scholarly journals Vaginal candidiasis among women of reproductive age in Dnipro city (Ukraine): Species spectrum of Candida and their susceptibility to antimycotics

2019 ◽  
Vol 10 (2) ◽  
pp. 172-176
Author(s):  
O. M. Starishko ◽  
Y. S. Voronkova ◽  
T. H. Ostanina ◽  
O. S. Voronkova
Keyword(s):  
Reproductive Tract ◽  
Active Form ◽  
Polymerase Chain Reaction Method ◽  
Reproductive Age ◽  
Effective Drug ◽  
Vaginal Candidiasis ◽  
Women Of Reproductive Age ◽  
Candida Spp ◽  
Antimicrobial Drugs ◽  
High Level

Candidiasis is one of the most common pathological processes, especially among women of reproductive age, especially pregnant. It can be expressed as Candida carriage and as an active form of infection. Although candidiasis is caused by opportunistic microorganisms, its effects can be quite significant, so it is necessary to treat it with the use of antimycotic drugs. In view of the spread among these microorganisms of resistance to antimicrobial drugs, the determining factor for the success of therapeutic measures, it is important to make a preliminary assessment of the susceptibility to antimycotics of strains isolated from persons with Candida carriage or active candidiasis. The aim of the research was to study the species range of fungi of the genus Candida isolated from the reproductive tract in women with dysbiosis and to study their susceptibility to antimycotics. Total of 227 samples of biological material from women aged 16 to 56 years have been investigated. Microscopic and cultural methods of detecting of fungi in the primary material were used for research. For the identification of species of Candida fungi, a polymerase chain reaction method in real-time was used. It was determined that the frequency of detection of Candida fungi in the composition of vaginal microbiome during inflammatory pathological processes was 76.7%. It was shown that the incidence of Candida carriage – 51.7% – slightly exceeded the frequency of detection of the active form of infection – 48.3%. The species spectrum of pathogens included: C. albicans (57.1%), C. krusei (12.6%), C. glabrata (19.5%) and Candida spp. (16.1%). In the case of active form of infection, C. albicans was prevalent – 64 (76.2%) cases. In the case of Candida carriage, other species were prevalent – 58 (64.4%) cases. The most effective drug against all isolates was amphotericin B – more than 87% of isolates were susceptible. The least effective drug was nystatin: less than 60% of isolates were susceptible. There is a rather high level of resistance to certain antimycotic drugs among the Candida species, which requires a prior preliminary study of the susceptibility of isolated strains to antimycotics for the purpose of choosing a rational and effective treatment scheme.

scholarly journals Socio-demographic Characteristics of Women with Reproductive Tract Infection Attending a Military Hospital

2020 ◽  
Vol 15 (2) ◽  
pp. 218-220
Author(s):  
ABM Belayet Hossain ◽  
Quazi Md Rashid Un Nabi ◽  
Md Julfikkar Alam ◽  
Sheikh Shahidul Islam ◽  
Shaikh Mohammad Edi Ameen
Keyword(s):  
Reproductive Tract ◽  
Educational Background ◽  
Demographic Characteristics ◽  
Reproductive Age ◽  
Personal Hygiene ◽  
Military Hospital ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Reproductive Tract Infection ◽  
Tract Infections

Introduction: Reproductive tract infections (RTIs) are being increasingly recognized as a serious global health problem with impact on individual women and men, their families and communities. RTIs are a group of disease that cause infection of the genital tract and include both those that are sexually transmitted and those that are not. RTIs are a significant cause of morbidity and mortality in both men and women, especially in women of reproductive age. Objectives: To determine the socio-demographic characteristics among women with RTIs attending at gynecology outpatient department, CMH, Dhaka. Materials and Methods: This descriptive cross-sectional study was carried out with a view to find out the socio-demographic characteristics of women with RTIs and their common clinical presentations. The study was conducted among women of reproductive age group of Bangladesh Armed Forces attending at Gynecology OPD, CMH Dhaka, for the period of 1st march to 30th June 2011. A total of 128 women (114 married and 14 were unmarried) were interviewed with the help of structured question and checklist. Data was collected through clinical diagnostic approach made by gynecologists. Results: It was found that highest percentage of respondents (32.8%) were in the age group of 30-34 years, mean age at marriage was 17.79 years. The highest percentage of respondents (46.5%) was married at the age range of 16-18 years. Among the respondents, 89.1% were married and 10.9% were unmarried. The women with higher education level had lower occurrence of RTIs than women with lower education. In relation to status of spouse of married women, RTIs were significantly more among the wife of other ranks. Practice of personal hygiene during menstruation showed safe positive impact on RTIs. It was found that 50% respondents were presenting with vaginal discharge (Leucorrhoea). Most of the causes were vaginitis (38.3%). Conclusion: Study findings indicate that high prevalence of RTIs among women is due to the influence of less educational status, low income and also husband's educational background and employment status. JAFMC Bangladesh. Vol 15, No 2 (December) 2019: 218-220

scholarly journals Efficiency of fenticonazole for the treatment of vaginal candidiasis

2012 ◽  
Vol 140 (7-8) ◽  
pp. 469-474 ◽  
Author(s):  
Biljana Zivaljevic ◽  
Ilija Golubovic ◽  
Jelena Seratlic ◽  
Petar Nikolic ◽  
Dusan Simic ◽  
...  
Keyword(s):  
Side Effects ◽  
Drug Application ◽  
Reproductive Age ◽  
Vaginal Candidiasis ◽  
Vaginal Smear ◽  
Efficacy And Safety ◽  
Treatment Results ◽  
Women Of Reproductive Age ◽  
Associated Symptoms ◽  
Candidiasis Treatment

Introduction. Uncomplicated vulvovaginal candidiasis appears in 75% women of reproductive age. The most frequent causes are Candida albicans (85-95%) or C. glabrata, and infrequently C. krusei, C. tropicalis, C. parapsilosis, C. pseudotropicalis, etc. Objective. The aim of the study was to investigate efficiency and safety of fenticonazole for vaginal candidiasis treatment. Methods. Therapeutic effect of a single 600 mg fenticonasole vaginal capsule was observed in 417 women, aged 16-67, in five centers in Serbia. In all women, before the treatment, vaginal candidiasis was confirmed by testing of vaginal smear. Based on smear findings and associated symptoms observed on the 7th and 28th day after therapy administration, treatment results were evaluated. On the next day after drug application the patients recorded by using a questionnaire their own feelings on withdrawal symptoms and possible side effects in the period prior to the first control. Results. Control after seven days showed a statistically significant decrease of symptoms. In 385 women, vaginal smear was found negative to yeast and yeast blastospores. Within the first seven days after treatment 84 women had to repeat therapy due to the persistence of symptoms or positive vaginal smear. After 28 days we recorded full recovery in 392 patients, clinical improvement in eight, no change in 16, and deterioration in one patient only. Side effects were very seldom, mostly in the form of a slight redness of the vulva and vagina, and mild itching during several days. Conclusion. Our observations confirmed good efficacy and safety of fenticonazole in the treatment of vaginal candidiasis.

scholarly journals Knowledge, health seeking behavior and barriers for treatment of reproductive tract infections among married women of reproductive age in Delhi

2021 ◽  
Vol 10 (2) ◽  
pp. 591
Author(s):  
Preety Doley ◽  
Geeta Yadav ◽  
Monika Gupta ◽  
Sumathi Muralidhar
Keyword(s):  
Health Problem ◽  
Reproductive Tract ◽  
Married Women ◽  
Reproductive Age ◽  
Health Seeking ◽  
Women Of Reproductive Age ◽  
Reproductive Tract Infections ◽  
Health Seeking Behavior ◽  
Seeking Behavior ◽  
Tract Infections

Background: Reproductive tract infections including sexually transmitted infections are an important public health problem among women of reproductive age group in developing countries. The perceptions or taboos related to RTIs act as an obstacle for seeking treatment ultimately leading to complications. The aim of the study was to assess the knowledge, health seeking behavior and barriers for treatment of reproductive tract infections among married women of reproductive age in Delhi.Methods: A community based cross-sectional study was undertaken in an urban field practice area of department of Community Medicine of VMMC and Safdarjung Hospital, New Delhi from November 2017 to April 2019. Sample size of 270 was collected using predesigned and pre- tested questionnaire by systematic random sampling.Results: Mere 16.6% of the women knew about symptoms of RTI/STIs. Out of 81 women having RTI/STI in past 3 months 30% did not seek treatment and out of 70% who took treatment for RTI, 30% did not complete treatment. Majority of the women who sought treatment preferred government hospital. The main barrier for seeking treatment was embarrassment, not considering it as an important health problem, lack of time.Conclusions: The overall knowledge about symptoms, mode of spread of RTIs/STIs was very poor among the study participants. Women seeking treatment are not completing it. Thus, there is need to emphasize on spreading knowledge about symptoms, mode of spread, need for treatment and its completion and clearing barriers related to RTI/STI among women. 

scholarly journals Influence of androgen deficiency on the endometrium structure in women of reproductive age

2021 ◽  
pp. 40-45
Author(s):  
L. V. Demyanenko ◽  
L. M. Semenyuk ◽  
T. Yu. Yuzvenko
Keyword(s):  
Hormonal Therapy ◽  
Androgen Receptors ◽  
Reproductive Age ◽  
Estradiol Valerate ◽  
Androgen Deficiency ◽  
Immunohistochemical Examination ◽  
Women Of Reproductive Age ◽  
Long Term Effect ◽  
Medium Level ◽  
High Level

Aim — to identify the relationship between androgen deficiency and the development of endometrial hypoplasia in women of reproductive age, to develop an algorithm for the diagnosis and treatment of this category of women. Materials and methods. Examination of patients with androgen deficiency revealed 48 patients with endometrial hypoplasia based on the ultrasound markers. After examination for CD138 and detection of chronic endometritis during the study, 9 patients were excluded. At the second stage, an immunohistochemical examination was performed for the expression of receptors for estrogen, progesterone and androgens. According to the results, the patients were divided into 2 groups: the first group (24 patients) with a high level of expression of androgen receptors and the second group (15 patients) with a low level of expression of androgen receptors. Theexpressionof receptors to estrogens and progesterone was on medium level and comparative in both groups. Both groups of patients underwent hormonal therapy for 3 months: estradiol valerate 1 g per day in a continuous mode and 200 mg of micronized progesterone from the sixteenth to twenty-fifth days of the menstrual cycle. Additionally, patients of the first group received dehydro­epian­drosterone(DHEA)in a dose of 25 mg per day continuously in the form sublingual spray. Results. According to the data of ultrasound examination in the first group of patients, the endometrium corresponded to normal parameters both during treatment and 1 and 3 months after stopping treatment. At the same time, in the second group of patients, there was an improvement in the thickness (more than 7 mm) and structure of the endometrium during treatment and the absence of these effects after the termination of hormonal therapy. Considering the recommendations of the Association of Endocrinologists on the superiority of non-tablet forms of androgen preparations in the treatment of androgen deficiency and having a positive and long-term effect when taking sublingual DHEA, it is possible to recommend adding the above form of DHEA to systemic therapy of endometrial hypoplasia against the background of androgen deficiency. Conclusions. Women with androgen deficiency are more likely to have concomitant endometrial hypoplasia. Immunohistochemical examination of the endometrium of women of reproductive age with androgen deficiency in 24 patients (61.5 %) revealed a high level of expression of androgen receptors. The effectiveness of therapy for endometrial hypoplasia in women with androgen deficiency with addition of androgens to the standard regimens is more effective and has a long-lasting effect. The combination of estrogen-gestagenic therapy and androgens has a positive effect on the gestational potential of the endometrium in women of reproductive age with androgen deficiency.

ASSISTED REPRODUCTIVE TECHNOLOGY EFFICIENCY IMPROVEMENT OF TUBAL-PERITONEAL INFERTILITY

2020 ◽  
Vol 73 (11) ◽  
pp. 2370-2377
Author(s):  
Victoria V. Orlova ◽  
Lidiia V. Suslikova ◽  
Olena A. Orlova ◽  
Dmytro V. Dmytriienko ◽  
Iryna V. Malysheva
Keyword(s):  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
Reproductive Age ◽  
Melatonin Level ◽  
Efficiency Improvement ◽  
Women Of Reproductive Age ◽  
Infertile Women ◽  
Apoptosis Regulation ◽  
Endogenous Melatonin

The aim: This study aims to develop and implement a complex of pregravid preparation based on endogenous melatonin level, development of oxidative stress and violation of apoptosis regulation in women with tubal-peritoneal infertility. Materials and methods: We have examined 100 women of reproductive age, including 65 women with tubal-peritoneal infertility treated by ART. All studied women were defined levels of endogenous melatonin, oxidative status and level of apoptosis in the endometrium and in follicular fluid (infertile women only). As a powerful free radical neutralizer, we used melatonin to improve the microenvironment of maturing oocytes and create favourable conditions for implantation in the endometrium. Results: Treatment by exogenous melatonin showed better results than standard therapy without antioxidants: the quality of oocytes and embryos, the level of ongoing pregnancies and childbirth was significantly higher. Conclusions: We achieved such results due to restoring the balance in pro / antioxidant system and apoptosis in female reproductive tract.

scholarly journals Prevalence and Factors associated with Reproductive Tract Infections among Married Women of Reproductive Age in Kaski District, Nepal

2013 ◽  
Vol 3 (4) ◽  
pp. 1-7
Author(s):  
Damaru Prasad Paneru
Keyword(s):  
At Risk ◽  
Reproductive Tract ◽  
Married Women ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Reproductive Tract Infections ◽  
Effective Prevention ◽  
Factors Associated ◽  
Sexual Contacts ◽  
Tract Infections

Objectives: Reproductive Tract Infections (RTIs) are common morbidities among women during reproductive age. These may lead to adverse health consequences including life threatening conditions. This study aims to identify prevalence and factors associated with RTIs among married women of reproductive age. Methods: Cross sectional study was conducted in 7 randomly selected Primary Health Care Centres and Health Posts of Kaski district, Nepal. 282 participants attending in aforementioned health facilities were probed for RTI symptoms according to WHO syndromic case management guideline. Data were collected by using pretested semi-structured schedule and analyzed by SPSS (16.0 Version). Chi square, Fisher’s Exact Test, Odds ratio were calculated and P <0.05 was considered significant. Results: Prevalence of RTI symptoms was estimated to be 78.9 percent. Common reported symptoms were backache (71%), low abdominal pain (67%), watery vaginal discharge (56%), genital itching (51%), burning urination (44%) and curdy discharge per vagina (26%). Most women with RTI were ?30 year’s age, ?19 year’s age at first pregnancy, had monthly income (NRs) <10000 and parity ?2, had sex during menstruation and did not clean genitalia after sex. Consistently, more than nine out of every ten illiterates, high parity (?4), having irregular menstrual cycle and abnormal bleeding had more RTIs as compared to their counterparts respectively. Illiterates, those who had sexual contacts during menstrual periods and those who do not clean genitalia after sexual act were significantly more at risk (OR=5.35,8.33 and 3.11) of having RTIs than those who do not had these attributes correspondingly. Illiterates, those who had sexual contacts during menstrual periods and those who do not clean genitalia after sexual act were significantly more at risk (OR=5.35,8.33 and 3.11) of having RTIs than those who do not had these attributes correspondingly. Conclusions: Burden of the RTIs among women is unexpectedly high; indicating the women’s vulnerability to reproductive morbidities, limited service accessibility and their reproductive fates. Further, majority were modifiable factors; reflecting the needs of information and empowerment and behavior changes for the effective prevention and management of RTIs.DOI: http://dx.doi.org/10.3126/ajms.v3i4.6066 Asian Journal of Medical Science Vol.3(4) 2012 pp1-7

scholarly journals Clinicoetiological Characterization of Infectious Vaginitis amongst Women of Reproductive Age Group from Navi Mumbai, India

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Anuradha Narayankhedkar ◽  
Anahita Hodiwala ◽  
Arati Mane
Keyword(s):  
Reproductive Tract ◽  
Reproductive Age ◽  
Sexually Active ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Reproductive Tract Infections ◽  
Presenting Symptoms ◽  
Tract Infections ◽  
Reproductive Age Group

Vaginitis is one of the commonest reproductive tract infections in sexually active women. In the present study clinicoetiological characterization of infectious vaginitis amongst 380 women of reproductive age group (18–45 years) was done. Bacterial vaginosis (BV) was detected by Nugent’s scoring, Candida infection by culture, and trichomoniasis (TV) by wet mount. One hundred and ten (28.9%) women presented with symptoms of vaginitis. The presenting symptoms were vaginal discharge 106 (96.4%), vulval itching/irritation 19 (17.3%), malodor 5 (4.5%), pain in abdomen 3 (2.7%), and dysuria 1 (0.9%). The commonest etiology detected was Candida in 33 (30%) cases, of which 18 (54.5%) were C. albicans and 15 (45.5%) non-albicans Candida (NAC) infections. The NAC isolates were C. glabrata (n=10), C. tropicalis (n=3), and C. krusei (n=2). BV and TV were observed in 19 (17.3%) and 2 (1.8%) cases, respectively. A statistically significant association between Candida infection and presence of curdy-white discharge (p=0.001) and vulval itching/irritation (p=0.007) was noted. To conclude, we observed the etiological predominance of Candida infection, with considerable prevalence of NAC, indicating the need for microbiological investigation up to species level in cases of Candida infections, to ensure appropriate management.

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