scholarly journals Factors influencing the erosion rate and the drug release kinetics from organogels designed as matrices for oral controlled release of a hydrophobic drug

2015 ◽  
Vol 42 (6) ◽  
pp. 985-997 ◽  
Author(s):  
Sarah Regina Pereira Camelo ◽  
Sophie Franceschi ◽  
Emile Perez ◽  
Sophie Girod Fullana ◽  
Maria Inês Ré
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Erosion Rate ◽  
Release Kinetics ◽  
Hydrophobic Drug ◽  
Drug Release Kinetics ◽  
Factors Influencing

scholarly journals Controlled release kinetics from a surface modified microgel-based reservoir device

2015 ◽  
Vol 3 (12) ◽  
pp. 2516-2521 ◽  
Author(s):  
Siyuan Guo ◽  
Yongfeng Gao ◽  
Menglian Wei ◽  
Qiang Matthew Zhang ◽  
Michael J. Serpe
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Release Kinetics ◽  
Fine Tuning ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Drug Release Kinetics ◽  
Surface Modified

Deposition of Si-based layers on top of a polymer-based “drug” delivery device allows fine-tuning of “drug” release kinetics.

Optimization Study to Develop Once-a-day Controlled Release Formulation of Metoclopramide with Predictable Design Space

1970 ◽  
Vol 1 (1) ◽  
pp. 71-76
Author(s):  
Rajesh Dubey ◽  
Udaya K. Chowdary ◽  
Venkateswarlu V.
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Design Space ◽  
Release Kinetics ◽  
Release Profile ◽  
Release Formulation ◽  
Linear Effect ◽  
Controlled Release Formulation ◽  
The Difference ◽  
Face Centered

A controlled release formulation of metoclopramide was developed using a combination of hypromellose (HPMC) and hydrogenated castor oil (HCO). Developed formulations released the drug over 20 hr with release kinetics following Higuchi model. Compared to HCO, HPMC showed significantly higher influence in controlling the drug release at initial as well as later phase. The difference in the influence can be explained by the different swelling and erosion behaviour of the polymers. Effect of the polymers on release was optimized using a face-centered central composite design to generate a predictable design space. Statistical analysis of the drug release at various levels indicated a linear effect of the polymers’ levels on the drug release. The release profile of formulations containing the polymer levels at extremes of their ranges in design space was found to be similar to the predicted release profile

Drug release kinetics from biodegradable UV-transparent hollow calcium-phosphate glass fibers

2017 ◽  
Vol 191 ◽  
pp. 116-118 ◽  
Author(s):  
Edoardo Ceci-Ginistrelli ◽  
Carlotta Pontremoli ◽  
Diego Pugliese ◽  
Nadia Barbero ◽  
Nadia G. Boetti ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Phosphate Glass ◽  
Release Kinetics ◽  
Glass Fibers ◽  
Drug Release Kinetics
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