Some Effects of Treatment with Ethinyl Oestradiol with or Without Polyoestradiol Phosphate in Patients with Prostatic Carcinoma

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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Neuroendocrine Differentiation in Prostatic Carcinoma

Scandinavian Journal of Urology and Nephrology ◽

10.1080/03008880310006922 ◽

2003 ◽

Vol 37 (0) ◽

pp. 28-36 ◽

Cited By ~ 32

Author(s):

Jens Hansson ◽

Per-Anders Abrahamsson

Keyword(s):

Prostatic Carcinoma ◽

Neuroendocrine Differentiation

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The Effects of Therapy with Oestriol Succinate and Ethinyl Oestradiol on the Haemostatic Mechanism in Post-Menopausal Women

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647935 ◽

1976 ◽

Vol 35 (02) ◽

pp. 403-414 ◽

Cited By ~ 19

Author(s):

Terence Davies ◽

Gillian Fieldhouse ◽

George P. McNicol

Keyword(s):

Coagulation Factors ◽

Factor Vii ◽

Oestrogen Therapy ◽

Qualitative And Quantitative ◽

Lysis Activity ◽

Menopausal Women ◽

Increased Sensitivity ◽

Post Menopausal ◽

Incremental Increase ◽

Ethinyl Oestradiol

SummaryThe effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 μg/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.

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ÉTUDES IN VIVO SUR LE MÉTABOLISME DES ANDROGÉNES APRES ADMINISTRATION DE STÉROÏDES INHIBITEURS DE L'OVULATION

Acta Endocrinologica ◽

10.1530/acta.0.0500131 ◽

1965 ◽

Vol 50 (1) ◽

pp. 131-144 ◽

Cited By ~ 1

Author(s):

P. Mauvais-Jarvis ◽

M. F. Jayle ◽

J. Decourt ◽

J. Louchart ◽

J. Truffert

Keyword(s):

Luteinizing Hormone ◽

Urinary Excretion ◽

Normal Subjects ◽

Hormone Activity ◽

Testosterone Production ◽

Normal Men ◽

Ethinyl Oestradiol

ABSTRACT Normal subjects and hirsute women with micropolycystic ovaries were treated with ethinyl-oestrenol + 3-methoxy-ethinyl-oestradiol (Lyndiol®), in view of studying the action of this compound on the production of androgens and on the urinary excretion of their metabolites. In normal men, the production of testosterone and the excretion of androsterone and aetiocholanolone are suppressed, whereas the excretion of other 17-ketosteroids and the production of dehydroepiandrosterone sulphate are unchanged. Moreover, the luteinizing hormone activity (LH) in plasma is depressed. It seems that the preparation inhibits specifically the testicular androgen production, by suppressing the hypothalamo-hypophyseal control of LH. Testosterone production and urinary 17-ketosteroid excretion are modified in the same way in women with Stein-Leventhal's syndrome. Physiopathological and therapeutical implications which come from these results are discussed.

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