Long-Term Topical Antiglaucoma Medications Cause Enhanced Tenon’s Capsule Fibroblast Proliferation and Abnormal TGF-β and MMP Expressions: Potential Effects on Glaucoma Filtering Surgery

2011 ◽  
Vol 36 (4) ◽  
pp. 301-309 ◽  
Author(s):  
Fei Leng ◽  
Ping Liu ◽  
Hulun Li ◽  
Jiaying Zhang
Keyword(s):  
Filtering Surgery ◽  
Fibroblast Proliferation ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

Limbal conjunctival approaches to extraocular muscles in the surgical treatment of previously operated strabismus

2021 ◽  
pp. 27-32
Author(s):  
V.N. Kurochkin ◽  
◽  
Y.I. Trilyudina ◽  
Keyword(s):  
Surgical Treatment ◽  
Strabismus Surgery ◽  
Main Group ◽  
Cosmetic Result ◽  
Control Group ◽  
Good Cosmetic Result ◽  
Tenon’S Capsule ◽  
Good Cosmetic ◽  
Tenon's Capsule

Purpose. Тo analyze clinical efficacy of the surgical treatment of previously operated strabismus using limbal incisions which are lengthening the conjunctiva and Tenon's capsule. Material and methods. The study included 440 patients (440 eyes) with previously operated strabismus at the age of 4 to 68 years old. The main group included 240 patients (240 eyes) who underwent strabismus surgery by limbal approach; the control group included 200 patients (200 eyes) who underwent surgery by paralimbal conjunctival approach. Horizontal strabismus occurred in 146 patients (60,8%) in the main group and in 158 (79%) in the control group. Horizontal strabismus in combination with vertical strabismus was found in 94 patients (39.2%) in the main group and in 42 patients (21%) in the control group respectively. The following approaches were applied: Y-shaped limbal approach, T-shaped incision of the conjunctiva, lower limbal peritomy, circular limbal approach with an additional horizontal incision towards the muscle being strengthened. Results. Good cosmetic result in the main group was achieved in 94.7% of cases, in the control group in 87% of cases, р<0.001. Re-surgery in the long term period was required for 39 patients (19.5%) in the control group and 14 patients (7%) in the main group, р<0.001. Conclusion. Limbal approaches performed to lengthening the conjunctiva and Tenon's capsule on the side of the weakened muscle and shortening on the side of the muscle being strengthened, are enhancing the effect of recession and resection, thereby contributing to the achievement of the state of orthotropy in 83% and have a good cosmetic result in 94.67% of cases. Key words: limbal conjunctival approaches, limbal conjunctival incisions, strabismus, children.

Effect of Cytokines on Regulation of the Production of Transforming Growth Factor Beta-1 in Cultured Human Tenon's Capsule Fibroblasts

2000 ◽  
Vol 10 (2) ◽  
pp. 110-115 ◽  
Author(s):  
P.O. Denk ◽  
S. Roth-Eichhorn ◽  
A.M. Gressner ◽  
M. Knorr
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Conditioned Media ◽  
Filtering Surgery ◽  
Potent Inducer ◽  
Tenon’S Capsule ◽  
Tenon's Capsule ◽  
Tgf Β1

Purpose Transforming growth factor-β1 (TGF-β1) is thought to play a pivotal role in the regulation of the wound healing process after glaucoma filtering surgery. The aim of the present study was to investigate whether platelet-derived growth factor isoforms (PDGF-AA, PDGF-BB), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), in-terleukin-1β (IL-1β) and transforming growth factor-β1 (TGF-β1) modulate the production of latent and/or active TGF-β1 by cultured human Tenon's capsule fibroblasts (HTF). Methods Human Tenon's capsule fibroblasts were seeded at two different densities (30 cells/mm2 and 150 cells/mm2) and stimulated for five days with PDGF-AA, PDGF-BB, bFGF, EGF, IL-1β and TGF-β1. Control cells were treated with serum-free medium (WM/F12). The concentrations of latent and active TGF-β1 in the medium were determined using an immunoassay before and after activation of TGF-β1 by transient acidification. Results The concentration of latent TGF-β1 in conditioned media from HTF seeded at high density (150 cells/mm2) significantly increased after stimulation with 5 ng/ml TGF-β1 (151.5 ± 41.7 pg/ml) or 10 ng/ml IL-1β (45.7 ± 8.1 pg/ml). The concentration of active TGF-β1 in conditioned media also significantly increased after stimulation of HTF with 5 ng/ml TGF-β1 (48.4 ± 27.5 pg/ml). Conclusions The present results indicate that TGF-β1 is the most potent inducer of its own synthesis in HTF. Activation of an autocrine TGF-β1 loop may play a role in the wound healing response after glaucoma filtering surgery.

TGF-β1 Stimulates Human Tenon's Capsule Fibroblast Proliferation by miR-200b and its Targeting of p27/kip1 and RND3

2014 ◽  
Vol 55 (4) ◽  
pp. 2747 ◽  
Author(s):  
Jun Tong ◽  
Yuxuan Fu ◽  
Xinyu Xu ◽  
Shuxin Fan ◽  
Hong Sun ◽  
...  
Keyword(s):  
Fibroblast Proliferation ◽  
Tenon’S Capsule ◽  
Tenon's Capsule ◽  
P27 Kip1 ◽  
Tgf Β1

Long-term Morphologic Effects of Antiglaucoma Drugs on the Conjunctiva and Tenon's Capsule in Glaucomatous Patients

Ophthalmology ◽  
1989 ◽  
Vol 96 (3) ◽  
pp. 327-335 ◽  
Author(s):  
Mark B. Sherwood ◽  
Ian Grierson ◽  
Lynn Milgar ◽  
Roger A. Hitchings
Keyword(s):  
Tenon’S Capsule ◽  
Tenon's Capsule
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