Endocrine Changes Before and After the Menarche: II.Serum Levels of Growth Hormone and Alkaline Phosphatase, and Urinary Excretion of 17-Ketosteroids and 17-Hydroxycorticosteroids

1975 ◽  
Vol 54 (1) ◽  
pp. 1-8 ◽  
Author(s):  
R. L. Kantero ◽  
L. Wide ◽  
O. Widholm
Keyword(s):  
Growth Hormone ◽  
Alkaline Phosphatase ◽  
Urinary Excretion ◽  
Before And After

THE EFFECT OF DIAZEPAM ON PITUITARY FUNCTION IN MAN

1972 ◽  
Vol 52 (1) ◽  
pp. 79-85 ◽  
Author(s):  
C. W. H. HAVARD ◽  
V. F. SALDANHA ◽  
R. BIRD ◽  
R. GARDNER
Keyword(s):  
Growth Hormone ◽  
Urinary Excretion ◽  
Blood Sugar ◽  
Adrenal Function ◽  
Pituitary Function ◽  
Hormone Production ◽  
Before And After ◽  
Corticosteroid Response

SUMMARY The integrity of pituitary—adrenal function and growth hormone production was determined in 15 patients before and after treatment with diazepam (30 mg daily). There was no evidence of impairment; nor was the urinary excretion of catecholamines significantly altered. The reproducibility of the plasma corticosteroid response to insulin-induced hypoglycaemia was separately assessed and both the degree of fall in blood sugar and the rise in plasma corticosteroid level were found to be similar.

Effects of strength training on bone mineral density: hormonal and bone turnover relationships

1994 ◽  
Vol 77 (4) ◽  
pp. 1678-1684 ◽  
Author(s):  
A. S. Ryan ◽  
M. S. Treuth ◽  
M. A. Rubin ◽  
J. P. Miller ◽  
B. J. Nicklas ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Alkaline Phosphatase ◽  
Growth Factor ◽  
Strength Training ◽  
Mineral Density ◽  
Factor I ◽  
Before And After ◽  
Skeletal Alkaline Phosphatase ◽  
Markers Of Bone Formation

The effects of a 16-wk strength-training program on bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry in 21 men [age 61 +/- 1 (SE) yr]. Sixteen men (age 59 +/- 2 yr) served as control subjects. To investigate the possible hormonal relationships underlying the effects on BMD, serum concentrations of growth hormone, insulin-like growth factor I, and testosterone were determined before and after training. In addition, osteocalcin and skeletal alkaline phosphatase (markers of bone formation) and tartrate-resistant acid phosphatase (a marker of bone resorption) were measured before and after training to assess bone turnover. The training program resulted in a 2.8 +/- 0.6% increase in femoral neck BMD (1.004 +/- 0.037 vs. 1.031 +/- 0.037 g/cm2; P < 0.001). However, there were no significant changes in total body, anterioposterior spine, lateral spine, Ward's triangle, or greater trochanter BMD. Moreover, there were no significant changes in growth hormone, insulin-like growth factor I, testosterone, osteocalcin, or skeletal alkaline phosphatase. There were no changes in the control group. Thus, strength training can increase femoral neck BMD, and this effect does not appear to be accompanied by changes in anabolic hormones or markers of bone formation and resorption.

Electron microscopic study of the membrane glycoproteins in the rat kidney after cisplatin treatment

1989 ◽  
Vol 47 ◽  
pp. 912-913
Author(s):  
S.K. Aggarwal
Keyword(s):  
Alkaline Phosphatase ◽  
Rat Kidney ◽  
Light And Electron Microscopy ◽  
Kidney Tissue ◽  
Membrane Glycoproteins ◽  
Electron Microscopic ◽  
Before And After ◽  
Interstrand Cross Links ◽  
Cross Links

The proposed primary mechanism of action of the anticancer drug cisplatin (Cis-DDP) is through its interaction with DNA, mostly through DNA intrastrand cross-links or DNA interstrand cross-links. DNA repair mechanisms can circumvent this arrest thus permitting replication and transcription to proceed. Various membrane transport enzymes have also been demonstrated to be effected by cisplatin. Glycoprotein alkaline phosphatase was looked at in the proximal tubule cells before and after cisplatin both in vivo and in vitro for its inactivation or its removal from the membrane using light and electron microscopy.Outbred male Swiss Webster (Crl: (WI) BR) rats weighing 150-250g were given ip injections of cisplatin (7mg/kg). Animals were killed on day 3 and day 5. Thick slices (20-50.um) of kidney tissue from treated and untreated animals were fixed in 1% buffered glutaraldehyde and 1% formaldehyde (0.05 M cacodylate buffer, pH 7.3) for 30 min at 4°C. Alkaline phosphatase activity and carbohydrates were demonstrated according to methods described earlier.

Changes In Prothrombin And Activated Partial Thromboplastin Time During Replacement Therapy With Human Recombinant Growth Hormone In Growth Hormone Deficient Adults

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S102-S103
Author(s):  
Y S Kamel
Keyword(s):  
Growth Hormone ◽  
Replacement Therapy ◽  
Healthy Subjects ◽  
Recombinant Growth Hormone ◽  
Gh Replacement ◽  
Coagulation Tests ◽  
Before And After ◽  
Human Recombinant Growth Hormone ◽  
Male Patients ◽  
One Year

Abstract Introduction/Objective The aim of this study was to investigate the effects of GH administration on basic coagulation parameters: PT, aPTT and fibrinogen concentrations in adult GHD patients before and during one year of GH replacement. Methods Twenty-one adult patients with severe GHD (mean age +/- SE: 38.6 +/- 2.8 years) were included in this hospital based, prospective, interventional study. All patients were treated with rhGH for 12 months (GH dose: 0.4 mg/day for male and 0.6 mg/day for female patients). IGF-1 concentrations were determined using RIA-INEP kits. Basic coagulation tests, i.e. aPTT and fibrinogen concentrations, were measured before and after 3, 6 and 12 months of treatment with rhGH. Control values were obtained from fourteen “healthy” subjects matched by age, sex and body mass index (BMI). Results At baseline, we observed no significant differences in PT, aPTT and fibrinogen values between GHD and healthy subjects. IGF-1 concentrations increased significantly within 3 months of GH therapy (8.2 +/- 1.5 vs. 24.2 +/- 2.9 nmol/l, p &lt;0.05) and remained stable thereafter. A significant increase in PT values, which was more pronounced in female subjects, was noted after 6 and 12 months of treatment with GH. aPTT values increased significantly after 12 months of treatment only in male patients (28.8 +/- 4.6 vs. 39.7 +/- 2.1 s.; p &lt;0.05). No significant changes in fibrinogen concentrations were found during the study. Conclusion Twelve months of GH replacement therapy led to a significant increase in PT and aPTT values in adult GHD patients, while fibrinogen concentrations did not change. Changes in PT were more pronounced in female GHD patients, while an increase in aPTT values was observed only in male patients with GHD. The clinical significance of these changes needs further evaluation.

Evaluation of attention before and after 2 years of growth hormone treatment in intrauterine growth retarded children

1997 ◽  
Vol 19 (1) ◽  
pp. 101-118 ◽  
Author(s):  
I.E.A. van der Reijden-Lakeman ◽  
Leo M.J. de Sonneville ◽  
Hanna J.T. Swaab-barneveld ◽  
Froukje M.E. Slijper ◽  
Frank C. Verhulst
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Intrauterine Growth ◽  
Before And After

Reduced Serum Somatomedin Activity in Patients with Chronic Liver Disease

1974 ◽  
Vol 47 (4) ◽  
pp. 359-366 ◽  
Author(s):  
A. Wu ◽  
D. B. Grant ◽  
Judy Hambley ◽  
A. J. Levi
Keyword(s):  
Growth Hormone ◽  
Alkaline Phosphatase ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Severe Disease ◽  
Chronic Liver ◽  
Hormone Deficiency ◽  
Factor Activity ◽  
Important Site ◽  
Low Serum

1. Somatomedin (SM; sulphation factor) activity was estimated by a chick-cartilage assay in fasting sera from twenty-one patients with chronic liver disease. 2. Low SM values were found in nine out of the ten patients with cirrhosis and in two other patients, one with hepatofibrosis and one with hepatoma. 3. In general, the lowest serum SM activities were found in those patients with the most severe disease and significant correlations were found between serum SM and serum albumin, alkaline phosphatase and bilirubin. 4. Growth hormone was also measured in the samples and concentrations above 10 units/ml were found in seven patients, all of whom had reduced serum SM activities. 5. These findings indicate that low serum SM activity in liver disease is not related to growth hormone deficiency and suggest that the liver may be an important site for SM synthesis in man.

scholarly journals Enterotoxin Production, DNA Repair and Alkaline Phosphatase of Vibrio cholerae Before and After Animal Passage

Microbiology ◽  
1982 ◽  
Vol 128 (9) ◽  
pp. 1927-1932 ◽  
Author(s):  
N. K. Roy ◽  
G. Das ◽  
T. S. Balganesh ◽  
S. N. Dey ◽  
R. K. Ghosh ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Dna Repair ◽  
Vibrio Cholerae ◽  
Enterotoxin Production ◽  
Before And After
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