scholarly journals Helicobacter Pylori Infection Increases the Incidence of Erosive Oral Lichen Planus and Alters the Oral Microbiome Composition

2021 ◽  
Author(s):  
Yangheng Zhang ◽  
Shutong Li ◽  
Jingyuan Li ◽  
Ya Li ◽  
Huanjie Li ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Microbiome ◽  
Oral Disease ◽  
Oral Diseases ◽  
Microbiome Composition ◽  
Carbon 14 ◽  
Increased Risk ◽  
H Pylori ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk for malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the etiological factors for OLP. Although H. pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection.Result In this study, the saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-14 urea breath test. The saliva samples were divided into the following four groups based on the H. pylori infection status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−) groups. The oral microbiome composition was significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, the incidence of erosive OLP and the salivary levels of cytokines were higher in the OLP+ group. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups.Conclusions This is the first report demonstrated that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP. The alleviation of H. pylori infection may decrease the incidence of erosive OLP.

scholarly journals Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shutong Li ◽  
Yangheng Zhang ◽  
Zongcheng Yang ◽  
Jingyuan Li ◽  
Ya Li ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Microbiome ◽  
Oral Disease ◽  
Oral Diseases ◽  
Microbiome Composition ◽  
Increased Risk ◽  
H Pylori ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Although Helicobacter pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection. Result In this study, saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-13-labeled urea breath test (UBT). The saliva samples were divided into the following four groups based on the H. pylori status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−). Oral microbiome compositions were significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, those in the OLP+ group had a higher incidence of erosive OLP and higher levels of salivary cytokines. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups. Conclusions This is the first report to demonstrate that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP.

Epithelial Loss Correlated with Decreased Beta Defensins and Increased Risk of Candida Infections in Oral Lichen Planus

2015 ◽  
Vol 119 (3) ◽  
pp. e111
Author(s):  
Jeyaseelan Augustine ◽  
Chiranjit Maity ◽  
Priya Kumar ◽  
Shalini Gupta ◽  
Dipankar Ghosh ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Increased Risk ◽  
Beta Defensins ◽  
Candida Infections ◽  
Oral Lichen

scholarly journals Validation of an Oral Disease Severity Score for use in oral lichen planus

2022 ◽  
Author(s):  
Martyn Ormond ◽  
Helen McParland ◽  
Priya Thakrar ◽  
Ana Donaldson ◽  
Manoharan Andiappan ◽  
...  
Keyword(s):  
Disease Severity ◽  
Lichen Planus ◽  
Severity Score ◽  
Oral Lichen Planus ◽  
Oral Disease ◽  
Disease Severity Score ◽  
Oral Lichen

Lichen Planus and Lichenoid Lesions of the Oral Cavity

1994 ◽  
Vol 103 (6) ◽  
pp. 495-497 ◽  
Author(s):  
John G. Batsakis ◽  
Karen R. Cleary ◽  
Kyung-Ja Cho
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Manifestations ◽  
Spontaneous Resolution ◽  
Increased Risk ◽  
History Of ◽  
Cutaneous Form ◽  
Oral Lichen ◽  
Chronic Course

Lichen planus is a mucocutaneous disease of unknown cause that has its principal clinical manifestations in the skin and mucosa of the oral cavity. The natural history of the cutaneous form is one of spontaneous resolution over time, while oral lichen planus pursues a much more chronic course with a low order of resolution. Oral lichen planus must be distinguished from lichenoid lesions, including lichenoid dysplasia. Malignant change in oral lichen planus is rare and is prompted by carcinogenic cofactors. There is no increased risk of development of carcinoma in cutaneous lichen planus.

Update On Oral Lichen Planus: Etiopathogenesis and Management

1998 ◽  
Vol 9 (1) ◽  
pp. 86-122 ◽  
Author(s):  
C. Scully ◽  
M. Beyli ◽  
M. C. Ferreiro ◽  
G. Ficarra ◽  
Y. Gill ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Dental Materials ◽  
Definitive Treatment ◽  
Environmental Aspects ◽  
New Associations ◽  
Increased Risk ◽  
Oral Lichen ◽  
Selection Of

Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

scholarly journals The Assessment of Angiogenesis by Microvessel Density in Patients With Atrophic/Erosive or Reticular Oral Lichen Planus

2021 ◽  
Author(s):  
Maryam Mardani ◽  
Azadeh Andisheh-Tadbir ◽  
Mahya Haghparast
Keyword(s):  
Lichen Planus ◽  
Microvessel Density ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Disease ◽  
Staining Procedure ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
Oral Lichen

The role of angiogenesis in the development of chronic inflammatory diseases, including oral lichen planus (OLP), is of great concern. The most representative method for the assessment of angiogenesis is the semi-quantification of microvessel density (MVD) using specific markers such as CD105. We aimed to assess the MVD in patients with OLP and find its clinical significance to differentiate the atrophic/erosive forms from reticular ones. This cross-sectional study was conducted on 82 patients with clinically and histopathologically proven cases of OLP, including reticular (n=52) or atrophic/erosive (n=30) lesions. The control group comprised 82 age- and sex-matched subjects without any oral disease. To assess the MVD using CD105, tissue blocks were sliced, and the immunoexpression of CD105 was measured by the standard immunohistochemical staining procedure. The mean value of MVD in OLP patients was significantly higher than that in the controls (14.61±12.48 vs. 8.67±1.76, P<0.0001). Furthermore, there was a significant difference in the mean MVD value between reticular and atrophic/erosive lesions (8.19±7.13 vs. 25.73±12.06, P=0.001). However, no significant difference was observed between the reticular lesions and normal tissues (P=0.58). An increased level of CD105 in OLP patients can improve our knowledge about the causes and mechanisms of the disease. The CD105-MVD assessment might be a useful method for semiquantitative measurement of angiogenesis in OLP patients as well as differentiating its clinical forms; therefore, it can open new vistas for formulating strategies based on antiangiogenic treatments for the management of OLP and other precancerous lesions.

scholarly journals Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review

2020 ◽  
Vol 30 (4) ◽  
Author(s):  
Paria Motahari ◽  
Fatemeh Pournaghi Azar ◽  
Arefeh Rasi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lichen Planus ◽  
Vitamin D Receptor ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Increased Risk ◽  
Review Study ◽  
Oral Lichen

BACKGROUND: Oral lichen planus (OLP) is known to be a chronic inflammatory disease associated with various other systemic disorders. Studies have shown that vitamin D deficiency can be involved in the pathogenesis of lichen planus. The aim of this study was to investigate the role of vitamin D and vitamin D receptor in OLP.METHODS: In this review study, all English and Persian articles were searched by relevant keywords from the Google scholar, PubMed, science direct, Cochrane, Scopus and Sid databases until January 2020.RESULTS: From the 16 articles obtained after reviewing the abstracts, finally 14 appropriate articles were included in this study.CONCLUSION: According to the results of the studies, vitamin D deficiency may be associated with an increased risk of OLP lesions.

scholarly journals Case Report: Treatment of Oral Lichen Planus With a Focus on Psychological Methods

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuli Song ◽  
Xueqi Wu ◽  
Chunye Wang ◽  
Shuguang Sun ◽  
Xiangyang Zhang
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Acute Stress ◽  
Oral Disease ◽  
Emotional Instability ◽  
Psychological Counseling ◽  
Mental Problems ◽  
Somatic Diseases ◽  
Oral Lichen

Oral lichen planus (OLP) is one of the most common chronic diseases; however, its etiology remains unknown. More and more studies have revealed that emotional instability is one of the risk factors for the onset and expansion of OLP, especially in patients suffering from depression, anxiety disorder, and acute stress. In this case report, we had a 32-year-old female OLP patient who had no obvious response to conventional OLP drugs. Then we switched to a combination of psychotropic drugs and psychotherapies. By regulating mood through drugs and psychological counseling, the patient's oral disease was alleviated. Our case shows that clinicians should consider the mental problems of OLP patients. It also emphasizes the importance of medications and psychological counseling in the treatment of somatic diseases.

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