Depression in Schizophrenia: A Descriptive Study

1996 ◽  
Vol 30 (3) ◽  
pp. 354-357 ◽  
Author(s):  
Petros Markou
Keyword(s):  
Rating Scale ◽  
Depressive Symptomatology ◽  
Structured Interview ◽  
Depression Score ◽  
Outcome Variable ◽  
Outpatient Group ◽  
Significant Difference ◽  
Significant Depression ◽  
Inpatient Group ◽  
Clinically Significant

Objective: To assess the level of depressive symptomatology among a group of patients with schizophrenia, both inpatients and outpatients, and speculate as to the reasons why differences among the groups may be occurring. Method: Fifty inpatients of Baillie Henderson Hospital, a chronic stay psychiatric hospital in Queensland, and 44 outpatients of this hospital were assessed on a number of measures including the Positive and Negative Syndrome Scale for Schizophrenia, Abnormal Involuntary Movements Scale, Hamilton Rating Scale for Depression and Beck Depression Inventory. All patients were assessed in a structured interview for 35–40 minutes by the same clinician. A chart review also occurred. The chief outcome variable was a Hamilton Depression Rating Scale of 17 or greater. Results: Clinically significant depression, as defined by a Hamilton Depression score of 17 or greater, was found in 10% (n = 5) of the inpatient sample. Of the outpatient sample, 4.5% (n = 2) showed a clinically significant depression, which was not significantly different to the inpatient group. The prevalence of mild to moderate depression, as defined by a Hamilton Depression score of between 10 and 17, was 42% in the inpatient group and 47.7% in the outpatient group. There was no significant difference between the two groups on the mean Hamilton Depression scores. Conclusions: The results suggest a high level of depressive symptomatology in patients with schizophrenia. As suicide is common in this group, this finding is important. Self-reporting of this problem by patients with schizophrenia, by means of questionnaire, is feasible and provides comparable results to objective clinician ratings.

scholarly journals Ischemic stroke and depression

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 379-379
Author(s):  
David W Desmond ◽  
Robert H Remien ◽  
Joan T Moroney ◽  
Yaakov Stern ◽  
Mary Sano ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Depressed Mood ◽  
Rating Scale ◽  
Structured Interview ◽  
Stroke Patients ◽  
Control Subjects ◽  
Interview Guide ◽  
Significant Depression ◽  
History Of ◽  
Clinically Significant

P219 Objective: To investigate the frequency and clinical determinants of depression after ischemic stroke. Methods: We administered the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) and neurological, neuropsychological, and functional assessments to 421 patients (age = 71.5 ± 8.0 years) three months after ischemic stroke and 249 stroke-free control subjects. We required a SIGH-D total score > 11 for the identification of clinically significant depression. Results: We identified clinically significant depression in 47 of the 421 patients (11.2%) and 13 of the 249 control subjects (5.2%), yielding an unadjusted odds ratio (OR) of 2.3 (95% confidence interval, 1.2 to 4.3) for depression associated with stroke. Logistic regression suggested that depression was independently associated with dementia (OR, 3.2), a major hemispheral stroke syndrome (OR, 1.7), infarcts in the anterior and posterior cerebral artery territories vs. infarcts in other vascular territories (OR, 1.6), and female sex (OR, 1.7). When present, depression tended to be mild and typically remitted in follow-up examinations. Somatic SIGH-D items but not depressed mood best distinguished stroke patients from control subjects and demented from nondemented stroke patients. Conclusions: Depression was less frequent, less severe, and less persistent in our stroke cohort than previously reported, possibly due to the underrepresentation of patients with a premorbid history of affective illness. It was associated with more severe stroke, particularly in vascular territories that supply limbic structures, and it was more frequent among patients with dementia and women. Somatic symptoms but not depressed mood best distinguished stroke patients from control subjects and demented from nondemented stroke patients, however, suggesting that stroke is more likely to be associated with a “pseudo-depression of dementia” than a “pseudo-dementia of depression.”

The choice of anesthetics and the effect on the Hamilton depression rating scale in therapy resistant depression

2017 ◽  
Vol 41 (S1) ◽  
pp. S327-S328
Author(s):  
F. van Mensvoort ◽  
R. Teijeiro Permuy ◽  
C. Rijnders
Keyword(s):  
Rating Scale ◽  
Depressive Symptomatology ◽  
Shock Duration ◽  
Hamilton Depression Rating Scale ◽  
Anesthetic Drugs ◽  
Significant Difference ◽  
Before And After ◽  
Resistant Depression ◽  
Competing Interest ◽  
Therapy Resistant Depression

IntroductionThe Dutch guideline ECT does not favor any anesthetic drug during electroconvulsive therapy. Although there are differences in seizure duration which may influence the effect of ECT, ethomidate, methohexital and propofol are “equal”. The influence of switching anesthetics during ECT is unknown. The reason for switching anesthetics is insufficient improvement in depressive symptomatology which is based on clinical picture. The Hamilton is a multiple item questionnaire which can give an indication of depression and which can evaluate recovery.ObjectivesDoes the choice of anesthetics or switching anesthetics influence the effect of ECT on the Hamilton depression rating scale?AimsTo determine whether the choice of anesthetic drugs in the case of switching influences the effect on the Hamilton depression rating scale.MethodsWe collected data of patients who received ECT for therapy resistant depression over the past five years. Choice of anesthetics, eventually switch and the score on the HDRS before and after ECT were included. The data was statistical analyzed.Results50 patients received ECT during past 5 years. ECT gives an improvement on the HDRS in all cases, whether there was a switch or not. Switching from methohexital to ethomidate when shock duration is less than 21 seconds gives a significant difference in improvement on the HDRS (BI 1.288 to 13.538) compared to patients who did not switch.ConclusionsThere are no significant differences on HDRS effect between the different anesthetics. Switching from methohexital to ethomidate gives a significant improvement on HDRS compared with no switch.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Depressive symptomatology in hospitalised children

Curationis ◽  
1993 ◽  
Vol 16 (2) ◽  
Author(s):  
M. Rangaka ◽  
C. Rose ◽  
L. Richter
Keyword(s):  
Depressive Symptoms ◽  
Rating Scale ◽  
Depressive Symptomatology ◽  
Structured Interview ◽  
Self Report ◽  
Coping Responses ◽  
Black South African ◽  
Post Test ◽  
Children's Coping ◽  
Mood Scale

This study was undertaken to determine the extent and nature of depressive symptoms exhibited by black South African children during hospitalisation for orthopaedic procedures. Social factors associated with the risk for depression, in response to hospitalisation, were also examined. Pre- and post-test assessments were conducted on a sample of 30 children aged between 6 and 12 years. The assessment entailed a structured interview, together with the following psychometric instruments: A Global Mood Scale, a Depressive Symptoms Checklist, a Hospital Fears Rating Scale and a Self Report Depression Rating Scale. A large proportion of the children were rated by ward sisters as showing high levels of depressive symptomatology two weeks after admission to hospital. As expected, discrepancies were found between adult and child self-ratings of depression. The results of this study indicate that hospitalisation for orthopaedic child patients is associated with the development of depressive symptomatology. It is suggested that emphasis be placed on the development of supportive programmes and procedures aimed at maximising children's coping responses to hospitalisation, particularly for children who find themselves Isolated from their communities and families, as a result of both centralised health services and poor socio-economic conditions.

413 Inpatient Sleep Screens: Effective for Screening but Poor Follow Up

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A164-A164
Author(s):  
Upneet Chawla ◽  
Avneet Chadha ◽  
Abigail Martin ◽  
Elizabeth Culnan ◽  
Aaron Kirkpatrick ◽  
...  
Keyword(s):  
Program Effectiveness ◽  
Categorical Variables ◽  
Apnea Hypopnea Index ◽  
Chi Square ◽  
Obstructive Sleep ◽  
Outpatient Group ◽  
Significant Difference ◽  
Inpatient Group ◽  
Portable Monitors

Abstract Introduction Only 20% of adult Americans with Obstructive Sleep Apnea (OSA) are thought to have been diagnosed. Portable monitors (PM) can provide shorter time to diagnosis and treatment in at risk populations including inpatients. Data on inpatient sleep screen testing outcomes and population phenotypes are limited. We hypothesized that inpatients undergoing sleep screens via PM have higher disease severity but are less adherent to follow up. Methods We conducted a retrospective observational study comparing severity of OSA based on apnea-hypopnea index (AHI) and compliance with follow up between patients who received inpatient vs. outpatient sleep screens. There was a total of 347 patients, 18 years and older, who received a sleep screen from August 2017 to August 2018. Exclusion criteria were cancellations/no shows (13.56% inpatients vs. 13.51% outpatients) or loss of data (26.12% inpatients vs. 23.72% outpatients). For analysis, t-test and chi-square were used for continuous and categorical variables respectively. Results The patients diagnosed with severe OSA were more than double in the inpatient group vs. the outpatient group, 46.7% and 21.7% respectively. The inpatient group had a higher average AHI (30/h) compared to the outpatient group (20.3/h). 30.7% of the inpatient group were adherent with their follow up vs. 83.3% of the outpatient group. A chi-square test of independence demonstrated a significant difference between testing location and follow up (p < .001). Those in the inpatient group were significantly older (mean 60.4 years old) than the outpatient group (47.5 years old). There was no significant difference in gender between the groups. The inpatient group had significantly higher average body mass index (39.9 kg/m2) when compared to the outpatient group (34.3 kg/m2). Conclusion Hospitalized patients screened for OSA with portable monitors are significantly more likely to have severe disease when compared to outpatients. Despite this, adherence to follow up is poor. Systematic evaluation of inpatient OSA screening program effectiveness and factors impacting adherence to follow up and treatment are needed. Support (if any):

scholarly journals A multicenter randomized controlled trial to compare a self-ligating bracket with a conventional bracket in a UK population: Part 2: Pain perception

2015 ◽  
Vol 86 (1) ◽  
pp. 149-156 ◽  
Author(s):  
Shahla Rahman ◽  
R. James Spencer ◽  
Simon J. Littlewood ◽  
Lian O'Dywer ◽  
Sophy K. Barber ◽  
...  
Keyword(s):  
Pain Perception ◽  
Soft Tissues ◽  
Rating Scale ◽  
Controlled Trial ◽  
Controlled Clinical Trial ◽  
Pain Experience ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Multicenter Randomized Controlled Trial ◽  
Clinically Significant

ABSTRACT Objective:  To compare pain experience between self-ligating and conventional preadjusted edgewise appliance systems with a two-arm parallel trial. Materials and Methods:  A prospective multicenter randomized controlled clinical trial was conducted in three hospital orthodontic departments. Subjects were randomly allocated to receive treatment with either a self-ligating (3M SmartClip™) or conventional (3M Victory™) bracket system with stratification for operator and center. Standardized protocol was followed for bracket bonding procedure and archwire sequence. Subject pain was recorded using a Verbal Rating Scale to assess discomfort felt on the teeth and soft tissues at the time of the appointment and 1, 3, and 5 days after each archwire change up to the working archwire. Multilevel modeling was used to analyze the data by blinded assessors. Results:  One hundred thirty-eight subjects (mean age 14 years 11 months) were enrolled in the study, of which 135 subjects (97.8%) completed the study and 113 (82%) returned the required data regarding pain/discomfort. Perceived pain was statistically higher with the SmartClip™ system compared to the Victory™ system, but this difference was not deemed to be clinically significant. Discomfort was greatest after placement of the initial 0.014-inch nickel-titanium archwire, compared with subsequent wires, and was greatest on day 1, less on day 3, and much less on day 5 after each archwire change. Age and gender did not affect the level of discomfort experienced by subjects undergoing fixed appliance treatment. Conclusion:  No clinically significant difference in pain experience was found between patients treated with a self-ligating bracket system compared to those treated with a conventional ligation system.

Depression in Persons With Dementia

1996 ◽  
Vol 8 (4) ◽  
pp. 609-622 ◽  
Author(s):  
Henry Brodaty ◽  
Georgina Luscombe
Keyword(s):  
Rating Scales ◽  
Rating Scale ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Geriatric Depression ◽  
Prevalence Of Depression ◽  
Significant Depression ◽  
Dsm Iv ◽  
Clinically Significant

The prevalence of depression in persons with dementia is controversial. Among 288 outpatients with dementia, a prevalence of 7.4% was found according to the Hamilton Rating Scale for Depression (HRSD), 8.0% using the Geriatric Depression Scale (GDS), and 6.3% according to DSM-IV criteria. Rates and levels of depression tended to be higher in vascular than in Alzheimer's dementia according to the rating scales, but not according to the DSM-IV criteria. Greater cognitive impairment was associated with higher HRSD (but not GDS) scores. Cases of clinical depression did not persist over 12 months' follow-up. These results sugguest that clinically significant depression in dementia is less common than previously reported and tends to remit.

scholarly journals Depression, Anxiety and Quality of Life in Greek Hospital Staff: A Study in the Aftermath of the Debt Crisis Era

2021 ◽  
Vol 28 (2) ◽  
pp. 3
Author(s):  
Despoina Melemeni ◽  
Konstantinos Mantzouranis ◽  
Vasiliki Epameinondas Georgakopoulou ◽  
Kyriakos Tarantinos ◽  
Nikolaos Garmpis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Rating Scale ◽  
Debt Crisis ◽  
Hospital Staff ◽  
Mean Difference ◽  
Depression And Anxiety ◽  
Significant Depression ◽  
Clinically Significant

Background: Several studies investigated the mental health needs of hospital staff in Greece during the debt crisis era. Yet, no relevant data are available regarding the mental health of hospital staff after this period. The aims of this study are: 1) To investigate the prevalence of clinically significant depression and anxiety in healthcare workers in a general hospital in Athens, Greece; 2) to search for the association of quality of life with anxiety and depression in those workers; 3) to investigate the association of sociodemographic characteristics with those parameters.Methods: The Zung Depression Rating Scale, the Zung Anxiety Rating Scale, the Short-Form Survey-12, assessing quality of life, and sociodemographic assessments were administrated in 110 workers of a public hospital in Athens, Greece. The assessments were completed during January, 2020.Results: Of the study participants, 38.2% had clinically significant anxiety and 6.4% had clinically significant depression. Males had lower scores of depression compared to females (p=0.003). As for the effects of educational level, differences were noted in psychological quality of life between secondary education participants when compared to tertiary education (Mean Difference -3.527, p=0.021), post-graduate (Mean Difference -3.937, p=0.012) and PhD participants (Mean Difference -5.100, p=0.007). Quality of life and its psychological and physical health subscales had strong inverse associations with depression and anxiety (p=0.000).Conclusions: Relevant interventions are necessary to decrease anxiety in hospital staff, which is elevated in the aftermath of the debt crisis period. In addition, health policy makers have to reduce the gender gap in mental health between male and female workers, since the latter had higher levels of depression.

scholarly journals A fixed-dose randomized controlled trial of olanzapine for psychosis in Parkinson disease

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 150 ◽  
Author(s):  
Michelle J Nichols ◽  
Johanna M Hartlein ◽  
Meredith GA Eicken ◽  
Brad A Racette ◽  
Kevin J Black
Keyword(s):  
Parkinson Disease ◽  
Repeated Measures ◽  
Rating Scale ◽  
Controlled Trial ◽  
Depression Score ◽  
Fixed Dose ◽  
Drug Induced ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Significant Difference

Background: Psychosis is a common and debilitating side effect of long-term dopaminergic treatment of Parkinson disease (PD). While clozapine is an effective treatment, the need for blood monitoring has limited its first-line use. Objective: Since olanzapine shows similar receptor affinity to clozapine, we hypothesized that it might be an effective alternative to clozapine for treatment of drug-induced psychosis (DIP) in PD, and that lower doses than usual might make it tolerable.Methods: In 1998-2003 we conducted a four-week, double-blind, placebo-controlled, parallel group, fixed-dose trial of olanzapine (0, 2.5mg, or 5mg) in 23 PD patients with DIP while allowing for clinically realistic dose adjustments of dopaminomimetic mid-study. The primary outcome measures were Brief Psychiatric Rating Scale (BPRS) ratings scored from videotaped interviews after study termination by an observer blinded to dose assignment and to interview timing, and CGI (Clinical Global Impression). The Unified Parkinson’s Disease Rating Scale motor subscale (UPDRS) was the primary measure of tolerability.Results: Intention-to-treat analysis found no significant differences among treatment groups in study completion or serious adverse events. However, a disproportionate number of olanzapine vs. placebo subjects reported mild side effects (p<0.04), many citing motor worsening. Fourteen patients completed the study (seven on placebo, two on 2.5mg olanzapine, five on 5mg olanzapine). In study completers, analysis by repeated measures ANOVA revealed no significant difference between olanzapine and placebo groups in BPRS psychosis reduction (p=0.536), parkinsonism (p=0.608), or any other measured parameters (CGI, MMSE, Beck Depression Inventory, Hamilton Depression score, PDQ‑39, Schwab-England ADL assessment, and sleep scores).Conclusion: This study adds to other evidence that olanzapine is ineffective in treating medication-induced psychosis in Parkinson disease.

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