Drug Resistance Pattern in the Clinical Isolates of Pulmonary Tuberculosis

This study was designed to determine the extent of drug resistance of M. tuberculosis (MTB) isolated from category II treatment failure pulmonary tuberculosis (PTB) patients. A total of 100 Ziehl-Neelsen (Z-N) smear positive category II failure PTB patients were included in this study. Sputum culture was done in Lowenstein-Jensen (L-J) media. Conventional proportion method on Lowenstein-Jensen (L-J) media was used to determine the drug susceptibility of M. tuberculosis to isoniazid (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA). Out of 100 sputum samples, a total of 87 samples were positive by culture. Drug susceptibility test (DST) revealed that 82 (94.25%) isolates were resistant to one or more anti -TB drugs. Resistance to isoniazide (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA) was 94.25%, 82.75%, 29.90% and 3.45% respectively. Among these isolates, 79.31% and 3.45% isolates were multi-drug resistant (MDR) and extended drug resistant (XDR) M. tuberculosis respectively. High rate of anti-tubercular drug resistance was observed among the category II treatment failure TB patients.DOI: http://dx.doi.org/10.3329/imcj.v7i1.17741 Ibrahim Med. Coll. J. 2013; 7(1): 9-11

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Drug-resistance pattern ofMycobacterium tuberculosisstrains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center

The Korean Journal of Internal Medicine ◽

10.3904/kjim.2015.30.3.325 ◽

2015 ◽

Vol 30 (3) ◽

pp. 325 ◽

Cited By ~ 14

Author(s):

Ho Young Lee ◽

Jin Lee ◽

Young Seok Lee ◽

Mi-Yeong Kim ◽

Hyun-Kyung Lee ◽

...

Keyword(s):

Drug Resistance ◽

Medical Center ◽

Extrapulmonary Tuberculosis ◽

Resistance Pattern ◽

Drug Resistance Pattern

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Changing patterns and widening of antibiotic resistance inShigellaspp. over a decade (2000–2011), Andaman Islands, India

Epidemiology and Infection ◽

10.1017/s0950268814000958 ◽

2014 ◽

Vol 143 (3) ◽

pp. 470-477 ◽

Cited By ~ 12

Author(s):

D. BHATTACHARYA ◽

H. BHATTACHARYA ◽

D. S. SAYI ◽

A. P. BHARADWAJ ◽

M. SINGHANIA ◽

...

Keyword(s):

Drug Resistance ◽

Antibiotic Resistance ◽

Wide Spectrum ◽

Resistance Pattern ◽

Third Generation ◽

Isolation And Identification ◽

Antimicrobial Drugs ◽

Drug Resistance Pattern ◽

Resistance Patterns ◽

Third Generation Cephalosporins

SUMMARYThis study is a part of the surveillance study on childhood diarrhoea in the Andaman and Nicobar Islands; here we report the drug resistance pattern of recent isolates ofShigellaspp. (2006–2011) obtained as part of that study and compare it with that ofShigellaisolates obtained earlier during 2000–2005. During 2006–2011, stool samples from paediatric diarrhoea patients were collected and processed for isolation and identification ofShigellaspp. Susceptibility to 22 antimicrobial drugs was tested and minimum inhibitory concentrations were determined for third-generation cephalosporins, quinolones, amoxicillin-clavulanic acid combinations and gentamicin. A wide spectrum of antibiotic resistance was observed in theShigellastrains obtained during 2006–2011. The proportions of resistant strains showed an increase from 2000–2005 to 2006–2011 in 20/22 antibiotics tested. The number of drug resistance patterns increased from 13 in 2000–2005 to 43 in 2006–2011. Resistance to newer generation fluoroquinolones, third-generation cephalosporins and augmentin, which was not observed during 2000–2005, appeared during 2006–2011. The frequency of resistance inShigellaisolates has increased substantially between 2000–2006 and 2006–2011, with a wide spectrum of resistance. At present, the option for antimicrobial therapy in shigellosis in Andaman is limited to a small number of drugs.

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