Long-Term Oral Ciprofloxacin in the Treatment of Prosthetic Valve Endocarditis due to Pseudomonas Aeruginosa

Abstract In nonoperated prosthetic valve endocarditis (PVE), long-term outcome is largely unknown. We report the follow-up of 129 nonoperated patients with PVE alive at discharge. At 1 year, the mortality rate was 24%; relapses and reinfection were rare (5% each). Enterococcal PVE was associated with a higher risk of relapse.

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Composite Aortic Root Replacement for Complex Prosthetic Valve Endocarditis: Initial Clinical Results and Long-Term Follow-Up of High-Risk Patients

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2012.06.027 ◽

2012 ◽

Vol 94 (6) ◽

pp. 1967-1974 ◽

Cited By ~ 12

Author(s):

Manuel Wilbring ◽

Sems Malte Tugtekin ◽

Konstantin Alexiou ◽

Klaus Matschke ◽

Utz Kappert

Keyword(s):

High Risk ◽

Aortic Root ◽

Prosthetic Valve ◽

Prosthetic Valve Endocarditis ◽

Clinical Results ◽

Aortic Root Replacement ◽

Long Term Follow Up ◽

Risk Patients

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Active Infective Native and Prosthetic Valve Endocarditis: Short- and Long-Term Outcomes of Patients after Surgical Treatment

Journal of Clinical Medicine ◽

10.3390/jcm10091868 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1868

Author(s):

Mohamed Salem ◽

Christine Friedrich ◽

Mohammed Saad ◽

Derk Frank ◽

Mostafa Salem ◽

...

Keyword(s):

Surgical Treatment ◽

Prosthetic Valve ◽

Pacemaker Implantation ◽

Prosthetic Valve Endocarditis ◽

Neurological Deficits ◽

Preoperative Embolization ◽

Duration Of Surgery ◽

Cerebral Embolization ◽

Short And Long Term

Background: Active infective endocarditis (IE) is a serious disease associated with high mortality. The current study represents our experience over 18 years with surgical treatment for active infective native and prosthetic valve endocarditis (INVE, IPVE). Method: Analysis of 413 patients (171 with IPVE vs. 242 with INVE) who underwent cardiac surgery due to IE between 2002 and 2020. Results: Patients with IPVE were significantly older (64.9 ± 13.2 years vs. 58.3 ± 15.5 years; p < 0.001) with higher EuroSCORE II (21.2 (12.7; 41.8) vs. 6.9 (3.0; 17.0); p < 0.001)) and coronary heart disease (50.6% vs. 38.0%; p < 0.011). Preoperative embolization was significantly higher within INVE (35.5% vs. 16.4%; p < 0.001) with high incidence of cerebral embolization (18.6% vs. 7.6%; p = 0.001) and underwent emergency curative surgery than the IPVE group (19.6% vs. 10.6%; p < 0.001). However, patients with IPVE were significantly represented with intracardiac abscess (44.4% vs.15.7%; p < 0.001). Intraoperatively, the duration of surgery was expectedly significantly higher in the IPVE group (356 min vs. 244 min.; p = 0.001) as well as transfusion of blood (4 units (0–27) vs. 2 units (0–14); p < 0.001). Post-operatively, the incidence of bleeding was markedly higher within the IPVE group (700 mL (438; 1163) vs. 500 mL (250; 1075); p = 0.005). IPVE required significantly more permanent pacemakers (17.6% vs. 7.5%: p = 0.002). The 30-day mortality was higher in the IPVE group (24.6% vs. 13.2%; p < 0.003). Conclusion: Patients with INVE suffered from a higher incidence of cerebral embolization and neurological deficits than patients with IPVE. Surgical treatment in INVE is performed mostly as an emergency indication. However, patients with IPVE were represented commonly with intracardiac abscess, and had a higher indication of pacemaker implantation. The short- and long-term mortality rate among those patients was still high.

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Long term follow up of prosthetic valve endocarditis: what characteristics identify patients who were treated successfully with antibiotics alone?

Heart ◽

10.1136/hrt.82.6.714 ◽

1999 ◽

Vol 82 (6) ◽

pp. 714-720 ◽

Cited By ~ 55

Author(s):

K Truninger ◽

C H A. Jost ◽

B Seifert ◽

P R Vogt ◽

F Follath ◽

...

Keyword(s):

Prosthetic Valve ◽

Prosthetic Valve Endocarditis ◽

Long Term Follow Up

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Clinical Outcome and Long-Term Prognosis of Late Prosthetic Valve Endocarditis: A 20-Year Experience

Clinical Infectious Diseases ◽

10.1093/clinids/24.3.381 ◽

1997 ◽

Vol 24 (3) ◽

pp. 381-386 ◽

Cited By ~ 71

Author(s):

P. Tornos ◽

B. Almirante ◽

M. Olona ◽

G. Permanyer ◽

T. Gonzalez ◽

...

Keyword(s):

Clinical Outcome ◽

Prosthetic Valve ◽

Prosthetic Valve Endocarditis ◽

Long Term Prognosis

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Protezinio infekcinio endokardito chirurginis gydymas: hospitalinis ir atokus išgyvenimas

Lietuvos chirurgija ◽

10.15388/lietchirur.2007.3.2206 ◽

2007 ◽

Vol 5 (3) ◽

pp. 0-0

Author(s):

Palmyra Semėnienė ◽

Arimantas Grebelis ◽

Rasa Joana Čypienė ◽

Giedrė Nogienė ◽

Gintaras Turkevičius

Keyword(s):

Surgical Treatment ◽

Survival Rate ◽

Infective Endocarditis ◽

Prosthetic Valve ◽

Prosthetic Valve Endocarditis ◽

Term Survival ◽

Vilnius University ◽

Group 2 ◽

Group 1

Palmyra Semėnienė1, Arimantas Grebelis1, Rasa Joana Čypienė1, Giedrė Nogienė1, Gintaras Turkevičius21 Vilniaus universiteto ligoninės Santariškių klinikų Širdies chirurgijos centras,Santariškių g, 2, LT-08661 Vilnius2 Vilniaus universiteto ligoninės Santariškių klinikų Širdies chirurgijos centras,Santariškių g. 2, LT-08661 VilniusEl paštas: [email protected] Tikslas Darbo tikslas – išanalizuoti pacientų, operuotų dėl protezinio infekcinio endokardito (PIE), hospitalinio ir atokiojo laikotarpio rezultatus. Ligoniai ir metodai Retrospektyviai analizuoti 41 paciento, operuoto dėl PIE Vilniaus universiteto Širdies chirurgijos centre, pooperaciniai ir atokieji rezultatai. Analizuojamas laikotarpis nuo 2000 m. sausio 1 d. iki 2006 m. liepos 1 d. Vidutinis pacientų amžius 51,2 ± 10,1 metų. Pirma grupė – 20 pacientų – anksčiau sirgę infekciniu endokarditu (IE), antra grupė – 21 pacientas – anksčiau operuoti dėl reumatinės, įgimtos ar kitos etiologijos širdies vožtuvų patologijos. Rezultatai Hospitaliniu laikotarpiu mirė 10 pacientų (26,8%). Pirmos grupės hospitalinis mirštamumas buvo 25,0%, antros grupės – 28,6%. Hospitalinis pirmos grupės pacientų išgyvenimas buvo 75,0%, o antros – 71,4%. Praėjus 5 metams po operacijos pirmos grupės pacientų išgyvenimas buvo 59,9%, o antros – 53,5%, p > 0,005. Išvada Pacientų, operuotų dėl PIE, hospitalinis mirštamumas tebėra didelis. Nepastebėta, kad pacientų, anksčiau operuotų dėl infekcinio endokardito, pooperacinis ir atokus išgyvenimas po reoperacijos dėl PIE reikšmingai skirtųsi nuo nesirgusiųjų infekciniu endokarditu išgyvenimo. Pagrindiniai žodžiai: infekcinis endokarditas, protezinis infekcinis endokarditas Surgical treatment of prosthetic valve endocarditis: early and long-term outcome Palmyra Semėnienė1, Arimantas Grebelis1, Rasa Joana Čypienė1, Giedrė Nogienė1, Gintaras Turkevičius21 Vilnius University Cardial Surgery Centre, Santariškių str. 2, LT-08661 Vinius, Lithuania2 Vilnius University Hospital „Santariškių klinikos“, Cardial Surgery Centre,Santariškių str. 2, LT-08661 Vinius, LithuaniaE-mail: [email protected] Objective The objective of the present study was to examine in-hospital and long-term outcomes after surgical treatment of prosthetic valve endocarditis (PVE) between 1 January 2000 and 1 July 2006. Patients and methods Group 1 comprised 20 patients with previous infective endocarditis (IE) and group 2 – 21 patients without previous IE. The mean age was 51.2 ± 10.1 years. Results Ten patients (26.8%) died within 30 days post operation for PVE. In-hospital mortality of group 1 patients was 25% and of group 2 – 28.6%. The five-year survival rate is 59.9% (gr. 1) and 53.5% (gr. 2), p > 0.005. Conclusions Operation for PVE carries a high 30-day mortality and a reduced long-term survival. There was no evidence that previous infective endocarditis had an impact on survival rate in patients operated on for PVE. Key words: infective endocarditis, prosthetic valve endocarditis

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