Deregulated phospholipase D2/mammalian target of rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with disease severity

2019 ◽  
Vol 98 ◽  
pp. 26-31
Author(s):  
Fang Wang ◽  
Jing Zhang ◽  
Gang Zhou
Keyword(s):  
T Lymphocytes ◽  
Disease Severity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Mammalian Target Of Rapamycin ◽  
Hypoxia Inducible Factor ◽  
Target Of Rapamycin ◽  
Hypoxia Inducible Factor 1 ◽  
Phospholipase D2 ◽  
Oral Lichen

IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus

2019 ◽  
Vol 98 ◽  
pp. 115-121
Author(s):  
Hui Wang ◽  
Yuchen Jiang ◽  
Hongning Wang ◽  
Zhenhua Luo ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Disease Severity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α

Blood ◽  
2012 ◽  
Vol 120 (15) ◽  
pp. 3118-3125 ◽  
Author(s):  
Alison M. McInturff ◽  
Mark J. Cody ◽  
Elizabeth A. Elliott ◽  
Jared W. Glenn ◽  
Jesse W. Rowley ◽  
...  
Keyword(s):  
Cell Function ◽  
Immune Cell ◽  
Mammalian Target Of Rapamycin ◽  
Hypoxia Inducible Factor ◽  
Severe Infection ◽  
Neutrophil Extracellular Trap ◽  
Target Of Rapamycin ◽  
Human Neutrophils ◽  
Bacterial Killing ◽  
Hypoxia Inducible Factor 1

Abstract Neutrophils are highly specialized innate immune effector cells that evolved for antimicrobial host defense. In response to inflammatory stimuli and pathogens, they form neutrophil extracellular traps (NETs), which capture and kill extracellular microbes. Deficient NET formation predisposes humans to severe infection, but, paradoxically, dysregulated NET formation contributes to inflammatory vascular injury and tissue damage. The molecular pathways and signaling mechanisms that control NET formation remain largely uncharacterized. Using primary human neutrophils and genetically manipulated myeloid leukocytes differentiated to surrogate neutrophils, we found that mammalian target of rapamycin (mTOR) regulates NET formation by posttranscriptional control of expression of hypoxia-inducible factor 1 α (HIF-1α), a critical modulator of antimicrobial defenses. Next-generation RNA sequencing, assays of mRNA and protein expression, and analysis of NET deployment by live cell imaging and quantitative histone release showed that mTOR controls NET formation and translation of HIF-1α mRNA in response to lipopolysaccharide. Pharmacologic and genetic knockdown of HIF-1α expression and activity inhibited NET deployment, and inhibition of mTOR and HIF-1α inhibited NET-mediated extracellular bacterial killing. Our studies define a pathway to NET formation involving 2 master regulators of immune cell function and identify potential points of molecular intervention in strategies to modify NETs in disease.

scholarly journals Validation of an Oral Disease Severity Score for use in oral lichen planus

2022 ◽  
Author(s):  
Martyn Ormond ◽  
Helen McParland ◽  
Priya Thakrar ◽  
Ana Donaldson ◽  
Manoharan Andiappan ◽  
...  
Keyword(s):  
Disease Severity ◽  
Lichen Planus ◽  
Severity Score ◽  
Oral Lichen Planus ◽  
Oral Disease ◽  
Disease Severity Score ◽  
Oral Lichen

A scoring system for mucosal disease severity with special reference to oral lichen planus

2007 ◽  
Vol 157 (4) ◽  
pp. 765-770 ◽  
Author(s):  
M. Escudier ◽  
N. Ahmed ◽  
P. Shirlaw ◽  
J. Setterfield ◽  
A. Tappuni ◽  
...  
Keyword(s):  
Special Reference ◽  
Disease Severity ◽  
Lichen Planus ◽  
Scoring System ◽  
Oral Lichen Planus ◽  
Mucosal Disease ◽  
Oral Lichen

Heat shock (stress) proteins and γδ T lymphocytes in oral lichen planus

1995 ◽  
Vol 80 (6) ◽  
pp. 698-704 ◽  
Author(s):  
Thomas E. Bramanti ◽  
Nusi P. Dekker ◽  
Francina Lozada-Nur ◽  
John J. Sauk ◽  
Joseph A. Regezi
Keyword(s):  
Heat Shock ◽  
T Lymphocytes ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Stress Proteins ◽  
Heat Shock Stress ◽  
Oral Lichen ◽  
Shock Stress

Intra-epithelial subpopulations of T lymphocytes and Langerhans cells in oral lichen planus

2007 ◽  
Vol 27 (3) ◽  
pp. 116-123 ◽  
Author(s):  
L. J. Walton ◽  
M. G. Macey ◽  
M. H. Thornhill ◽  
P. M. Farthing
Keyword(s):  
T Lymphocytes ◽  
Lichen Planus ◽  
Langerhans Cells ◽  
Oral Lichen Planus ◽  
Oral Lichen

Increased B7-H1 Expression on Peripheral Blood T Cells in Oral Lichen Planus Correlated with Disease Severity

2012 ◽  
Vol 32 (4) ◽  
pp. 794-801 ◽  
Author(s):  
Gang Zhou ◽  
Jing Zhang ◽  
Xiang-wei Ren ◽  
Jing-yu Hu ◽  
Ge-fei Du ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Severity ◽  
Lichen Planus ◽  
Peripheral Blood ◽  
Oral Lichen Planus ◽  
Oral Lichen
Sign in / Sign up

Export Citation Format

Share Document