scholarly journals Influence of androgen deficiency on the endometrium structure in women of reproductive age

2021 ◽  
pp. 40-45
Author(s):  
L. V. Demyanenko ◽  
L. M. Semenyuk ◽  
T. Yu. Yuzvenko
Keyword(s):  
Hormonal Therapy ◽  
Androgen Receptors ◽  
Reproductive Age ◽  
Estradiol Valerate ◽  
Androgen Deficiency ◽  
Immunohistochemical Examination ◽  
Women Of Reproductive Age ◽  
Long Term Effect ◽  
Medium Level ◽  
High Level

Aim — to identify the relationship between androgen deficiency and the development of endometrial hypoplasia in women of reproductive age, to develop an algorithm for the diagnosis and treatment of this category of women. Materials and methods. Examination of patients with androgen deficiency revealed 48 patients with endometrial hypoplasia based on the ultrasound markers. After examination for CD138 and detection of chronic endometritis during the study, 9 patients were excluded. At the second stage, an immunohistochemical examination was performed for the expression of receptors for estrogen, progesterone and androgens. According to the results, the patients were divided into 2 groups: the first group (24 patients) with a high level of expression of androgen receptors and the second group (15 patients) with a low level of expression of androgen receptors. Theexpressionof receptors to estrogens and progesterone was on medium level and comparative in both groups. Both groups of patients underwent hormonal therapy for 3 months: estradiol valerate 1 g per day in a continuous mode and 200 mg of micronized progesterone from the sixteenth to twenty-fifth days of the menstrual cycle. Additionally, patients of the first group received dehydro­epian­drosterone(DHEA)in a dose of 25 mg per day continuously in the form sublingual spray. Results. According to the data of ultrasound examination in the first group of patients, the endometrium corresponded to normal parameters both during treatment and 1 and 3 months after stopping treatment. At the same time, in the second group of patients, there was an improvement in the thickness (more than 7 mm) and structure of the endometrium during treatment and the absence of these effects after the termination of hormonal therapy. Considering the recommendations of the Association of Endocrinologists on the superiority of non-tablet forms of androgen preparations in the treatment of androgen deficiency and having a positive and long-term effect when taking sublingual DHEA, it is possible to recommend adding the above form of DHEA to systemic therapy of endometrial hypoplasia against the background of androgen deficiency. Conclusions. Women with androgen deficiency are more likely to have concomitant endometrial hypoplasia. Immunohistochemical examination of the endometrium of women of reproductive age with androgen deficiency in 24 patients (61.5 %) revealed a high level of expression of androgen receptors. The effectiveness of therapy for endometrial hypoplasia in women with androgen deficiency with addition of androgens to the standard regimens is more effective and has a long-lasting effect. The combination of estrogen-gestagenic therapy and androgens has a positive effect on the gestational potential of the endometrium in women of reproductive age with androgen deficiency.

scholarly journals Knowledge, Attitude, and Practice (KAP) towards Family Planning among Women of Reproductive Age in Fiji

2021 ◽  
Vol 13 (4) ◽  
pp. 24
Author(s):  
Jay Lincoln ◽  
Masoud Mohammadnezhad ◽  
Sabiha Khan
Keyword(s):  
Family Planning ◽  
Health Belief ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Change Models ◽  
Medium Level ◽  
Level Of Knowledge ◽  
Belief Model ◽  
High Level

BACKGROUND: Globally, family planning is one of the most important public health issues in both developed and developing countries due to high unmet needs. OBJECTIVE: To assess the level of knowledge, attitudes and practice (KAP) towards family planning among women of reproductive age in Suva, Fiji. METHODS: The study applies a cross-sectional quantitative method using a self-administered questionnaire to collect data. Using random sampling, a sample of 325 women was used for the study and they were sought from three health clinics in Suva, Fiji. The questionnaire was administered to the respondents who met the inclusion criteria and they provided information that mostly involved rating the different issues and identifying their level of KAP. This data was analyzed using the statistics program SPSS version 25. RESULTS: The mean age of the participants was 31.53 (±7.35) years. A majority of the participants (64.6%) belonged to a Christian church while 65.2% belonged to iTaukei ethnic group. Approximately half of them (45.6%) had a high level of knowledge while 53.5% had moderate knowledge with only 0.9% reporting that they had poor knowledge. In terms of attitudes, 54.2% of the participants had high level or positive attitudes towards family planning with only a small proportion of 0.3% had low level or poor attitudes. In terms of practice, a majority of the participants (65.9%) had medium level of practice towards family planning while 24.6% showed a poor level with 9.5% having a high or good level of practice towards family planning. CONCLUSIONS: This study identified that women had medium level of knowledge and practice towards family planning, but their attitude was relatively high. Using behavioral change models such as health belief model (HBM) that focus on perceived benefits and barriers may help to promote KAP towards family planning among Fijian women.

scholarly journals Receptor-related aspects of reduced lubrication in women of reproductive age with hypoandrogenism

2021 ◽  
pp. 53-59
Author(s):  
L. M. Semenyuk ◽  
T. Yu. Yuzvenko ◽  
L. V. Demyanenko ◽  
L. S. Chernuha ◽  
A. O. Belebeyeva
Keyword(s):  
Sexual Dysfunction ◽  
Estrogen Receptors ◽  
Intermediate Layer ◽  
Female Sexual Dysfunction ◽  
Androgen Receptors ◽  
Basal Layer ◽  
Vaginal Epithelium ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age

Aim — to investigate receptivity of the vaginal epithelium in women with the female sexual dysfunction and hypoandrogenism.Materials and methods. The immunohistochemical investigation has been performed to define the density of androgen receptors (AR) and estrogen receptors (ER) in the distal part of the vaginal tract of women of reproductive age with hypoandrogenic provision of their hormonal background. For immunohistological examination, a biopsy of the lower third of the vaginal mucosa was taken using a dermopunch with a diameter of 3 mm in 20 women with female sexual dysfunction (FSD) and hypo­andro­genism. The control group consisted of 20 women of reproductive age without FSDmanifestations and disturbances in their hormonal levels. The survey was carried out at the stage of pre-conceptional preparation. Location: Ukrainian Scientific and Prac­tical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine.Results. Immunoreactivity of ERα in the epithelium in the main and control groupswas 47.2 ± 22.2 and 86.1 ± 8.0 (p < 0.001), in the stroma — respectively 13.9 ± 16.8 and 86.1 ± 8.3 (p < 0.001), that is, immunoreactivity in the epithelium was significantly higher thanin the stroma (p < 0,01). The ERα locationin the vaginal epithelium was the samein both groups: cellsof the basal-intermediate layer along the basement membrane and the intermediate layer. No cells, expressing ERα, were detected in the surface layer. In stromal cells, ERαcontained in fibroblasts and smooth muscle cells. ERβ was found in cellsof thebasal — parabasal layer, the intermediate layer, occasionally —on the surface layerof vaginal epithelium, as well as in fibroblasts, vascular endothelium, where both nuclear andcytoplasmic staining was revealed. According to the results of immunohistochemical study of AR invagina, the proportion of AR-positive cells in healthy women was negligible (3.8 ± 2.2), that is considerably less than in patients with androgen deficiency (18.8 ± 8.3) and compared withother receptors. AR were localized mainly in the basal layer alongbasement membrane. Single AR-positive fibroblasts occurred in the stroma.Conclusions. Estrogen receptors α (ERα) are involved in the regulation of the processes of proliferation and differentiation of the vaginal epithelium under the influence of estrogen, as evidenced by a 1.8-fold increase in the density of stained ERα in women of the control group. The absence of correlations between ЕRα and ЕRβ receptors (r = 0.24; p < 0.05) may indicate the ability to change in the same tissue depending on the strength of estrogen effects on the body of a woman. Topical localization of androgen receptors in the basal layer testifies in favour of the safe use of local formsof androgensto overcome the reduced lubrication.

scholarly journals Valproate and epilepsy: for women as well as men

2018 ◽  
Vol 18 (3) ◽  
pp. 222-223 ◽  
Author(s):  
Charlotte Lawthom
Keyword(s):  
Learning Disabilities ◽  
Sodium Valproate ◽  
Gold Standard ◽  
Refractory Epilepsy ◽  
Reproductive Age ◽  
Fetal Malformation ◽  
Women Of Reproductive Age ◽  
Drug Of Choice ◽  
Drug Choice ◽  
High Level

Sodium valproate remains the best drug for idiopathic generalised epilepsy. For men with the latter diagnosis, this is the drug of choice. Sodium valproate has an unacceptably high level of major fetal malformation and also causes learning disabilities in many children exposed to the drug in utero. Women of reproductive age should not normally be offered this drug. There are many women with refractory epilepsy who would benefit from this drug and who are not planning pregnancy. Individualised epilepsy care is the gold standard, not blanket bans on drug choice based on gender.

Influence of endometriosis and some methods of its treatment on the quality of life of women of reproductive age

2021 ◽  
Vol 50 (3) ◽  
pp. 100-102
Author(s):  
V. I. Konovalov ◽  
M. A. Zvychayny
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Operative Treatment ◽  
Hormonal Therapy ◽  
Life Quality ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Surgical Interventions

The aim of the study was to investigate the effect of endometriosis and somewide-spread contemporary methods of its conservative hormonal and operative treatment on the life quality of women of reproductive age. 546 women, aged 20-40, were examined: 371 patients with initially diagnosed endometriosis, 64 after conservative hormonal therapy, 111 after efficient surgical interventions and 30 healthy women (a control group). The following conclusion has been made: endometriosis arising at the reproductive age greatly deteriorates the life quality of women as compared to the healthy ones but none of the studied methods of its conservative hormonal therapy and efficient surgical treatment enables its rehabilitation.

scholarly journals Possibilities of non-hormonal therapy of uterine fibroids in women of reproductive age

2018 ◽  
Vol 0 (41) ◽  
pp. 38-41
Author(s):  
А. Г. Корнацька ◽  
Г. В. Чубей ◽  
М. А. Флаксемберг ◽  
О. О. Ровенько
Keyword(s):  
Hormonal Therapy ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Women Of Reproductive Age

scholarly journals Vaginal candidiasis among women of reproductive age in Dnipro city (Ukraine): Species spectrum of Candida and their susceptibility to antimycotics

2019 ◽  
Vol 10 (2) ◽  
pp. 172-176
Author(s):  
O. M. Starishko ◽  
Y. S. Voronkova ◽  
T. H. Ostanina ◽  
O. S. Voronkova
Keyword(s):  
Reproductive Tract ◽  
Active Form ◽  
Polymerase Chain Reaction Method ◽  
Reproductive Age ◽  
Effective Drug ◽  
Vaginal Candidiasis ◽  
Women Of Reproductive Age ◽  
Candida Spp ◽  
Antimicrobial Drugs ◽  
High Level

Candidiasis is one of the most common pathological processes, especially among women of reproductive age, especially pregnant. It can be expressed as Candida carriage and as an active form of infection. Although candidiasis is caused by opportunistic microorganisms, its effects can be quite significant, so it is necessary to treat it with the use of antimycotic drugs. In view of the spread among these microorganisms of resistance to antimicrobial drugs, the determining factor for the success of therapeutic measures, it is important to make a preliminary assessment of the susceptibility to antimycotics of strains isolated from persons with Candida carriage or active candidiasis. The aim of the research was to study the species range of fungi of the genus Candida isolated from the reproductive tract in women with dysbiosis and to study their susceptibility to antimycotics. Total of 227 samples of biological material from women aged 16 to 56 years have been investigated. Microscopic and cultural methods of detecting of fungi in the primary material were used for research. For the identification of species of Candida fungi, a polymerase chain reaction method in real-time was used. It was determined that the frequency of detection of Candida fungi in the composition of vaginal microbiome during inflammatory pathological processes was 76.7%. It was shown that the incidence of Candida carriage – 51.7% – slightly exceeded the frequency of detection of the active form of infection – 48.3%. The species spectrum of pathogens included: C. albicans (57.1%), C. krusei (12.6%), C. glabrata (19.5%) and Candida spp. (16.1%). In the case of active form of infection, C. albicans was prevalent – 64 (76.2%) cases. In the case of Candida carriage, other species were prevalent – 58 (64.4%) cases. The most effective drug against all isolates was amphotericin B – more than 87% of isolates were susceptible. The least effective drug was nystatin: less than 60% of isolates were susceptible. There is a rather high level of resistance to certain antimycotic drugs among the Candida species, which requires a prior preliminary study of the susceptibility of isolated strains to antimycotics for the purpose of choosing a rational and effective treatment scheme.

scholarly journals ADMINISTRATION OF A COMBINED ORAL CONTRACEPTIVE CONTAINING ESTRADIOL VALERATE/DIENOGEST (E2V/DNG) BY WOMEN WITH MENORRHAGIA

2017 ◽  
pp. 31-37
Author(s):  
E. R. Dovlethanova ◽  
E. A. Mezhevitinova ◽  
A. N. Mgeryan ◽  
P. R. Abakarova
Keyword(s):  
Oral Contraceptive ◽  
Pathological Condition ◽  
Reproductive Age ◽  
Estradiol Valerate ◽  
Women Of Reproductive Age ◽  
Combined Oral Contraceptives ◽  
Combined Oral Contraceptive ◽  
Quality Life ◽  
Choice Of Therapy ◽  
Excessive Proliferation

Menorrhagia is the pathological condition which is negatively affecting physical, emotional and social quality life of the woman. Medicines of the choice of therapy of uterine bleedings are the combined oral contraceptives (COC). The estradiol valerate/ dienogest (E2V/DNG), represents the combined oral contraceptive (COC) recommended for women as contraceptive. Gives to feature of influence of medicine on endometrium the chance of its application in case of uterine bleedings. The hormones which are a part suppress excessive proliferation of endometrium that leads to reduction of amount of menstrual allocations. Results of a research which confirm successful application of E2V/DNG in case of the menorrhagia at the women of reproductive age in clinical situations who aren’t requiring operational treatment are provided.

Evaluation of concomitant gynecological pathology in group of patients of reproductive age with tumors and tumor formations

2020 ◽  
pp. 10-14
Author(s):  
N. V. Spiridonova ◽  
A. A. Demura ◽  
V. Yu. Schukin
Keyword(s):  
Diagnostic Errors ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Predisposing Factor ◽  
Ovarian Tumours ◽  
Preoperative Diagnostic ◽  
Neoplastic Process ◽  
History Of ◽  
The Moment

According to modern literature, the frequency of preoperative diagnostic errors for tumour-like formations is 30.9–45.6%, for malignant ovarian tumors is 25.0–51.0%. The complexity of this situation is asymptomatic tumor in the ovaries and failure to identify a neoplastic process, which is especially important for young women, as well as ease the transition of tumors from one category to another (evolution of the tumor) and the source of the aggressive behavior of the tumor. The purpose of our study was to evaluate the history of concomitant gynecological pathology in a group of patients of reproductive age with ovarian tumors and tumoroid formations, as a predisposing factor for the development of neoplastic process in the ovaries. In our work, we collected and processed complaints and data of obstetric and gynecological anamnesis of 168 patients of reproductive age (18–40 years), operated on the basis of the Department of oncogynecology for tumors and ovarian tumours in the Samara Regional Clinical Oncology Dispensary from 2012 to 2015. We can conclude that since the prognosis of neoplastic process in the ovaries is generally good with timely detection and this disease occurs mainly in women of reproductive age, doctors need to know that when assessing the parity and the presence of gynecological pathology at the moment or in anamnesis, it is not possible to identify alarming risk factors for the development of cancer in the ovaries.

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