Clinical case of severe community-acquired pneumonia, complicated by acute respiratory distress syndrome

2020 ◽  
Vol 0 (1) ◽  
pp. 62-68
Author(s):  
N.I. Pytetska ◽  
P.L. Kaseev ◽  
Yu.V. Bondar ◽  
Yu.M. Ilyashenko ◽  
I.I. Kirichenko
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Clinical Case ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia ◽  
Severe Community Acquired Pneumonia

scholarly journals Serum Exosomal MicroRNAs Predict Acute Respiratory Distress Syndrome Events in Patients with Severe Community-Acquired Pneumonia

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Xu Wu ◽  
Chengzhi Wu ◽  
Wenyu Gu ◽  
Haiying Ji ◽  
Lei Zhu
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Community Acquired Pneumonia ◽  
Operating Characteristics ◽  
Predictive Values ◽  
Severe Community Acquired Pneumonia

Background. Severe community-acquired pneumonia (SCAP) requiring intensive care unit (ICU) treatment commonly causes acute respiratory distress syndrome (ARDS) with high mortality. This study was aimed at evaluating whether microRNAs (miRNAs) in circulating exosomes have the predictive values for patients at risk of developing ARDS due to SCAP. Methods. ARDS/ALI-relevant miRNAs were obtained by literature search. Exosomes in serum were isolated by ultracentrifugation method and identified by Transmission Electron Microscopy. Then the miR profiling in the exosomes using real-time PCR was analyzed in SCAP patients with or without ARDS. Moreover, multivariate Cox proportional regression analysis was performed to estimate the odds ratio of miRNA for the occurrence of ARDS and prognosis. The receiver operating characteristics (ROC) curves were calculated to discriminate ARDS cases. Finally, the Kaplan-Meier curve using log-rank method was performed to test the equality for survival distributions with different miRNA classifiers. Results. A total of 53 SCAP patients were finally recruited. Ten miRNAs were picked out. Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 –1). Only miR-126 was selected to have potential to predict the 28-day mortality (OR=1.002, P=0.024) with its median value classifier. Conclusions. The altered levels of circulating exosomal microRNAs may be useful biologic confirmation of ARDS in patients with SCAP.

Differential Characteristics of Patients With Mild Acute Respiratory Distress Syndrome Due to Community-Acquired Pneumonia Admitted to ICU

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 176A
Author(s):  
Laura Novella ◽  
Francisco Sanz ◽  
Estrella Fernández-Fabrellas ◽  
Ángela Cervera ◽  
Maria Luisa Briones ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia

Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome

2018 ◽  
pp. 123-128
Author(s):  
Duncan McLean ◽  
Matthias Eikermann
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Clinical Case ◽  
Distress Syndrome ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
Neuromuscular Blockers ◽  
Study Intervention

This chapter provides a summary of the landmark study known as Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome. Do neuromuscular blocking agents (NMBs) improve outcomes in patients with acute respiratory distress syndrome who are receiving mechanical ventilation? Starting with that question, the chapter describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism, and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. The study found that patients with severe ARDS may benefit from short-term NMB infusions with certain caveats, as noted in the chapter.

scholarly journals Hydroxyzine revealing acquired neuromuscular weakness in a patient with COVID-19 disease

2021 ◽  
Vol 9 (40) ◽  
pp. 74-76
Author(s):  
Mohamed Bahi ◽  
Younes Aissaoui ◽  
Ayoub Belhadj ◽  
Youssef Qamouss ◽  
Rachid Seddiki
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Side Effects ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Clinical Case ◽  
Distress Syndrome

Acquired neuromuscular weakness often develops in patients with an acute respiratory distress syndrome (ARDS), in particular in patients who are ventilated and sedated for long periods. This has been rarely described in the literature on ARDS secondary to SARS-CoV-2 infection. Our clinical case revealed the existence of these neuromuscular manifestations in the COVID-19 disease after the use of hydroxyzine, an antihistamine whose respiratory side-effects are unknown. Keywords: Neuromuscular weakness, COVID-19, hydroxyzine, hypercapnia.

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