〈1381〉 Assessment of Elastomeric Component Used in Injectable Pharmaceutical Product Packaging/Delivery Systems

Every year, more than thirty thousand tons of Cashew gum (Anacardium occidentale, family: Anacardiaceae) are produced in Brazil; however, only a small amount is used for different applications in foodstuff and in pharmaceutical industries. As a raw material for the production of drug delivery systems, cashew gum is still regarded as an innovative compound worth to be exploited. In this work, cashew gum was extracted from the crude exudate of cashew tree employing four methodologies resulting in a light brown powder in different yields (40.61% to 58.40%). The total ashes (0.34% to 1.05%) and moisture (12.90% to 14.81%) were also dependent on the purification approach. FTIR spectra showed the typical bands of purified cashew gum samples, confirming their suitability for the development of a pharmaceutical product. Cashew gum nanoparticles were produced by nanoprecipitation resulting in particles of low polydispersity (<0.2) and an average size depending on the percentage of the oil. The zeta potential of nanoparticles was found to be below 20 mV, which promotes electrostatic stability. Encapsulation efficiencies were above 99.9%, while loading capacity increased with the increase of the percentage of the oil content of particles. The release of the oil from the nanoparticles followed the Korsmeyer–Peppas kinetics model, while particles did not show any signs of toxicity when tested in three distinct cell lines (LLC-MK2, HepG2, and THP-1). Our study highlights the potential added value of using a protein-, lignans-, and nucleic acids-enriched resin obtained from crude extract as a new raw material for the production of drug delivery systems.

Download Full-text

Powder Coating for Healthcare Aluminum Packaging

Cosmetics ◽

10.3390/cosmetics7020020 ◽

2020 ◽

Vol 7 (2) ◽

pp. 20

Author(s):

Stefano Rossi ◽

Massimo Calovi ◽

Matteo Tonelli

Keyword(s):

Dimethyl Ether ◽

Chemical Resistance ◽

Powder Coating ◽

Visual Observation ◽

Pharmaceutical Product ◽

Powder Coatings ◽

Product Packaging ◽

Alcohol Water ◽

Protective System ◽

Aluminum Cans

Restrictive regulations concerning the toxicity of certain compounds and the use and disposal of solvents present in the liquid epoxy protection system have been analyzed in this work to evaluate powder coatings as an alternative in the protection of aerosol aluminum cans, which are employed in cosmetics and pharmaceutical product packaging. In this paper, the chemical resistance of polyester and mixed epoxy-polyester powder coatings is assessed, considering different aggressive environments employed in healthcare commercial products. The samples’ performances are also compared with the currently used liquid organic coatings. The pack test has been used to evaluate the protective system behavior in contact with both the liquid and the gaseous part of the cosmetic product. However, the visual observation, required by the test, enabled the highlight of only very evident degradation phenomena. The chemical resistance of the powder coatings has proved to be appropriate only for less aggressive environment, where the critical compounds are propellants, propane, butane and isobutane. When exposed to other environments containing alcohol, water and dimethyl ether, most samples have been susceptible to layer degradation phenomena. Polyester layers lose their corrosion protection properties. Epoxy systems, instead, result more performant than polyester resins, but they particularly suffer from the contact with dimethyl ether.

Download Full-text

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Download Full-text