scholarly journals Drug resistance pattern of M. tuberculosis in category II treatment failure pulmonary tuberculosis patients

2014 ◽  
Vol 7 (1) ◽  
pp. 9-11
Author(s):  
Fahmida Rahman ◽  
Sadia Sharmin ◽  
Md Mustafa Kamal ◽  
Md Ruhul Amin Miah
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Treatment Failure ◽  
Drug Susceptibility ◽  
High Rate ◽  
Resistance Pattern ◽  
Drug Resistant ◽  
Drug Resistance Pattern ◽  
Lowenstein Jensen ◽  
Proportion Method

This study was designed to determine the extent of drug resistance of M. tuberculosis (MTB) isolated from category II treatment failure pulmonary tuberculosis (PTB) patients. A total of 100 Ziehl-Neelsen (Z-N) smear positive category II failure PTB patients were included in this study. Sputum culture was done in Lowenstein-Jensen (L-J) media. Conventional proportion method on Lowenstein-Jensen (L-J) media was used to determine the drug susceptibility of M. tuberculosis to isoniazid (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA). Out of 100 sputum  samples, a total of 87 samples were positive by culture. Drug susceptibility test (DST) revealed that 82 (94.25%) isolates were resistant to one or more anti -TB drugs. Resistance to isoniazide (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA) was 94.25%, 82.75%, 29.90% and 3.45% respectively. Among these isolates, 79.31% and 3.45% isolates were multi-drug resistant (MDR) and extended drug resistant (XDR) M. tuberculosis respectively. High rate of anti-tubercular drug resistance was observed among the category II treatment failure TB patients.DOI: http://dx.doi.org/10.3329/imcj.v7i1.17741 Ibrahim Med. Coll. J. 2013; 7(1): 9-11

scholarly journals There is no correlation between sublineages and drug resistance ofMycobacterium tuberculosisBeijing/W lineage clinical isolates in Xinjiang, China

2014 ◽  
Vol 143 (1) ◽  
pp. 141-149 ◽  
Author(s):  
L. YUAN ◽  
Y. HUANG ◽  
L. G. MI ◽  
Y. X. LI ◽  
P. Z. LIU ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Culture Medium ◽  
Drug Susceptibility ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Drug Susceptibility Test ◽  
Study Results ◽  
Lowenstein Jensen ◽  
Proportion Method ◽  
Polymerase Chain

SUMMARYThe Beijing/W lineage strains are the major prevalent strains in China. The prevalence, mortality and drug-resistant rates of tuberculosis in Xinjiang, Northwestern China are higher than in other parts of the country. Our previous study results showed that the dominant strains ofMycobacterium tuberculosis(MTB) were ‘Beijing/W lineage’ MTB in Xinjiang; those strains had no significant correlation with drug resistance. We investigated whether the prevalence of ‘Beijing/W lineage’ sublineage strains was associated with drug resistance. We collected 478 sputum specimens from patients with pulmonary tuberculosis. Beijing/W strains and their sublineages were identified by distinguishing five specific large sequence polymorphisms, using polymerase chain reaction. All strains were subjected to a drug susceptibility test using the proportion method on Löwenstein–Jensen culture medium. In total, 379 clinical isolates of MTB were isolated and identified, 57·26% of these isolates were identified as Beijing/W strains, of which 11·06% isolates were in sublineage 105, 14·74% isolates in sublineage 207, 69·59% isolates in sublineage 181, and 4·61% isolates in sublineage 150. None of the isolates was in sublineage 142. Our data showed there were four sublineages of Beijing/W isolates in Xinjiang province, China. However, there were no correlations between drug resistance and the sublineages of Beijing/W strains.

scholarly journals Prevalence of Human Immunodeficiency Virus Infection among Tuberculosis Patients at Infectious Disease Hospital, Kano State, Nigeria

2020 ◽  
pp. 50-57
Author(s):  
Aminu A.I. ◽  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Drug Susceptibility ◽  
Resistance Pattern ◽  
Drug Resistant ◽  
Tuberculosis Patients ◽  
Drug Resistance Pattern ◽  
Immunodeficiency Virus

The epidemic of Human Immunodeficiency Virus (HIV) and the emergence of drug resistant Mycobacterium tuberculosis strains have been recognized as the most important factors contributing to increasing resurgence of tuberculosis (TB). This study was conducted to determine the prevalence of HIV among tuberculosis patients and drug sensitivity pattern of some of the mycobacterial isolates. One hundred and sixty eight (168) sputum samples from tuberculosis patients attending Infectious Diseases Hospital, Kano were collected and processed for the presence of Mycobacteria. Blood samples of the patients were also screened for the presence of HIV. The drug susceptibility test (DST) was performed using the BACTEC Mycobacteria Growth Inhibitory Test (MGIT) M960 technique. Results revealed that out of the 168 patients studied 24 (14.29%) were TB and HIV co-infected and 135 (68.88%) were males while 61 (31.12%) were females (P = 0.001). Majority of the studied cases were of the age groups 15-24 years and 25-34 years (P = 0.001). Ten (58.82%) of the 17 isolates that were subjected to DST against the first-line anti-TB drugs (isoniazid, rifampicin, ethambutol, pyrazinamide) were found to be resistant against the various drugs to which they were tested; out of which 7 (41.17%) exhibited a primary drug resistance pattern, 3 (17.65%) exhibited acquired drug resistance pattern and 2 (11.74%) were multi-drug resistant TB. The highest drug resistance of 23.53% was recorded against isoniazid, followed by rifampicin, ethambutol and pyrazinamide each with a resistance of 17.65%. The study recommends screening of all TB patients for early diagnosis of HIV co-infection as well as conducting DST which will inform prompt management of the infected individuals and designing appropriate treatment schedule for effective TB/HV control as well as preventing transmission of drug resistant TB. Key words: Tuberculosis, Human Immunodeficiency Virus, Infection, Prevalence, Drug Susceptibility.

scholarly journals Drug resistance pattern of M. tuberculosis in those who developed the disease after exposure to MDR/XDR pulmonary tuberculosis

2020 ◽  
Vol 97 (12) ◽  
pp. 57-57
Author(s):  
K. A. Glebov ◽  
V. A. Guseva ◽  
I. A. Burmistrova ◽  
O. V. Lovacheva ◽  
A. G. Samoylova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Resistance Pattern ◽  
Drug Resistance Pattern

.

scholarly journals First Line Anti-Tubercular Drug Resistance Pattern of Mycobacterium Tuberculosis Isolated From Specialized Hospitals of Dhaka City

2016 ◽  
Vol 8 (2) ◽  
pp. 41-46 ◽  
Author(s):  
Md Mohiuddin ◽  
J Ashraful Haq
Keyword(s):  
Drug Resistance ◽  
Extrapulmonary Tuberculosis ◽  
Surrogate Marker ◽  
Cross Resistance ◽  
Resistance Pattern ◽  
First Line ◽  
Drug Resistance Pattern ◽  
Mdr Tb ◽  
Lowenstein Jensen ◽  
High Level

The present study was undertaken to determine the drug resistance pattern of M. tuberculosis isolated from 225 pulmonary and 45 extrapulmonary tuberculosis cases. The samples were cultured on Lowenstein Jensen (L-J) media for isolation of M. tuberculosis. Drug resistance to first line anti tubercular drugsnamely isoniazid (INH), rifampicin (RIF), Ethambutol (ETH) and streptomycin (SM) were determined by indirect proportion method. The overall drug resistance of M. tuberculosis was 53.6% to any of the first line anti tubercular drugs. Rate of multi drug resistant tuberculosis (MDR-TB) among the untreated cases was 4.2%, while it was 36.0% in previously treated cases. It was found that 83.3% rifampicin resistant M. tuberculosis was cross resistant to one or more of other first line anti-tubercular drugs, while cross resistance of INH, ETH and SM resistant isolates was much low. The present study revealed that high level of drug resistance exists to individual anti tubercular drugs and MDR-TB is an emerging problem, particularly in treated cases. Rifampicin resistance could be used as a surrogate marker for drug resistance to other first line anti tubercular drugs.Ibrahim Med. Coll. J. 2014; 8(2): 41-46

scholarly journals Anti-tuberculosis Drug Resistance Pattern among Different Category of Tuberculosis Patients

1970 ◽  
Vol 10 (2) ◽  
pp. 45-47 ◽  
Author(s):  
Mostafizur Rahman ◽  
SM Mostafa Kamal ◽  
Fazle Rabbi Mohammed ◽  
Md Billal Alam ◽  
HAM Nazmul Ahasan
Keyword(s):  
Drug Resistance ◽  
Susceptibility Testing ◽  
Absolute Number ◽  
Drug Susceptibility ◽  
Drug Susceptibility Testing ◽  
Therapeutic Interventions ◽  
Multi Drug Resistance ◽  
Resistance Pattern ◽  
Drug Resistance Pattern ◽  
Mdr Tb

Background: Anti-Tuberculosis (TB) drug resistance is emerging as a new global health problem. No national data on drug resistance is available in Bangladesh. The absolute number of multidrug resistant TB (MDR-TB) is expected to be high considering high TB burden. This study was aimed to determine the resistance pattern of mycobacterium tuberculosis (MTB) isolates among different category of patient. Method: A total 1123 randomly selected patients having clinical and or radiological features of tuberculosis attending out patients department of NIDCH were enrolled in this study during January to December, 2008. Sputum were collected and processed for culture by digestion, decontamination and concentration following modified Petroff's method and were inoculated on to two slopes of Lowenstein- Jensen (L-J) media for six weeks. The identity of the isolates was made by growth rate, colony morphology, P-nitrobenzoic acid (PNB) susceptibility, catalase and nitrate reduction tests. Ultimately drug susceptibility testing (DST) were performed. Result: Drug susceptibility testing for Isoniazid (INH), Rifampicin (RIF), Ethambutol (EMB) and Streptomycin (SM) was done among 363 cases. Resistance rates for INH, RIF, EMB and SM were 76.03%, 71.63%, 27.55% and 55.65% respectively. According to DST report, total 221 cases were detected as multi drug resistant TB (MDR-TB). Among them, 87% cases were MDR-TB in category II (CAT - II) failure and 13% were MDR-TB in category I (CAT - I) failure and it was 0% in new cases. Conclusion: Pattern of anti TB drug resistance was identified in this study. More surveillance and immediate therapeutic interventions should be performed in order to combat the threat of MDR-TB to the general population. Keywords: Tuberculosis, Multi drug resistance, Drug susceptibility testing.   doi: 10.3329/jom.v10i2.2812 J MEDICINE 2009; 10 : 45-47

scholarly journals SURVEILLANCE OF ANTI-TUBERCULAR DRUG RESISTANCE

2003 ◽  
Vol 41 (142) ◽  
pp. 311-313
Author(s):  
G GC ◽  
Basista Rijal ◽  
A P Sharma
Keyword(s):  
Drug Resistance ◽  
Early Detection ◽  
Cause Of Death ◽  
Teaching Hospital ◽  
University Teaching ◽  
Resistance Pattern ◽  
Drug Resistant ◽  
Representative Data ◽  
Drug Resistance Pattern

Tuberculosis is the leading cause of death in Nepal. Failure in early detection anddrug resistance are two most important problems in treatment and cure of thetuberculosis. The objective of the study was to assess the drug resistance pattern inMycobacterium tuberculosis isolated in Tribhuvan University teaching Hospital. Morethan 85% of isolates were sensitive to all the four drugs and 5.5% of isolates weremultidrug resistant. The drug resistant isolates were obtained more frequently frompreviously treated patients. More extensive studies should be carried out by independentorganizations to collect more representative data on drug resistance tuberculosis.Key Words: Tuberculosis, drug resistance and surveillance.

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