Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

2013 ◽  
Vol 90 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Kimihiko Sugaya ◽  
Tomohisa Hirobe
Keyword(s):  
Hair Follicle ◽  
Gamma Rays ◽  
Hair Cycle ◽  
Anagen Phase

scholarly journals Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

2020 ◽  
Vol 6 (30) ◽  
pp. eaba1685 ◽  
Author(s):  
Shiqi Hu ◽  
Zhenhua Li ◽  
Halle Lutz ◽  
Ke Huang ◽  
Teng Su ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Hair Cycle ◽  
Paracrine Signaling ◽  
Hair Regrowth ◽  
Study Results ◽  
Anagen Phase ◽  
Hair Follicle Cycle

The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

scholarly journals What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

2020 ◽  
Vol 10 (14) ◽  
pp. 4996
Author(s):  
Nicole Braun ◽  
Ulrike Heinrich
Keyword(s):  
Hair Follicle ◽  
Dietary Supplements ◽  
Hair Loss ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
Widespread Occurrence ◽  
Non Invasive ◽  
Anagen Phase

Hair plays a major role in perception within a society. It provides information about gender, age, health, and social status. It is therefore not surprising that those affected are exposed to great suffering due to the widespread occurrence of hair loss. As a result, the demand for new products to remedy this problem is not diminishing. Hair grows in cycles, and a hair follicle goes through several phases called the hair cycle. The active growth phase (anagen phase) lasts 2–6 years. In this state a hair follicle shows a growth of about 1 cm per month. In order to improve the existing hair status, hair should be kept in the active anagen phase as long as possible, or the transition to anagen should be stimulated. A number of reviews already describe the influence of individual active ingredients on hair growth. However, the following review describes existing studies of complex dietary supplements with their experimental weaknesses and strengths and their influence on hair loss. Also, for the determination of hair loss, it is important to use a valid method with high acceptance by the test persons. In this context, the TrichoScale® is a validated and non-invasive tool for quantifying hair loss/hair growth. Thus, it is an ideal measuring instrument to objectively quantify the effectiveness of a hair loss treatment.

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

2014 ◽  
Vol 23 (7) ◽  
pp. 486-491 ◽  
Author(s):  
Jing Jing ◽  
Xian-jie Wu ◽  
Yun-ling Li ◽  
Sui-Qing Cai ◽  
Min Zheng ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Hair Follicle Cycle ◽  
Cycle Dependence

The PD-1/PD-L1 pathway in murine hair cycle transition: a potential anagen phase regulator

2021 ◽  
Author(s):  
Lijuan Zhou ◽  
Liang Wen ◽  
Youyu Sheng ◽  
Jinghao Lu ◽  
Ruiming Hu ◽  
...  
Keyword(s):  
Hair Cycle ◽  
Anagen Phase

scholarly journals Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle

2021 ◽  
Author(s):  
Megan A. Palmer ◽  
Eleanor Smart ◽  
Iain S. Haslam
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Vital Role ◽  
Transport Proteins ◽  
Hair Follicles ◽  
Regulatory Control ◽  
Cholesterol Transport ◽  
Hair Cycle ◽  
Human Hair Follicle

AbstractCholesterol has long been suspected of influencing hair biology, with dysregulated homeostasis implicated in several disorders of hair growth and cycling. Cholesterol transport proteins play a vital role in the control of cellular cholesterol levels and compartmentalisation. This research aimed to determine the cellular localisation, transport capability and regulatory control of cholesterol transport proteins across the hair cycle. Immunofluorescence microscopy in human hair follicle sections revealed differential expression of ATP-binding cassette (ABC) transporters across the hair cycle. Cholesterol transporter expression (ABCA1, ABCG1, ABCA5 and SCARB1) reduced as hair follicles transitioned from growth to regression. Staining for free cholesterol (filipin) revealed prominent cholesterol striations within the basement membrane of the hair bulb. Liver X receptor agonism demonstrated active regulation of ABCA1 and ABCG1, but not ABCA5 or SCARB1 in human hair follicles and primary keratinocytes. These results demonstrate the capacity of human hair follicles for cholesterol transport and trafficking. Future studies examining the role of cholesterol transport across the hair cycle may shed light on the role of lipid homeostasis in human hair disorders.

A Selectable Biomarker in Hair Follicle Cycles – Cathepsins: A Preliminary Study in Murine

2021 ◽  
pp. 1-7
Author(s):  
Jingzhu Bai ◽  
Zijian Gong ◽  
Qingfang Xu ◽  
Haiyan Chen ◽  
Qiaoping Chen ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Cycle ◽  
Biological Factors ◽  
Outer Root Sheath ◽  
Physiological Processes ◽  
Intervention Measures ◽  
Root Sheath ◽  
Inner Root Sheath ◽  
Preliminary Study ◽  
Paraffin Method

<b><i>Background/Objective:</i></b> Hair cycle is regulated by many biological factors. Cathepsins are involved in various physiological processes in human skin. Here, we investigated the cathepsin expression and distribution changes in follicular growth cycles for better understanding the hair cycles and to explore new intervention measures. <b><i>Methods:</i></b> The 24 mice (C57BL/6, female, 7-week old) were selected and removed the back hair via rosin/paraffin method. At Day 8, Day 20, and Day 25, biopsy on post-plucking area was done. Immunohistochemical staining, Western blot, and Q-PCR were used to test the cathepsin B/D/L/E. <b><i>Results:</i></b> In anagen, cathepsins (B, D, L, and E) were distributed in the hair follicle matrix, inner hair root sheath, and hair. In catagen, cathepsins were mainly observed in un-apoptosis inner root sheath and outer root sheath. Expression of cathepsins B-mRNA and L-mRNA was decreased from anagen and catagen to telogen. Cathepsin D-mRNA was increased in catagen and then decreased in telogen. Cathepsin E-mRNA was decreased in catagen and slightly increased in telogen. <b><i>Conclusions:</i></b> The distribution and expression of cathepsins B, D, L, and E in hair follicle changed with hair growth process which indicated that cathepsins might act as selectable biomarkers of hair cycle in different stages.

Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation.

1993 ◽  
Vol 101 (s1) ◽  
pp. 16S-26S ◽  
Author(s):  
Robert M. Lavker ◽  
Stanley Miller ◽  
Caroline Wilson ◽  
George Cotsarelis ◽  
Zhi-Gang Wei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Hair Cycle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 105
Author(s):  
Kristelle Hughes ◽  
Raimana Ho ◽  
Stéphane Greff ◽  
Gaëtan Herbette ◽  
Edith Filaire ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Pearson Correlation ◽  
Dermal Papilla ◽  
French Polynesia ◽  
Bioactive Molecules ◽  
Molecular Networks ◽  
Bioactive Metabolites ◽  
Hair Cycle ◽  
Bidens Pilosa ◽  
Dermal Papilla Cells

The term cosmetopoeia refers to the use of plants in folks’ cosmetics. The aerial parts of Bidens pilosa L., the leaves of Calophyllum inophyllum L. and the fruits of Fagraea berteroana A.Gray ex Benth are traditionally used in French Polynesia for hair and skin care. During the hair cycle, dermal papilla cells and their interaction with epithelial cells are essential to promote hair follicle elongation. The aim of our investigations was the identification of metabolites from these three plants and chemical families responsible for their hair growth activity. A bioactivity-based molecular network was produced by mapping the correlation between features obtained from LC-MS/MS data and dermal papilla cell proliferation, using the Pearson correlation coefficient. The analyses pointed out glycosylated flavonols and phenolic acids from B. pilosa and C. inophyllum, along with C-flavonoids, iridoids and secoiridoids from F. berteroana, as potential bioactive molecules involved in the proliferation of hair follicle dermal papilla cells. Our results highlight the metabolites of the plant species potentially involved in the induction of hair follicle growth and support the traditional uses of these plants in hair care.

The effect of plucking hairs during different phases of the follicular cycle

Development ◽  
1964 ◽  
Vol 12 (3) ◽  
pp. 465-474
Author(s):  
Elizabeth Johnson ◽  
F. J. Ebling
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
The Dead

Hair growth is intermittent; periods of activity when the follicle is producing the hair alternating with periods of rest when the dead hair is retained. In the rat, hair growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958). It has long been known (Collins, 1918; David, 1934) that if hairs are pulled out of resting follicles activity is induced. To explain this phenomenon, Chase (1955) put forward the view that an inhibitor accumulates in the hair follicle during active growth and is dissipated during the resting stage. Plucking during the resting stage removes this inhibitor along with the club hair, so that activity recommences. Preliminary observations on rats with plucked follicles indicated that the response to plucking varied at different stages of the hair cycle. A detailed study seemed desirable, therefore, in order to test more closely than hitherto the validity of the inhibitor hypothesis.

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