 days. Antiurolithiatic activity was evaluated by measuring the difference between the weight of the implanted zinc discs at the time of implantation and the final weight of the dried calculi taken out from the bladder at the end of the 20 days period of treatment. Results: Extract of B. trifoliata significantly reduced calculi deposition around the implanted zinc disc at all doses (50, 100, and 150 mg/kg). Conclusion: Treatment with methanolic extract of B. trifoliata is useful agent against the kidney stone formation.