Powdered Echinacea angustifolia Extract

2021 ◽  
Keyword(s):  
Echinacea Angustifolia

Dormancy-breaking Studies on Echinacea angustifolia

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 456f-457 ◽  
Author(s):  
Ali O. Sari ◽  
Mario R. Morales ◽  
James E. Simon
Keyword(s):  
Native Americans ◽  
Seed Germination ◽  
Tap Water ◽  
The United States ◽  
Market Demand ◽  
Dormancy Breaking ◽  
Echinacea Angustifolia ◽  
Native Populations ◽  
Percent Germination ◽  
Dry Heating

Echinacea is a medicinal plant native to North America. It was used extensively by native Americans in the treatment of their ailments. It is presently one of the most popular medicinal plants in the United States. Its popularity has created a large market demand for the roots and foliage of the plant. The gathering of echinacea from the wild is leading to the reduction of native populations and the destruction of its genetic diversity. Cultivation of medicinal echinaceas is hindered by a low seed germination. Dormancy breaking studies were done on freshly harvested seeds of Echinacea angustifolia. Seed lots were placed under light at a constant temperature of 25 °C and at alternate temperatures of 25/15 °C for 14/10 h, respectively. Germination was more rapid and uniform and percent germination higher at 25 °C than at 25/15 °C. Seed tap-water soaking, dry heating, and sharp heating alteration did not increase germination. The application of 1.0 mM ethephon (2-chloroethylphosphoric acid) increased seed germination to 94% at 25 °C and 86% at 25/15 °C. Untreated seeds gave 65% germination at 25 °C and 11% at 25/15 °C. The application of 2500 mg·L–1 and 3500 mg·L–1 of GA to dry seeds and 2500 mg·L–1 to seeds that have been soaked under tap water and then dried increased germination to 82%, 83%, and 83% at 25 °C and 64%, 78%, and 64% at 25/15 °C, respectively.

scholarly journals The Effect of Plant Inbreeding and Stoichiometry on Interactions with Herbivores in Nature: Echinacea angustifolia and Its Specialist Aphid

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24762 ◽  
Author(s):  
Caroline E. Ridley ◽  
Helen H. Hangelbroek ◽  
Stuart Wagenius ◽  
John Stanton-Geddes ◽  
Ruth G. Shaw
Keyword(s):  
Echinacea Angustifolia

scholarly journals Simultaneous Quantification of Echinacea Species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae Combinations by Rapid Resolution Liquid Chromatography

2011 ◽  
Vol 6 (5) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Jie Ma ◽  
Yuan-Chun Ma ◽  
Carina Cai ◽  
Daniel Wang ◽  
Fei Fei Hou ◽  
...  
Keyword(s):  
Acute Bronchitis ◽  
Phosphoric Acid Solution ◽  
Upper Respiratory Tract ◽  
Echinacea Angustifolia ◽  
Rapid Resolution ◽  
Flos Lonicerae ◽  
Radix Scutellariae ◽  
Acidic Conditions ◽  
Upper Respiratory ◽  
Liquid Chromatographic

Echinacea angustifolia and E. purpurea are commonly used in North America for their antibacterial effects. Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae are traditional Chinese medicinal herbs commonly used for the treatment of complaints such as pneumonia, acute upper respiratory tract infection, and acute bronchitis. A reproducible, simple, and reliable rapid resolution liquid chromatographic (RRLC) method has been developed to analyze extracts of products formulated containing E. angustifolia, E. purpurea, Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae simultaneously in one run in less than 6 minutes. The method uses a C18-HST column, a mobile phase consisting of 0.1% aqueous phosphoric acid solution and acetonitrile, and UV detection at 327 nm and 229 nm. A stability test was performed that revealed that chlorogenic acid is more stable in acidic pH, and hence it is best to keep the extract of E. augustifolia, E. purpurea, Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae in mild acidic conditions at approximately pH 5.

Echinacea angustifolia

2012 ◽  
pp. 114-114
Author(s):  
Shakhnoza S. Azimova ◽  
Anna I. Glushenkova
Keyword(s):  
Echinacea Angustifolia

Effect of latitude on narrow-leaved purple coneflower (Echinacea angustifolia DC.) yield and phytochemical quality

2020 ◽  
Vol 100 (1) ◽  
pp. 103-112
Author(s):  
Ian R. Willick ◽  
Branka Barl ◽  
Karen K. Tanino
Keyword(s):  
Chlorogenic Acid ◽  
Acid Content ◽  
Western Canada ◽  
Root Yield ◽  
Field Site ◽  
Echinacea Angustifolia ◽  
Phytochemical Content ◽  
Purple Coneflower ◽  
Cash Crops ◽  
Northern Latitudes

The worldwide increase in demand for plant-derived drugs has increased interest in medicinal plants as alternative cash crops across western Canada. The objective of this research was to determine if the Northern Vigor® phenomenon, expressed as a combination of elevated crop yield and phytomedicinal quality in crops grown in northern latitudes, exists in narrow-leaved purple coneflower (Echinacea angustifolia DC.). In a 2-yr study, narrow-leaved purple coneflower was grown in three field sites in Saskatchewan, Canada (SK; Saskatoon, La Ronge, and Outlook) and one field site in Oregon, United States (Madras), to test the effects of latitude on root yield, phenolic, and alkylamide phytochemical markers. Roots harvested in 1999 (all three SK sites) and 2000 (two SK sites) had higher root biomass compared with roots harvested in Oregon. Root echinacoside and cynarin content were significantly higher in both years in the three Saskatchewan sites compared with Madras, whereas root chlorogenic acid content and total alkylamides were significantly higher in all three Saskatchewan sites in 1999. In 2000, root chlorogenic acid content and total alkylamides were higher in two of the three Saskatchewan sites compared with Madras. While Aster Yellows were prevalent in Echinacea in Saskatchewan, this disease did not significantly decrease root yield phenolic or phytochemical content. These data suggest that Saskatchewan has a competitive advantage in producing premium-quality narrow-leaved purple coneflower root in North America.

scholarly journals Echinacea angustifolia DC. Lipophilic Extract Patch for Skin Application: Preparation, In Vitro and In Vivo Studies

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1096
Author(s):  
Dritan Hasa ◽  
Simon Žakelj ◽  
Iztok Grabnar ◽  
Francesco Cilurzo ◽  
Stefano Dall’Acqua ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Skin Permeation ◽  
In Vivo Studies ◽  
Pharmacokinetic Analysis ◽  
Echinacea Angustifolia ◽  
Transdermal Administration ◽  
Lipophilic Extract ◽  
Main Component

Dodeca-2E,4E,8Z,10E/Z-tetraenoic isobutylamide (tetraene) is the main component of Echinacea angustifolia DC. lipophilic extract, the bioavailability and immunomodulatory effect after oral administration in soft gel capsules in healthy volunteers of which we have already demonstrated. In the present work, we assessed the transdermal administration as an alternative route of administration of such an alkamide. The first step, therefore, encompassed the preparation of a drug-in-adhesive patch with an area of 868 mm2 and containing a dose of 0.64 mg of tetraene. In vitro skin permeation studies in Franz-type diffusion chambers resulted in a tetraene flux of (103 ± 10) ng × cm−2 × h−1 with a very good linearity (r = 0.99). The relatively low lag time of just 13 min indicates low binding and the accumulation of tetraene in the skin. Finally, the patch was administered to six healthy volunteers, and the pharmacokinetic analysis was performed by nonlinear mixed effects modelling with soft gel oral capsules serving as the reference formulation. The in vivo results correlated well with the in vitro permeation and indicated an initial burst tetraene absorption from the patch that was in parallel with the zero-order kinetics of absorption. The rate of the latter process was in good agreement with the one estimated in vitro. The tetraene absorption rate was therefore slow and prolonged with time, resulting in a bioavailability of 39% relative to the soft gel capsules and a very flat plasma concentration profile.

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