Differences in acute metabolism of fructose between hemodialysis patients and healthy subjects

2013 ◽  
Vol 73 (2) ◽  
pp. 154-160 ◽  
Author(s):  
Björn Anderstam ◽  
Ann-Christin Bragfors-Helin ◽  
Jonas Axelsson ◽  
Abdul R. Qureshi ◽  
Rolf Wibom ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Hemodialysis Patients

scholarly journals The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients

2021 ◽  
Vol 18 (12) ◽  
pp. 6282
Author(s):  
Magda Wiśniewska ◽  
Natalia Serwin ◽  
Violetta Dziedziejko ◽  
Małgorzata Marchelek-Myśliwiec ◽  
Barbara Dołęgowska ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Plasma Concentrations ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Pressure Regulation ◽  
Serum Concentrations ◽  
Monoamine Oxidase Activity ◽  
Normal Kidney ◽  
Bilateral Nephrectomy ◽  
Arterial Blood

Background/Aims: Renalase is an enzyme with monoamine oxidase activity that metabolizes catecholamines; therefore, it has a significant influence on arterial blood pressure regulation and the development of cardiovascular diseases. Renalase is mainly produced in the kidneys. Nephrectomy and hemodialysis (HD) may alter the production and metabolism of renalase. The aim of this study was to examine the effect of bilateral nephrectomy on renalase levels in the serum and erythrocytes of hemodialysis patients. Methods: This study included 27 hemodialysis patients post-bilateral nephrectomy, 46 hemodialysis patients without nephrectomy but with chronic kidney disease and anuria and 30 healthy subjects with normal kidney function. Renalase levels in the serum and erythrocytes were measured using an ELISA kit. Results: Serum concentrations of renalase were significantly higher in post-bilateral nephrectomy patients when compared with those of control subjects (101.1 ± 65.5 vs. 19.6 ± 5.0; p < 0.01). Additionally, renalase concentrations, calculated per gram of hemoglobin, were significantly higher in patients after bilateral nephrectomy in comparison with those of healthy subjects (994.9 ± 345.5 vs. 697.6 ± 273.4, p = 0.015). There were no statistically significant differences in plasma concentrations of noradrenaline or adrenaline. In contrast, the concentration of dopamine was significantly lower in post-nephrectomy patients when compared with those of healthy subjects (116.8 ± 147.7 vs. 440.9 ± 343.2, p < 0.01). Conclusions: Increased serum levels of renalase in post-bilateral nephrectomy hemodialysis patients are likely related to production in extra-renal organs as a result of changes in the cardiovascular system and hypertension.

Comparability of Insulin Binding to Erythrocytes and Monocytes from Hemodialysis Patients and Healthy Subjects

1981 ◽  
Vol 1 (1) ◽  
pp. 41-44 ◽  
Author(s):  
William A. Briggs ◽  
Kenneth S. Wielechowski ◽  
Sudesh K. Mahajan ◽  
Franklin D. McDonald
Keyword(s):  
Healthy Subjects ◽  
Insulin Binding ◽  
Hemodialysis Patients

scholarly journals Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects

2006 ◽  
Vol 84 (1) ◽  
pp. 252-262 ◽  
Author(s):  
Patricia Castilla ◽  
Rocío Echarri ◽  
Alberto Dávalos ◽  
Francisca Cerrato ◽  
Henar Ortega ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Grape Juice ◽  
Hemodialysis Patients ◽  
Red Grape Juice ◽  
Red Grape ◽  
Antiinflammatory Effects

The ionized fraction of serum total magnesium in hemodialysis patients: is it really lower than in healthy subjects?

2002 ◽  
Vol 58 (09) ◽  
pp. 205-210 ◽  
Author(s):  
K. Dewitte ◽  
A. Dhondt ◽  
N. Lameire ◽  
D. Stöckl ◽  
L.M. Thienpont
Keyword(s):  
Healthy Subjects ◽  
Hemodialysis Patients ◽  
Total Magnesium

scholarly journals Serum concentrations of free ubiquitin and multiubiquitin chains

1997 ◽  
Vol 43 (7) ◽  
pp. 1188-1195 ◽  
Author(s):  
Koji Takada ◽  
Hidekazu Nasu ◽  
Nozomu Hibi ◽  
Yutaka Tsukada ◽  
Toshiaki Shibasaki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Healthy Subjects ◽  
Prognostic Value ◽  
Room Temperature ◽  
Acute Viral Hepatitis ◽  
Recovery Phase ◽  
Hemodialysis Patients ◽  
Cellular Proteins ◽  
Serum Concentrations ◽  
Free Ubiquitin

Abstract Ubiquitin, which can conjugate with cellular proteins, is classified into two forms: free ubiquitin and multiubiquitin chains. The latter is active as a signal for degradation of the targeted proteins. We found both forms in human serum and, using two immunoassays, quantitated them in sera from healthy subjects and patients with some diseases. Because of putative leakage of erythrocyte ubiquitin, hemolytic serum and serum obtained after long incubation (&gt;1–2 h) of blood at room temperature were excluded. Serum concentrations of multiubiquitin chains and free ubiquitin were substantially higher in rheumatoid arthritis and hemodialysis patients, respectively, than healthy subjects. Additionally, in acute viral hepatitis, serum multiubiquitin chain concentrations were increased in the acute phase, decreased in the recovery phase, and correlated with alanine and aspartate aminotransferase activities (r = 0.676 and 0.610, P &lt;0.0001 and &lt;0.001, respectively). Therefore, serum ubiquitin may have prognostic value.

Cold Stress Provokes Sympathoinhibitory Presyncope in Healthy Subjects and Hemodialysis Patients With Low Cardiac Output

Circulation ◽  
1997 ◽  
Vol 95 (9) ◽  
pp. 2271-2276 ◽  
Author(s):  
G. Ligtenberg ◽  
P. J. Blankestijn ◽  
P. L. Oey ◽  
G. H. Wieneke ◽  
A. C. van Huffelen ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Cold Stress ◽  
Healthy Subjects ◽  
Hemodialysis Patients ◽  
Low Cardiac Output

Determinants of Resting Energy Expenditure in Hemodialysis Patients, and Comparison With Healthy Subjects

2009 ◽  
Vol 19 (4) ◽  
pp. 283-290 ◽  
Author(s):  
Maria Skouroliakou ◽  
Maria Stathopoulou ◽  
Aikaterini Koulouri ◽  
Ifigenia Giannopoulou ◽  
Dimitrios Stamatiades ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Healthy Subjects ◽  
Resting Energy Expenditure ◽  
Hemodialysis Patients ◽  
Resting Energy

scholarly journals Serum Testosterone Levels Are Not Modified by Vitamin D Supplementation in Dialysis Patients and Healthy Subjects

Nephron ◽  
2021 ◽  
pp. 1-5
Author(s):  
Christof Ulrich ◽  
Bogusz Trojanowicz ◽  
Roman Fiedler ◽  
Frank Bernhard Kraus ◽  
Gabriele I. Stangl ◽  
...  
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Healthy Subjects ◽  
Serum Testosterone ◽  
Hemodialysis Patients ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Healthy Individuals ◽  
Dialysis Patients ◽  
Testosterone Levels

<b><i>Introduction:</i></b> Low serum testosterone is related to increased mortality in male dialysis patients. An association of vitamin D status with serum androgen levels with concordant seasonal variation has been described, but it is undecided whether vitamin D supplementation improves testosterone levels. <b><i>Methods:</i></b> In a randomized, placebo-controlled, and double-blind manner, we investigated the effects of an oral vitamin D supplementation in healthy subjects and hemodialysis patients on testosterone levels. One hundred three healthy individuals received cholecalciferol 800 IE/day (<i>n</i> = 52) or placebo (<i>n</i> = 51) for 12 weeks. Thirty-three hemodialysis patients received cholecalciferol adapted to their serum levels following current guidelines (<i>n</i> = 15) or placebo (<i>n</i> = 18) for 12 weeks. <b><i>Results:</i></b> In healthy individuals, 25(OH)D3 levels rose significantly in the verum group (38.1 ± 13.7 vs. 72.5 ± 15.4 nmol/L, <i>p</i> &#x3c; 0.001), whereas in the placebo group, levels dropped (37.7 ± 14.7 vs. 31.9 ± 13.1, <i>p</i> &#x3c; 0.001). Testosterone levels did not change significantly (verum, males: 20.9 ± 6.6 vs. 20.5 ± 7.9 nmol/L, <i>p</i> = 0.6; verum, females: 0.9 ± 0.5 vs. 0.92 ± 0.5, <i>p</i> = 0.4; placebo, males: 18.5 ± 10.2 vs. 21.8 ± 16.5, <i>p</i> = 0.07, placebo, females: 1.6 ± 4.2 vs. 1.6 ± 4.9, <i>p</i> = 0.6). In dialysis patients, the mean cholecalciferol level was only 32.3 ± 17.8 nmol/L, with only 2% of the values being within the normal range. Cholecalciferol levels normalized in the verum group (29.4 ± 11.2 vs. 87.8 ± 22.3, <i>p</i> &#x3c; 0.001), whereas levels dropped further in the placebo group (33.6 ± 16.6 vs. 24.6 ± 8.0 nmol/L, <i>p</i> &#x3c; 0.001). Testosterone levels did not change significantly (verum, males: 8.0 ± 3.7 vs. 7.8 ± 3.8, <i>p</i> = 0.8; verum, females: 1.3 ± 1.0 vs. 1.2 ± 1.0 nmol/L, <i>p</i> = 0.5; placebo, males: 11.9 ± 5.0 vs. 11.6 ± 4.0 nmol/L, <i>p</i> = 0.6; placebo, females: 0.8 ± 0.5 vs. 0.7 ± 0.4 nmol/L, <i>p</i> = 0.8). <b><i>Conclusion:</i></b> Serum testosterone levels in hemodialysis patients and healthy individuals are independent from vitamin D status and cannot be significantly increased by cholecalciferol supplementation.

scholarly journals Zinc Burden Evokes Copper Deficiency in the Hypoalbuminemic Hemodialysis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 577 ◽  
Author(s):  
Keizo Nishime ◽  
Morihiro Kondo ◽  
Kazuhiro Saito ◽  
Hisashi Miyawaki ◽  
Takahiko Nakagawa
Keyword(s):  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Acetate ◽  
Healthy Subjects ◽  
Copper Deficiency ◽  
Zinc Concentration ◽  
Zinc Level ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Upper Limit

Background: Recent research has focused on the roles of trace minerals such as zinc and copper. In 2017, oral zinc acetate was approved to treat zinc deficiency, and the next year, the Japanese Society for Clinical Nutrition developed the guidelines for diagnosis and treatment for zinc deficiency. Accordingly, hemodialysis patients began receiving zinc acetate when zinc deficiency was diagnosed. However, studies regarding the values of zinc and copper in hemodialysis patients are extremely poor, thus it remains unclear if the guidelines for healthy subjects can be applied to hemodialysis patients. Methods: We conducted a descriptive study, in which 132 patients were subjected to simply examine serum zinc concentration and its association with copper levels in hemodialysis patients (N = 65) versus healthy individuals attending a routine check-up (control group; N = 67) in our hospital. Analyses were performed with BellCurve for Excel (Social Survey Research Information Co., Ltd. Tokyo, Japan). Results: The distribution of zinc level in the hemodialysis group was distinct from that in the control group (P < 0.001). The zinc level was correlated with serum albumin concentration. Zinc concentration was also negatively correlated with serum copper level in both groups. In the hemodialysis group, the upper limit of zinc to avoid copper deficiency was 109.7 μg/dL, and the safety upper limit was 78.3 μg/dL. Conclusions: Hemodialysis patients exhibited a lower level of zinc concentration compared to normal healthy subjects. Since albumin binds to zinc as a carrier, low zinc levels could be attributed to lower level of serum albumin. Importantly, zinc and copper levels were inversely correlated, thus administration of oral zinc acetate could increase a risk for copper deficiency. It might be better to check both zinc and copper values monthly after prescribing zinc acetate.

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