VALIDATION OF ORAL DISEASE SEVERITY SCALE (ODSS) IN ORAL LICHEN PLANUS

The role of angiogenesis in the development of chronic inflammatory diseases, including oral lichen planus (OLP), is of great concern. The most representative method for the assessment of angiogenesis is the semi-quantification of microvessel density (MVD) using specific markers such as CD105. We aimed to assess the MVD in patients with OLP and find its clinical significance to differentiate the atrophic/erosive forms from reticular ones. This cross-sectional study was conducted on 82 patients with clinically and histopathologically proven cases of OLP, including reticular (n=52) or atrophic/erosive (n=30) lesions. The control group comprised 82 age- and sex-matched subjects without any oral disease. To assess the MVD using CD105, tissue blocks were sliced, and the immunoexpression of CD105 was measured by the standard immunohistochemical staining procedure. The mean value of MVD in OLP patients was significantly higher than that in the controls (14.61±12.48 vs. 8.67±1.76, P<0.0001). Furthermore, there was a significant difference in the mean MVD value between reticular and atrophic/erosive lesions (8.19±7.13 vs. 25.73±12.06, P=0.001). However, no significant difference was observed between the reticular lesions and normal tissues (P=0.58). An increased level of CD105 in OLP patients can improve our knowledge about the causes and mechanisms of the disease. The CD105-MVD assessment might be a useful method for semiquantitative measurement of angiogenesis in OLP patients as well as differentiating its clinical forms; therefore, it can open new vistas for formulating strategies based on antiangiogenic treatments for the management of OLP and other precancerous lesions.

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Case Report: Treatment of Oral Lichen Planus With a Focus on Psychological Methods

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.731093 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xiuli Song ◽

Xueqi Wu ◽

Chunye Wang ◽

Shuguang Sun ◽

Xiangyang Zhang

Keyword(s):

Case Report ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Acute Stress ◽

Oral Disease ◽

Emotional Instability ◽

Psychological Counseling ◽

Mental Problems ◽

Somatic Diseases ◽

Oral Lichen

Oral lichen planus (OLP) is one of the most common chronic diseases; however, its etiology remains unknown. More and more studies have revealed that emotional instability is one of the risk factors for the onset and expansion of OLP, especially in patients suffering from depression, anxiety disorder, and acute stress. In this case report, we had a 32-year-old female OLP patient who had no obvious response to conventional OLP drugs. Then we switched to a combination of psychotropic drugs and psychotherapies. By regulating mood through drugs and psychological counseling, the patient's oral disease was alleviated. Our case shows that clinicians should consider the mental problems of OLP patients. It also emphasizes the importance of medications and psychological counseling in the treatment of somatic diseases.

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Helicobacter Pylori Infection Increases the Incidence of Erosive Oral Lichen Planus and Alters the Oral Microbiome Composition

10.21203/rs.3.rs-135416/v1 ◽

2021 ◽

Author(s):

Yangheng Zhang ◽

Shutong Li ◽

Jingyuan Li ◽

Ya Li ◽

Huanjie Li ◽

...

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Oral Microbiome ◽

Oral Disease ◽

Oral Diseases ◽

Microbiome Composition ◽

Carbon 14 ◽

Increased Risk ◽

H Pylori ◽

Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk for malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the etiological factors for OLP. Although H. pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection.Result In this study, the saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-14 urea breath test. The saliva samples were divided into the following four groups based on the H. pylori infection status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−) groups. The oral microbiome composition was significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, the incidence of erosive OLP and the salivary levels of cytokines were higher in the OLP+ group. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups.Conclusions This is the first report demonstrated that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP. The alleviation of H. pylori infection may decrease the incidence of erosive OLP.

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Increased B7-H1 Expression on Peripheral Blood T Cells in Oral Lichen Planus Correlated with Disease Severity

Journal of Clinical Immunology ◽

10.1007/s10875-012-9683-2 ◽

2012 ◽

Vol 32 (4) ◽

pp. 794-801 ◽

Cited By ~ 33

Author(s):

Gang Zhou ◽

Jing Zhang ◽

Xiang-wei Ren ◽

Jing-yu Hu ◽

Ge-fei Du ◽

...

Keyword(s):

T Cells ◽

Disease Severity ◽

Lichen Planus ◽

Peripheral Blood ◽

Oral Lichen Planus ◽

Oral Lichen

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Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition

BMC Microbiology ◽

10.1186/s12866-021-02188-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shutong Li ◽

Yangheng Zhang ◽

Zongcheng Yang ◽

Jingyuan Li ◽

Ya Li ◽

...

Keyword(s):

Helicobacter Pylori ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Oral Microbiome ◽

Oral Disease ◽

Oral Diseases ◽

Microbiome Composition ◽

Increased Risk ◽

H Pylori ◽

Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Although Helicobacter pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection. Result In this study, saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-13-labeled urea breath test (UBT). The saliva samples were divided into the following four groups based on the H. pylori status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−). Oral microbiome compositions were significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, those in the OLP+ group had a higher incidence of erosive OLP and higher levels of salivary cytokines. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups. Conclusions This is the first report to demonstrate that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP.

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Matrix Metalloproteinases Neutralizing Agents: A Possible Treatment Modality for Oral Lichen Planus (Preliminary Study)

10.21203/rs.3.rs-152543/v1 ◽

2021 ◽

Author(s):

Hossam Elsabagh ◽

Yasmine Gaweesh ◽

Jaylane Ghonima

Keyword(s):

Matrix Metalloproteinases ◽

Disease Severity ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Test Group ◽

Control Group ◽

Oral Diseases ◽

The Mean ◽

Oral Lichen

Abstract Background: Oral lichen planus is one of the most prevalent oral diseases. Matrix metalloproteinases have been implicated in its pathogenesis thus this study was executed to evaluate the effectiveness of matrix metalloproteinases neutralizing agents in the treatment of oral lichen planus. Methods: Patients were assigned to either control group who received topical corticosteroids and antifungal treatment, or test group who received matrix metalloproteinases neutralizing spray. All patients were evaluated for disease severity and pain at baseline, 1 week, and 4 weeks after treatment. Results: The mean pain score in test and control groups was 9.00 (0.89), and 9.33 (0.82), respectively, at baseline while it was 2.33 (1.75) and 2.83 (1.72) at 4th week follow up. The mean disease severity score was 4.33 (0.52) for test group and 4.50 (0.55) for control group at baseline and decreased to 1.83 (0.75) and 2.17 (0.98) at 4th week follow up. Despite the better results seen in test group on the expense of control group, no statistically significant differences could be detected between groups at any timepoint. Conclusion: The use of matrix metalloproteinases neutralizing agents might be an equally effective sole treatment for erosive oral lichen planus compared to the conventional treatment, without the risk of secondary candidiasis. Trial registration: The study was registered retrospectively at ClinicalTrials.gov (NCT04336488), date (07/04/2020)

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